Frontiers in nephrology最新文献

{"title":"Case Report: Kidney injury following non-medical massage.","authors":"Michael Hieu Truong, Vanessa Quynh Tran, Spencer Doan Tran, Calvin Tuan Nguyen, Phuong Chi Pham, Quynh Giao Pham","doi":"10.3389/fneph.2026.1730580","DOIUrl":"https://doi.org/10.3389/fneph.2026.1730580","url":null,"abstract":"<p><strong>Background: </strong>Deep tissue massage is widely used for musculoskeletal pain and is generally considered safe. We report a case of acute kidney injury following non-medical deep tissue massage.</p><p><strong>Case presentation: </strong>A 50-year-old healthy man presented with acute right lower quadrant abdominal pain 4 h after receiving a deep tissue massage for low back pain from an unlicensed therapist. CT angiography revealed a segmental acute infarction of the right kidney with occlusion of the superior segmental artery. The patient was successfully treated with anticoagulation therapy with gradual resolution of symptoms.</p><p><strong>Conclusions: </strong>This case highlights the potential for severe vascular complications from deep tissue massage, even in healthy individuals. The proposed mechanism is direct mechanical trauma to the renal artery. Prompt evaluation of abdominal pain following massage is essential.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"6 ","pages":"1730580"},"PeriodicalIF":0.0,"publicationDate":"2026-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12920239/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147273205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the resistive index: value of color-coded duplex sonography parameters in kidney transplantation.","authors":"Katharina Konzett, Sabrina Neururer, Martin Tiefenthaler","doi":"10.3389/fneph.2026.1718842","DOIUrl":"https://doi.org/10.3389/fneph.2026.1718842","url":null,"abstract":"<p><p>Sonography is a key method in examining kidney transplants. Recent reports on the limited diagnostic value of an elevated resistive index (RI) in detecting rejection have cast doubt on the overall utility of color-coded duplex sonography (CCDS). This study evaluated additional CCDS parameters - percentage of vascularization (POV) and periphery vessel distance (PVD) - and investigated their association with histopathologic findings in allograft dysfunction. In a retrospective single-center study, 350 kidney transplant biopsies performed between 2013 and 2022 were analyzed. Standardized sonographic evaluation, including POV, PVD, and RI, was conducted at biopsy request. Histopathologic lesions were scored according to Banff criteria. Multivariable logistic regression identified independent predictors of abnormal CCDS parameters. Recipient age, severe tubular atrophy (ct), and arterial intimal fibrosis (cv) were independent negative predictors of POV > 50%. PVD ≥ 0.25 cm was associated with recipient age and moderate tubular atrophy (ct). RI showed no association with histopathologic lesions. These findings identify POV and PVD as non-invasive markers of chronic injury in kidney allografts, highlighting their potential adjunctive role in detecting parenchymal damage. As such, CCDS may support - but not replace - biopsy, which remains essential for establishing a definitive diagnosis in graft dysfunction.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"6 ","pages":"1718842"},"PeriodicalIF":0.0,"publicationDate":"2026-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12913139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146229968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The border between progenitor cell recruitment and nephron shaping in the fetal human kidney during late gestation: a basic but understudied region.","authors":"Will W Minuth","doi":"10.3389/fneph.2025.1719394","DOIUrl":"https://doi.org/10.3389/fneph.2025.1719394","url":null,"abstract":"<p><strong>Introduction: </strong>The last 3 months of pregnancy are formative for the development of the fetal human kidney. Clinical experience with preterm and low birth weight infants indicates particular vulnerability during this period, as different noxae can terminate the development of new nephrons. This leads to oligonephropathy, which is associated with serious health consequences later in life. While the clinical aspects have been intensely investigated, few data point to the traces left by these noxae. In the nephrogenic zone, a reduction in its width and the absence of S-shaped bodies have been reported.