Frontiers in clinical diabetes and healthcare最新文献

{"title":"Predicting diabetic retinopathy stages using a simple nerve conduction measuring device, DPNCheck^®: a retrospective observational study.","authors":"Mayu Sakai, Takehiro Kato, Takuma Ishihara, Ken Takao, Tokuyuki Hirose, Sodai Kubota, Saki Kubota-Okamoto, Toshinori Imaizumi, Yoshihiro Takahashi, Masami Mizuno, Takuo Hirota, Yukio Horikawa, Hirokazu Sakaguchi, Shin Tsunekawa, Daisuke Yabe","doi":"10.3389/fcdhc.2025.1590407","DOIUrl":"10.3389/fcdhc.2025.1590407","url":null,"abstract":"<p><strong>Aims/introduction: </strong>Diabetic retinopathy (DR) often remains asymptomatic until it reaches advanced stages, when delayed treatment can lead to irreversible visual impairment. To promote timely ophthalmology visits, this study investigated the utility of a simple nerve conduction device, DPNCheck^®, as a predictor of DR severity. Previous research has established a relationship between diabetic neuropathy (assessed by conventional nerve conduction studies) and DR progression; however, the specialized equipment and expertise required limit its practicality. In contrast, DPNCheck^® is a simpler alternative that quantifies neuropathy severity through the severity of the estimated modified Baba classification (eMBC).</p><p><strong>Materials and methods: </strong>Using electronic medical records (EHRs), we identified individuals with diabetes who underwent DPNCheck^® and subsequent ophthalmologic assessment for DR. Based on age and sural nerve conduction data, an eMBC was calculated. Meanwhile, DR severity was scored using a modified Davis classification, defining four stages (DR severity scores 0-3).</p><p><strong>Results: </strong>Of 181 individuals extracted from our hospital's EHRs, 146 were eligible for analysis. Ordinal logistic regression showed that eMBC was significantly associated with DR stage, independent of diabetes duration and HbA1c. Receiver operating characteristic (ROC) curve analyses yielded eMBC cut-off values of 1.11, 1.51, and 1.51 to predict DR severity scores of ≥1, ≥2, and ≥3, respectively. Sensitivities ranged from 0.67 to 0.78, and specificities from 0.66 to 0.81. An eMBC of 1.51 or above was strongly associated with preproliferative or proliferative DR, indicating a need for urgent ophthalmology referral.</p><p><strong>Conclusions: </strong>DPNCheck^®, a simple nerve conduction measurement device, may help predict DR severity and facilitate timely ophthalmologic care.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1590407"},"PeriodicalIF":2.2,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Underestimated reason of hyperkalemia in diabetic patients: type IV renal tubular acidosis- mini review.","authors":"Sibel Ertek, Kayser Caglar","doi":"10.3389/fcdhc.2025.1570868","DOIUrl":"10.3389/fcdhc.2025.1570868","url":null,"abstract":"<p><p>Diabetes mellitus is chronic disease with increasing prevalence, and may cause many organ complications, including kidneys. Reduced creatinine clearance and kidney failure are important, but hyperkalemia may be present in diabetic patients even before these problems. There may be many reasons of hyperkalemia in this group of patients. Type IV renal tubular acidosis is important cause of generally mild hyperkalemia, and it is a treatable condition. ''Polypharmacy'' -which is very common in diabetic patients due to accompanying other diseases- may trigger electrolyte imbalance. Underlying causes should be investigated and treatment should be done before it worsens.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1570868"},"PeriodicalIF":2.2,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12289468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the multifaceted roles of GLP-1 receptor agonists; a comprehensive review.","authors":"Bisma Fatima Hammad, Nimrah Zafar, Muneeb Ullah, Syeda Jazilah Faisal, Fizzah Iftikhar, Haadia Waheed, Muhammad Waleed Muzaffar, Khadija Ahmed, Faz Ashraf, Komal Zahid, Maimoona Akhtar, Mohammed Mahmmoud Fadelallah Eljack","doi":"10.3389/fcdhc.2025.1590530","DOIUrl":"10.3389/fcdhc.2025.1590530","url":null,"abstract":"<p><p>Traditionally, Glucagon-like peptide-1 (GLP-1) receptor agonists (GLP-1RAs), a pivotal class of drug, mimics the actions of endogenous Glucagon-like peptide-1, which have been found to be remarkable in the treatment of type 2 diabetes alongside other comorbidities. GLP-1 receptors being widely available in the different organs and tissues such as the brain, lung, pancreas, stomach, heart, and endometrium has explained the broader therapeutic application of GLP-1RA. The recent studies have explored the physiological effects of GLP-1RA on body organs, establishing them as a potential therapeutic option for a wide range of diseases. Activation of GLP-1 receptors contribute to regulation of blood glucose levels, weight management, cardiovascular health, and potential neuroprotection, while also having a positive influence on musculoskeletal health. This review has emphasized the expanded role of GLP-1RA by highlighting the most significant and notable studies. While GLP-1RA has proven clinical efficacy, the need for more comprehensive studies, to ensure their long-term safety, is essential to optimize their therapeutic role and improve patient outcomes on a global scale. Addressing the significant gap for research on cost effectiveness of these drugs is also crucial for their accessibility in comparison to other drugs. Nevertheless, the limited data available calls for a platform for future research to carry out the expanded therapeutic effects of GLP-1RA.