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Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages. 肥胖和减肥手术中肠道微环境对巨噬细胞形成的影响。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-11-28 eCollection Date: 2023-10-01 DOI: 10.1097/IN9.0000000000000033
Michael Leyderman, Joel R Wilmore, Timothy Shope, Robert N Cooney, Norifumi Urao
{"title":"Impact of intestinal microenvironments in obesity and bariatric surgery on shaping macrophages.","authors":"Michael Leyderman, Joel R Wilmore, Timothy Shope, Robert N Cooney, Norifumi Urao","doi":"10.1097/IN9.0000000000000033","DOIUrl":"10.1097/IN9.0000000000000033","url":null,"abstract":"<p><p>Obesity is associated with alterations in tissue composition, systemic cellular metabolism, and low-grade chronic inflammation. Macrophages are heterogenous innate immune cells ubiquitously localized throughout the body and are key components of tissue homeostasis, inflammation, wound healing, and various disease states. Macrophages are highly plastic and can switch their phenotypic polarization and change function in response to their local environments. Here, we discuss how obesity alters the intestinal microenvironment and potential key factors that can influence intestinal macrophages as well as macrophages in other organs, including adipose tissue and hematopoietic organs. As bariatric surgery can induce metabolic adaptation systemically, we discuss the potential mechanisms through which bariatric surgery reshapes macrophages in obesity.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 4","pages":"e00033"},"PeriodicalIF":2.9,"publicationDate":"2023-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10683977/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138465525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
N-linked glycans: an underappreciated key determinant of T cell development, activation, and function. n -链聚糖:T细胞发育、激活和功能的关键决定因素。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-11-21 eCollection Date: 2023-10-01 DOI: 10.1097/IN9.0000000000000035
Mahmoud Abdelbary, Jeffrey C Nolz
{"title":"<i>N</i>-linked glycans: an underappreciated key determinant of T cell development, activation, and function.","authors":"Mahmoud Abdelbary, Jeffrey C Nolz","doi":"10.1097/IN9.0000000000000035","DOIUrl":"10.1097/IN9.0000000000000035","url":null,"abstract":"<p><p>N-linked glycosylation is a post-translational modification that results in the decoration of newly synthesized proteins with diverse types of oligosaccharides that originate from the amide group of the amino acid asparagine. The sequential and collective action of multiple glycosidases and glycosyltransferases are responsible for determining the overall size, composition, and location of <i>N</i>-linked glycans that become covalently linked to an asparagine during and after protein translation. A growing body of evidence supports the critical role of <i>N</i>-linked glycan synthesis in regulating many features of T cell biology, including thymocyte development and tolerance, as well as T cell activation and differentiation. Here, we provide an overview of how specific glycosidases and glycosyltransferases contribute to the generation of different types of <i>N</i>-linked glycans and how these post-translational modifications ultimately regulate multiple facets of T cell biology.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 4","pages":"e00035"},"PeriodicalIF":2.9,"publicationDate":"2023-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10662610/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138464787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inflammatory mechanisms in post-traumatic osteoarthritis: a role for CaMKK2. 创伤后骨关节炎的炎症机制：CaMKK2的作用。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-10-16 eCollection Date: 2023-10-01 DOI: 10.1097/IN9.0000000000000031
Keegan C Riggs, Uma Sankar
{"title":"Inflammatory mechanisms in post-traumatic osteoarthritis: a role for CaMKK2.","authors":"Keegan C Riggs, Uma Sankar","doi":"10.1097/IN9.0000000000000031","DOIUrl":"10.1097/IN9.0000000000000031","url":null,"abstract":"<p><p>Post-traumatic osteoarthritis (PTOA) is a multifactorial disease of the cartilage, synovium, and subchondral bone resulting from direct joint trauma and altered joint mechanics after traumatic injury. There are no current disease-modifying therapies for PTOA, and early surgical interventions focused on stabilizing the joint do not halt disease progression. Chronic pain and functional disability negatively affect the quality of life and take an economic toll on affected patients. While multiple