</p><p><strong>Purpose: </strong>Not only the targets of noxae but also the site and early links of nephron formation remain poorly investigated. This concerns the individual compartments of the nephrogenic zone and the border between the district of progenitor cell recruitment (DPCR) and the area of nephron shaping (ANS) as a potential target of noxae.</p><p><strong>Methods: </strong>To shed initial light on this issue, the border between the DPCR and ANS was recorded using microanatomical criteria.</p><p><strong>Results: </strong>Nephron morphogenesis is shown to start at the far end of a cap mesenchyme, with the condensate opposite the head of a collecting duct (CD) ampulla still located within the DPCR. Driven by the mesenchymal-to-epithelial transition, the pretubular aggregate also arises at this site. Its proximal end remains adjacent to the connecting tubule of a previously formed nephron. Subsequently, it converts into the primitive renal vesicle, which thereafter expands within the ANS. Although separation is incomplete, the medial part of the distal pole adheres to the CD ampulla at the section border between its head and conus. This linkage of the future connecting tubule suggests that the conus of the CD ampulla co-elongates with the medial aspect of the shaping nephron stages.</p><p><strong>Conclusions: </strong>Closely related key points during early nephron formation are identified. Damage to only one of these points may result in either developmental arrest. Knowledge of these structural details is vital for pathological screening, interpretation of cell biological labeling, and identification of imprints left by noxae.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1719394"},"PeriodicalIF":0.0,"publicationDate":"2026-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12909212/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146222475","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The potential of neutrophil gelatinase-associated lipocalin in management of acute kidney injury and peritoneal dialysis-related peritonitis: a narrative review.","authors":"Xiao Fu, Yiting Shu, Yun Zhang","doi":"10.3389/fneph.2025.1749827","DOIUrl":"10.3389/fneph.2025.1749827","url":null,"abstract":"<p><p>Neutrophil gelatinase-associated lipocalin (NGAL) is a biomarker extensively studied in multiple diseases. While its application in chronic kidney disease (CKD) and kidney transplant patients is relatively limited, NGAL has shown significant promise in the early detection and diagnosis of acute kidney injury (AKI), which may improve more timely management and potentially better clinical outcomes. In addition, NGAL has demonstrated promising utility in identifying peritoneal dialysis-related peritonitis (PDRP) and monitoring the treatment response. This review aims to provide an in-depth overview of the available research findings of NGAL in the management of AKI and PDRP, having these two conditions discussed together is particularly important for nephrologists who manage both conditions, especially to explore the potential of more specific NGAL forms, such as monomer NGAL and homodimer NGAL, to enhance early diagnosis and effective management of AKI and PDRP.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1749827"},"PeriodicalIF":0.0,"publicationDate":"2026-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12886388/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146167907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reflective versus predictive value of urinary podocin, nephrin, and their ratio in diabetic kidney disease: a 12-month retrospective cohort study.","authors":"Pringgodigdo Nugroho, Jeremia Siregar, Tri Juli Edi Tarigan, Kuntjoro Harimurti, Aida Lydia, Evy Yunihastuti, Pradana Soewondo, Hamzah Shatri","doi":"10.3389/fneph.2025.1681679","DOIUrl":"10.3389/fneph.2025.1681679","url":null,"abstract":"<p><strong>Introduction: </strong>Podocyte injury plays a central role in the development of diabetic kidney disease (DKD). Urinary podocin, nephrin, and the podocin-nephrin ratio (PNR) have been proposed as early indicators of glomerular injury, but their prognostic value remains uncertain. This study aimed to evaluate whether baseline urinary podocyte biomarkers reflect current disease severity and predict DKD progression.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study involving 119 adults with type 2 diabetes and DKD. Baseline urinary podocin, nephrin, and PNR were measured using ELISA. Kidney outcomes were assessed over 12 months. DKD progression was defined as ≥5 mL/min/1.73 m² decline in estimated glomerular filtration rate (eGFR) and/or ≥30% increase in urine albumin-creatinine ratio (uACR). Follow-up uACR data were available for 52 participants. ROC analyses evaluated predictive performance.