Immunome research最新文献

Immunome research Pub Date : 2021-01-01 DOI: 10.35248/1745-7580.21.S4.8088

Justin Jose

引用次数: 0

The Downside of Beauty: ASIA Syndrome Associated with Local Silicone Injections: A Literature Review 美容的缺点:与局部硅胶注射相关的亚洲综合症:文献综述

Immunome research Pub Date : 2021-01-01 DOI: 10.35248/1745-7580.21.S4.7391

Mirabelle Ruyer-Thompson, A. Gurin, Vnia Borba, J. Haik, M. Harats, Hector Enrique Quiros-Lim, Y. Shoenfeld

引用次数: 0

Vaccines and Optic Neuritis: Consequence or Coincidence? 疫苗与视神经炎:结果还是巧合?

Immunome research Pub Date : 2021-01-01 DOI: 10.35248/1745-7580.21.S4.7467

J. Roszkiewicz, Y. Shoenfeld

{"title":"Vaccines and Optic Neuritis: Consequence or Coincidence?","authors":"J. Roszkiewicz, Y. Shoenfeld","doi":"10.35248/1745-7580.21.S4.7467","DOIUrl":"https://doi.org/10.35248/1745-7580.21.S4.7467","url":null,"abstract":"A mosaic of various inflammatory diseases associated with the administration of vaccines has been reported in the literature. Optic Neuritis (ON), a primary inflammation of the optic nerve, serves as an prominent piece of it, presenting the features of autoimmune phenomena including Treg/Th17 cell imbalance and the abundance of proinflammatory cytokines. A PubMed search revealed 48 cases of vaccination-related ON, from which 32 were reports as isolated ON, 9 occurred as the first symptom of neuromyelitis optica spectrum diseases (NMOSD) and 6 were inscribed in clinical course of Acute Disseminated Encephalomyelitis (ADEM). In Vaccine Adverse Effects Reporting System (VAERS) 537 reports of ON were identified, the vast majority of them was isolated (n=284), followed by ON preceding multiple sclerosis (n=99), ADEM (n=30) and NMOSD (n=20). Influenza vaccine was the leading cause of isolated ON, hepatitis B vaccine (HBV) was mostly associated with diseases entailing further demyelination, such as multiple sclerosis. Moreover, the time interval between vaccine delivery and symptoms of ON occurrences was shorter in cases of isolated-ON in comparison to ON-MS and ON-NMOSD. This time gap was also considerably longer after vaccines enriched with aluminum adjuvant. This article presents the thorough analysis of vaccination related ON cases and focuses on the possible pathomechanism of this autoimmune interplay, including the impact of adjuvants and the mechanism of molecular mimicry.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"1 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69964981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 7

Mirage of Waning Immunity against SARS CoV-2 SARS - CoV-2免疫减弱的海市蜃楼

Immunome research Pub Date : 2021-01-01 DOI: 10.35248/1745-7580.21.S4.7206

K. Goyal, Parakriti Gupta, Poonam Chauhan, K. Sangeetha, Komal Chikkara, Mini P. Singh

引用次数: 0

Immunoinformatics Approach for Designing an Epitope-Based Peptide Vaccine against Treponema pallidum Outer Membrane Beta-Barrel Protein 基于表位的梅毒螺旋体外膜-桶蛋白肽疫苗设计的免疫信息学方法

Immunome research Pub Date : 2020-01-01 DOI: 10.35248/1745-

Mustafa Elhag, Moaaz Mohammed Saadaldin, A. H. Abdelmoneim, T. Taha, F. Abdelrahman, Mohamed A. Hassan

