Frontiers in clinical diabetes and healthcare最新文献

{"title":"Advanced hybrid closed-loop therapy in an older adult with 55-year type 1 diabetes: a CARE-based case report.","authors":"Kamila Susuł, Bartłomiej Matejko, Paulina Suduł, Maciej T Małecki, Tomasz Klupa, Katarzyna Cyranka","doi":"10.3389/fcdhc.2026.1870978","DOIUrl":"10.3389/fcdhc.2026.1870978","url":null,"abstract":"<p><p>This case describes a 66-year-old man with long-standing type 1 diabetes (diagnosed in 1969) complicated by polyneuropathy, autonomic neuropathy with hypoglycemia unawareness, and advanced diabetic retinopathy. Despite many years of treatment and consistent self-management, he experienced substantial glycemic variability, chronic hyperglycemia (HbA1c 9.2%), and a pronounced fear of hypoglycemia that led to insulin underdosing and maladaptive coping behaviors. Following admission to the Diabetes Clinic of the University Hospital in Krakow, structured diabetes education and psychological support were provided. The patient was subsequently enrolled in a research program and transitioned to the MiniMed™ 780G Advanced Hybrid Closed Loop (AHCL) system, which automatically adjusts insulin delivery based on continuous glucose monitoring. After nine months of AHCL use, the patient showed clinically meaningful improvement in CGM-derived metabolic outcomes (mean glucose 128 mg/dL, GMI 6.4%, TIR 91%, TBR 1%), with no episodes of severe hypoglycemia reported during follow-up. Standardized psychological assessment showed improvement in well-being and reductions in diabetes-related distress and depressive symptoms: WHO-5 increased from 9 to 14, DDS global score decreased from 3.2 to 1.8, PHQ-9 decreased from 7 to 3, and PAID global score decreased from 42 to 35. This CARE-based case report illustrates that AHCL therapy, when implemented together with structured education and psychological support, may be associated with improved glycemic outcomes and reduced psychological burden in selected older adults with long-standing type 1 diabetes. The findings should be interpreted cautiously because they derive from a single case.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1870978"},"PeriodicalIF":3.5,"publicationDate":"2026-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13349767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148427009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Time-restricted eating in adults with type 2 diabetes mellitus on concomitant glucagon-like peptide-1 receptor agonists: case report.","authors":"Kyla L Laing, Jordan L Levy, Michael J Wilkinson, Shweta Varshney, Satchidananda Panda, Pam R Taub, Emily N C Manoogian","doi":"10.3389/fcdhc.2026.1725278","DOIUrl":"10.3389/fcdhc.2026.1725278","url":null,"abstract":"<p><p>Type 2 diabetes mellitus (T2DM), marked by insulin resistance and impaired blood glucose regulation, can lead to serious complications when poorly controlled. Recent studies highlight interactions between diet, sleep, and metabolic disorders, showing that elevated nighttime glucose levels are associated with a higher risk of cardiometabolic disorders. Time-restricted eating (TRE) is a lifestyle strategy that aligns dietary intake with the circadian system with a consistent 8- to 10-hour eating window during the day. TRE is a safe and effective lifestyle intervention that improves cardiovascular health and glycemic control, and may provide additional benefits beyond stable use of a glucagon-like peptide-1 receptor agonist (GLP-1RA). The three patients presented here participated in a clinical trial for adults with T2DM in which they were instructed to follow a consistent 8 to 10-hour TRE intervention for 3 months (NCT05365529). Assessments, including fasted blood draws, 10-day continuous glucose monitor (CGM) use, and 14-day actigraphy to measure sleep-wake cycles, were conducted at baseline and 3 months. At baseline, all 3 patients were on stable GLP-1RA and exhibited high mean glucose levels (>130mg/dL) during their nightly sleep. Following the 3-month TRE intervention, all 3 patients experienced reductions in hemoglobin A1c (HbA1c) and nighttime glucose, along with improved time in range (TIR) during sleep. This case series highlights the potential benefits of TRE, alongside GLP-1RA use, on nighttime glucose levels, while also underscoring the potential of CGM to identify glycemic phenotypes that may predict specific responses to TRE, demonstrating the importance of a personalized approach.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1725278"},"PeriodicalIF":3.5,"publicationDate":"2026-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13337375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148407274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between routine blood count-derived inflammatory markers and left ventricular hypertrophy in diabetic kidney disease patients: a cross-sectional study.","authors":"Rui Wu, Gaiqi Yao","doi":"10.3389/fcdhc.2026.1790675","DOIUrl":"10.3389/fcdhc.2026.1790675","url":null,"abstract":"<p><strong>Background: </strong>Adverse cardiovascular events are one of the most serious complications of diabetic kidney disease (DKD), and left ventricular hypertrophy (LVH) is a reliable predictor. The low-grade inflammatory state in patients with DKD further aggravates the damage to the kidneys and cardiovascular system. This study aims to explore the relationship between routine blood count-derived inflammatory markers in the peripheral blood of DKD patients and LVH.