Frontiers in clinical diabetes and healthcare最新文献

{"title":"\"This is going to be a nice-to-know, not a need-to-know\": absence of concern - a qualitative study of risk perception in early detection of type 1 diabetes.","authors":"Emilia Bjergskov Pedersen, Pernille Bech Flarup, Louise Norman Jespersen, Mette Due-Christensen, Julie Christine Antvorskov, Flemming Pociot, Dan Grabowski","doi":"10.3389/fcdhc.2026.1925120","DOIUrl":"10.3389/fcdhc.2026.1925120","url":null,"abstract":"<p><strong>Background: </strong>Type 1 Diabetes (T1D) is a chronic and demanding condition. In recent years, the development of immunomodulatory therapies has increased interest in early detection programs, which may delay disease onset and enable psychological preparedness. However, such programs also introduce new psychosocial considerations. This study explores how first-degree relatives of individuals with T1D perceive and experience participation in an early detection program.</p><p><strong>Methods: </strong>Semi-structured interviews were conducted with 28 adults aged 18-42 years participating in a Danish early detection program for T1D (DiaUnion). Data were analyzed using reflexive thematic analysis to explore patterns related to risk perception and meaning-making.</p><p><strong>Results: </strong>The analysis identified three main themes. First, narrative understanding of diabetes based on parental experience illustrates how perceptions of risk are shaped by family narratives and lived experiences. Second, general understanding of diabetes shows that perceptions are often informed by personal beliefs rather than biomedical knowledge. Third, interpretation of the screening result demonstrates that results are frequently downplayed and assigned limited personal significance. Across themes, participants actively constructed meaning around their risk through coping strategies such as normalization, reframing, and emphasizing controllability, which contributed to a generally low perceived risk.</p><p><strong>Conclusion: </strong>Risk perception among first-degree relatives is shaped by pre-existing personal and familial narratives, which influence how screening results are interpreted. Early detection programs should therefore move beyond standardized communication and adopt more individualized approaches that account for participants' existing frameworks of understanding and coping.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1925120"},"PeriodicalIF":3.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13671937/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149217517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prediction of metabolic dysfunction-associated steatotic liver disease among patients with type 2 diabetes mellitus using liver fat indices in a resource-limited clinical setting.","authors":"Kkdsd Kannangara, Wac Karunarathne, Nrp Perera, Uditha Bulugahapitiya, Jmkb Jayasekara, Nimantha Karunathilaka","doi":"10.3389/fcdhc.2026.1916533","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1916533","url":null,"abstract":"<p><strong>Introduction: </strong>Metabolic dysfunction-associated steatotic liver disease (MASLD), previously termed non-alcoholic fatty liver disease (NAFLD), is the hepatic presentation of metabolic syndrome. It shares the common pathophysiology of insulin resistance with type 2 diabetic mellitus (T2DM). The aim of this study was to establish the predictive ability of non-invasive liver fat indices-Fatty Liver Index (FLI), Hepatic Steatosis Index (HSI), Visceral Adiposity Index (VAI), Triglyceride and Glucose Index (TyG), and NAFLD-Liver Fat Score (NAFLD-LFS)-to determine fatty liver among patients with T2DM.</p><p><strong>Methodology: </strong>A cross-sectional analytical study was conducted on 260 newly diagnosed patients with type 2 diabetes. Anthropometric measurements were taken, while ultrasound scan was performed to determine fatty liver; its grade and blood samples were used to determine biochemical parameters. Liver fat index scores were calculated using standardized equations and analyzed using the statistical software SPSS version 23.0.</p><p><strong>Results: </strong>The incidence of MASLD among patients with T2DM was 69.2%. Three of the liver fat indices-FLI, HSI, and NAFLD-LFS-showed strong statistically significant correlations (<i>p</i> < 0.001) with liver ultrasonographic findings while the remaining indices-VAI and TyG-showed moderately significant correlations (<i>p</i> < 0.01). The cutoff values, sensitivities, and specificities of each index were determined by receiver operating characteristic (ROC) curve analysis. FLI showed the highest diagnostic performance [area under the curve (AUC) = 0.947; 95% confidence interval (CI): 0.923-0.971] with 75% sensitivity and 100% specificity with a cutoff value of 46.12. Both HSI (AUC = 0.847; 95% CI: 0.812-0.902) and NAFLD-LFS (AUC = 0.847; 95% CI: 0.800-0.894) showed good diagnostic performance with sensitivities of 68.3% and 76.1%, specificities of 95.5% and 85%, and cutoff values of 37.02 and 0.906, respectively. A moderate diagnostic performance was observed in the remaining indices: TyG (AUC = 0.707; 95% CI: 0.642-0.772) and VAI (AUC = 0.670; 95% CI: 0.602-0.739). Based on the multivariable logistic regression analysis, both FLI [adjusted odds ratio (aOR) = 1.144, 95% CI: 1.090-1.201, <i>p</i> ≤ 0.001] and HSI (aOR = 1.366, 95% CI: 1.157-1.614, <i>p</i> ≤ 0.001) were able to independently predict the presence or absence of fatty liver.</p><p><strong>Conclusion: </strong>The current study showed that all five liver fat indices have the ability to predict the presence or absence of fatty liver among patients with T2DM. FLI and HSI showed the highest performance among the five indices, which can be used as screening tools for fatty liver more efficiently. The findings provide reliable alternative methods for detecting fatty liver in a resource-limited clinical setting simplifying patient management.