{"title":"Immunoinformatics Approach for Designing an Epitope-Based Peptide Vaccine against Treponema pallidum Outer Membrane Beta-Barrel Protein","authors":"Mustafa Elhag, Moaaz Mohammed Saadaldin, A. H. Abdelmoneim, T. Taha, F. Abdelrahman, Mohamed A. Hassan","doi":"10.35248/1745-","DOIUrl":"https://doi.org/10.35248/1745-","url":null,"abstract":"Treponema pallidum is a gram negative bacteria and the main cause of syphilis which is classified as chronic inflammatory discompose antecedent transmitted sexually. Syphilis affects the central nervous system and the cardiovascular system, potentially leading to hearing or visual loss, aortic aneurism, stroke-like syndrome, dementia and paralysis. T. pallidum has the ability to stimulate adaptive immune and corresponding innate procedures in tissue and blood that might set the era for the HIV’s bidirectional transmission. This study expects a real epitope-based vaccine against β-Barrel outer membrane protein of Treponema pallidum designed by immunoinformatics approaches. The sequences were saved from NCBI and a number of prediction tests were undertaken to explore possible epitopes for B-cell, T-cell MHC class I and II. 3D structure of the most hopeful epitopes was illustrated. Two epitopes showed high binding affinity for B-cells, while five epitopes showed high binding affinity for MHCI and MHCII. The results were hopeful to formulate a vaccine with 71.88% world population coverage. We expect that these hopeful epitopes helps as a preventive formula for the disease in the future and recommend further in vitro and in vivo studies","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"16 1","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69964683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Gastrointestinal Microbiota Impact on the Development of Food Allergy Immune Phenotype 胃肠道微生物群对食物过敏免疫表型发展的影响

Immunome research Pub Date : 2020-01-01 DOI: 10.35248/1745-7580.20.16.174

I. Constantinescu, R. Sfrenț-Cornățeanu

引用次数: 0

Evaluation of Immunology 免疫学评价

Immunome research Pub Date : 2020-01-01 DOI: 10.35248/1745-7580.20.16.191

Aniekan Jumbo

引用次数: 0

Efficacy of Subcutaneous Immunoglobulin Replacement Therapy in Treating Secondary Immunodeficiency Disorders 皮下免疫球蛋白替代疗法治疗继发性免疫缺陷疾病的疗效观察

Immunome research Pub Date : 2020-01-01 DOI: 10.35248/1745-7580.20.16.6074

Pranav Vadlamudi, P. Gordon

{"title":"Efficacy of Subcutaneous Immunoglobulin Replacement Therapy in Treating Secondary Immunodeficiency Disorders","authors":"Pranav Vadlamudi, P. Gordon","doi":"10.35248/1745-7580.20.16.6074","DOIUrl":"https://doi.org/10.35248/1745-7580.20.16.6074","url":null,"abstract":"In 1952, the first immunoglobulin products, made from human plasma, were used to combat infectious diseases such as primary immunodeficiencies during World War II. In addition, during the last 50 years, further research has been conducted to prove whether or not immunoglobulin therapy can truly be effective against primary immunodeficiencies such as X-linked agammaglobulinemia or Common Variable Immunodeficiency Disorder through both intravenous and subcutaneous administration. Intravenous administration has been effective in increasing overall Ig serum concentration in the blood for patients with primary or secondary disorders. However, as more research was conducted, scientists had concluded that the overall cost, maintenance, and at times, lack of efficiency, makes intravenous administration a burden. Thus, scientists have looked for an alternative through subcutaneous administration. For patients with primary immunodeficiencies, subcutaneous has been proven effective in increasing immunoglobulin concentration, even more than intravenous has. The benefit of subcutaneous administration at-home, the low cost, and the heightened efficacy make subcutaneous administration far better than intravenous for primary immunodeficiency patients. However for secondary immunodeficiency patients, the efficacy of subcutaneous administration has not been fully proven and the research is scarce and unreliable. Our literary review explores the advent of immunoglobulin therapy and its past research on both intravenous and subcutaneous administration for primary and secondary immunodeficiency disorders. We sought out to find potential experimental values researchers can conduct experiments to enhance the research on subcutaneous administration for secondary immunodeficiency patients","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"16 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69964776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancement of Innate Immunity to COVID-19 with Natural Measures 以自然措施增强对COVID-19的先天免疫