</p><p><strong>Methods: </strong>In this cross-sectional study, 419 patients with DKD G2 ~ G4, who received treatment at the Peking University Third Hospital from January 2020 to September 2025 were enrolled. Based on the echocardiographic findings, the participants were categorized into two groups: those with LVH and those without. Logistic regression was employed to examine the factors associated with LVH, as well as the interactions among neutrophil, the systemic immune-inflammation index (SII), and the stages of DKD. Additionally, receiver operating characteristic (ROC) curves and the optimal cut-off values of the SII and neutrophil were generated.</p><p><strong>Results: </strong>Among the 419 participants included in the study, there were 239 males and 180 females, with a baseline age of 66 years. 106 individuals were categorized in the LVH group. Multivariate logistic regression analysis revealed that neutrophil (<i>OR</i> = 1.31, <i>P</i> = 0.011), SII (<i>OR</i> = 1.01, <i>P</i> = 0.011), uric acid (<i>OR</i> = 1.01, <i>P<</i>0.01), and urea (<i>OR</i> = 1.02, <i>P</i> = 0.002) are positive correlation factors for LVH. In contrast, male gender (<i>OR</i> = 0.33, <i>P<</i>0.01) and calcium (<i>OR</i> = 0.07, <i>P</i> = 0.001) serve as negative correlation factors for LVH. Furthermore, DKD stage did not significantly modify the effects of neutrophil (interaction <i>P</i> = 0.09) and SII (interaction <i>P</i> = 0.22). The area under the curve (AUC) for basic variables, which include gender, calcium, uric acid, and urea, when combined with neutrophil and SII, was 0.816. This AUC, along with that of basic variables combined with SII (0.810), exceeded the AUC of basic variables alone (0.782), with the difference reaching statistical significance (<i>P</i> < 0.05). The optimal cut-off value for neutrophil is 4.14×10⁹/L, and the optimal cutoff value for SII is 491.78×10⁹/L.</p><p><strong>Conclusion: </strong>In DKD G2 ~ G4 patients, neutrophil, SII, uric acid and urea sever as independent positive correlation factors for LVH. In contrast, male gender and calcium serves as negative correlation factors.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1790675"},"PeriodicalIF":3.5,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318648/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with treatment compliance among middle-aged patients with type 2 diabetes mellitus in King Abdulaziz University Hospital, Jeddah, Saudi Arabia.","authors":"Abdulrahman Abudawood, Leen Algaidy, Manal Almazroui, Shaima Albeladi, Arwa Albeladi, Lama Alnamani, Bedoor Alghanmi, Iman Wahby, Salhah Alsulami","doi":"10.3389/fcdhc.2026.1824629","DOIUrl":"10.3389/fcdhc.2026.1824629","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetes mellitus (T2DM) is a chronic condition requiring sustained medication adherence and lifestyle modification. In Saudi Arabia, T2DM affects 21-24% of the population, with prevalence projected to rise by 2030. Demographic factors and comorbidities pose significant challenges to treatment compliance, particularly among middle-aged adults.</p><p><strong>Objective: </strong>To examine factors influencing treatment adherence among middle-aged adults (40-65 years) with T2DM at King Abdulaziz University Hospital, Jeddah.</p><p><strong>Methods: </strong>An analytical cross-sectional study was conducted at King Abdulaziz University Hospital, Jeddah. Data were collected via face-to-face interviews using a validated bilingual questionnaire covering demographics and treatment compliance. A total of 393 participants were enrolled, exceeding the minimum calculated sample of 365 (95% confidence level, 5% margin of error). Data were analysed using SPSS Version 20, with statistical significance set at p < 0.05.</p><p><strong>Results: </strong>Suboptimal adherence was reported by 78.4% of participants. Univariate logistic regression identified five predictors of suboptimal adherence: absence of treatment plan clarification (OR 3.197), lack of explanation of diabetes complications (OR 3.120), discontinuation of medication without consulting a provider (OR 0.130), non-commitment to medication dispensing dates (OR 0.139), and non-commitment to doctor appointments (OR 0.093). Multivariate backward stepwise logistic regression identified four independent predictors: age 51-55 years was associated with reduced odds of suboptimal adherence compared to age 40-45 years (aOR 0.235; p = 0.027); second-hand smoke exposure was associated with reduced odds compared to non-smokers (aOR 0.295; p = 0.027); working more than 55 hours per week was associated with reduced odds compared to working fewer than 35 hours (aOR 0.141; p = 0.038); and a diabetes diagnosis duration of 6-10 years was associated with increased odds compared to 1-5 years (aOR 2.553; p = 0.047).</p><p><strong>Conclusion: </strong>Adherence to anti-diabetic therapy remains suboptimal among middle-aged Saudi adults. Key contributors to poor adherence include missed appointments, unclear treatment plans, inadequate education on diabetes complications, and self-discontinuation of medications.