mechanisms are at play in disease progression, joint inflammation is a key contributor. Impact-induced mitochondrial dysfunction and cell death or altered joint mechanics after trauma culminate in inflammatory cytokine release from synoviocytes and chondrocytes, cartilage catabolism, suppression of cartilage anabolism, synovitis, and subchondral bone disease, highlighting the complexity of the disease. Current understanding of the cellular and molecular mechanisms underlying the disease pathology has allowed for the investigation of a variety of therapeutic strategies that target unique apoptotic and/or inflammatory processes in the joint. This review provides a concise overview of the inflammatory and apoptotic mechanisms underlying PTOA pathogenesis and identifies potential therapeutic targets to mitigate disease progression. We highlight Ca<sup>2+</sup>/calmodulin-dependent protein kinase kinase 2 (CaMKK2), a serine/threonine protein kinase that was recently identified to play a role in murine and human osteoarthritis pathogenesis by coordinating chondrocyte inflammatory responses and apoptosis. Given its additional effects in regulating macrophage inflammatory signaling and bone remodeling, CaMKK2 emerges as a promising disease-modifying therapeutic target against PTOA.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 4","pages":"e00031"},"PeriodicalIF":2.9,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578519/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Macrophage immunometabolism in diabetes-associated atherosclerosis. 糖尿病相关动脉粥样硬化的巨噬细胞免疫代谢。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-10-16 eCollection Date: 2023-10-01 DOI: 10.1097/IN9.0000000000000032
Bernardo Gindri Dos Santos, Leigh Goedeke
{"title":"Macrophage immunometabolism in diabetes-associated atherosclerosis.","authors":"Bernardo Gindri Dos Santos, Leigh Goedeke","doi":"10.1097/IN9.0000000000000032","DOIUrl":"10.1097/IN9.0000000000000032","url":null,"abstract":"<p><p>Macrophages play fundamental roles in atherosclerotic plaque formation, growth, and regression. These cells are extremely plastic and perform different immune functions depending on the stimuli they receive. Initial in vitro studies have identified specific metabolic pathways that are crucial for the proper function of pro-inflammatory and pro-resolving macrophages. However, the plaque microenvironment, especially in the context of insulin resistance and type 2 diabetes, constantly challenges macrophages with several simultaneous inflammatory and metabolic stimuli, which may explain why atherosclerosis is accelerated in diabetic patients. In this mini review, we discuss how macrophage mitochondrial function and metabolism of carbohydrates, lipids, and amino acids may be affected by this complex plaque microenvironment and how risk factors associated with type 2 diabetes alter the metabolic rewiring of macrophages and disease progression. We also briefly discuss current challenges in assessing macrophage metabolism and identify future tools and possible strategies to alter macrophage metabolism to improve treatment options for diabetes-associated atherosclerosis.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 4","pages":"e00032"},"PeriodicalIF":2.9,"publicationDate":"2023-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10578522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41241801","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Dietary cholesterol in alcohol-associated liver disease. 酒精相关肝病中的膳食胆固醇。
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-05-03 eCollection Date: 2023-04-01 DOI: 10.1097/IN9.0000000000000026
Lin Jia
{"title":"Dietary cholesterol in alcohol-associated liver disease.","authors":"Lin Jia","doi":"10.1097/IN9.0000000000000026","DOIUrl":"10.1097/IN9.0000000000000026","url":null,"abstract":"<p><p>There is an increasing prevalence of alcohol-associated liver disease (ALD) worldwide. In addition to excessive alcohol consumption, other nutritional factors have been shown to affect the initiation and progression of ALD. The emerging role of cholesterol in exacerbating ALD has been reported recently and the underlying mechanisms are discussed. In addition, the interplay between dietary cholesterol and alcohol on cholesterol metabolism is reviewed. Furthermore, we highlight the therapeutic potential of cholesterol-lowering drugs in managing the onset and severity of ALD. Finally, we suggest the future mechanistic investigation of the effect of cholesterol on insulin resistance and intestinal inflammation in the exacerbation of alcohol-induced cellular and systemic dysfunction.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 2","pages":"e00026"},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10158609/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9485197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tissue- and temporal-specific roles of extracellular ATP on T cell metabolism and function. 细胞外 ATP 对 T 细胞新陈代谢和功能的作用具有组织和时间特异性。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-05-01 eCollection Date: 2023-04-01 DOI: 10.1097/IN9.0000000000000025
