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Impact of zinc on immunometabolism and its putative role on respiratory diseases. 锌对免疫代谢的影响及其在呼吸系统疾病中的作用。
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-03-05 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000057
Jonathan H Yao, Edwin F Ortega, Alexander Panda
{"title":"Impact of zinc on immunometabolism and its putative role on respiratory diseases.","authors":"Jonathan H Yao, Edwin F Ortega, Alexander Panda","doi":"10.1097/IN9.0000000000000057","DOIUrl":"10.1097/IN9.0000000000000057","url":null,"abstract":"<p><p>Zinc is the second most abundant trace mineral in the human body and plays a critical role in immune cell function and metabolism. Zinc deficiency impairs immune cell function and is associated with increased susceptibility to respiratory diseases, including pneumonia, influenza, and COVID-19. Zinc homeostasis, maintained by numerous zinc transporters and metal-binding proteins (ie, metallothionein), is essential for coordinating immune cell signaling, gene expression, and enzymatic activities in response to respiratory infections. This article highlights the emerging role of zinc in various aspects of immune function, particularly through its influence on cellular metabolism. Given the significant global burden of respiratory diseases, there is a need to identify effective nutritional interventions that could be readily leveraged to prevent and/or mitigate respiratory disease risk, particularly in older adults who are prone to zinc deficiency. However, the immunometabolic mechanisms underlying zinc's protective effects remain poorly characterized. Future research should focus on elucidating how micronutrients, such as zinc, can support changes in immune cell metabolism in response to infections. Such efforts will help determine how zinc metabolism and zinc intervention strategies may best be leveraged to prevent or mitigate respiratory disease.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"7 1","pages":"e00057"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11882175/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Protein phosphatases in systemic autoimmunity. 系统性自身免疫中的蛋白磷酸酶
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-02-10 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000056
Wenliang Pan, Maria G Tsokos, Wei Li, George C Tsokos
{"title":"Protein phosphatases in systemic autoimmunity.","authors":"Wenliang Pan, Maria G Tsokos, Wei Li, George C Tsokos","doi":"10.1097/IN9.0000000000000056","DOIUrl":"10.1097/IN9.0000000000000056","url":null,"abstract":"<p><p>Protein phosphatases play a critical role in maintaining immune homeostasis by regulating various signaling pathways involved in immune cell activation, differentiation, and function. In the context of systemic autoimmune diseases, dysregulation of phosphatase activity contributes to aberrant immune responses, leading to chronic inflammation and tissue damage. This review explores the role of key phosphatases from the protein serine/threonine phosphatase and protein tyrosine phosphatase families that are implicated in systemic autoimmunity. We discuss their diverse roles in immune cell subsets, the mechanisms by which their dysregulation drives autoimmune pathogenesis, and the therapeutic potential of targeting these enzymes.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"7 1","pages":"e00056"},"PeriodicalIF":2.9,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143411872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
La dolce vita: fueling chimeric antigen receptor (CAR) T cells with Glut1 to improve therapeutic efficacy. 甜蜜的生活：用Glut1刺激嵌合抗原受体（CAR） T细胞以提高治疗效果。
IF 3.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-01-13 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000055
Karen Slattery, David K Finlay, Phillip K Darcy
{"title":"La dolce vita: fueling chimeric antigen receptor (CAR) T cells with Glut1 to improve therapeutic efficacy.","authors":"Karen Slattery, David K Finlay, Phillip K Darcy","doi":"10.1097/IN9.0000000000000055","DOIUrl":"10.1097/IN9.0000000000000055","url":null,"abstract":"<p><p>The approval of chimeric antigen receptor (CAR) T cell therapies for the treatment of hematological cancers has marked a new era in cancer care, with seven products being FDA approved since 2017. However, challenges remain, and while profound effects are observed initially in myeloma, the majority of patients relapse, which is concomitant with poor CAR T cell persistence. Similarly, the efficacy of CAR T cell therapy is limited in solid tumors, largely due to tumor antigen heterogeneity, immune evasion mechanisms, and poor infiltration and persistence. In this recent study, Guerrero et al endeavor to improve the efficacy of human CAR T cells by overexpressing the glucose transporter <i>GLUT1</i> and show that <i>GLUT1</i> overexpressing CAR T cells have improved capacity to persist and control tumor burden in vivo.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"7 1","pages":"e00055"},"PeriodicalIF":3.9,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731213/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity. 导航一个复杂的舞蹈：在口腔上皮可塑性中rna结合蛋白和T细胞之间的相互作用。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000054
Anitha Vijayakumar, Sekar Vasudevan, Samu John, Michelle A Ozbun, Eric Bartee, Viswanathan Palanisamy