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1590530"},"PeriodicalIF":2.2,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144710112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin autofluorescence is associated with blood glucose levels, especially in children with type 1 diabetes.","authors":"Tinghan Deng, Jingping Wu, Hongbin Cheng","doi":"10.3389/fcdhc.2025.1590288","DOIUrl":"10.3389/fcdhc.2025.1590288","url":null,"abstract":"<p><strong>Background: </strong>This study examines the correlation between skin autofluorescence (SAF) and blood glucose levels, emphasizing the accumulation of advanced glycation end-products (AGEs). We hypothesize that SAF levels are closely linked to type 1 diabetes complications in children. The aim is to evaluate SAF's relationship with type 1 diabetes progression in children and its potential as a non-invasive tool for disease detection and monitoring complications. The research was registered with PROSPERO (CRD42021284774).</p><p><strong>Methods: </strong>We conducted a meta-analysis by extracting studies from databases including PubMed, MEDLINE, EMBASE, Cochrane, Science Direct, Scopus, and Web of Science. A random effects model was used to assess if SAF measurement could serve as a non-invasive marker for type 1 diabetes and its complications. SAF values were compared between children with type 1 diabetes and controls, calculating the mean difference and 95% confidence intervals.</p><p><strong>Results: </strong>The analysis included three case-control studies and one retrospective cohort study, all using the AGE Reader^® (DiagnOptics Technologies). Data analysis showed significant heterogeneity (I² = 82%, P < 0.05). The random effects model revealed a positive correlation between higher SAF levels and type 1 diabetes in children [mean difference = 0.20 (0.16, 0.25)], indicating elevated SAF in diabetic children compared to non-diabetic peers.</p><p><strong>Conclusion: </strong>This research supports SAF measurement as a non-invasive indicator for type 1 diabetes and its complications in children. However, further studies with larger samples and longer follow-up are needed for definitive conclusions and detailed insights into complications. Additionally, the skin's multifaceted roles require further investigation.</p><p><strong>Systematic review registration: </strong>https://www.crd.york.ac.uk/prospero/, identifier CRD42021284774.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1590288"},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12258062/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144638858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic Foot Talk-Time: framework for effective communication in diabetic foot management.","authors":"Lavinia Cacciatore, Marco Meloni","doi":"10.3389/fcdhc.2025.1590570","DOIUrl":"10.3389/fcdhc.2025.1590570","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Introduction: &lt;/strong&gt;Diabetic foot syndrome is a prevalent and costly chronic complication of diabetes mellitus, linked to high mortality rates and significant psychological and social burdens. These challenges exacerbate the disease's impact and can hinder the ability of healthcare professionals to effectively connect with patients. Therapeutic education and effective communication can play crucial roles in fostering patient empowerment and adherence to care, which can help reduce frustration for both patients and caregivers. However, there is currently a lack of specific guidelines to direct healthcare professionals in diabetic foot care. This study employs a mixed-methods approach, integrating a systematic literature review and a cross-sectional survey, to evaluate existing communication strategies and develop a structured digital framework aimed at improving diabetic foot care. The research focuses on reviewing recent literature (from the past five years) on effective communication and therapeutic education in the prevention and management of Diabetic Foot Syndrome. Additionally, it includes an analysis of existing manuals on communication strategies and a descriptive survey to assess professional-patient and interprofessional communication challenges, identify areas for improvement, and measure levels of awareness among diabetic patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;The literature review was conducted using the PICO method on the Medline database through PubMed, yielding 273 articles, of which eight were selected for in-depth analysis. A survey, conducted over four months, included 165 participants divided into professional and diabetic groups, each receiving targeted questionnaires.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The analysis of selected articles and communication manuals highlighted key themes aligned with the study's objectives. Findings emphasized that self-management, effective communication, professional training in therapeutic education, and the use of information and communication technologies (ICT) are essential to improving patient adherence to diabetic foot care and optimizing therapeutic outcomes. Survey results revealed that a large proportion of diabetic patients reported either not receiving information on diabetic foot syndrome from healthcare professionals or only receiving it post-complication, leading many to seek information online. Both professionals and patients acknowledged that online resources enhance adherence to care.