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1916533"},"PeriodicalIF":3.5,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13649460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149171839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toward standardized continuous glucose monitoring validation: lessons from the Sinocare iCan i3 accuracy study.","authors":"Auda Ameur","doi":"10.3389/fcdhc.2026.1941126","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1941126","url":null,"abstract":"<p><p>Continuous glucose monitoring (CGM) has transformed diabetes management by providing real-time glucose measurements and supporting improved glycemic control. Consequently, the methodological quality of CGM accuracy studies has become increasingly important for clinicians, regulatory agencies, and healthcare decision-makers. The recent real-world evaluation of the Sinocare iCan i3 CGM system provides valuable evidence regarding device performance under routine clinical conditions. However, several methodological aspects warrant further consideration before the reported findings can be generalized to clinical practice. This perspective critically examines key aspects of CGM validation, including study design, selection of the reference glucose measurement, statistical methodology, temporal pairing strategies, sensor survival analysis, potential sponsorship-related bias, and interpretation of clinical accuracy metrics. We also discuss additional methodological considerations that were not fully addressed in the original publication, including uncertainty estimation, subgroup analyses, longitudinal sensor performance, missing-data mechanisms, and reproducibility assessment. Finally, we propose recommendations aimed at improving the methodological rigor of future real-world CGM validation studies and facilitating meaningful comparisons across CGM technologies.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1941126"},"PeriodicalIF":3.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13623611/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The correlation between serum magnesium, phosphorus, and calcium levels during pregnancy and the risk of gestational diabetes mellitus as well as adverse pregnancy outcomes.","authors":"Achou Su, Jie Zhang, Xizhenzi Fan, Wenhui Song, Mingwei Li, Tianxiao Yu, Jin Zhang","doi":"10.3389/fcdhc.2026.1939424","DOIUrl":"10.3389/fcdhc.2026.1939424","url":null,"abstract":"<p><strong>Introduction: </strong>This retrospective cohort study included 700 pregnant women who underwent antenatal check-ups and delivered at the Fourth Hospital of Shijiazhuang from January 2022 to December 2023, aiming to investigate the associations of second°trimester serum magnesium, phosphorus, and calcium with adverse pregnancy outcomes including gestational diabetes mellitus (GDM), anemia, and preterm birth. Mineral indicators were measured at 24-28 weeks of gestation, and baseline data were collected.</p><p><strong>Methods: </strong>Mann-Whitney U test was adopted to compare the serum mineral levels among women with different pregnancy outcomes, multivariable logistic regression and ROC curve analysis was utilized to further explore the correlations.</p><p><strong>Results: </strong>After adjusting for potential confounders, magnesium, phosphorus, and calcium levels were correlated with GDM risk, with magnesium and calcium exerting statistically significant protective effects against GDM while high phosphorus serving as a statistically significant GDM risk factor. High calcium was also negatively associated with the risks of anemia and preterm birth whereas high phosphorus was positively linked to preterm birth risk.</p><p><strong>Discussion: </strong>These findings demonstrate that second-trimester serum magnesium, phosphorus, and calcium levels are associated with GDM, providing clinical evidence for glycemic control interventions and individualized nutritional guidance during pregnancy.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1939424"},"PeriodicalIF":3.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13619502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149083105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 pandemic and the management of type-2 diabetes mellitus among women in Fiji: concerns and context specific interventions.","authors":"Eunice Okyere, Kissinger Marfoh, Ramneek Goundar, Litia Makutu, Ditoga Kabukeinamala","doi":"10.3389/fcdhc.2026.1846673","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1846673","url":null,"abstract":"<p><strong>Introduction: </strong>The COVID-19 preventive strategies had a profound impact on type-2 diabetes management, creating challenges for individuals who depended on routine in-person consultations with healthcare workers. Given that the pandemic did not affect diabetic women equally across countries worldwide, this research was conducted in Fiji to explore how women living with type-2 diabetes managed their condition during the COVID-19 pandemic.</p><p><strong>Materials and methods: </strong>This study used a qualitative approach from a descriptive phenomenological lens. A total of 45 women with type-2 diabetes were purposively selected for in-depth interviews, as the study depended on participants ability to provide relevant information on the phenomenon being investigated. The data collection involved using a semi-structured interview guide with participants selected from different ethnic groups, ages, religions and settings to enhance data diversity. The data were analyzed using an inductive thematic analysis approach.