Food chemistry advances最新文献

{"title":"Computational analysis of azadirachta indica-derived phytochemicals targeting α-amylase and α-glucosidase for antidiabetic activity","authors":"Ali Mohamod Wasaf Hasan ,&nbsp;Md. Sakib Al Hasan ,&nbsp;Emon Mia ,&nbsp;Mohammed Burhan Uddin ,&nbsp;Sumaya Akter Bithi ,&nbsp;Noshin Tasnim Yana ,&nbsp;Imam Hossen Rakib ,&nbsp;Md. Arif Hossain ,&nbsp;Muhammad Torequl Islam","doi":"10.1016/j.focha.2025.101132","DOIUrl":"10.1016/j.focha.2025.101132","url":null,"abstract":"<div><div><em>Azadirachta indica</em> L. (<em>A. indica</em>, neem), has long been used in the treatment of diabetes in numerous countries. This study aims to explore the molecular interactions of bioactive phytochemicals isolated from <em>A. indica</em> with two key enzymes involved in diabetes, human pancreatic α-amylase (4W93) and α-glucosidase (3CTT), using <em>in silico</em> approaches. Molecular docking was conducted with various ligands to evaluate their potential as inhibitors. Molecular docking analyses revealed that 24-methylene cycloartanol (24-MCL), stigmasterol (SML), and β-sitosterol (BSL) exhibited strong binding affinities (‒9.4 kcal/mol) to α-amylase, with SML forming one hydrogen bond (HB) along with multiple hydrophobic interactions. In contrast, montbretin A (MNA) showed a binding energy of ‒8.7 kcal/mol and formed several HBs. For α-glucosidase, gedunin (GN) showed the highest binding energy (‒9.1 kcal/mol), while SML exhibited a binding energy of ‒8.6 kcal/mol with one HB. Drug-likeness assessment using Lipinski’s Rule of 5 indicated that casuarine (CRE), catechin (CTN), and GN complied with the criteria without violations, while 24-MCL, SML, and BSL had one violation. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) predictions highlighted favorable absorption profiles for 24-MCL, GN, and BSL, while MNA exhibited poor pharmacokinetic properties. Additionally, prediction of activity spectra for substances (PASS) prediction results further supported the antidiabetic potential of certain compounds. These findings warrant further <em>in vivo</em> and <em>in vitro</em> validation and clinical trials to assess 24-MCL and GN’s antidiabetic potential, while structural optimization could enhance potency for developing safer, more effective plant-based antidiabetic drugs.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101132"},"PeriodicalIF":0.0,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1H NMR metabolic profiling and antioxidant activity of Papua Arabica green coffee beans","authors":"Septiani Mangiwa ,&nbsp;Nizar Happyana ,&nbsp;Handajaya Rusli","doi":"10.1016/j.focha.2025.101131","DOIUrl":"10.1016/j.focha.2025.101131","url":null,"abstract":"<div><div>Papua Arabica is an authentic Indonesian coffee with a unique sensory profile. It is chemically linked to its metabolites. However, the metabolite profiles and bioactivity of Papua Arabica remain largely unexplored. The metabolic profiling of Arabica green coffee beans from four Papua regions (Jayawijaya, Pegunungan Bintang, Lanny Jaya, and Yahukimo) was investigated using ¹H NMR. The antioxidant activity was evaluated through the DPPH and FRAP assays. A total of 28 metabolites were successfully identified in all samples, including 6 amino acids, 4 fatty acids, 8 organic acids, 3 sugars, 1 sugar alcohol, 2 alkaloids, 3 phenolics, and anothercompound. Sucrose (a sugar compound) was the most abundant (4.16-5.55%) of the total metabolite composition. The OPLS-DA statistical model effectively distinguished samples based on their geographical origin and postharvest treatment. In addition, potential markers for different coffees were also identified, including fatty acids and leucine (Jayawijaya); sucrose, citric acid, quinic acid, and GABA (Pegunungan Bintang); trigonelline and malic acid (Lanny Jaya); CQAs (Yahukimo); acetic acid and GABA (natural); citric acid (semi-wash); and fatty acids with CQAs (full-wash). Papua Arabica green coffee beans exhibited significant antioxidant activity in the DPPH assay (IC₅₀ = 33.27-39.02 mg/L) and the FRAP assay (29.99-36.45 mg/L). CQAs were identified as key contributors to the antioxidant activity. This study provides novel insights into the metabolic profiling of Papua Arabica green coffee beans by ¹H NMR and its correlation with the antioxidant activity, contributing to the development of the coffee industry and potential health benefits.