Frontiers in clinical diabetes and healthcare最新文献

{"title":"Doxorubicin-induced cardiometabolic disturbances: what can we do?","authors":"Ashot Avagimyan, Nana Pogosova, Manfredi Rizzo, Nizal Sarrafzadegan","doi":"10.3389/fcdhc.2025.1537699","DOIUrl":"https://doi.org/10.3389/fcdhc.2025.1537699","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1537699"},"PeriodicalIF":0.0,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11868090/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143544635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The development of a CBT-informed approach to supporting type 2 diabetes self-management.","authors":"Elné Visagie, Elmari Deacon, Rümando Kok","doi":"10.3389/fcdhc.2025.1421678","DOIUrl":"10.3389/fcdhc.2025.1421678","url":null,"abstract":"<p><strong>Background: </strong>The self-management of adults with type 2 diabetes proves to be a continuous challenge. Within the South African context, socio-economic disparities, unequal access to healthcare and varying healthcare beliefs augment these challenges. CBT is a time-sensitive and structured intervention that has been effectively implemented for chronic diseases. CBT has been employed to improve psychological outcomes in adults with type 2 diabetes, but there is limited research on how this therapeutic intervention can enhance self-management outcomes of type 2 diabetes. Adaptable CBT-based interventions are needed to promote a holistic approach to type 2 diabetes self-management and empower a broader range of healthcare professionals to provide targeted interventions. Flexible interventions can promote patient engagement and be integrated into various healthcare settings where patients already access services.</p><p><strong>Method: </strong>The study employed document analysis to develop CBT-informed guidelines. Data was analysed by means of content analysis. Two research studies formed the dataset, and categories and subcategories were identified. The categories were integrated and used to develop the CBT-informed guidelines.</p><p><strong>Results: </strong>These guidelines were based on core CBT components and divided into the introduction, working, and consolidation phases. The guidelines specified the roles of healthcare practitioners who would implement them and provided skills and techniques for healthcare professionals and patients within each phase.</p><p><strong>Conclusion: </strong>The CBT-based interventions aimed to provide a tool for healthcare practitioners and patients in terms of flexibility, accessibility, and personalisation.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"6 ","pages":"1421678"},"PeriodicalIF":0.0,"publicationDate":"2025-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11835925/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictors of glycemic control among type 1 pediatric diabetes patients-Northeast Ethiopia.","authors":"Hiwot Adege, Gedefaw Getnet, Abyou Seyfu Ambaye, Mekuanint Terefe Kassa, Bedilu Linger Endalifer","doi":"10.3389/fcdhc.2024.1449641","DOIUrl":"10.3389/fcdhc.2024.1449641","url":null,"abstract":"<p><strong>Introduction: </strong>Type 1 diabetes mellitus is the most common endocrine-metabolic disorder in children and adolescents worldwide. This study aims to determine the metabolic glycemic control levels and predictors among pediatric type 1 diabetes patients.</p><p><strong>Methods: </strong>An institution-based prospective cross-sectional study was conducted from July 01, 2022 to October 30, 2022 among patients attending pediatric chronic follow-up at Dessie Comprehensive Specialized Hospital, Northeast Ethiopia. Patients on follow-up for more than 3 months and aged under 18 years were enrolled in the study consecutively based on their visits. Data were entered into Epidata version 3.1 and exported to SPSS version 26 for analysis. Bivariate and multivariate analyses were done to identify the factors affecting glycemic control.</p><p><strong>Result: </strong>Among 203 patients with type 1 diabetes, the average age was 8.72 ± 4.25 years, with the largest group of participants being over 10 years old (77 patients, 37%). The majority of the patients were female, totaling 126 (62.1%), and about 69 (34.0%) were in grades 7-10. Retinopathy, nephropathy, and diabetic ketoacidosis were commonly observed diabetic-related complications in this study. More than half of the patients, 107 (52.7%), had good diabetic control, while 96 (47.3%) had poor diabetic control. Factors significantly associated with poor glycemic control include having diabetes for more than 5 years (aOR: 1.45; 95% CI: 0.47, 0.91), being a third-born child (aOR: 0.22; 95% CI: 0.05, 0.92), having a comorbid disease condition (aOR: 1.84; 95% CI: 0.29, 0.92), and experiencing diabetes-related complications (aOR: 0.26; 95% CI: 0.08, 0.97).