Immunometabolism (Cobham (Surrey, England))最新文献

La dolce vita: fueling chimeric antigen receptor (CAR) T cells with Glut1 to improve therapeutic efficacy. 甜蜜的生活：用Glut1刺激嵌合抗原受体（CAR） T细胞以提高治疗效果。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000055

Karen Slattery, David K Finlay, Phillip K Darcy

引用次数: 0

Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity. 导航一个复杂的舞蹈：在口腔上皮可塑性中rna结合蛋白和T细胞之间的相互作用。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000054

Anitha Vijayakumar, Sekar Vasudevan, Samu John, Michelle A Ozbun, Eric Bartee, Viswanathan Palanisamy

引用次数: 0

Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation. 揭示NLRP3的舞蹈：炎症小体激活的时空模式。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000053

Lauren Spector, Naeha Subramanian

{"title":"Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation.","authors":"Lauren Spector, Naeha Subramanian","doi":"10.1097/IN9.0000000000000053","DOIUrl":"10.1097/IN9.0000000000000053","url":null,"abstract":"The nucleotide-binding domain, leucine-rich repeat, and pyrin domain containing-protein 3 (NLRP3) inflammasome is a multiprotein complex that plays a critical role in the innate immune response to both infections and sterile stressors. Dysregulated NLRP3 activation has been implicated in a variety of autoimmune and inflammatory diseases, including cryopyrin-associated periodic fever syndromes, diabetes, atherosclerosis, Alzheimer's disease, inflammatory bowel disease, and cancer. Consequently, fine-tuning NLRP3 activity holds significant therapeutic potential. Studies have implicated several organelles, including mitochondria, lysosomes, the endoplasmic reticulum (ER), the Golgi apparatus, endosomes, and the centrosome, in NLRP3 localization and inflammasome assembly. However, reports of conflict and many factors regulating interactions between NLRP3 and subcellular organelles remain unknown. This review synthesizes the current understanding of NLRP3 spatiotemporal dynamics, focusing on recent literature that elucidates the roles of subcellular localization and organelle stress in NLRP3 signaling and its crosstalk with other innate immune pathways converging at these organelles.","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"7 1","pages":"e00053"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating diurnal rhythms of host responses to enteric norovirus infection in mouse models. 在小鼠模型中评估宿主对肠道诺如病毒感染反应的昼夜节律。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-12-03 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000052

Jianglin Zhang, Robert C Orchard, Zheng Kuang

引用次数: 0

Immunometabolic effects of β-carotene and vitamin A in atherogenesis. β-胡萝卜素和维生素A在动脉粥样硬化中的免疫代谢作用。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-11-28 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000051

Amparo Blanco, Jaume Amengual

引用次数: 0

Impact of gut microbiota and its metabolites on immunometabolism in colorectal cancer. 肠道菌群及其代谢产物对结直肠癌免疫代谢的影响。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-11-28 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000050

Madison Flory, Paloma Bravo, Ashfaqul Alam

{"title":"Impact of gut microbiota and its metabolites on immunometabolism in colorectal cancer.","authors":"Madison Flory, Paloma Bravo, Ashfaqul Alam","doi":"10.1097/IN9.0000000000000050","DOIUrl":"10.1097/IN9.0000000000000050","url":null,"abstract":"Colorectal cancer (CRC) is highly prevalent, accounting for approximately one-tenth of cancer cases and deaths globally. It stands as the second most deadly and third most common cancer type. Although the gut microbiota has been implicated in CRC carcinogenesis for the last several decades, it remains one of the least understood risk factors for CRC development, as the gut microbiota is highly diverse and variable. Many studies have uncovered unique microbial signatures in CRC patients compared with healthy matched controls, with variations dependent on patient age, disease stage, and location. In addition, mechanistic studies revealed that tumor-associated bacteria produce diverse metabolites, proteins, and macromolecules during tumor development and progression in the colon, which impact both cancer cells and immune cells. Here, we summarize microbiota's role in tumor development and progression, then we discuss how the metabolic alterations in CRC tumor cells, immune cells, and the tumor microenvironment result in the reprogramming of activation, differentiation, functions, and phenotypes of immune cells within the tumor. Tumor-associated microbiota also undergoes metabolic adaptation to survive within the tumor environment, leading to immune evasion, accumulation of mutations, and impairment of immune cells. Finally, we conclude with a discussion on the interplay between gut microbiota, immunometabolism, and CRC, highlighting a complex interaction that influences cancer development, progression, and cancer therapy efficacy.","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 4","pages":"e00050"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oxidative stress in gut T_H17 cells makes mice susceptible to bacterial infection. 肠道 TH17 细胞的氧化应激使小鼠易受细菌感染。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-11-13 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000049

