Frontiers in clinical diabetes and healthcare最新文献

{"title":"Platelet-rich plasma combined with multimodal therapy for diabetic foot ulcer with tophi: a case report.","authors":"Xinjie Duan, Xinjuan Sun, Yang Liu, Maoyuan Chen, Li Dong","doi":"10.3389/fcdhc.2026.1795474","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1795474","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the comprehensive therapeutic value of platelet-rich plasma (PRP) combined with antibiotic-loaded bone cement, systemic metabolic management, and topical herbal preparation for diabetic foot ulcer (DFU) with tophi.</p><p><strong>Methods: </strong>A 55-year-old male with tophaceous DFU received multimodal treatment, including debridement, antibiotic-impregnated bone cement implantation, local autologous PRP injections, topical Xiang Lei Tang Zu Ointment, and systemic control of glucose and uric acid. Efficacy was assessed via wound area, laboratory tests, and imaging.</p><p><strong>Results: </strong>After 4 months, the ulcers were nearly healed with significant reduction in wound area, healthy granulation tissue, and complete re-epithelialization. Serum uric acid decreased from 564 μmol/L to normal range, alongside reduced inflammatory markers.</p><p><strong>Conclusion: </strong>This multimodal strategy integrating local anti-infection, bioactive repair, topical agents, and systemic regulation effectively controlled infection, promoted tissue regeneration, and improved the metabolic microenvironment, offering a promising integrative model for refractory tophaceous DFU.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1795474"},"PeriodicalIF":2.2,"publicationDate":"2026-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138994/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of integrative therapies on glycemic control in type 1 diabetes: a systematic review and global research landscape.","authors":"Acharya Balkrishna, Jaya Upreti, Muskan Chauhan, Mayur Chauhan, Prashant Katiyar, Anurag Dabas, Vedpriya Arya","doi":"10.3389/fcdhc.2026.1739023","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1739023","url":null,"abstract":"<p><strong>Background: </strong>Type 1 diabetes mellitus (T1DM) requires lifelong insulin therapy due to autoimmune destruction of pancreatic β-cells, the difficulty of achieving ideal glycemic control despite advancements in conventional care has led to a rise interest in alternative and integrative medicine (CIM) practices like naturopathy, yoga, and Ayurveda.</p><p><strong>Objective: </strong>This systematic review and meta-analysis aimed to evaluate the effects of integrative therapies on glycemic control in individuals with T1DM and to map the global research landscape through bibliometric analysis.</p><p><strong>Methods: </strong>Following PRISMA, a thorough literature search was carried out in PubMed, Scopus, Embase, and Google Scholar. Included were studies evaluating CIM interventions for T1DM, such as yoga, naturopathy, and Ayurvedic treatments. Both qualitative and quantitative methods were used to synthesise the data, and bibliometric studies were conducted to evaluate country-level output, temporal trends, institutional contributions, and keyword network analysis.</p><p><strong>Results: </strong>Out 612 screened records, 12 studies met inclusion criteria for qualitative and quantitative analysis. Integrative therapies showed adjunctive benefits to insulin therapy, including improved glycemic control, insulin sensitivity, stress reduction and quality of life. After 2023, bibliometric study showed a growing research trend, In the context of citation impact, Italy and Vietnam are leading, whereas India leads in publications. Keyword network analysis revealed strong associations between integrative practices, particularly yoga and lifestyle modification and glycemic outcomes.</p><p><strong>Conclusion: </strong>Integrative therapies appear to be promising alternative in the management of T1DM, supporting glycemic control and holistic well-being. However, larger multicenter clinical trials are required to strengthen the evidence base and support their integration into standard diabetes care frameworks. Broader clinical integration, rigorous multicentric trials, and greater alignment with national AYUSH policies are recommended to optimize T1DM management in India and potentially enhance outcomes globally.