</p><p><strong>Conclusion: </strong>The study found that glycemic control is significantly poor among pediatric patients with type 1 diabetes. As a result, these patients require special attention to prevent the long-term consequences of diabetes.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1449641"},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11782554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082502","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diabetic ketoacidosis treatment outcomes and its associated factors among adult patients with diabetes mellitus admitted to public hospitals in Nekemte Town, Ethiopia: a cross-sectional study.","authors":"Daniel Mitiku Yigazu, Matiyos Lema, Firomsa Bekele, Dawit Tesfaye Daka, Dagim Samuel, Nigatu Addisu","doi":"10.3389/fcdhc.2024.1446543","DOIUrl":"10.3389/fcdhc.2024.1446543","url":null,"abstract":"<p><strong>Background: </strong>Diabetic ketoacidosis (DKA) is a serious and acute complication of diabetes mellitus. In Ethiopia, the mortality associated with acute diabetes complications ranges from 9.8% to 12%. Despite this, there is limited information on the clinical outcomes of DKA in our study location. Therefore, this study aimed to assess the magnitude and associated factors of DKA treatment outcomes among adult patients with diabetes admitted to public hospitals in Nekemte Town, Ethiopia.</p><p><strong>Objective: </strong>To assess the DKA treatment outcomes and their associated factors among adult patients with diabetes admitted to public hospitals in Nekemte Town.</p><p><strong>Methods: </strong>A 5-year cross-sectional study was conducted using a systematic random sampling technique among 201 patients from 1 July to 31 August 2023. DKA treatment outcomes were assessed at discharge. Pharmacists collected data by reviewing patient charts using Kobo Toolbox software. The data were then exported to SPSS Version 27 for analysis. Both bivariable and multivariable logistic regression analyses were performed. Variables with a P-value < 0.25 in the bivariable logistic regression were entered into the multivariable regression analysis to control for potential confounders. An adjusted odds ratio with a 95% confidence interval was used to identify predictors of treatment outcomes. A P-value < 0.05 was considered significant in the multivariable analysis.</p><p><strong>Result: </strong>Complete data was available for 201 patients admitted with DKA. The majority, 178 (88.6%), improved and were discharged. Independent predictors of DKA recovery were comorbidities [AOR: 3.45, 95% CI: 1.33, 9.72], admission Glasgow Coma Scale (GCS) score (<8) [AOR: 2.74, 95% CI: 1.02, 7.34], random blood glucose (RBS) (≥ 500) [AOR: 3.07 (95% CI: 1.12, 8.39)], and urine ketones (≥ +3) [AOR: 3.24, 95% CI: 1.18, 8.88].</p><p><strong>Conclusion and recommendation: </strong>Most of the treated patients with DKA were discharged with improvement. Comorbidity, admission GCS, RBS, and urine ketones were independently associated with DKA recovery. In general, significant consideration should be given to DKA prevention, early detection, and appropriate hospital management.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1446543"},"PeriodicalIF":0.0,"publicationDate":"2025-01-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11772411/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GLP-1 receptor agonists in diabetes and weight loss: the double-edged sword of innovation and risks.","authors":"Ioannis Ilias, Lina Zabuliene, Manfredi Rizzo","doi":"10.3389/fcdhc.2024.1530811","DOIUrl":"10.3389/fcdhc.2024.1530811","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1530811"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Technology usage and glycaemic outcomes in a single tertiary centre with an ethnically diverse and socioeconomically deprived cohort of children with type 1 diabetes mellitus.","authors":"India Dickinson, Ankita Gupta, Gar Mun