</p><p><strong>Results: </strong>At baseline, median eGFR was 68.1 mL/min/1.73 m² and median uACR was 112 mg/g. Over 12 months, eGFR declined significantly, while uACR showed high variability without consistent change. Among participants with complete outcome data, 19 (36.5%) experienced eGFR decline and 17 (32.7%) showed uACR progression. Baseline podocin, nephrin, and PNR were numerically higher in progressors but showed no significant group differences (all p > 0.3). Predictive performance was poor: AUCs for eGFR decline were 0.504 (podocin), 0.512 (nephrin), and 0.523 (PNR). For albuminuria progression, AUCs were 0.563, 0.524, and 0.544, respectively. Subgroup analyses similarly showed no significant predictive value.</p><p><strong>Discussion: </strong>These results suggest that single baseline measurements of podocin, nephrin, or PNR may have limited short-term prognostic value in DKD. However, the presence of these markers, even in patients with only moderate disease, supports their role as early indicators of podocyte stress.</p><p><strong>Conclusion: </strong>While urinary podocyte-associated proteins reflect early glomerular injury, their utility as stand-alone prognostic biomarkers over a one-year period may be limited. Larger longitudinal studies assessing biomarker trajectories and integrating additional molecular markers are warranted.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1681679"},"PeriodicalIF":0.0,"publicationDate":"2026-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12867881/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146127680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New insights into contrast-associated acute kidney injury: the key role of endothelial dysfunction.","authors":"Mohamed Fakhfakh, Taha Lassoued, Firas Nouri, Nizar Ibn El Mechri, Ala Daly, Salem Abdessalem, Souad Ferjani, Sami Milouchi","doi":"10.3389/fneph.2025.1582775","DOIUrl":"10.3389/fneph.2025.1582775","url":null,"abstract":"<p><strong>Background: </strong>Contrast-Associated Acute Kidney Injury (CA-AKI) is a major cause of acute kidney injury in hospitalized patients, which is triggered by the administration of iodinated contrast agents during computed tomography scans and angiographic procedures. It significantly elevates cardiovascular risk and stands as a major complication of coronary angiography, contributing to a marked deterioration in patient prognosis with elevated rates of morbidity and mortality.</p><p><strong>Aim: </strong>Our main goal was to assess the predictive factors of CA-AKI and investigate a possible association between pre-existing endothelial dysfunction and the occurrence of CA-AKI following Percutaneous Coronary Interventions (PCI). We also intended to explore possible preventive measures of CA-AKI.</p><p><strong>Methods: </strong>We conducted a prospective observational longitudinal study enrolling patients with an indication for PCI. Patients underwent an assessment of renal function (baseline creatinine, 24h and 48-72h after administration of contrast agent). We also evaluated renal function at one month as a secondary endpoint. Then, we analyzed Endothelial Quality Index (EQI) by Finger Thermal Monitoring (FTM) with E4 diagnosis Polymath.</p><p><strong>Results: </strong>We enrolled 187 patients (134 males, 53 females) in our study with a mean age of 61.1± 11.8 years. Over half (56.7%) were type 2 diabetes. A total of 60 cases of CA-AKI were reported (33.7%). The mean EQI was 0.86 ± 0.61. The vast majority of our study population (n=178; 95.2%) had endothelial dysfunction (EQI<2), and a significant proportion (n=142; 75.9%) had severe endothelial dysfunction (EQI<1). In our study, CA-AKI incidence was significantly associated with severe endothelial dysfunction (p=0.007). It was also strongly correlated to the rescue PCI (p=0.002), contrast media volume>100ml (p=0.015) and the presence of a two-vessel coronary artery disease (p=0.008). In multivariate analysis, severe endothelial dysfunction (OR = 5.46; p = 0.014), rescue PCI (OR = 5.77; p = 0.04) and contrast medica volume equal or over 140 ml (OR = 6.96; p = 0.036) were independent risk factors of CA-AKI. We found that pre- and post-hydration with isotonic saline solution and that patients whose baseline treatment includes statins, were significantly prevented from developing CA-AKI. (p=0.007 and 0.008 respectively).</p><p><strong>Conclusion: </strong>Our study showed a significant association between the presence of severe endothelial dysfunction, assessed non-invasively by FTM, and the risk of developing CA-AKI. These results appear to be relevant considering that EQI is a low-cost, non-invasive and easily reproducible marker of endothelial dysfunction.