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1824629"},"PeriodicalIF":3.5,"publicationDate":"2026-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13318602/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148371396","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Exploring the benefits of digital health technologies in diabetes management.","authors":"Anouk Geraets, Artur Rydosz, Frank Snoek","doi":"10.3389/fcdhc.2026.1843985","DOIUrl":"10.3389/fcdhc.2026.1843985","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1843985"},"PeriodicalIF":3.5,"publicationDate":"2026-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13314505/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148363951","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Early assessment of diabetes care target attainment in Mexico's federalized public health system: alignment with Global Diabetes Compact 2030.","authors":"Rubén Silva-Tinoco, Alejandro Avalos-Bracho, Vladimir Martínez-de la Cruz, Gabriel Gutiérrez-Morales, Arturo González-Ledesma, Arlette Saavedra-Romero, María Fernanda Bernal-Ceballos","doi":"10.3389/fcdhc.2026.1837250","DOIUrl":"10.3389/fcdhc.2026.1837250","url":null,"abstract":"<p><strong>Background: </strong>Robust system-level monitoring tools are essential to assess the performance of diabetes care within healthcare systems. We report an early assessment from an integrated monitoring platform in Mexico's emerging federalized public health system, focusing on indicators aligned with the World Health Organization Global Diabetes Compact 2030 targets.</p><p><strong>Methods: </strong>We conducted a descriptive health services research analysis using routinely collected clinical data from a national monitoring platform that enables longitudinal and subnational analyses. Key system-level indicators included attainment of glycemic control, blood pressure control, and statin use.</p><p><strong>Results: </strong>From 2023 to September 2025, data from 544,978 individuals across participating states were registered in the platform, of whom 316,947 with a recent diabetes care record were included in the analysis. Among individuals with a recent diabetes care record, 59.3% achieved glycemic control, 76.6% achieved blood pressure control, and 30.2% were receiving statin therapy. Marked geographic heterogeneity was observed across states, with glycemic control ranging from 49% to 70%, blood pressure control from 65.8% to 82.4%, and statin use from 15.3% to 53%. Women showed higher attainment of blood pressure control and statin use, whereas older individuals demonstrated higher glycemic control than younger age groups.</p><p><strong>Conclusions: </strong>Routine clinical data provides valuable system-level insights into progress toward diabetes care targets. Early findings from Mexico's emerging federalized public health system reveal substantial gaps and territorial variation in key indicators, highlighting priority areas for strengthening diabetes care in primary healthcare.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1837250"},"PeriodicalIF":3.5,"publicationDate":"2026-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13310749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148354382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"\"My greatest fear is that he'll get diabetes\": a qualitative study of families' psychosocial responses to early detection of type 1 diabetes.","authors":"Pernille Bech Flarup, Dan Grabowski, Patricia DeCosta, Julie Christine Antvorskov, Flemming Pociot, Louise Norman Jespersen","doi":"10.3389/fcdhc.2026.1796164","DOIUrl":"10.3389/fcdhc.2026.1796164","url":null,"abstract":"<p><strong>Background: </strong>The incidence of type 1 diabetes (T1D) among European children has nearly doubled over the past three decades. Emerging disease-modifying therapies highlight the importance of early detection to delay disease onset and enhance psychosocial preparedness. However, participation in early detection may also evoke parental anxiety, underscoring the need to understand families' psychosocial experiences to ensure ethically and emotionally responsive screening programs. This study explores how families experience participation in early detection when children are first-degree relatives of individuals with T1D.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with 31 parents of children aged 1-17 years participating in a Danish early detection program for T1D (DiaUnion). Data were analyzed using Antonovsky's Sense of Coherence framework to examine how families perceive, manage, and make sense of disease-related uncertainty during participation.</p><p><strong>Results: </strong>Three themes describe how families experience participation in early detection. First, The Family Narrative illustrates how parents' prior experiences with T1D shape expectations and emotional responses to screening, often combining practical knowledge with heightened concern. Second, Diabetes in Everyday Life shows how families integrate early detection into daily routines and draw on experiential knowledge to manage uncertainty and interpret potential symptoms. Third, Children's Involvement highlights how parents navigate decisions about how and when to involve their children in discussions about risk and screening. Across themes, clear communication and procedural transparency were central in supporting families' sense of coherence and their ability to manage uncertainty.