Lau, Pranav Viswanath Iyer, John Stuart Pemberton, Suma Uday","doi":"10.3389/fcdhc.2024.1417287","DOIUrl":"10.3389/fcdhc.2024.1417287","url":null,"abstract":"<p><strong>Background: </strong>The UK National Paediatric Diabetes Audit (NPDA) data reports disparities in Haemoglobin A1c (HbA1c) levels among children and young people (CYP) with Type 1 Diabetes (T1D), with higher levels in those of Black ethnic background and lower socioeconomic status who have less access to technology. We investigate HbA1c differences in a T1D cohort with higher than national average technology uptake where > 60% come from an ethnic minority and/or socioeconomically deprived population.</p><p><strong>Design & methods: </strong>Retrospective cross-sectional study investigating the influence of demographic factors, technology use, and socioeconomic status (SES) on glycaemic outcomes. The study population was 222 CYP with T1D who attended the diabetes clinic in 2022 at a single tertiary paediatric diabetes centre.</p><p><strong>Results: </strong>Among 222 CYP, 60% were of ethnic minority (Asian, Black, Mixed and Other were 32%, 12%, 6% and 10% respectively) and 40% of white heritage. 94% used Continuous Glucose Monitoring (CGM) and 60% used Continuous Subcutaneous Insulin Infusion (CSII) via open or closed loop. 6% used Self-Monitoring of Blood Glucose (SMBG) and Multiple Daily Injections (MDI), 34% used CGM and MDI, 38% used CGM and CSII and 22% used Hybrid Closed-Loop (HCL) systems. Significant differences in HbA1c across therapy groups (p < 0.001) was noted with lowest HbA1c in HCL group (55 mmol/mol; p <0.001). Despite adjusting for therapy type, the Black group had higher HbA1c than their white and Asian counterparts (p<0.001). CYP from the most deprived tertile had significantly higher HbA1c levels (p < 0.001) but the difference was not sustained after adjusting for therapy type.</p><p><strong>Conclusion: </strong>Advanced diabetes technologies improve glycaemic control. Whilst equalising technology access mitigates socioeconomic disparities in HbA1c, CYP from Black ethnic background continue to display a higher HbA1c. The study underscores the necessity of fair technology distribution and further research into elevated HbA1c levels among Black CYP using advanced diabetes technology.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1417287"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754227/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Altered kidney function in fatty liver disease: confronting the \"MAFLD-renal syndrome\".","authors":"Suleiman Al Ashi, Ali A Rizvi, Manfredi Rizzo","doi":"10.3389/fcdhc.2024.1539117","DOIUrl":"10.3389/fcdhc.2024.1539117","url":null,"abstract":"","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1539117"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11751235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025901","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-cutting effect of type 2 diabetes on the sensorimotor control of balance.","authors":"Trevor Lopatin, Ben Borngesser, Joshua Haworth","doi":"10.3389/fcdhc.2024.1441947","DOIUrl":"10.3389/fcdhc.2024.1441947","url":null,"abstract":"<p><p>Type 2 Diabetes is a highly prevalent chronic disorder that affects multiple systems through microvascular complications. Complications such as diabetic peripheral neuropathy, diabetic retinopathy, and diabetic vestibular dysfunction (vestibulopathy) all directly interfere with the sensory components of balance and postural stability. The resulting impairments cause increased falls risk and instability, making it difficult to perform daily task or exercise. This commentary will provide clarity on the causes and relationship between the sensory complications of T2D, balance, and excise, while also providing recommendations and precautions for exercising with one of these sensory complications.