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1582775"},"PeriodicalIF":0.0,"publicationDate":"2026-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12864088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146121343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory and lipotoxicity mechanisms in obesity related CKD.","authors":"Jorge Rico-Fontalvo, Maria Raad-Sarabia, Juan Montejo Hernández, Tomas Rodríguez Yánez, Lacides Rafael Caparroso Ramos, Paula Parra Sánchez, Ana Alexandra Ovalle Gomez, Javier Jimenez Quintero, Rodrido Daza-Arnedo","doi":"10.3389/fneph.2025.1684004","DOIUrl":"10.3389/fneph.2025.1684004","url":null,"abstract":"<p><p>Obesity has been a systemic disease that has been underrecognized for years. Obesity-related chronic kidney disease (Ob-CKD) is a multifaceted disorder that affects patients with CKD to varying degrees. Among the structural changes associated with obesity, obesity-related glomerulopathy (ORG) stands out (glomerular hypertrophy, podocytopathy, mesangial matrix expansion, focal segmental glomerulosclerosis, tubulointerstitial fibrosis, vascular lesions, and tubular atrophy) associated with other kidney diseases. There are direct and indirect mechanisms that affect the kidneys of obese patients. Among the direct mechanisms, several effects may occur: hyperfiltration, activation of the renin-angiotensin-aldosterone system (RAAS), inflammation, lipotoxicity, and neurohormonal activation. This is a narrative review that will detail the inflammatory and lipotoxicity mechanisms involved in the genesis of Ob-CKD.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1684004"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12846998/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evanescent extraosseous calcifications in low turnover bone: management and outcomes: a case report.","authors":"Mariel Hernandez-Pérez, Daniel Enos","doi":"10.3389/fneph.2025.1702475","DOIUrl":"10.3389/fneph.2025.1702475","url":null,"abstract":"<p><strong>Introduction: </strong>The prevalence of bone disease in peritoneal dialysis patients has been recently shown to exceed 54%, including patients with parathormone (PTH) levels within the theoretical adequate target, yet demonstrating low bone turnover on histomorphometry. Moreover, bone disease is often associated with abnormalities in calcium and phosphate metabolism, leading to tissular deposits such as extraosseous calcifications.</p><p><strong>Case presentation: </strong>We present a 22-year-old female patient managed on peritoneal dialysis with persistent swelling of all four extremities, including the fingers, hands, and feet, accompanied by a marked decrease in PTH. Many extraosseous calcifications in the hands were seen in the X-ray images, prompting a switch from peritoneal dialysis to conventional high-flow haemodialysis and intravenous sodium thiosulphate (STS) therapy. The patient showed adequate treatment tolerance, with most calcifications disappearing after 3 months of therapy.</p><p><strong>Conclusions: </strong>Our experience suggests that the treatment of extraosseous calcifications requires timely and multi-angle intervention. At the same time, treatment with STS has proven effective and well tolerated in this patient.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1702475"},"PeriodicalIF":0.0,"publicationDate":"2026-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12847024/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146088314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient satisfaction with dialysis services provided across different providers in Saudi Arabia.","authors":"Sarah S Monshi, Hatoon M Alamri, Afnan M Almuaddi, Fatemah M Almutairi, Hala R Aljishi, Khulud A Alfaki, Maram S AlTurki, Rayyan M Saqah, Mohammed S Aldossary","doi":"10.3389/fneph.2025.1691773","DOIUrl":"10.3389/fneph.2025.1691773","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate patient satisfaction with dialysis services provided across different healthcare sectors in Saudi Arabia, including governmental and private facilities, and to identify key determinants influencing satisfaction levels.</p><p><strong>Methods: </strong>A cross-sectional observational study was conducted using secondary data from dialysis patients attending Ministry of Health, Diaverum, and DaVita facilities between January and December 2023. Patient satisfaction data were collected through the Press Ganey survey, a validated instrument assessing six domains: registration, care, dialysis, pharmacy, personal issues, and personal experience. Descriptive statistics summarized patient demographics and satisfaction scores, while regression analysis identified factors associated with satisfaction.