Immunome research最新文献_第3页

Major Considerations and Outcomes of Clinical Studies on Vitamin D Deficiency in Patients with Crohn’s Disease: Systematic Review 克罗恩病患者维生素D缺乏症临床研究的主要考虑因素和结果:系统综述

Immunome research Pub Date : 2018-08-15 DOI: 10.4172/1745-7580.1000163

Gouvêa Ma, D. Lg, Kaiser Junior Rl, Liedtke Kaiser Fs, L. Crivelin, Z. Ij, Dennis Mf, T. Casella

{"title":"Major Considerations and Outcomes of Clinical Studies on Vitamin D Deficiency in Patients with Crohn’s Disease: Systematic Review","authors":"Gouvêa Ma, D. Lg, Kaiser Junior Rl, Liedtke Kaiser Fs, L. Crivelin, Z. Ij, Dennis Mf, T. Casella","doi":"10.4172/1745-7580.1000163","DOIUrl":"https://doi.org/10.4172/1745-7580.1000163","url":null,"abstract":"Introduction: The literature shows a bimodal incidence of Crohn's disease in relation to age, with peaks from 15-40 and from 50-80 years and more women have Crohn's disease than men. Clinical studies have shown a direct correlation of vitamin D deficiency with Crohn's disease. \u0000 \u0000Objective: Using a systematic review, the objective of this study was to identify the main correlations and outcomes of clinical studies about vitamin D in Crohn's disease. \u0000 \u0000Methods: Following the rules for systematic reviews (PRISMA), the key search terms used were Crohn’s disease, vitamin D, clinical studies, immunotherapy and quality of life. After applying exclusion criteria, 117 articles were included and discussed in this study. \u0000 \u0000Conclusion: The prevalence of low serum vitamin D levels has been demonstrated in patients suffering from Crohn's disease. However, further studies that are more comprehensive are still needed, in particular investigations that aim to evaluate the effects of serum vitamin D levels on clinical treatment and the effects of vitamin D supplementation on disease activity and mucosal healing. Thus, it may be possible to optimize the treatment of Crohn's disease patients thereby improving their quality of life.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"14 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41779251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MET activation drives resistance to cetuximab in head and neck cancer MET激活导致头颈癌患者对西妥昔单抗产生耐药性

Immunome research Pub Date : 2018-03-16 DOI: 10.4172/1745-7580-C1-014

J. Baselga

引用次数: 2

The Use of Indigenous Plants in the Attenuation of a Live-Attenuated Salmonella Vaccine to Protect Against Poultry 本土植物在减毒沙门氏菌活疫苗中的应用

Immunome research Pub Date : 2018-02-16 DOI: 10.4172/1745-7580.1000150

Suzette E. Curtello, A. Vaillant, Hellen Asemota

引用次数: 1

Inhibition of the Reactivity of Coombs Sera with Igg-Sensitized Human Erythrocytes by Streptococcal Protein-G (Spg) 链球菌蛋白g (Spg)对igg致敏人红细胞Coombs血清反应性的抑制作用

Immunome research Pub Date : 2018-01-01 DOI: 10.4172/1745-7580.1000157

A. Vaillant, M. Smikle, W. Mohammed

{"title":"Inhibition of the Reactivity of Coombs Sera with Igg-Sensitized Human Erythrocytes by Streptococcal Protein-G (Spg)","authors":"A. Vaillant, M. Smikle, W. Mohammed","doi":"10.4172/1745-7580.1000157","DOIUrl":"https://doi.org/10.4172/1745-7580.1000157","url":null,"abstract":"Streptococcal protein-G (SpG), type III bacterial Fc receptor, is a small globular protein produced by several Streptococcal species and it is composed of two or three nearly identical domains, each of 55 amino acids. Streptococcal protein G has been shown to have high binding affinity to sera from various mammalian species including rabbit, human, pig, goat, sheep, cow and many other animal species. Of concern are patients with invasive infections by Streptococcus spp, where large amount of secreted SpG could interfere with the outcome of the gel technique by getting false negative tests. It has been shown and reported that the bacterial protein SpA was already found to inhibit the Coomb's test. We hypothesize that SpG as well as many other immunoglobulin-binding bacterial proteins with binding affinity to human IgG could cause false negative results in patients with bacteraemia. With the intention of proving this hypothesis we conducted two sets of experiments, which proved that SpG has the potential of inhibiting the gel test for the detection of sensitized erythrocytes in vitro. We concluded that is important to exercise caution, when evaluating a result of gel technique in patients with septicemia caused by IgG-producer Streptococci. The experiments used in this research were novel modifications of existent techniques and they proved reliable in demonstrating our hypothesis.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"14 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70940456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Hospitalization Rates Difference of Adult Emergency Patients between Urban and Suburban in Tianjin 天津市城区与郊区成人急诊患者住院率差异分析

