{"title":"Therapeutic and Diagnostic Innovation for Parasitology: Grand Challenges.","authors":"Richard J Martin","doi":"10.3389/fpara.2022.963671","DOIUrl":"10.3389/fpara.2022.963671","url":null,"abstract":"","PeriodicalId":73098,"journal":{"name":"Frontiers in parasitology","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10249670/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9707062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Frontiers in parasitologyPub Date : 2022-04-28eCollection Date: 2022-01-01DOI: 10.3389/fpara.2022.902098
Alex Loukas
{"title":"Frontiers in Parasitology Grand Challenge.","authors":"Alex Loukas","doi":"10.3389/fpara.2022.902098","DOIUrl":"10.3389/fpara.2022.902098","url":null,"abstract":"","PeriodicalId":73098,"journal":{"name":"Frontiers in parasitology","volume":" ","pages":"902098"},"PeriodicalIF":0.0,"publicationDate":"2022-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731821/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46844110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Mun Hua Tan, Heejung Shim, Yao-Ban Chan, Karen P Day
{"title":"Unravelling <i>var</i> complexity: Relationship between DBLα types and <i>var</i> genes in <i>Plasmodium falciparum</i>.","authors":"Mun Hua Tan, Heejung Shim, Yao-Ban Chan, Karen P Day","doi":"10.3389/fpara.2022.1006341","DOIUrl":"10.3389/fpara.2022.1006341","url":null,"abstract":"<p><p>The enormous diversity and complexity of <i>var</i> genes that diversify rapidly by recombination has led to the exclusion of assembly of these genes from major genome initiatives (e.g., Pf6). A scalable solution in epidemiological surveillance of <i>var</i> genes is to use a small 'tag' region encoding the immunogenic DBLα domain as a marker to estimate <i>var</i> diversity. As <i>var</i> genes diversify by recombination, it is not clear the extent to which the same tag can appear in multiple <i>var</i> genes. This relationship between marker and gene has not been investigated in natural populations. Analyses of <i>in vitro</i> recombination within and between <i>var</i> genes have suggested that this relationship would not be exclusive. Using a dataset of publicly-available assembled <i>var</i> sequences, we test this hypothesis by studying DBLα-<i>var</i> relationships for four study sites in four countries: Pursat (Cambodia) and Mae Sot (Thailand), representing low malaria transmission, and Navrongo (Ghana) and Chikwawa (Malawi), representing high malaria transmission. In all study sites, DBLα-<i>var</i> relationships were shown to be predominantly 1-to-1, followed by a second largest proportion of 1-to-2 DBLα-<i>var</i> relationships. This finding indicates that DBLα tags can be used to estimate not just DBLα diversity but <i>var</i> gene diversity when applied in a local endemic area. Epidemiological applications of this result are discussed.</p>","PeriodicalId":73098,"journal":{"name":"Frontiers in parasitology","volume":"1 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10060044/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9288204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}