{"title":"Navigating a complex dance: the interplay between RNA-binding proteins and T cells in oral epithelial plasticity.","authors":"Anitha Vijayakumar, Sekar Vasudevan, Samu John, Michelle A Ozbun, Eric Bartee, Viswanathan Palanisamy","doi":"10.1097/IN9.0000000000000054","DOIUrl":"10.1097/IN9.0000000000000054","url":null,"abstract":"<p><p>The oral epithelium, a dynamic interface constantly facing environmental challenges, relies on intricate molecular pathways to maintain its homeostasis. This comprehensive review delves into the nuanced interplay between T-lymphocytic cells (T cells) and RNA-binding proteins (RBPs) within the oral epithelium, elucidating their roles in orchestrating immune responses and influencing tissue plasticity. By synthesizing current knowledge, we aim to unravel the molecular intricacies that govern this interplay, with a focus on potential therapeutic implications for oral health and diseases. Understanding the regulatory networks shaped by T cells and RBPs in the oral epithelial microenvironment holds promise for innovative strategies in managing conditions associated with epithelial dysfunction.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"7 1","pages":"e00054"},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation. 揭示NLRP3的舞蹈：炎症小体激活的时空模式。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2025-01-10 eCollection Date: 2025-01-01 DOI: 10.1097/IN9.0000000000000053
Lauren Spector, Naeha Subramanian
{"title":"Revealing the dance of NLRP3: spatiotemporal patterns in inflammasome activation.","authors":"Lauren Spector, Naeha Subramanian","doi":"10.1097/IN9.0000000000000053","DOIUrl":"10.1097/IN9.0000000000000053","url":null,"abstract":"<p><p>The nucleotide-binding domain, leucine-rich repeat, and pyrin domain containing-protein 3 (NLRP3) inflammasome is a multiprotein complex that plays a critical role in the innate immune response to both infections and sterile stressors. Dysregulated NLRP3 activation has been implicated in a variety of autoimmune and inflammatory diseases, including cryopyrin-associated periodic fever syndromes, diabetes, atherosclerosis, Alzheimer's disease, inflammatory bowel disease, and cancer. Consequently, fine-tuning NLRP3 activity holds significant therapeutic potential. Studies have implicated several organelles, including mitochondria, lysosomes, the endoplasmic reticulum (ER), the Golgi apparatus, endosomes, and the centrosome, in NLRP3 localization and inflammasome assembly. However, reports of conflict and many factors regulating interactions between NLRP3 and subcellular organelles remain unknown. This review synthesizes the current understanding of NLRP3 spatiotemporal dynamics, focusing on recent literature that elucidates the roles of subcellular localization and organelle stress in NLRP3 signaling and its crosstalk with other innate immune pathways converging at these organelles.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"7 1","pages":"e00053"},"PeriodicalIF":2.9,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017537","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluating diurnal rhythms of host responses to enteric norovirus infection in mouse models. 在小鼠模型中评估宿主对肠道诺如病毒感染反应的昼夜节律。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-12-03 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000052
Jianglin Zhang, Robert C Orchard, Zheng Kuang
{"title":"Evaluating diurnal rhythms of host responses to enteric norovirus infection in mouse models.","authors":"Jianglin Zhang, Robert C Orchard, Zheng Kuang","doi":"10.1097/IN9.0000000000000052","DOIUrl":"10.1097/IN9.0000000000000052","url":null,"abstract":"<p><p>Norovirus is a leading cause of gastroenteritis worldwide. The factors required for the life cycle and pathogenesis of norovirus in humans remain unclear. Mouse models of norovirus infection have been widely used to explore the crosstalk between norovirus and the host. The circadian clock entrains biological processes and behaviors including eating and sleeping in response to day-night cycles. How the mucosal immunity is diurnally programmed in response to norovirus infection remains largely unknown. Here, we provide procedures for preparing a murine norovirus strain CR6 and for infection in mouse models under normal day/night light cycles or jet-lag conditions. We also present procedures to quantify viral copies and antiviral response transcripts in host tissues. These protocols will help facilitate studies of norovirus infection and immunometabolic responses from the circadian perspective.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 4","pages":"e00052"},"PeriodicalIF":2.9,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11614453/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142782015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunometabolic effects of β-carotene and vitamin A in atherogenesis. β-胡萝卜素和维生素A在动脉粥样硬化中的免疫代谢作用。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-11-28 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000051
Amparo Blanco, Jaume Amengual
{"title":"Immunometabolic effects of <i>β</i>-carotene and vitamin A in atherogenesis.","authors":"Amparo Blanco, Jaume Amengual","doi":"10.1097/IN9.0000000000000051","DOIUrl":"10.1097/IN9.0000000000000051","url":null,"abstract":"<p><p>Carotenoids are a diverse group of lipids produced by photosynthetic organisms, and therefore, these compounds are major components of healthy diets. Carotenoids are among the most extensively studied micronutrients to date due to their antioxidant and provitamin A properties. <i>β</i>-carotene is one of the most abundant carotenoids in our diet, but more importantly, it is the main vitamin A precursor in humans. This review summarizes the key metabolic steps involved in vitamin A formation in mammals. It also highlights the recent advancements in the bioactive properties of <i>β</i>-carotene and vitamin A in relationship with atherosclerotic cardiovascular disease. We examine the dual effect retinoic acid, the transcriptionally active form of vitamin A, has on lipid metabolism and atherosclerosis development. Finally, we cover recent findings on the immunomodulatory role retinoic acid plays in macrophages and T cells in the context of atherosclerosis development and resolution.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 4","pages":"e00051"},"PeriodicalIF":2.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of gut microbiota and its metabolites on immunometabolism in colorectal cancer. 肠道菌群及其代谢产物对结直肠癌免疫代谢的影响。