</p><p><strong>Results: </strong>A total of 5,472 patients were included, with an overall satisfaction score of 89.84 ± 14.25. The mean satisfaction score was highest in the personal experience domain (91.39 ± 17.02) and lowest in the dialysis domain (88.45 ± 18.65). Private facilities had statistically significant higher satisfaction scores (90.41 ± 13.31) compared to governmental hospitals (88.57 ± 16.08). Females reported significantly higher satisfaction than males (91.96 ± 12.15 vs. 88.91 ± 14.60), respectively. Pediatric patients demonstrated significantly higher satisfaction (age ≤18 years: 93.80 ± 11.42) compared to young adults (age = 19-29 years: 89.18 ± 14.62). Regional differences were observed, with the Southern region reporting the highest satisfaction (91.37 ± 14.18) and the Eastern region the lowest (88.60 ± 15.59). Regression analysis identified gender (B = 2.943, 95% CI [2.165, 3.722], p < 0.001) and facility type (B = 1.108, 95% CI [0.243, 1.973], p = 0.012) as significant predictors of satisfaction.</p><p><strong>Conclusion: </strong>Patient satisfaction with dialysis services in Saudi Arabia is generally high, with statistically significant but modest differences across regions, facility types, age groups, and genders. Improving dialysis-related education, addressing regional disparities, and enhancing patient-centered care, particularly in governmental facilities, could further optimize satisfaction outcomes.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1691773"},"PeriodicalIF":0.0,"publicationDate":"2026-01-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12832406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146069034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression of immunoglobulin A nephropathy (IgAN) in a Hispanic/Latinx population in the United States.","authors":"John J Sim, Nancy T Cannizzaro, Qiaoling Chen, Sasikiran Nunna, Mohit Mathur, Cibele Pinto","doi":"10.3389/fneph.2025.1744454","DOIUrl":"10.3389/fneph.2025.1744454","url":null,"abstract":"<p><strong>Background: </strong>Immunoglobulin A nephropathy (IgAN) is a leading cause of chronic kidney disease (CKD) worldwide. While racial and ethnic differences in disease progression are well documented, the Hispanic/Latinx populations remain understudied despite their elevated risk of kidney failure among other CKD populations.</p><p><strong>Objective: </strong>This study aimed to evaluate the kidney function decline and progression in Hispanic/Latinx patients with biopsy-proven IgAN within a large, integrated healthcare system and to contextualize to other racial/ethnic groups.</p><p><strong>Methods: </strong>We conducted a retrospective case series study of 259 Hispanic/Latinx adults with biopsy-proven IgAN from the Kaiser Permanente Southern California (KPSC) health system. Patients were followed from biopsy to ≥50% decline in the estimated glomerular filtration rate (eGFR), kidney failure, mortality, the study end date of November 30, 2022, or disenrollment. Annualized eGFR decline and the incidence of composite kidney outcomes were assessed.</p><p><strong>Results: </strong>At diagnosis, Hispanic/Latinx patients had significant CKD and a high risk of progression to kidney failure, indicated by a median eGFR of 56 ml min^-1 1.73 m^-2 and a median urine protein/creatinine ratio of 1.8 g/g. Common treatments included immunosuppressive agents (41%), angiotensin-converting enzyme (ACE) inhibitors (48%), and angiotensin receptor blockers (ARBs; 20%). The mean annual eGFR decline was -4.5 ml min^-1 1.73 m^-2, and 30.9% experienced rapid decline (>5 ml min^-1 1.73 m^-2 per year). The composite kidney outcome occurred at 73.3 events per 1,000 patient-years, with a median time to event of 2.8 years and a median age at event of 46 years.</p><p><strong>Conclusion: </strong>Hispanic/Latinx patients with IgAN demonstrate rapid kidney function decline and early-onset kidney failure. These findings underscore the need for earlier detection and targeted management in this underserved group.</p>","PeriodicalId":73091,"journal":{"name":"Frontiers in nephrology","volume":"5 ","pages":"1744454"},"PeriodicalIF":0.0,"publicationDate":"2026-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12827094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146047436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}