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1739023"},"PeriodicalIF":2.2,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135930/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147846897","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The association between sleep duration, insomnia and sleep patterns with metabolic syndrome: an integrative review.","authors":"Bekalu Bewket, Adriano Marçal Pimenta","doi":"10.3389/fcdhc.2026.1794920","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1794920","url":null,"abstract":"<p><strong>Introduction: </strong>Due to the use of various methods across different studies, the association between sleep duration, insomnia and sleep pattern with metabolic syndrome (MetS) remains inconsistent. Integrative reviews that thoroughly synthesize data from various study types are therefore required in order to clarify the relationships between particular aspects of sleep and MetS. Therefore, this integrative review aimed to assess and summarize the most recent data regarding the relationship between sleep duration, sleep patterns and insomnia with MetS.</p><p><strong>Design: </strong>Integrative review.</p><p><strong>Methods: </strong>Problem identification, literature search, data evaluation, data analysis, and presentation five stage methodology developed by Whitmore and Knaff's (2005) guided this review. Four databases including; PubMed, Embase, Scopus and Web of Science were utilized. The quality of included studies were assessed by the Mixed Methods Appraisal Tool (2018). Conventional quantitative content analysis method was used to analyze extracted date and the preferred reporting items for systematic reviews and meta analyses checklist guided the reports of this review.</p><p><strong>Result: </strong>Initially a total of 25,472 articles were retrieved, 12 cross-sectional, 5 cohorts, 1 case-control studies were finally included. This study revealed sleep duration, insomnia and specific sleep characteristics such as; long daytime napping > 90 minutes, irregular sleep, social jetlag and early wake-up linked with increased risk of MetS.</p><p><strong>Conclusion: </strong>MetS is a complex problem and could be affected by the interaction of multiple sleep characteristics. Short sleep duration consistently was associated with MetS. However, the association between long sleep duration and insomnia with MetS remained inconsistent.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1794920"},"PeriodicalIF":2.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13128672/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824140","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of the Roy Adaptation Model in clinical nursing care of an adolescent diagnosed with type 1 diabetes (case report).","authors":"Ecem Oksal Güneş, Senay Cetinkaya","doi":"10.3389/fcdhc.2026.1721420","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1721420","url":null,"abstract":"<p><p>Adolescence is considered one of the most difficult periods in life due to the physical, cognitive, emotional and social changes that occur. With the developmental characteristics of adolescence and the existence of a chronic disease such as type 1 diabetes (T1D), adolescents may face problems such as a decrease in self-esteem, feeling different from their peers, and not being able to be included in peer groups. In this case report, nursing approaches to improve the physical, psychological, and psychosocial adaptation of an adolescent diagnosed with T1D were implemented based on the Roy Adaptation nursing model. In line with data obtained (with permission) from a 14 -year-old patient with T1D, pain, nutritional insufficiency, hyperglycemia, fatigue, decreased social interaction, lack of knowledge, anxiety, inadequacy in individual coping, ineffective role performance and impairment in social interaction were diagnosed and appropriate nursing interventions were implemented. In this context, the patient was given counseling and nursing care on the complications of diabetes, insulin administration training, and diet training, ensuring the organization of her self-concept, roles, and responsibilities, eliminating the lack of information regarding the diagnosis of diabetes, and ensuring compliance with the diagnosis of diabetes. At the end of the nursing interventions, the patient's pain was relieved. Since nausea is the cause of the patient's \"nutrition less than the body requirement\" problem, interventions to relieve nausea have yielded positive results. Fatigue decreased and the patient was more willing to perform activities. The patient's lack of information about her ilnesses was addressed. Despite all nursing interventions about the patient's role function and mutual interaction areas, she still expresses the changes caused by her illness in her school life with negative evaluations. In this case report, it was seen that the use of the Roy Adaptation Model was appropriate and beneficial, considering that the most common problems among adolescents hospitalized for T1D are physical, psychological, and psychosocial adaptation to the illness.