IF 2.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-11-28 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000050
Madison Flory, Paloma Bravo, Ashfaqul Alam
{"title":"Impact of gut microbiota and its metabolites on immunometabolism in colorectal cancer.","authors":"Madison Flory, Paloma Bravo, Ashfaqul Alam","doi":"10.1097/IN9.0000000000000050","DOIUrl":"10.1097/IN9.0000000000000050","url":null,"abstract":"<p><p>Colorectal cancer (CRC) is highly prevalent, accounting for approximately one-tenth of cancer cases and deaths globally. It stands as the second most deadly and third most common cancer type. Although the gut microbiota has been implicated in CRC carcinogenesis for the last several decades, it remains one of the least understood risk factors for CRC development, as the gut microbiota is highly diverse and variable. Many studies have uncovered unique microbial signatures in CRC patients compared with healthy matched controls, with variations dependent on patient age, disease stage, and location. In addition, mechanistic studies revealed that tumor-associated bacteria produce diverse metabolites, proteins, and macromolecules during tumor development and progression in the colon, which impact both cancer cells and immune cells. Here, we summarize microbiota's role in tumor development and progression, then we discuss how the metabolic alterations in CRC tumor cells, immune cells, and the tumor microenvironment result in the reprogramming of activation, differentiation, functions, and phenotypes of immune cells within the tumor. Tumor-associated microbiota also undergoes metabolic adaptation to survive within the tumor environment, leading to immune evasion, accumulation of mutations, and impairment of immune cells. Finally, we conclude with a discussion on the interplay between gut microbiota, immunometabolism, and CRC, highlighting a complex interaction that influences cancer development, progression, and cancer therapy efficacy.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 4","pages":"e00050"},"PeriodicalIF":2.9,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11608621/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oxidative stress in gut TH17 cells makes mice susceptible to bacterial infection. 肠道 TH17 细胞的氧化应激使小鼠易受细菌感染。
IF 3.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-11-13 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000049
Simon O'Shaughnessy, David K Finlay
{"title":"Oxidative stress in gut T<sub>H</sub>17 cells makes mice susceptible to bacterial infection.","authors":"Simon O'Shaughnessy, David K Finlay","doi":"10.1097/IN9.0000000000000049","DOIUrl":"10.1097/IN9.0000000000000049","url":null,"abstract":"<p><p>A recent paper published in <i>Cell Metabolism</i> in August 2024 by Dirk Brenner's laboratory highlights the importance of effectively managing reactive oxygen species (ROS) in gut T<sub>H</sub>17 T cells for minimizing the damage caused by intestinal bacterial infection. This commentary will discuss the control of cellular ROS by glutathione and the emerging understanding that neutralizing ROS in immune cells is essential for the individualized functions of different immune subsets. In the case of this study, managing ROS within T<sub>H</sub>17 cells in the gut was shown to be essential to sustain the production of IL22 cytokine to maintain gut homeostasis in response to bacterial infection.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 4","pages":"e00049"},"PeriodicalIF":3.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11559963/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction. CD38和线粒体钙离子单向传输器导致了与年龄相关的造血干细胞功能障碍。
IF 3.9
Immunometabolism (Cobham (Surrey, England)) Pub Date : 2024-10-08 eCollection Date: 2024-10-01 DOI: 10.1097/IN9.0000000000000048
Connor S R Jankowski, Thomas Weichhart
{"title":"CD38 and the mitochondrial calcium uniporter contribute to age-related hematopoietic stem cell dysfunction.","authors":"Connor S R Jankowski, Thomas Weichhart","doi":"10.1097/IN9.0000000000000048","DOIUrl":"10.1097/IN9.0000000000000048","url":null,"abstract":"<p><p>Hematopoietic stem cells (HSCs) are the multipotent progenitors of all immune cells. During aging, their regenerative capacity decreases for reasons that are not well understood. Recently, Song et al investigated the roles of two metabolic proteins in age-related HSC dysfunction: CD38 (a membrane-bound NADase) and the mitochondrial calcium uniporter that transports calcium into the mitochondrial matrix. They found that the interplay between these proteins is deranged in aged HSCs, contributing to their diminished renewal capacity. These findings implicate compromised nicotinamide adenine dinucleotide metabolism as underlying HSC dysfunction in aging.</p>","PeriodicalId":73349,"journal":{"name":"Immunometabolism (Cobham (Surrey, England))","volume":"6 4","pages":"e00048"},"PeriodicalIF":3.9,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11462411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395732","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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