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1441947"},"PeriodicalIF":0.0,"publicationDate":"2025-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11750827/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How to facilitate peer support - learnings from the development of a peer support program for people with T2DM via instant messaging service to improve diabetes self-management.","authors":"Ursula Hemetek, Tatjana Aubram, Johanna Grüblbauer, Elisabeth Höld","doi":"10.3389/fcdhc.2024.1491865","DOIUrl":"10.3389/fcdhc.2024.1491865","url":null,"abstract":"<p><p>This study explores the use of Instant Messaging Services (IMS) for peer support among individuals with Type 2 Diabetes Mellitus (T2DM). Leveraging the popularity of IMS within the affected age group, the DiabPeerS study implemented a peer support intervention aimed at improving long-term blood glucose levels (HbA1c) in a randomized controlled trial (RCT). This article describes the development and acceptance of the IMS intervention used in the DiabPeerS study. The intervention included a communication strategy and content designed for lay moderators to facilitate group interaction among people with Type 2 Diabetes mellitus (PWT2D). The intervention's acceptance was determined by conducting participant interviews, moderator meetings, and analysis of IMS chat protocols. Results indicate that the intervention was well-received, with participants engaging in meaningful exchange about diabetes self-management (DSM). However, those less familiar with online communication may benefit from preparational training and initial face-to-face meetings could enhance group cohesion. This research offers insights into the practical application of IMS for diabetes peer support, highlighting both its benefits and room for improvement.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1491865"},"PeriodicalIF":0.0,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743560/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Status of diabetes mellitus in different regions of KSA and update on its management.","authors":"Mabrouk Al-Rasheedi, Yasir Alhazmi, Lamees Abdullah AlDaiji, Lamya Abdullah AlDaiji, Fatimah Ismail Mobarki, Khuzama Mohammed Almuhaysini, Jawza Salem Alshammari, Nouf Awadh Almistadi, Saeed Adnan Yoldash, Nouf Almaqwashi, Rawabi Saleh Al Abdulgader, Mohammed Yahya Mashyakhi, Sadin Alamro, Ismail A Walbi, Khawaja Husnain Haider","doi":"10.3389/fcdhc.2024.1482090","DOIUrl":"https://doi.org/10.3389/fcdhc.2024.1482090","url":null,"abstract":"<p><strong>Background: </strong>Complications of diabetes and its associated comorbidities can cause rapid progression of type II diabetes mellitus (T2DM). It comes at high costs and affects a patient's quality of life. We aim to assess T2DM in KSA, including the demographics, medications, complications, and comorbidities, as it remains an integral part of Vision 2030.</p><p><strong>Methods: </strong>Observational retrospective study was designed spanning five administrative regions of KSA. A total of 638 patients' records were randomly selected from general hospitals and diabetes centers from 2017 to 2020, and the collected were statistically analyzed.</p><p><strong>Results: </strong>Most (77%) selected patients had uncontrolled diabetes, showing a statistically significant correlation between regions and diabetes control. The Northern, Central, and Southern regions had the highest uncontrolled percentage with less than 20% control, while Western and Eastern regions' control percentages were around 40% of subjects. Eighty percent of the uncontrolled BP patients had uncontrolled diabetes contrasting the 68% of the BP-controlled patients. Biguanides, DPP-4 inhibitors, GLP-1 agonists, Insulin, and SGLT-2 inhibitors are the most common diabetes medications. Metformin was the most prescribed in all regions, followed by DPP4. Results showed that patients used one to four non-diabetes drugs on average. Dispensing of vitamin B complex and statins were higher in diabetes centers than in hospitals. Retinopathy and peripheral neuropathy were the most common complications, while hypertension and ASCVD were the most common comorbidities.</p><p><strong>Conclusion: </strong>Results showed a poor glycemic control situation in the kingdom that necessitates implementing stricter measures to hinder disease progression and reduce complications and comorbidities. Increasing awareness, training, and monitoring programs with larger sample sizes and broader distribution is highly recommended nationally.</p>","PeriodicalId":73075,"journal":{"name":"Frontiers in clinical diabetes and healthcare","volume":"5 ","pages":"1482090"},"PeriodicalIF":0.0,"publicationDate":"2024-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11695327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142933997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}