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1721420"},"PeriodicalIF":2.2,"publicationDate":"2026-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13129417/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824179","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of infection in amputations in patients with diabetic foot ulcer: a retrospective study.","authors":"Kaitlyn Depinet, Bryce Hockman, Rodica Muraru, David A Ajayi, Zachary Carr, Beth Altenburger, Jaimee Haan, Gregory Westin, Emma Holler, Christopher A Harle, Mithun Sinha","doi":"10.3389/fcdhc.2026.1746688","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1746688","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the prevalence of infection in diabetic foot ulcers (DFUs) and its association with lower limb major and minor amputations, examining demographic and socioeconomic factors influencing DFU outcomes.</p><p><strong>Research design and methods: </strong>This retrospective study analyzed data from the Indiana Network for Patient Care (INPC) from January 2019 to May 2024. A total of 27,078 patients with DFUs were included, aged 9 to 103 years. Data included demographics, clinical encounters, ICD-10, CPT codes, laboratory values, and microbiological assessments. Analyses included Pearson correlation, logistic regression, and one-sample proportion tests.</p><p><strong>Results: </strong>Patients were predominately male (64.3%) and female (35.7%) with a mean age of 63.8 years. DFU prevalence showed significant inverse correlation with median income (r=0.2108, p=0.0016); lower-income areas (median income < $64,200) had DFU rates > 5.0 per 1,000 population. Of cultured specimens, 33.79% showed infections, primarily <i>Staphylococcus</i> spp. (22.52%) and <i>Streptococcus</i> spp. (11.27%). In major and minor amputation cases with microbial data available, <i>Staphylococcus</i> spp. (22.75%), <i>Enterococcus</i> spp. (11.86%) and <i>Streptococcus</i> spp. (10.42%) genera were most common. Osteomyelitis increased amputation odds by 7.83 times (p<0.001).</p><p><strong>Conclusions: </strong>Bacterial infections, particularly <i>Staphylococcus</i>, <i>Enterococcus</i> and <i>Streptococcus</i> genera were strongly associated with amputation risk. These findings have important clinical implications: early identification of these specific bacterial pathogens could guide targeted antibiotic therapy and inform risk stratification for amputation prevention. Improved bacterial identification could enhance DFU management and reduce complications such as amputation.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1746688"},"PeriodicalIF":2.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective observational cohort of algorithm-guided reassessment in diabetic foot: real-world outcomes and prognostic associations.","authors":"João Antônio Correa, Gabriela Tessaro Cremoneis, Paula Stefany Santos Caetano, Isabela Yones Nogara, Sidnei José Galego, Rafael Vilhena de Carvalho Furst, João Paulo Tardivo, Rodrigo Daminello Raimundo","doi":"10.3389/fcdhc.2026.1799455","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1799455","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot is among the most frequent complications of diabetes mellitus (DM), with potentially dramatic consequences ranging from chronic wounds to major lower-limb amputations. The Tardivo Algorithm is a simple prognostic scoring system designed to support risk stratification and structured longitudinal reassessment in routine clinical care.</p><p><strong>Objective: </strong>To describe the real-world implementation and feasibility of dynamic risk reassessment using the Tardivo Algorithm in a prospective observational cohort of patients with diabetic foot managed in a vascular surgery outpatient setting, and to explore associations between baseline risk stratification and clinical outcomes.</p><p><strong>Methods: </strong>This prospective observational cohort study was conducted in a routine outpatient clinic for complex wounds. Adult patients with diabetic foot were classified according to the Tardivo Algorithm at baseline and underwent structured serial reassessments at each follow-up visit as part of usual multidisciplinary care. No comparator group was included. Patients were followed for 6-18 months, and outcomes were descriptively recorded as minor amputation, major amputation, wound in process of healing, or complete healing.