Immunome research Pub Date : 2020-01-01 DOI: 10.35248/1745-7580.20.16.6736

B. Bale, A. Doneen, Thomas Hight, David J. Vigerust

{"title":"Enhancement of Innate Immunity to COVID-19 with Natural Measures","authors":"B. Bale, A. Doneen, Thomas Hight, David J. Vigerust","doi":"10.35248/1745-7580.20.16.6736","DOIUrl":"https://doi.org/10.35248/1745-7580.20.16.6736","url":null,"abstract":"The strength of Corona virus disease 2019 (COVID-19) is the fact that it is a novel virus to humans. Being a neoteric virus yields a significant advantage as the person infected possess no immunity to the pathogen. The most significant protection against a new viral infection is the ancient innate immune system. When the virus invades our cells, receptors in the cytoplasm recognize the foreign intruder and induce innate immune responses to block replication of the virus. A robust response is critical as it takes three to five days to generate the beginnings of an adaptive immune response. The front line innate immune response is often powerful enough to eliminate the virus before the development of more severe late-phase infection, which relies on acquired immunity for resolution. A recent scientific discovery demonstrates a natural, safe, and accessible self-administered procedure that enhances our innate immunity. Non-myeloid epithelial cells are capable of producing the viricidal substance hypochlorous acid (HOCL). The amount of HOCL generated is dependent on the concentration of intracellular chloride that is available. In vitro, saline exposure of epithelial cells infected with coronavirus significantly reduced viral replication. In vivo, hypertonic saline nasal irrigation and gargle (HSNIG) in patients who had upper respiratory infections (URI) caused by coronavirus significantly reduced the duration and severity of the URI compared to similarly infected patients treated with the standard of care. HSNIG can suppress viral replication of COVID-19 mitigating the spread during the asymptomatic phase and reducing the risk of an asymptomatic or symptomatic case progressing to a severe infection.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"16 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69964805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

The Best IgG Subclass for the Development of Therapeutic Monoclonal Antibody Drugs and their Commercial Production: A Review 治疗性单克隆抗体药物的最佳IgG亚类及其商业化生产综述

Immunome research Pub Date : 2020-01-01 DOI: 10.35248/1745-7580.20.16.173

Y. Muhammed

{"title":"The Best IgG Subclass for the Development of Therapeutic Monoclonal Antibody Drugs and their Commercial Production: A Review","authors":"Y. Muhammed","doi":"10.35248/1745-7580.20.16.173","DOIUrl":"https://doi.org/10.35248/1745-7580.20.16.173","url":null,"abstract":"Most of the clinically available monoclonal antibody (mAbs) drugs are Immunoglobulin G's (IgG's). The variability of the IgG subclasses is in the amino acid content of the hinge region which forms the basis of their stability and suitability for therapeutics development. Monoclonal antibody drug development is a tedious and long-term process requiring putting many factors into consideration. The variability in the stability, flexibility, mediation of antibody dependent cell cytotoxicity (ADCC), mediation of cellular dependent cytotoxicity (CDC), and C1q protein binding are major factors that determine the suitability of IgG subclasses for the development of therapeutics. It was reviewed that most of the marketed mAbs therapeutics are IgG1 subclass, this is due to its stability and less aggregate formation, triggering of effector function via the action of Fc domain binding to FcyRI, FcyRII, and FcyRIII, resulting to mediation of ADCC, CDC, and C1q cascade of signaling. However, IgG2 is also utilized for the development of therapeutic when neutralization of soluble antigen with reduce effector function is required, with some drugs in late stage development and also approved for commercial use. Also, IgG4 is utilized for the development of therapeutics drugs when the recruitment of the host effector function is not required. But IgG3 utilization for the development of therapeutics requires engineering of the amino acids content of the hinge region, without any commercially available drug that is IgG3. This review examines the suitable IgG subclasses with the capability of ADCC, CDC, and C1q mediation, and also provides future recommendation on the suitability of less stable IgG subclasses in the therapeutic development.","PeriodicalId":73347,"journal":{"name":"Immunome research","volume":"16 1","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69964454","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 8