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47P Correlation of clinical, genetic and transcriptomic traits with PD-L1 positivity in TNBC patients TNBC患者PD-L1阳性与临床、遗传和转录组学特征的相关性
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.101007
A. Semertzidou , S. Hassanieh , E.M. Wigmore , O. Arqués , Z. Lai , A.E. Storti , M. Heininen-Brown , S. Willis , B. Nuttall , M. Scaltriti , R. Stewart , E. De Bruin , H. Angell
{"title":"47P Correlation of clinical, genetic and transcriptomic traits with PD-L1 positivity in TNBC patients","authors":"A. Semertzidou , S. Hassanieh , E.M. Wigmore , O. Arqués , Z. Lai , A.E. Storti , M. Heininen-Brown , S. Willis , B. Nuttall , M. Scaltriti , R. Stewart , E. De Bruin , H. Angell","doi":"10.1016/j.iotech.2024.101007","DOIUrl":"10.1016/j.iotech.2024.101007","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 101007"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143135182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
11P Tumor-infiltrating lymphocytes on routine H&E staining with automated quantification predict outcomes in resectable non-small cell lung cancer 11P肿瘤浸润淋巴细胞常规H&E染色自动定量预测可切除非小细胞肺癌的预后
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100894
G. van den Heuvel , F. Ciompi , M. van den Heuvel , J. Spronck , S. Vos , L.V. Eekelen , E. Aarntzen , I. Walraven
{"title":"11P Tumor-infiltrating lymphocytes on routine H&E staining with automated quantification predict outcomes in resectable non-small cell lung cancer","authors":"G. van den Heuvel , F. Ciompi , M. van den Heuvel , J. Spronck , S. Vos , L.V. Eekelen , E. Aarntzen , I. Walraven","doi":"10.1016/j.iotech.2024.100894","DOIUrl":"10.1016/j.iotech.2024.100894","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100894"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143175729","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
15P Verteporfin might potentiate the effects of anti-PD-1 therapy in melanoma-bearing mice model 15P维替波芬可能增强黑色素瘤小鼠模型抗pd -1治疗的作用
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100898
S.A. Kovács , T. Kovács , A. Lánczky , Á. Paál , Z. Hegedus , A. Kovács , L. Szabó , N. Sayour , Z. Varga , P. Ferdinandy , J.T. Fekete , B. Győrffy
{"title":"15P Verteporfin might potentiate the effects of anti-PD-1 therapy in melanoma-bearing mice model","authors":"S.A. Kovács , T. Kovács , A. Lánczky , Á. Paál , Z. Hegedus , A. Kovács , L. Szabó , N. Sayour , Z. Varga , P. Ferdinandy , J.T. Fekete , B. Győrffy","doi":"10.1016/j.iotech.2024.100898","DOIUrl":"10.1016/j.iotech.2024.100898","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100898"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177054","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
45P Gut microbiome signatures for exploring the correlation between gut microbiome and immune therapy response using machine learning approach 使用机器学习方法探索肠道微生物组与免疫治疗反应之间的相关性的肠道微生物组特征
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.101005
H. Li , D-X. Wang , H. Zhao , L. Zhao , T. Li
{"title":"45P Gut microbiome signatures for exploring the correlation between gut microbiome and immune therapy response using machine learning approach","authors":"H. Li , D-X. Wang , H. Zhao , L. Zhao , T. Li","doi":"10.1016/j.iotech.2024.101005","DOIUrl":"10.1016/j.iotech.2024.101005","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 101005"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
81P Predictive value of inflammatory ratios on the outcome of advanced melanoma patients treated with anti-PD1 monotherapy: A multicentric analysis 炎症比例对晚期黑色素瘤患者抗pd1单药治疗预后的预测价值：一项多中心分析
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100824
A. Popovic , B. Dujović , A. Stojkovic , I. Jocic , E. Sokolovic , A. Jalovcic-Suljevic , I.Z. Petkovic , L. Kandolf Sekulovic
{"title":"81P Predictive value of inflammatory ratios on the outcome of advanced melanoma patients treated with anti-PD1 monotherapy: A multicentric analysis","authors":"A. Popovic , B. Dujović , A. Stojkovic , I. Jocic , E. Sokolovic , A. Jalovcic-Suljevic , I.Z. Petkovic , L. Kandolf Sekulovic","doi":"10.1016/j.iotech.2024.100824","DOIUrl":"10.1016/j.iotech.2024.100824","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100824"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
2O TILs and PD-L1 early dynamics in the randomized Neo-CheckRay phase II trial evaluating neo-adjuvant immuno-radiation and adenosine pathway blockade for early-stage, high risk ER+/HER2- breast cancer (BC) 随机Neo-CheckRay II期试验评估新辅助免疫放疗和腺苷途径阻断治疗早期、高风险ER+/HER2-乳腺癌（BC）的2O TILs和PD-L1早期动态
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100886
A. De Caluwé , X. Catteau , Z. Denis , M. Carausu , I. Desmoulins , E. Romano , V. Remouchamps , A. Baten , P. Poortmans , C. Van Marcke , F. Rothé , M. Ignatiadis , M. Piccart , D. Larsimont , J. Stagg , C. Sotiriou , R.F. Salgado , L. Buisseret
{"title":"2O TILs and PD-L1 early dynamics in the randomized Neo-CheckRay phase II trial evaluating neo-adjuvant immuno-radiation and adenosine pathway blockade for early-stage, high risk ER+/HER2- breast cancer (BC)","authors":"A. De Caluwé , X. Catteau , Z. Denis , M. Carausu , I. Desmoulins , E. Romano , V. Remouchamps , A. Baten , P. Poortmans , C. Van Marcke , F. Rothé , M. Ignatiadis , M. Piccart , D. Larsimont , J. Stagg , C. Sotiriou , R.F. Salgado , L. Buisseret","doi":"10.1016/j.iotech.2024.100886","DOIUrl":"10.1016/j.iotech.2024.100886","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100886"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