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101131"},"PeriodicalIF":0.0,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From peel to power: Exploring the potential of fruit waste in a circular economy","authors":"Pardeep Kumar Sadh ,&nbsp;Ajay Kamboj ,&nbsp;Babli Yadav ,&nbsp;Prince Chawla ,&nbsp;Manju Nehra ,&nbsp;Basanti Brar ,&nbsp;Baljeet Singh Saharan ,&nbsp;Surekha Duhan ,&nbsp;Joginder Singh Duhan","doi":"10.1016/j.focha.2025.101133","DOIUrl":"10.1016/j.focha.2025.101133","url":null,"abstract":"<div><div>Fruits are vital for a balanced diet due to their rich natural antioxidant content, which has been demonstrated to be effective in managing various chronic disorders. The several types of waste produced by the fruit industry are seen as an international issue. As a rich source of secondary metabolites, fruit waste offers an opportunity for the sustainable use of waste materials, helping to attain the global objective of “zero waste.” Fruit waste includes a variety of phytochemicals, including colours, and other valuable substances, including polyphenols and polysaccharides. The use of phenolic compounds in functional meals and nutritional supplements has made them more desirable to the business. The single-cell protein (SCP) technique has recently gained popularity as a solution to two key problems: the growing global protein shortage resulting from population growth, and the significant increase in industrial waste production rates. Over the years, fruit production has expanded worldwide. Fruit wastes unsuitable for consumption are often discarded into the environment, causing environmental pollution. However, these residues are rich in fermentable sugars and essential nutrients that microorganisms can use as substrates to produce microbial products such as protein, bioethanol and biogas. This review investigates the utilisation of fruit wastes as a substrate for SCP creation in light of this. Plant- and animal-based functional food components, including omega-3 fatty acids, soy protein isolate, whey protein isolate, and dietary fibre, have been widely utilised to produce essential food products. Most byproducts of fruit processing, including those from oranges, apples, and grapes, are rich in dietary fibre, unsaturated fatty acids, and bioactive phytochemicals, making them potentially useful in functional foods. Currently, integrated and multidisciplinary approaches are being employed to investigate the key components and related bioactivities of fruit waste, exploring new application areas and creating value in terms of social, environmental, and economic aspects, thereby developing an environmentally friendly method for handling fruit waste. Thus, this review aims to present comprehensive information on the bioactive chemicals, antioxidants, and antiviral activity found in fruit waste, as well as value-added products, including polyphenols, single-cell proteins, bioethanol, and bioplastic enzymes.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101133"},"PeriodicalIF":0.0,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268841","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dietary energy, antioxidant molecules, nutritional and lifestyle determinants pointers of brain cancer","authors":"Joel Okpoghono ,&nbsp;Clive Isioma Okonta ,&nbsp;Godson Oseahumen Omoike ,&nbsp;Patience Onakurhefe","doi":"10.1016/j.focha.2025.101130","DOIUrl":"10.1016/j.focha.2025.101130","url":null,"abstract":"<div><div>Brain cancers have been identified to be the leading cause of premature death in developed countries. The aim of the review was to appraise the dietary energy, nutritional factors, antioxidants rich bioactive molecules and lifestyle in the prevention of brain tumor. The scientific articles used in this review were obtained from the SciELO, PubMed, Science Direct, and Google Scholar databases. The review utilized only articles that were published between 2011 and 2025. The outcome of the review indicated that proper nutritional habits and lifestyle factors can prevent 30–50 % of cancer types. A diet rich in vegetables and antioxidants (e.g., vitamins C and resveratrol) may protect against glioma. Maintaining a healthy body weight and engaging in daily physical activity appear to be important. To enhance and apprehend the relationship between selected factors and the prevalence of gliomas, larger clinical studies across global regions and cultural practices are required.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101130"},"PeriodicalIF":0.0,"publicationDate":"2025-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sustainability challenges in the bovine sector and the implementation of waste management policies within the EU framework","authors":"Antonia Terpou ,&nbsp;Olga Arvaniti ,&nbsp;Nikos Afratis ,&nbsp;Theodore Zahariadis","doi":"10.1016/j.focha.2025.101129","DOIUrl":"10.1016/j.focha.2025.101129","url":null,"abstract":"<div><div>Globally, the agri-food chain produces nearly 1.3 billion tonnes of waste each year, with the bovine sector being a major contributor. As meat production has soared by more than 40% since 2000, and animal products now provide around 40% of the world’s protein, livestock stands as both a cornerstone of global nutrition and a source of pressing environmental challenges. While existing EU waste policies often focus on volume reduction, a transition toward circular and sustainable waste management is essential to ensure long-term sectoral resilience. The Circular Economy Action Plan, a cornerstone of the European Union’s Green Deal, provides a framework for advancing sustainability and resource