Immunome research Pub Date : 2018-01-01 DOI: 10.4172/1745-7580.1000159

Lijun Wang

{"title":"Hospitalization Rates Difference of Adult Emergency Patients between Urban and Suburban in Tianjin","authors":"Lijun Wang","doi":"10.4172/1745-7580.1000159","DOIUrl":"https://doi.org/10.4172/1745-7580.1000159","url":null,"abstract":"Aim: Compare the hospitalization rate of adult emergency patients within 6 h of arrival between urban and suburban hospitals in Tianjin.Method: We analyzed a cross-sectional survey data for adult emergency patients. Fifty hospitals were divided into two groups: urban and suburban group according to geographical location. Each group was classified into two (secondary and tertiary hospital) subgroups. The emergency hospitalization rate within 6 h of arrival, gender and age of patients, Emergency Severity Index (ESI), as well as the mode of arrival and primary diagnosis, were collected and compared using Student’s t-test, χ2 test, or Fisher’s exact test as appropriate between both groups and subgroups.Results: 1) 6569 patients visited emergency departments and 494 (7.52%) were hospitalized within 6 h of arrival. 178 of 3680 (4.84%) and 316 of 2889 (10.94%) patients were hospitalized in the urban and suburban group, there was a significant difference between two groups (P <0.05). 2) Concerning tertiary subgroup, 157 of 2984 (5.26%) urban and 253 of 1833 (13.80%) suburban patients were hospitalized; in secondary subgroup, 21 of 696 (3.02%) urban and 63 of 1056 (5.97%) suburban patients were hospitalized, there were a significant difference between both two subgroups (P<0.05). 3) There was a significant difference in age, yet no significant difference in other aspects. 4) Injury patients in suburban hospitals were more than urban hospitals while pregnancy/childbirth patients were converse (P<0.05).Conclusions: Adult emergency patients' hospitalization rate was 7.52% in Tianjin and suburban tertiary hospitals possess the relatively higher hospitalization rate.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"56 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70940796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Newborn Babies with Tetanus in Maternity Children Hospital Makah:- Center Experience from its Application to Prevent in the Kingdom of Saudi Arabia 马卡妇产医院新生儿破伤风:中心在沙特阿拉伯王国预防破伤风应用的经验

Immunome research Pub Date : 2018-01-01 DOI: 10.4172/1745-7580.1000149

Najia Ahojaili, A. Alzahrani, Helal Al-malki, Ibraheem Kotbi, Liza Salam, Reem Batawi

{"title":"Newborn Babies with Tetanus in Maternity Children Hospital Makah:- Center Experience from its Application to Prevent in the Kingdom of Saudi Arabia","authors":"Najia Ahojaili, A. Alzahrani, Helal Al-malki, Ibraheem Kotbi, Liza Salam, Reem Batawi","doi":"10.4172/1745-7580.1000149","DOIUrl":"https://doi.org/10.4172/1745-7580.1000149","url":null,"abstract":"Neonatal tetanus (NNT), a disease preventable by immunization, is a major problem and a leading cause of neonatal mortality. To study the epidemiology, clinical appearances and outcomes of all patients diagnosed with neonatal tetanus. Moreover, to develop and supply a council to prevent NNT in the KSA. This cross sectional study was conducted at Maternity and Children’s Hospital, Makkah, KSA; a medical centre; from 2013 to 2017. All medical data for patients with suspected diagnosis of NNT were examined to get information about socio demographic properties. Fifty one patients were diagnosed with neonatal tetanus over 5 years in our hospital. All the cases are house delivery for unvaccinated mothers with cut the umbilical cord using unsterilized household scissors. Most of the patients presented with muscle spasms, refusal to eat and abnormal posture. All of the patients were intubated and receiving mechanical ventilation. Two of the patients died. It is essential to begin battle to achieve complete maternal tetanus toxoid immunization at primary health centers, during antenatal care. Immunization needs to be planed so pregnant women can be informed regarding the importance of authority clinics and the risks of unhygienic house birth, and immunization should be addressed with sufficient data. Pregnant women and those of childbearing age should be the first targets for these actions.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"14 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70940172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prediction of Multiple Peptide Based Vaccine from E1, E2 and Capsid Proteins of Rubella Virus: An In-Silico Approach 基于风疹病毒E1、E2和衣壳蛋白的多肽疫苗的预测:一种计算机方法

Immunome research Pub Date : 2018-01-01 DOI: 10.4172/1745-7580.1000146

Shaima N. Elgenaid, Ebrahim Mohammed Al-Hajj, A. Ibrahim, M. Essa, Ahmed Hamdi Abu-haraz, K. A. Abd-elrahman, Mohamed A. Hassan