</p><p><strong>Results: </strong>A total of 42 patients were followed for up to 18 months. Mean initial Tardivo score was 7.6 ± 4.8, with 19% classified as high risk (≥12 points). Limb preservation was observed in 94.3% of participants, and complete healing occurred in 57%, with a mean healing time of 5.05 ± 1.95 months. Higher baseline Tardivo scores were positively associated with peripheral arterial disease (r = 0.740; p < 0.001), while healing time correlated with both PAD (r = 0.547; p = 0.006) and prior amputations (r = 0.523; p = 0.009). These correlations were not independent in multivariable models. Findings reflect associations observed in a real-world, structured outpatient care model.</p><p><strong>Conclusion: </strong>In this prospective real-world cohort, structured application of the Tardivo Algorithm was feasible and allowed dynamic clinical monitoring. Clinical outcomes observed during follow-up are described within the context of this non-controlled design and should be interpreted as observational associations rather than indicators of therapeutic effect. Controlled studies are required to determine the independent impact of algorithm-guided reassessment and adjunctive therapies.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1799455"},"PeriodicalIF":2.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125071/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147824157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics of patients with diabetic peripheral neuropathy: a retrospective descriptive study.","authors":"Dana Rashwan, Bashair M Mussa, Amena Sadiya, Rawoof Khan, Salah Abusnana","doi":"10.3389/fcdhc.2026.1792894","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1792894","url":null,"abstract":"<p><strong>Background: </strong>Diabetic Peripheral Neuropathy (DPN) is a common complication of diabetes, particularly in regions with high disease prevalence, such as the United Arab Emirates (UAE). This study aims to describe the clinical characteristics of patients with DPN and compare differences in patient profiles according to the status of protective foot sensation.</p><p><strong>Methods: </strong>This retrospective cross-sectional study included 387 patients with Type 2 diabetes diagnosed with DPN at University Hospital Sharjah (UHS) between 2019 and 2024. Data were extracted from medical records. Patients were grouped by protective sensation status and compared using t-tests, chi-square tests, and logistic regression.</p><p><strong>Results: </strong>Among the cohort, 45% had Loss of Protective sensation(LOPS) and 55% had reduced protective sensation (RPS). Significant differences were observed in smoking status, active ulcers, amputation, Chronic Kidney Disease severity, lipid profile, and HbA1c levels. Multivariable regression analysis identified smoking (OR = 38.91), ulcer history (OR = 3.35), amputation (OR = 3.46), and severe CKD (OR = 6.04) as predictors of LOPS (all p<0.01).</p><p><strong>Conclusion: </strong>This study confirms prior findings on DPN and highlights new associations related to loss of protective sensation. Patients with LOPS had higher rates of smoking, renal dysfunction, dyslipidemia, foot complications, and osteomyelitis. Smoking, ulcer or amputation history, and advanced CKD were significantly associated with LOPS. These findings emphasize the need for early detection and targeted interventions to prevent DPN progression.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1792894"},"PeriodicalIF":2.2,"publicationDate":"2026-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13125168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147823842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Observational studies on the association of outpatient antidiabetic medication use and COVID-19 outcomes: are the findings more relevant to diabetes management than to COVID-19 pathology? A mini-review.","authors":"Jelena Dimnjaković, Tamara Buble, Ognjen Brborović","doi":"10.3389/fcdhc.2026.1760695","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1760695","url":null,"abstract":"<p><p>At the start of the COVID-19 pandemic, there were concerns that some antidiabetic medications might worsen outcomes, though anti-inflammatory properties suggested possible benefits. Many observational studies examined antidiabetic medications use and COVID-19 outcomes. Meta-analyses showed that insulin was linked to worse outcomes, while metformin, sodium-glucose cotransporter 2 (SGLT-2) inhibitors, and glucagon-like peptide-1 (GLP-1) agonists were associated with better outcomes. Findings on dipeptidyl peptidase-4 (DPP-4) inhibitors, pioglitazone, and sulfonylureas were mixed-showing neutral, beneficial, or negative effects. However, randomized controlled trials (RCTs) testing these medications after SARS-CoV-2 infection found no effect on COVID-19 outcomes, implying that their anti-inflammatory effects do not translate into meaningful clinical