efficiency. Within this context, integrating advanced technologies such as such as artificial intelligence (AI), precision farming, and real-time data analytics offer pathways to reduce waste and improve resource efficiency. Their effective use, however, relies on interdisciplinary collaboration to improve efficiency, minimize waste, and strengthen productivity across the bovine supply chain. This report examines current gaps in both policy and practice within the bovine sector, highlights innovative smart farming solutions, and anticipates emerging sustainability challenges. It further identifies practical opportunities for enhancing circularity and resource efficiency, with implications exceeding beyond the bovine industry to the broader agri-food system.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101129"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268840","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Heavy metals pollution in cancer and wound-healing medicinal plants: A comprehensive assessment of health risk","authors":"Molla Tefera,&nbsp;Gobezie Demissie,&nbsp;Atnafu Guadie,&nbsp;Worku Lakew,&nbsp;Banchamlak Sewachen,&nbsp;Menilek Ayalew,&nbsp;Desta Shumye","doi":"10.1016/j.focha.2025.101123","DOIUrl":"10.1016/j.focha.2025.101123","url":null,"abstract":"<div><div>The use of medicinal plants for treating diseases is a common practice in Ethiopia, where people have limited access to modern health care, without understanding their chemical composition or the health hazards. Thus, this study was aimed at quantifying the amount of heavy metals in medicinal plants that are found in the Simada district, Ethiopia. A 0.5 g of powdered samples was digested using a mixture of HNO₃ and HClO₄ acids. The results indicated that the mean concentration of heavy metals in <em>C. macrostachyus, C. africana, O. europaea, C. spinarum, C. anisata, C. aurea,</em> and <em>M. arbutifolia</em> ranged from 131.2 ± 4.5 to 236.2 ± 9.1, 30.6 ± 1 to 48.7 ± 0.7), 21.3 ± 2.1 to 114.2 ± 8.4, 31.7 ± 4.5 to 154.4 ± 11.2, and BDL to 6.3 ± 0.3 for Fe, Zn, Cu, Mn and Pb, respectively. Cd was below the detection limit. Except the concentration of Cu in <em>C. spinarum</em> (114.25 mg/kg), the concentrations of other heavy metals were below WHO values. THQ and HI levels are less than unity, demonstrating that heavy metals have no substantial non-carcinogenic effect on users. Similarly, the carcinogenic risk (CR) values were less than tolerable limits (10^–6), showing that ingesting medicinal plants in the study area did not pose any carcinogenic health risk.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101123"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"GC–MS spectroscopic analysis of antimicrobial and antioxidant properties of bangladeshi spice piper chaba H. stems: a potential natural preservative for food","authors":"Shabiba Parvin Shandhi ,&nbsp;Kiron Sikdar ,&nbsp;Sharmin Ahmed ,&nbsp;Mst Maya Khatun ,&nbsp;Aynun Nahar","doi":"10.1016/j.focha.2025.101127","DOIUrl":"10.1016/j.focha.2025.101127","url":null,"abstract":"<div><div><em>Piper chaba</em> Hunter <em>(P. chaba</em>) stem is a popular spice in Bangladesh. Our present study focuses on this popular medicinal spice, which is collected from the northern part of Bangladesh. The <em>P. chaba</em> species of this region has not been studied much. GC–MS analysis confirmed the presence of Caryophyllene and Nerolidol (E-Nerolidol) in <em>P. chaba</em> stems, marking the first such report. (E)-5-(Benzo[d] [1,3] dioxol-5-yl)-1-(piperidin-1-yl) pent‑2-en-1-one is found as a principal constituent (34.56 %) in this investigation, which was not reported earlier. Antioxidant activity study reveals IC₅₀ values at 20.15µg/ml and 31.14µg/ml for methanol extract and ethyl acetate fractions, which are much higher than previous studies. Chloroform fractions and methanol extract have shown a zone of inhibition (ZOI) of 26 ± 0.5 mm against <em>Enterococcus faecalis</em> and <em>Vibrio parahaemolyticus,</em> respectively. These results are more significant than those of many studies done before on this plant’s stem. Other fractions have also shown significant ZOI in the case of all microbes reported in this study. This study reveals that this popular spice can be used as a healthy food additive and preservative, owing to its prominent medicinal benefits for human health.