ESMO Immuno-Oncology Congress 2024 Officers 2024年ESMO免疫肿瘤学大会官员
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/S2590-0188(24)00317-4
{"title":"ESMO Immuno-Oncology Congress 2024 Officers","authors":"","doi":"10.1016/S2590-0188(24)00317-4","DOIUrl":"10.1016/S2590-0188(24)00317-4","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 101020"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143177788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
9P CXCR6+PD-1- Tissue resident memory T cells are associated with poor prognosis in patients with metastatic colorectal cancer 9P CXCR6+PD-1-组织常驻记忆T细胞与转移性结直肠癌患者预后不良相关
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100892
E. Laloy , A. El Kaddissi , F. Monnien , L. Spehner , J.R. Pallandre , A. Bouard , V. Mougey , A. Vienot , R. Loyon , M. Kroemer , A. Doussot , Z. Lakkis , C. Borg , S. Abdeljaoued
{"title":"9P CXCR6+PD-1- Tissue resident memory T cells are associated with poor prognosis in patients with metastatic colorectal cancer","authors":"E. Laloy , A. El Kaddissi , F. Monnien , L. Spehner , J.R. Pallandre , A. Bouard , V. Mougey , A. Vienot , R. Loyon , M. Kroemer , A. Doussot , Z. Lakkis , C. Borg , S. Abdeljaoued","doi":"10.1016/j.iotech.2024.100892","DOIUrl":"10.1016/j.iotech.2024.100892","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100892"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143128926","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
83P Effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery in patients with resectable esophageal squamous cell carcinoma: A retrospective cohort study 可切除食管鳞状细胞癌伴和不伴手术新辅助免疫化疗的有效性和安全性：一项回顾性队列研究
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100826
X. Liao, X. Chen, W. Hong, F. Chen, G. Li, L. Li
{"title":"83P Effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery in patients with resectable esophageal squamous cell carcinoma: A retrospective cohort study","authors":"X. Liao, X. Chen, W. Hong, F. Chen, G. Li, L. Li","doi":"10.1016/j.iotech.2024.100826","DOIUrl":"10.1016/j.iotech.2024.100826","url":null,"abstract":"","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100826"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143129136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Durable complete response after combined treatment with tumor-infiltrating lymphocytes and oncolytic adenovirus (TILT-123) in a patient with metastatic mucosal melanoma 转移性粘膜黑色素瘤患者在肿瘤浸润淋巴细胞和溶瘤腺病毒（TILT-123）联合治疗后的持久完全缓解。
Immuno-oncology technology Pub Date : 2024-12-01 DOI: 10.1016/j.iotech.2024.100726
T.J. Monberg , T. Kudling , B. Albieri , S. Pakola , E. Ellebaek , M. Donia , R.L. Eefsen , C. von Buchwald , C. Kistler , J.M. Santos , J. Clubb , L. Haybout , M.C.W. Westergaard , D.C.A. Quixabeira , E. Jirovec , R. Havunen , S. Sorsa , V. Cervera-Carrascon , A. Hemminki , I.M. Svane
{"title":"Durable complete response after combined treatment with tumor-infiltrating lymphocytes and oncolytic adenovirus (TILT-123) in a patient with metastatic mucosal melanoma","authors":"T.J. Monberg ,&nbsp;T. Kudling ,&nbsp;B. Albieri ,&nbsp;S. Pakola ,&nbsp;E. Ellebaek ,&nbsp;M. Donia ,&nbsp;R.L. Eefsen ,&nbsp;C. von Buchwald ,&nbsp;C. Kistler ,&nbsp;J.M. Santos ,&nbsp;J. Clubb ,&nbsp;L. Haybout ,&nbsp;M.C.W. Westergaard ,&nbsp;D.C.A. Quixabeira ,&nbsp;E. Jirovec ,&nbsp;R. Havunen ,&nbsp;S. Sorsa ,&nbsp;V. Cervera-Carrascon ,&nbsp;A. Hemminki ,&nbsp;I.M. Svane","doi":"10.1016/j.iotech.2024.100726","DOIUrl":"10.1016/j.iotech.2024.100726","url":null,"abstract":"<div><h3>Background</h3><div>Despite significant advancements in the treatment of malignant melanoma, metastatic mucosal melanoma remains a therapeutic challenge due to its complex pathogenesis, distinct pathological characteristics, and limited response to immunotherapy. Combining different immunotherapeutic approaches offers a potential strategy to address these challenges. Tumor-infiltrating lymphocyte (TIL) therapy and oncolytic virus therapy represent promising treatment modalities that may synergize with each other.</div></div><div><h3>Patient and methods</h3><div>We present a case of a 48-year-old woman with metastatic sinonasal mucosal melanoma who achieved a durable complete pathological response following treatment with multiple injections of the oncolytic virus TILT-123 (igrelimogene litadenorepvec) and a single infusion of TILs, without preconditioning chemotherapy or postconditioning interleukin-2.</div></div><div><h3>Results</h3><div>Immunohistochemical analysis and single-cell sequencing revealed interesting alterations in injected and noninjected tumors as well as in peripheral blood, during the treatment course, suggesting that TILT-123 facilitated TIL engraftment into the tumor, ultimately leading to a complete response.</div></div><div><h3>Conclusions</h3><div>This case underscores the potential of combined immunotherapeutic approaches as a promising strategy for patients with metastatic mucosal melanoma.</div></div>","PeriodicalId":73352,"journal":{"name":"Immuno-oncology technology","volume":"24 ","pages":"Article 100726"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11725143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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