</p><p><strong>Results: </strong>The themes that emerged were the perceived impact of the COVID-19 pandemic on T2DM management, coping strategies and recommended interventions. The perceived impact of the COVID-19 pandemic on diabetes management included limited access to healthcare workers and diabetes supplies, canceled or postponed appointments, changes in physical activities, difficulty in maintaining standard diets and diabetes complications. The coping strategies identified were emotional eating, religious practices, family support and the use of herbal medications. Participants recommended the need for financial support, accessible specialized healthcare services, intensifying diabetes education, virtual clinics and providing door-to-door diabetes supplies in crises, like the COVID-19 pandemic.</p><p><strong>Conclusion: </strong>The findings underscore the need for stakeholders to mitigate the pandemic's impact on women with type-2 diabetes by ensuring better access to healthcare services, providers, and essential supplies to improve disease management. To ensure continuity of care during emergency situations, policy makers and health managers should implement interventions including virtual clinics and home deliveries of diabetes supplies. Strengthening education on diabetes management can prevent complications by addressing behavioral and safety issues such as emotional eating and the unauthorized use of herbal medications.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1846673"},"PeriodicalIF":3.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149066464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fetal behavior as a window to later gross motor function: a 10-year follow-up of children prenatally exposed to gestational diabetes mellitus.","authors":"Oliver Vasilj, Dora Marinić, Tatjana Trošt, Zoran Žeželj","doi":"10.3389/fcdhc.2026.1938676","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1938676","url":null,"abstract":"<p><strong>Introduction: </strong>Gestational diabetes mellitus (GDM) has been associated with adverse neurodevelopmental outcomes in early childhood, but evidence regarding its long-term association with gross motor functioning remains limited. This 10-year follow-up study examined gross motor outcomes at approximately ten years of age in children prenatally exposed to diet-treated GDM and children from uncomplicated pregnancies, building on a prospectively established cohort in which fetal neurobehavior had previously been assessed.</p><p><strong>Methods: </strong>The study included 100 children, with 50 participants in each group. Gross motor functioning was assessed across six domains: coordination, agility, flexibility, explosive strength, muscular endurance, and balance. Given that several motor outcomes deviated from normality, Aligned Rank Transform (ART) factorial ANOVA was used to examine the effects of group, sex, and the group × sex interaction. Benjamini-Hochberg false discovery rate correction was applied to the p-values for the main effect of group to account for multiple comparisons.</p><p><strong>Results: </strong>Gross motor functioning was largely comparable between the groups, with no significant main effect of group for most motor outcomes or any balance parameter. However, significant group effects were identified for three specific motor tasks and remained statistically significant after FDR correction: children in the GDM-exposed group performed poorer in squats and ball rolling with the non-dominant hand, while they performed better in the straddle forward bend. The magnitude of the group effects was moderate for squats and straddle forward bend and large for ball rolling with the non-dominant hand.</p><p><strong>Discussion: </strong>These findings do not indicate generalized gross motor impairment but suggest that prenatal exposure to the metabolic environment associated with GDM may be related to subtle, task-specific differences in motor functioning that remain detectable during school age. Further longitudinal research is needed to determine the developmental stability and clinical relevance of these outcomes.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1938676"},"PeriodicalIF":3.5,"publicationDate":"2026-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13612258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149065972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Oxidative stress and inflammation in type 2 diabetes: pathways to organ complications.","authors":"Toshiki Otoda, Teruki Miyake, Shusuke Yagi, Ken-Ichi Aihara, Keizo Kanasaki","doi":"10.3389/fcdhc.2026.1976753","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1976753","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1976753"},"PeriodicalIF":3.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13598320/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single-cell RNA sequencing in diabetic foot ulcers: pathogenesis, biomarkers, and translational potential.","authors":"Shuhan Yang, Siqian Wang, Ruiyi Yang, Ke Xu, Xiaofeng Yang, Yifeng Zhao","doi":"10.3389/fcdhc.2026.1833678","DOIUrl":"10.3389/fcdhc.2026.1833678","url":null,"abstract":"<p><p>Diabetic foot ulcer (DFU), a common diabetic complication driven by impaired angiogenesis, neuropathy and metabolic disorders, has complex pathogenesis and poses great challenges to clinical management. Single-cell RNA sequencing (scRNA-seq), an emerging transcriptomic technique, allows disease profiling at single-cell resolution. This review summarizes recent advances in scRNA-seq-based DFU research, revealing that JMJD3-mediated macrophage polarization failure and dysregulated IGF-1-SP1-CD248 pathway hinder wound repair, with <i>MMP1, MMP3, MMP11</i>, JMJD3 and <i>HIF1A</i> identified as valuable biomarkers and therapeutic targets. It highlights scRNA-seq's utility in unraveling pathogenic mechanisms, discovering therapeutic targets and biomarkers, and facilitating precision medicine, to provide new insights and research directions for DFU therapy.