</p><p><strong>Conclusion: </strong>Early detection programs for T1D should attend not only to clinical accuracy but also to families' psychosocial needs. Clear communication, transparency, and structured psychosocial support are essential to strengthen families' capacity to manage uncertainty and ensure that early detection is both effective and acceptable.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1796164"},"PeriodicalIF":3.5,"publicationDate":"2026-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13303781/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The diabetes distress experience from the perspective of adolescents and their parents.","authors":"Raman Sangha, Natalie Grieve, Kyra Braaten, Simran Gill, Titilola Yakubu, Tom Warshawski, Tricia S Tang, Trent Smith, Mary Jung, Elijah M K Haynes, Christine Voss","doi":"10.3389/fcdhc.2026.1652578","DOIUrl":"10.3389/fcdhc.2026.1652578","url":null,"abstract":"<p><strong>Objective: </strong>To explore sources of diabetes distress (DD) and resources for mental health support for adolescents with type 1 diabetes (T1D) and their parents/guardians.</p><p><strong>Methods: </strong>We recruited adolescents with T1D and parents of adolescents with T1D using an explanatory sequential mixed methods design. Participants completed measures of DD for adolescents (Problem Areas in Diabetes-Teen, PAID-T) or parents (P-PAID-T), followed by separate focus groups that elicited information on common concerns related to living with T1D, types of mental and emotional support accessed, and additional support sources desired. Data were analyzed using an interpretive description approach and collaborative analysis techniques.</p><p><strong>Results: </strong>Six adolescents and five parents participated. All adolescents reported high levels of DD (median (IQR) PAID-T score 71 (59-86), cutoff ≥ 44), while most parents reported low levels of DD (P-PAID-T score 46 (35-66), cutoff ≥ 54). Across all focus groups, five themes were identified: DD can cause burnout and indifference; T1D disrupts activities of daily living; More peer support is desired; Society is unaware of how T1D is managed; and Concern about future financial burden. The parent focus groups also identified: Parental concerns around transfer of management of responsibilities to their children.</p><p><strong>Conclusion: </strong>An improved understanding of the key sources of DD and how they compare between adolescents and parents will facilitate the design of more effective mental health support interventions for T1D.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1652578"},"PeriodicalIF":3.5,"publicationDate":"2026-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13293899/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148347510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neuropathy predicts early renal impairment in diabetes mellitus-the almost forgotten historical evidence. In memoriam Professor Göran Sundkvist.","authors":"Peter Kempler, Dóra Marietta Balogh, Viktor J Horváth, Adrienn Menyhárt, Manfredi Rizzo, Solomon Tesfaye, Vincenza Spallone","doi":"10.3389/fcdhc.2026.1875311","DOIUrl":"10.3389/fcdhc.2026.1875311","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1875311"},"PeriodicalIF":3.5,"publicationDate":"2026-06-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13286767/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148320755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Age, dyslipidemia, and gamma-glutamyl transferase are associated with diabetes in obesity: a cross-sectional study.","authors":"Shaomei Wang, Yongdong Su, Yanfeng Zhu, Lingyu Zhong, Xi Wang","doi":"10.3389/fcdhc.2026.1826118","DOIUrl":"10.3389/fcdhc.2026.1826118","url":null,"abstract":"<p><strong>Purpose: </strong>Obesity can lead to various complications, particularly diabetes, which imposes a substantial health and economic burden on affected individuals. However, there remains limited research on identifying which subgroups of individuals with obesity are at higher risk of developing diabetes.</p><p><strong>Patients and methods: </strong>A convenience sampling method was used to select individuals with primary obesity from a hospital. Binary logistic regression analysis was employed to identify associated factors for the co-occurrence of diabetes and obesity.</p><p><strong>Results: </strong>The prevalence of diabetes among individuals with obesity was 20.97%. The group with both obesity and diabetes showed a higher waist-to-hip ratio (WHR) and lower muscle mass percentages in both lower limbs compared to individuals with obesity but without diabetes. Age (<i>OR</i> = 1.04; <i>95% CI</i>: 1.00-1.08), dyslipidemia (<i>OR</i> = 2.45; <i>95% CI:</i> 1.01-6.25) and gamma-glutamyl transferase (GGT) (<i>OR</i> = 1.01; <i>95% CI</i>: 1.00-1.03) were associated with diabetes comorbidity in individuals with obesity.</p><p><strong>Conclusion: </strong>Age, dyslipidemia, and GGT may help identify individuals with obesity at higher diabetes risk. Abnormal findings in these markers may warrant timely intervention to reduce diabetes incidence.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1826118"},"PeriodicalIF":3.5,"publicationDate":"2026-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13259638/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}