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Discussion: &lt;/strong&gt;The study underscores the need for reliable, accessible resources, including multimedia support for active health education aimed at both healthcare professionals and diabetic patients at risk of foot complications. Based on these findings, a prototype framework was developed-a web platform designed to support professionals and diabetic patients with features such as daily podiatric routines, alert systems, instructional images, and pr","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1590570"},"PeriodicalIF":0.0,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12232915/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144585776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Social support groups and policy recommendations for managing type 2 diabetes: perspective of healthcare professionals in Ghana.","authors":"Christine Ahiale, Augustine Kumah","doi":"10.3389/fcdhc.2025.1604828","DOIUrl":"10.3389/fcdhc.2025.1604828","url":null,"abstract":"<p><strong>Background: </strong>Over the last decades, non-communicable diseases such as diabetes have remarkably increased due to rapid urbanization, unhealthy lifestyles, and ageing. The World Health Organization (WHO) indicates that the \"diabetes epidemic\" will continue in the coming decades, yielding enormous human and economic costs around the world. This study explores healthcare workers' views on social support groups and policy recommendations for managing type 2 diabetes in Ghana.</p><p><strong>Method: </strong>This study utilized a facility-based cross-sectional qualitative research design to explore healthcare workers' views on social support groups and policy recommendations for managing type 2 diabetes in Ghana between January and May 2023. Health workers who worked in the three selected regional hospitals for at least one year and at the diabetic clinics of the three selected regional hospitals of the respective regions at the time of this study were included. The study used purposive sampling to select 12 health workers (Nurses) as key informants. One (1) facility head of each facility and three (3) health workers, each working in the diabetic clinic of each regional hospital, were selected for key informant interviews. The interviews were recorded and transcribed in English. Notes from the interview were transcribed after the key informant interview. Data was imported into the Nvivo 7 software. The results were presented as prose, analyzed, and discussed in themes.</p><p><strong>Results: </strong>Major challenges facing people living with diabetes were the cost of medication, limited NHIS coverage, frequent morbidity and the chronic nature of the disease, putting psychological pressure on the patients. The policy recommendation was on mass education and the expansion of NHIS coverage.</p><p><strong>Conclusion: </strong>The study has noted some significant challenges faced in managing type 2 diabetes mellitus in Ghana. Addressing the diabetes epidemic in Ghana requires a comprehensive and multi-pronged approach, focusing on prevention, early detection, access to care, and diabetes education. Implementing the policy recommendations outlined in this study can significantly improve diabetes management in Ghana, reduce the burden of the disease, and enhance the overall health and well-being of the population.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1604828"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A bibliometric analysis of global research hotspots and development trends in diabetic wound treatment.","authors":"Yin Wen, Kaiyu Nie","doi":"10.3389/fcdhc.2025.1603206","DOIUrl":"10.3389/fcdhc.2025.1603206","url":null,"abstract":"<p><strong>Background: </strong>Diabetic wounds are a serious complication for diabetic patients, characterized by refractoriness, high recurrence rates, and susceptibility to infection. Although current guidelines recommend evidence-based treatment strategies, clinical outcomes remain suboptimal. This paper reviews the current research status and development trends in diabetic wound treatment.</p><p><strong>Methods: </strong>Articles on diabetic wound treatment published between 2014 and 2023 were identified using the Web of Science Core Collection database, resulting in a total of 9,099 articles. Bibliometric methods were employed to analyze authors, institutions, countries, journals, keywords and references using CiteSpace and VOSviewer.</p><p><strong>Results: </strong>China has published the most articles in the field, followed by the United States. Shanghai Jiao Tong University is the leading institution in diabetic wound treatment research, and David G. Armstrong from the United States has made significant contributions to this field. \"Wound Repair and Regeneration\" was identified as the most influential journal. Cluster analysis of keywords revealed four main categories: (1) mechanisms of diabetic wound healing, (2) prognosis, (3) treatment, and (4) management.</p><p><strong>Conclusion: </strong>This paper systematically reviews the research on diabetic wound treatment from 2014 to 2023, outlining and forecasting global research hotspots and trends. Future research is expected to focus on treatment strategies for diabetic wounds, while interdisciplinary collaboration and advancements in intelligent management technologies have the potential to improve patient outcomes.