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1833678"},"PeriodicalIF":3.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13583914/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moisturizer formulations for diabetic foot xerosis: a systematic review and meta-analysis of randomized controlled trials.","authors":"Karin Borgström, Sebastian Björklund, Petri Gudmundsson, Anna Ericsson, Stefan Acosta","doi":"10.3389/fcdhc.2026.1922860","DOIUrl":"10.3389/fcdhc.2026.1922860","url":null,"abstract":"<p><strong>Background: </strong>Foot xerosis in people with diabetes increases the risk of skin fissuring, ulceration and complications like amputation, sepsis and death. Preventive skin care is therefore important, yet evidence-based guidance on the most effective formulations remains limited. This systematic review aimed to identify effective ingredients and formulations to treat diabetic foot xerosis.</p><p><strong>Methods: </strong>A literature search was conducted in Medline, Cinahl, Embase, CENTRAL and Scopus. Randomized controlled trials (RCTs) involving adults with diabetes and foot xerosis (without ulcers) that compared topical formulations were eligible. Reviewers screened studies, extracted data, assessed risk of bias and certainty of evidence in accordance with Cochrane Intervention Review standards. Outcomes included xerosis severity, skin hydration, skin barrier integrity and adverse events. Meta-analyses of RCTs were conducted. The review was registered in PROSPERO (CRD42024579919).</p><p><strong>Results: </strong>Eleven articles reporting twelve RCTs were included. Functional creams (i.e., base formulations with added ingredients, most commonly humectants, intended to enhance their effect) significantly reduced xerosis severity compared with standard base formulations after both two weeks (standardized mean difference [SMD] -0.58, 95% CI -1.05 to -0.11) and four weeks (SMD -0.30, 95% CI -0.46 to -0.14). The certainty of evidence was moderate. Functional creams significantly increased skin hydration (SMD 0.31, 95% CI 0.11 to 0.52), although the certainty of evidence was low. Creams containing urea were more effective than standard base creams after four weeks (SMD -0.36, 95% CI -0.55 to - 0.17), with high-certainty evidence. Adverse events were rare and mild.</p><p><strong>Conclusions: </strong>Functional creams, particularly those containing humectants and primarily urea, show greater efficacy than standard bases. However, high-quality randomized controlled trials with long-term outcomes such as risk of foot ulcers are warranted.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/PROSPERO/view/CRD42024579919, identifier CRD42024579919.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1922860"},"PeriodicalIF":3.5,"publicationDate":"2026-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13581737/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social determinants of health influencing diabetes self-care behaviors among immigrants: a scoping review.","authors":"Rie Kudoh, Taiga Shibayama","doi":"10.3389/fcdhc.2026.1915588","DOIUrl":"10.3389/fcdhc.2026.1915588","url":null,"abstract":"<p><strong>Background: </strong>As globalization accelerates, immigrants face diabetes management challenges that are a public health concern. Although Social Determinants of Health (SDOH) are recognized as key drivers of health status and access to care, their role in diabetes self-care behaviors among immigrants remains unclear.</p><p><strong>Objectives: </strong>This scoping review aimed to identify and map SDOH influencing diabetes self-care behaviors among immigrants in host countries.</p><p><strong>Methods: </strong>PubMed and Web of Science were searched for peer-reviewed empirical studies (qualitative, quantitative, or mixed-methods) published in English between 2020 and 2024, following PRISMA-ScR framework, using terms related to immigrants, diabetes, self-care, and SDOH.</p><p><strong>Results: </strong>Twenty-five studies met inclusion criteria, predominantly from the North America and Caribbean region (n = 17), with no studies identified from South-East Asia or Africa. All six SDOH domains were associated with at least one of five self-care behaviors. Community and Social Context was the most pervasive domain, influencing all behaviors. Economic Stability, Health and Healthcare System, and Education Access and Quality were associated with multiple behaviors, with financial constraints and language barriers. Food Environment and Neighborhood and Physical Environment, as environmental factors, were more selectively associated; Food Environment with diet, and Neighborhood and Physical Environment with physical activity and medical visits.</p><p><strong>Conclusion: </strong>Diabetes self-care among immigrants is shaped by a complex interplay of structural and environmental factors, highlighting the need for culturally tailored, multilevel interventions to reduce self-care disparities. The absence of evidence from South-East Asia and Africa represents a critical gap, and future research in these underrepresented regions is warranted.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1915588"},"PeriodicalIF":3.5,"publicationDate":"2026-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13574606/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148978904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}