Igor Santiago-Carvalho, Alma Banuelos, Henrique Borges da Silva
{"title":"Tissue- and temporal-specific roles of extracellular ATP on T cell metabolism and function.","authors":"Igor Santiago-Carvalho, Alma Banuelos, Henrique Borges da Silva","doi":"10.1097/IN9.0000000000000025","DOIUrl":"10.1097/IN9.0000000000000025","url":null,"abstract":"<p><p>The activation and function of T cells is fundamental for the control of infectious diseases and cancer, and conversely can mediate several autoimmune diseases. Among the signaling pathways leading to T cell activation and function, the sensing of extracellular adenosine triphosphate (eATP) has been recently appreciated as an important component. Through a plethora of purinergic receptors, most prominently P2RX7, eATP sensing can induce a wide variety of processes in T cells, such as proliferation, subset differentiation, survival, or cell death. The downstream roles of eATP sensing can vary according to (a) the T cell subset, (b) the tissue where T cells are, and (c) the time after antigen exposure. In this mini-review, we revisit the recent findings on how eATP signaling pathways regulate T-cell immune responses and posit important unanswered questions on this field.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 2","pages":"e00025"},"PeriodicalIF":2.9,"publicationDate":"2023-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10150631/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9416366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peptidoglycan-induced modulation of metabolic and inflammatory responses. 肽聚糖诱导的代谢和炎症反应调节。
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-04-28 eCollection Date: 2023-04-01 DOI: 10.1097/IN9.0000000000000024
Andrea J Wolf
{"title":"Peptidoglycan-induced modulation of metabolic and inflammatory responses.","authors":"Andrea J Wolf","doi":"10.1097/IN9.0000000000000024","DOIUrl":"10.1097/IN9.0000000000000024","url":null,"abstract":"<p><p>Bacterial cell wall peptidoglycan is composed of innate immune ligands and, due to its important structural role, also regulates access to many other innate immune ligands contained within the bacteria. There is a growing body of literature demonstrating how innate immune recognition impacts the metabolic functions of immune cells and how metabolic changes are not only important to inflammatory responses but are often essential. Peptidoglycan is primarily sensed in the context of the whole bacteria during lysosomal degradation; consequently, the innate immune receptors for peptidoglycan are primarily intracellular cytosolic innate immune sensors. However, during bacterial growth, peptidoglycan fragments are shed and can be found in the bloodstream of humans and mice, not only during infection but also derived from the abundant bacterial component of the gut microbiota. These peptidoglycan fragments influence cells throughout the body and are important for regulating inflammation and whole-body metabolic function. Therefore, it is important to understand how peptidoglycan-induced signals in innate immune cells and cells throughout the body interact to regulate how the body responds to both pathogenic and nonpathogenic bacteria. This mini-review will highlight key research regarding how cellular metabolism shifts in response to peptidoglycan and how systemic peptidoglycan sensing impacts whole-body metabolic function.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 2","pages":"e00024"},"PeriodicalIF":0.0,"publicationDate":"2023-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9398977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Overview of diet and autoimmune demyelinating optic neuritis: a narrative review. 饮食与自身免疫性脱髓鞘性视神经炎概述：叙述性综述。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-04-27 eCollection Date: 2023-04-01 DOI: 10.1097/IN9.0000000000000022
Scott M Plafker, Tyler Titcomb, Katarzyna Zyla-Jackson, Aneta Kolakowska, Terry Wahls