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1603206"},"PeriodicalIF":0.0,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12226289/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial: Metabolic syndrome in patients with diabetes: identification of biomarkers.","authors":"Surjya Narayan Dash, Mónica Muñoz-Úbeda, Faisal Aziz","doi":"10.3389/fcdhc.2025.1620665","DOIUrl":"10.3389/fcdhc.2025.1620665","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1620665"},"PeriodicalIF":0.0,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12197939/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A health promotion model approach in exploring self-management and glycemic control in type 2 diabetes: the moderating effects of self-efficacy and social support.","authors":"Sylvi Ndatila Amunkete, Elihuruma Eliufoo Stephano, Mtoro J Mtoro, Feng Hui","doi":"10.3389/fcdhc.2025.1573805","DOIUrl":"10.3389/fcdhc.2025.1573805","url":null,"abstract":"<p><strong>Background: </strong>As the prevalence of diabetes and its related complications continues to rise, understanding the factors that influence glycemic control is crucial for improving patient outcomes. This study aimed to explore the roles of self-management, social support, and self-efficacy in moderating fasting blood glucose (FBG) levels in individuals with type 2 diabetes mellitus (T2DM).</p><p><strong>Methods: </strong>A health facility-based cross-sectional study was conducted in Windhoek, Namibia with a sample size of 315 T2DM patients receiving follow-up care. Descriptive statistics and Pearson correlation analysis were conducted to examine the relationship between self-management and FBG. Linear regression and moderation analyses were used to determine the moderating effects.</p><p><strong>Results: </strong>The study revealed 34.3% engaged in self-monitoring of FBG, while medication adherence was high at an average of 7 days. A significant negative correlation between self-management practices and FBG levels was identified (r = -0.349, p < 0.028). Self-management, self-efficacy, and social support accounted for 43.1% of FBG variation, with self-management emerging as a significant predictor (β = -0.903, p < 0.001). Additionally, social support and self-efficacy significantly moderated the relationship between self-management and FBG levels.</p><p><strong>Conclusion: </strong>This study showed the significant moderating roles of social support and self-efficacy in the relationship between self-management practices and FBG levels in patients with diabetes. These results highlight the importance of comprehensive diabetes management programs focusing on individual behavioral changes, enhancing social support networks, and boosting self-efficacy.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1573805"},"PeriodicalIF":0.0,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12187595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144499695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The status and trends of type 2 diabetic osteoporosis research: a global bibliometric and visualization analysis over the past 20 years.","authors":"Haiyan Hou, Liying Zhu","doi":"10.3389/fcdhc.2025.1596938","DOIUrl":"10.3389/fcdhc.2025.1596938","url":null,"abstract":"<p><strong>Background: </strong>Type 2 diabetic osteoporosis (T2DOP) has received considerable attention due to its accelerated bone deterioration and significantly increased fracture risk. Unlike classical osteoporosis, patients with T2DOP often exhibit a paradoxical pattern: they have normal or even elevated bone mineral density (BMD) in early stages despite deterioration in bone microarchitecture. This paradox highlights the clinical importance of identifying T2DOP as a distinct and critical subtype of secondary osteoporosis.</p><p><strong>Methods: </strong>We conducted a bibliometric analysis of literature on T2DOP published over the past 20 Years(from 2001 to 2020), using data retrieved from the Web of Science Core Collection database. Bibliometric networks were visualized and analyzed using VOSviewer. Publication trends, geographic contributions, research hotspots, and keyword clusters were systematically examined.</p><p><strong>Results: </strong>Over the past 20 Years, global research output on T2DOP steadily increased, with major contributions from North America, East Asia, and Western Europe. Identified research hotspots included risk prediction, biomarkers (e.g., advanced glycation end-products), complication management, population-specific characteristics (e.g., postmenopausal women), and therapeutic strategies (e.g., metformin). Notably, lifestyle intervention has recently emerged as an important new research direction.</p><p><strong>Conclusions: </strong>This study provides the first comprehensive bibliometric analysis and visualization of global research trends and hotspots in T2DOP, highlighting critical insights for clinical practice, including the identification of at-risk populations, biomarker-guided risk assessment, and therapeutic optimization, which complements existing clinical meta-analyses. Future research efforts should emphasize multidisciplinary collaboration and validation of the long-term efficacy of lifestyle interventions. For clinical practice, integrating bone density evaluation with biomarker screening (e.g., osteocalcin) in diabetic patients could enhance early fracture prevention. Public health initiatives should prioritize lifestyle interventions in high-risk populations (e.g., postmenopausal women) to mitigate the growing burden of diabetic osteoporosis.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1596938"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}