{"title":"Prediction of Multiple Peptide Based Vaccine from E1, E2 and Capsid Proteins of Rubella Virus: An In-Silico Approach","authors":"Shaima N. Elgenaid, Ebrahim Mohammed Al-Hajj, A. Ibrahim, M. Essa, Ahmed Hamdi Abu-haraz, K. A. Abd-elrahman, Mohamed A. Hassan","doi":"10.4172/1745-7580.1000146","DOIUrl":"https://doi.org/10.4172/1745-7580.1000146","url":null,"abstract":"Rubella is a single strand RNA virus in structure that belongs to Togaviridae family. It causes rubella by respiratory droplet transmission and congenital rubella syndrome if infection to the mother occurs during pregnancy. The current life attenuated vaccine is given as part of MMR vaccine. It has many side effects and contraindicated in pregnancy and immunosuppressed persons. The aim of this study is to determine antigenic peptides from E1, E2, and Capsid proteins that can be used for multiple peptide vaccine design using In-Silico study. A total of 189 sequences of three proteins were obtained from NCBI and subjected to multiple sequence alignments using CLUSTALW tool to determine conserved regions. Immune Epitope Data Base tools were used to determine B cell epitopes, these tools are Bepipred Linear B cell epitopes prediction, surface accessibility and antigenicity prediction. Epitope binding to MHC class I and class II and their population coverage were also determined using IEDB software. The analysis results are as follow, for B cell binding from E1 were (PVCQRHSP, QYHPTAC, and QVPPD), from E2 (AQYPP, PAHP and TTAANSTTAATPATA), and (PPPP, PPQQPQPP and PPHT) from capsid protein. All these peptides have high score in Linear B cell epitopes prediction, surface accessibility and antigenicity prediction. On another hand peptides that reacted to MHC class I were (YFNPGGSYY, FVLLVPWVL and FTNLGTPPL) form E1, E2 and capsid protein respectively. It worth noting that the peptide FVLLVPWVL from E2 protein is also binds to MHC class II with high affinity. All T cell peptides had highest population coverage, and the combined coverage for all peptides in this study was found to be 100%. Using In-Silico studies will ensure less risk of virulence and side effects. Evaluation of antibodies response in animal models is needed to confirm efficacy of these epitopes in inducing protective immune response.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"14 1","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70940082","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 6

Inflammatory Bowel Disease 2018: Consistency and Controversy 炎症性肠病2018:一致性和争议

Immunome research Pub Date : 2018-01-01 DOI: 10.4172/1745-7580.1000158

G. Actis

引用次数: 2

Evaluation of Diagnostic Significance and Cost Effectiveness of ELISA and IFA for the Diagnosis of Autoimmune Disorders ELISA和IFA诊断自身免疫性疾病的诊断意义和成本效益评价

Immunome research Pub Date : 2018-01-01 DOI: 10.4172/1745-7580.1000155

Deepthi Karumanchi, S. Oommen

{"title":"Evaluation of Diagnostic Significance and Cost Effectiveness of ELISA and IFA for the Diagnosis of Autoimmune Disorders","authors":"Deepthi Karumanchi, S. Oommen","doi":"10.4172/1745-7580.1000155","DOIUrl":"https://doi.org/10.4172/1745-7580.1000155","url":null,"abstract":"Background: The presence of antinuclear antibodies (ANA) is a hallmark of autoimmune diseases. As Clinicopathological classification of autoimmune diseases is difficult without laboratory support, laboratory testing is of helps in diagnosis, treatment, prognosis, and prediction of the pathological changes by disease activity. Although different tests are available for ANA detection enzyme linked immunosorbent assay (ELISA) is the mainstay of diagnosis in most routine laboratories. Indirect immunofluorescence antinuclear antibody test (IFA) though currently the “gold standard” it is not widely practiced. Most studies have used Hep2 cells for the detection of autoantibodies by IFA. However Hep 2000 Ro is superior compared to Hep 2 which lacks capability of detecting some autoantibodies like Ro antibodies. Hence, this study was undertaken to compare the diagnostic value and cost effectiveness of ANA pattern, ELISA with profile testing for patients suspected to have autoimmune disorders. Results: In the present study we observed high prevalence of autoimmune diseases in females (75.82%).ANA-ELISA in criteria matched cases with respect to ANA-IFA had a low sensitivity (59% versus 80%), higher specificity (84% versus 70%). Statistical analysis of ELISA and IFA with respect to ANA Profile showed a very less sensitivity by ELISA over IFA (51% vs. 78%) and equal specificity (70-72%) in 142 criteria matched cases. Conclusions: Statistically significant differences between ELISA and IFA infers IFA-ANA is a very appropriate method for screening purposes also IFA have capability of finding anti-mitochondrial and other cytoplasmic antibodies, which is not possible with ELISA.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"54 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.4172/1745-7580.1000155","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"70940628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

T Cell-Dependent in Situ Initiation and Systemic Regulation Model of Immune Responses T细胞依赖性免疫反应的原位启动和全身调节模型

Immunome research Pub Date : 2018-01-01 DOI: 10.4172/1745-7580.1000162

T. Oelert

引用次数: 0