Simon O'Shaughnessy, David K Finlay

引用次数: 0

CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction. CD38和线粒体钙离子单向传输器导致了与年龄相关的造血干细胞功能障碍。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-10-08 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000048

Connor S R Jankowski, Thomas Weichhart

引用次数: 0

Mechanisms and metabolic consequences of adipocyte progenitor replicative senescence. 脂肪细胞祖细胞复制衰老的机制和代谢后果

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-08-28 eCollection Date: 2024-07-01 DOI: 10.1097/IN9.0000000000000046

Tonghui Lin, Aftab Mohammad, Mikhail G Kolonin, Kristin L Eckel-Mahan

{"title":"Mechanisms and metabolic consequences of adipocyte progenitor replicative senescence.","authors":"Tonghui Lin, Aftab Mohammad, Mikhail G Kolonin, Kristin L Eckel-Mahan","doi":"10.1097/IN9.0000000000000046","DOIUrl":"10.1097/IN9.0000000000000046","url":null,"abstract":"In recent decades, obesity has become a worldwide epidemic. As a result, the importance of adipose tissue (AT) as a metabolically active storage depot for lipids and a key mediator of body-wide metabolism and energy balance has been increasingly recognized. Emerging from the studies of AT in metabolic disease is a recognition of the importance of the adipocyte progenitor cell (APC) population of AT being the gatekeeper of adipocyte function. APCs have the capability to self-renew and undergo adipogenesis to propagate new adipocytes capable of lipid storage, which is important for maintaining a healthy fat pad, devoid of dysfunctional lipid droplet hypertrophy, inflammation, and fibrosis, which is linked to metabolic diseases, including type 2 diabetes. Like other dividing cells, APCs are at risk for undergoing cell senescence, a state of irreversible cell proliferation arrest that occurs under a variety of stress conditions, including DNA damage and telomere attrition. APC proliferation is controlled by a variety of factors, including paracrine and endocrine factors, quality and timing of energy intake, and the circadian clock system. Therefore, alteration in any of the underlying signaling pathways resulting in excessive proliferation of APCs can lead to premature APC senescence. Better understanding of APCs senescence mechanisms will lead to new interventions extending metabolic health.","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 3","pages":"e00046"},"PeriodicalIF":0.0,"publicationDate":"2024-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11356692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142115697","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Imaging immunometabolism in situ in live animals. 活体动物原位免疫代谢成像。

Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-07-01 Epub Date: 2024-07-31 DOI: 10.1097/IN9.0000000000000044

Nicole Molnar, Veronika Miskolci

{"title":"Imaging immunometabolism in situ in live animals.","authors":"Nicole Molnar, Veronika Miskolci","doi":"10.1097/IN9.0000000000000044","DOIUrl":"https://doi.org/10.1097/IN9.0000000000000044","url":null,"abstract":"Immunometabolism is a rapidly developing field that holds great promise for diagnostic and therapeutic benefits to human diseases. The field has emerged based on seminal findings from in vitro and ex vivo studies that established the fundamental role of metabolism in immune cell effector functions. Currently, the field is acknowledging the necessity of investigating cellular metabolism within the natural context of biological processes. Examining cells in their native microenvironment is essential not only to reveal cell-intrinsic mechanisms but also to understand how cross-talk between neighboring cells regulates metabolism at the tissue level in a local niche. This necessity is driving innovation and advancement in multiple imaging-based technologies to enable analysis of dynamic intracellular metabolism at the single-cell level, with spatial and temporal resolution. In this review, we tally the currently available imaging-based technologies and explore the emerging methods of Raman and autofluorescence lifetime imaging microscopy, which hold significant potential and offer broad applications in the field of immunometabolism.","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11406703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0