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101127"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Euphorbia pulcherrima leaves facilitated preparation of silver/silver chloride nanoparticles with antioxidant and in vivo anticancer potentials against Ehrlich ascites carcinoma","authors":"Md. Shahin Ali ,&nbsp;Shajahan Talukder ,&nbsp;Md. Deluar Hossain ,&nbsp;Md. Arif Akhter ,&nbsp;Md. Abdul Aziz ,&nbsp;Md. Habibur Rahman ,&nbsp;M. Ahasanur Rabbi ,&nbsp;Md. Rowshanul Habib ,&nbsp;Md. Rezaul Karim","doi":"10.1016/j.focha.2025.101128","DOIUrl":"10.1016/j.focha.2025.101128","url":null,"abstract":"<div><div>The study investigates the use of <em>Euphorbia pulcherrima</em> leaves as natural reducers for producing silver and silver chloride nanoparticles (EP-Ag/AgCl-NPs), assessing their safety, free radical scavenging activity, and anticancer potential against Ehrlich ascites carcinoma (EAC) in mice. EP-Ag/AgCl-NPs formation was verified by a color change from light green to dark brown. UV–Vis tests found <em>An spr</em> peak at 410 nm. The FT-IR analysis identified the functional groups responsible for reducing and stabilizing the nanoparticle. The spherical shape and nano size of EP-Ag/AgCl-NPs were confirmed by XRD, DLS, and SEM analysis. The study found that EP-Ag/AgCl-NPs, with EC₅₀ values of 81.47 μg/mL (DPPH) and 92.77 μg/mL (ABTS), moderately scavenged free radicals compared to vitamin C. Hemolysis tests revealed that nanoparticles are not safe for blood when compared to the recommended value of below 5 %. In cancer studies, EP-Ag/AgCl-NPs reduced tumor cell growth and weight loss in mice with EAC. They also helped restore normal blood and organ functions. Microscopic examination of treated cancer cells showed signs of apoptotic cell death, with increased levels of p53 and Bax genes. Meanwhile, anti-apoptotic genes (Bcl-2 and NF-κB) were suppressed. These findings imply that plant-based EP-Ag/AgCl-NPs might be useful in developing strong treatments for cancer.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101128"},"PeriodicalIF":0.0,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quality of eggless Brioche (Bread Loaf) made from Aquafaba","authors":"Fatemah B. Alsalman,&nbsp;Linu Thomas","doi":"10.1016/j.focha.2025.101125","DOIUrl":"10.1016/j.focha.2025.101125","url":null,"abstract":"<div><div>Egg allergy is one of the most reported food allergen (2.7 %) worldwide. A study that was conducted for Kuwaiti children aged 0 to 13 years found that eggs were the second-most common food allergen where 48 % were allergic to eggs. This increases the necessity of finding egg replacers in our daily recipes. The objective was to use aquafaba as an egg replacer in Brioche (bread loaf). Control sample including eggs was produced at the beginning followed the production of eggless brioche loaf by replacing aquafaba instead of eggs. Quality tests were conducted after baking such as texture profile analysis, V-squeeze test, proximate composition, and scanning electron microscopy. Results found that aquafaba was a great egg replacer compared to control sample. Aquafaba brioche was fluffier and the loaf had less firmness compared to control loaf. Aquafaba dough had as well higher yeast activity and higher extensibility than control dough. Sensory evaluation also showed the success of the product in general and of aquafaba specifically being a perfect ingredient in brioche production.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101125"},"PeriodicalIF":0.0,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145221584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of extraction solvents on phenolic contents, in vitro antioxidant, and antimicrobial activities of roselle (Hibiscus sabdariffa L.) Calyx","authors":"Belay Haile Kebede ,&nbsp;Reath Lul Them ,&nbsp;Betelhem Abera Mengistu","doi":"10.1016/j.focha.2025.101119","DOIUrl":"10.1016/j.focha.2025.101119","url":null,"abstract":"<div><div><em>Hibiscus sabdariffa</em> L., commonly known as Roselle, is a valued plant of the Malvaceae family, cultivated in tropical and subtropical regions. Roselle is consumed as a vegetable in hot and cold preparations and is associated with numerous health benefits. Despite its widespread use, research on bioactive compounds remains limited, particularly in Ethiopia. This study investigated effects of extraction solvents on phytochemical content, antioxidant and antimicrobial activity of Roselle calyx. The 80 % methanolic extract showed highest total phenolic content, while n-hexane extracts (60 % and 80 %) had lowest. Total flavonoid content peaked in 80 % chloroform extract, with n-hexane showing lowest levels. In antioxidant assays, 80 % methanol demonstrated strongest activity (lowest IC₅₀ in DPPH assay), while 60 % n-hexane was weakest. Antibacterial tests revealed 80 % methanol and cold water extracts were effective against <em>Escherichia coli</em> and <em>S. aureus</em> (25 mm inhibition zones) whereas n-hexane showed no antibacterial activity. Greatest fungal biomass reduction occurred with 80 % n-hexane, while 60 % methanol showed least reduction. A strong negative correlation (<em>r</em> = −0.882; <em>p</em> &lt; 0.05) between IC₅₀ of DPPH and total phenolic content highlighted antioxidant-phenolic relationship. Further research on Roselle's health-promoting qualities could advance natural medicine and nutrition, offering opportunities for functional foods and therapeutic applications.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101119"},"PeriodicalIF":0.0,"publicationDate":"2025-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145159158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}