benefits during acute infection. This discrepancy prompts questioning what observational studies actually measured. Given that many studies applied robust statistical methods, their results are unlikely solely due to confounding or indication bias. We hypothesize that these studies reveal broader cardiovascular effects and illuminate diabetes management more than they inform COVID-19 pathology. Their findings align with current 2022 American Diabetes Association/European Association for the Study of Diabetes (ADA/EASD) consensus guidelines for the management of type 2 diabetes mellitus endorsing metformin, SGLT-2 inhibitors, and GLP-1 agonists as first-line therapies, recommending cautious early insulin use, and reserving DPP-4 inhibitors, sulfonylureas, and pioglitazone for selective cases. This is applicable regardless of COVID-19 status. Further research should determine whether infection-related clinical endpoints, such as mortality or hospitalization from COVID-19 or other infections, might serve as valid surrogate markers for cardiovascular outcomes.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1760695"},"PeriodicalIF":2.2,"publicationDate":"2026-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13121069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790636","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of chromogranin A cleavage products in onset of type 1 and 2 diabetes.","authors":"Gustaf Christoffersson, Elke M Muntjewerff","doi":"10.3389/fcdhc.2026.1812936","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1812936","url":null,"abstract":"<p><p>Chromogranin A (CgA) is a pro-hormone widely expressed in neuroendocrine tissues and elevated in both type 1 (T1D) and type 2 diabetes (T2D). Its diverse biological effects arise from proteolytic cleavage into six bioactive peptides: vasostatin I and II (VS-I/II), chromofungin (CHR), pancreastatin (PST), catestatin (CST), WE-14, and serpinin-each exerting distinct and sometimes opposing functions. This review covers current knowledge on the activity, circulating levels, and mechanistic roles of these peptides in diabetes pathogenesis and progression. Evidence indicates contrasting peptide profiles in T1D and T2D: PST levels are elevated in T2D and promote inflammation, gluconeogenesis, and insulin resistance, whereas CST levels are reduced and exert anti-inflammatory and insulin-sensitizing effects. In T1D, CST and VS-I are increased early after diagnosis, with VS-I and WE-14 functioning as autoantigens that drive autoreactive T cell responses. Knockout mouse models further demonstrate that loss of CgA or CST profoundly alters glucose homeostasis, macrophage polarization, catecholamine release, and diabetes susceptibility. Emerging data highlight a complex nerve-immune-endocrine axis through which CgA peptides regulate metabolic and inflammatory pathways. Collectively, CgA-derived peptides represent promising biomarkers and therapeutic targets, though further translational studies remain essential to define their diagnostic and clinical potential.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1812936"},"PeriodicalIF":2.2,"publicationDate":"2026-04-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13110968/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of GLP-1 receptor agonist therapy in the management of steroid-induced diabetes: a narrative review.","authors":"Aleksandra Jędrasek, Karolina Lisowska, Leszek Czupryniak","doi":"10.3389/fcdhc.2026.1772391","DOIUrl":"https://doi.org/10.3389/fcdhc.2026.1772391","url":null,"abstract":"<p><p>Glucocorticosteroids (GCs) are commonly used in the treatment of autoimmune, inflammatory and neoplastic diseases. Although clinically effective, they are associated with significant metabolic side effects, including increased insulin resistance, impaired function of pancreatic <i>β</i>-cells, and, finally, weight gain. These effects can result in steroid-induced hyperglycemia (SIH) and steroid-induced diabetes (SID), both of which increase the risk of complications such as infections and prolonged hospitalisation. Intensive insulin therapy remains the standard treatment for SID. However, emerging evidence suggests that glucagon-like peptide 1 receptor agonists (GLP-1 RAs) may have therapeutic potential to counteract the metabolic effects of steroids. This review evaluates the efficacy and safety of GLP-1 RAs for the treatment of SIH and SID.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"7 ","pages":"1772391"},"PeriodicalIF":2.2,"publicationDate":"2026-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13105962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147790592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}