{"title":"Overview of diet and autoimmune demyelinating optic neuritis: a narrative review.","authors":"Scott M Plafker, Tyler Titcomb, Katarzyna Zyla-Jackson, Aneta Kolakowska, Terry Wahls","doi":"10.1097/IN9.0000000000000022","DOIUrl":"10.1097/IN9.0000000000000022","url":null,"abstract":"<p><p>This review summarizes the cellular and molecular underpinnings of autoimmune demyelinating optic neuritis (ADON), a common sequela of multiple sclerosis and other demyelinating diseases. We further present nutritional interventions tested for people with multiple sclerosis focusing on strategies that have shown efficacy or associations with disease course and clinical outcomes. We then close by discuss the potential dietary guidance for preventing and/or ameliorating ADON.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 2","pages":"e00022"},"PeriodicalIF":2.9,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144304/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Adipose tissue metabolic changes in chronic kidney disease. 慢性肾脏疾病的脂肪组织代谢变化。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-04-27 eCollection Date: 2023-04-01 DOI: 10.1097/IN9.0000000000000023
Eurico Serrano, Prashamsa Shenoy, Maria Paula Martinez Cantarin
{"title":"Adipose tissue metabolic changes in chronic kidney disease.","authors":"Eurico Serrano, Prashamsa Shenoy, Maria Paula Martinez Cantarin","doi":"10.1097/IN9.0000000000000023","DOIUrl":"10.1097/IN9.0000000000000023","url":null,"abstract":"<p><p>Adipose tissue is a complex organ whose functions go beyond being an energy reservoir to sustain proper body energy homeostasis. Functioning as an endocrine organ, the adipose tissue has an active role in the body's metabolic balance regulation through several secreted factors generally termed as adipokines. Thus, adipose tissue dysregulation in chronic kidney disease (CKD) can have a deep impact in the pathophysiology of diseases associated with metabolic dysregulation including metabolic syndrome, insulin resistance (IR), atherosclerosis, and even cachexia. CKD is a progressive disorder linked to increased morbidity and mortality. Despite being characterized by renal function loss, CKD is accompanied by metabolic disturbances such as dyslipidemia, protein energy wasting, chronic low-grade inflammation, IR, and lipid redistribution. Thus far, the mechanisms by which these changes occur and the role of adipose tissue in CKD development and progression are unclear. Further understanding of how these factors develop could have implications for the management of CKD by helping identify pharmacological targets to improve CKD outcomes.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 2","pages":"e00023"},"PeriodicalIF":2.9,"publicationDate":"2023-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10144329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9768471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Metabolic regulation of NK cell function: implications for immunotherapy. NK细胞功能的代谢调节：对免疫治疗的影响。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2023-01-23 eCollection Date: 2023-01-01 DOI: 10.1097/IN9.0000000000000020
Hyogon Sohn, Megan A Cooper
{"title":"Metabolic regulation of NK cell function: implications for immunotherapy.","authors":"Hyogon Sohn, Megan A Cooper","doi":"10.1097/IN9.0000000000000020","DOIUrl":"10.1097/IN9.0000000000000020","url":null,"abstract":"<p><p>Natural killer (NK) cells are innate immune lymphocytes capable of rapidly responding to tumors and infection without prior sensitization. There is increasing interest and success in harnessing NK cell function for the treatment of disease, in particular cancers. NK cell activation is dependent on integration of signals through cytokine and germline-encoded activating and inhibitory receptors. The availability of metabolic fuels and pathways is required for NK effector functions including proliferation, killing, and production of interferon gamma (IFN-γ). An understanding of NK cell immunometabolism is thus essential for developing immunotherapy approaches that will allow for optimal effector functions in patients. Studies in mice and humans have demonstrated stimulation-dependent metabolic changes that are required for NK cell function. Here we review the most recent findings in NK cell immunometabolism relevant to disease models and translation to therapy of patients.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"5 1","pages":"e00020"},"PeriodicalIF":2.9,"publicationDate":"2023-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9869966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10582200","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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