Food chemistry advances最新文献_第10页

Simultaneous extraction of caffeine and chlorogenic acid from Arabica coffee using microwave-assisted extraction 用微波辅助萃取法同时提取阿拉比卡咖啡中的咖啡因和绿原酸

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-11-01 DOI: 10.1016/j.focha.2025.101158

Yuyun Yuniati , Rosidah Wahyu Ningtyas , Exist Saraswati , Maria Agustini , Mahfud Mahfud

{"title":"Simultaneous extraction of caffeine and chlorogenic acid from Arabica coffee using microwave-assisted extraction","authors":"Yuyun Yuniati , Rosidah Wahyu Ningtyas , Exist Saraswati , Maria Agustini , Mahfud Mahfud","doi":"10.1016/j.focha.2025.101158","DOIUrl":"10.1016/j.focha.2025.101158","url":null,"abstract":"<div><div>This study aimed to optimize the microwave-assisted extraction (MAE) process for the selective decaffeination of Gayo Aceh Arabica coffee, focusing on the simultaneous reduction of caffeine (CF) and preservation of chlorogenic acid (CGA), while maintaining sensory quality and antioxidant potential. Response Surface Methodology (RSM) with a Face-Centered Central Composite Design (FCCD) was employed to evaluate the effects of microwave power (300–600 W), extraction time (2–10 min), and feed-to-solvent ratio (F/S) (0.100–0.150 g/mL). The optimal conditions were identified as 450 W microwave power, 10 min of extraction time, and a F/S of 0.125 g/mL. Under these settings, CF reduction reached 68.97 %, while 88.25 % of CGA was retained, resulting in a high selectivity ratio of 1.74. ANOVA and normal probability plot analyses confirmed the validity and predictive accuracy of the developed models. Compared to conventional decaffeination methods such as solvent-based or supercritical CO₂ extraction, MAE demonstrated superior efficiency, shorter processing time, and improved sustainability. Sensory analysis using the Kruskal-Wallis test showed no significant differences (p > 0.05) between decaffeinated and control samples in terms of aroma and taste acceptability. These findings highlight MAE as a viable, eco-friendly alternative for producing functional and specialty coffee products with preserved bioactive and sensory attributes.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101158"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145474213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A review of the most important microRNAs involved in fruit postharvest properties 参与水果采后特性的最重要的microrna综述

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-11-15 DOI: 10.1016/j.focha.2025.101168

Seyed Mohammad Samadi , Keyvan Asefpour Vakilian , Seyed Mohamad Javidan

{"title":"A review of the most important microRNAs involved in fruit postharvest properties","authors":"Seyed Mohammad Samadi , Keyvan Asefpour Vakilian , Seyed Mohamad Javidan","doi":"10.1016/j.focha.2025.101168","DOIUrl":"10.1016/j.focha.2025.101168","url":null,"abstract":"<div><div>Although extensive studies have been conducted on fruit microRNAs, they have mostly focused on microRNA identification and target gene prediction and validation. This review aims to find connections between microRNAs and postharvest properties of fruits based on publications over the last two decades. The postharvest characteristics investigated in this work include fruit ripening and aging, fruit color and browning, fruit sugars and organic acids, and fruit texture. Although an in-depth analysis of downstream signaling pathways is not provided in this study, it is an effort to identify which fruits and which microRNA families have received the most research. This review reveals that miR156, miR164, miR172, miR319, miR396, miR397, miR399, and miR828, with target genes of <em>SPL, MYB, NAC, BGA, LAC</em>, and <em>ACO</em>, have been investigated the most in previous studies. Moreover, it suggests that although microRNAs have essential effects on fruit quality regulation, current research has focused on a limited number of fruit models. Ongoing research on microRNAs in various fruit types will expand our knowledge of their regulatory functions, providing valuable insights into their role in fruit growth and ripening processes.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101168"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Untangling the biological efficacy and chemical composition of different solvent extractives from Brownlowia elata Roxb. leaves 褐花不同溶剂提取物的生物药效及化学成分研究。叶子

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-11-14 DOI: 10.1016/j.focha.2025.101160

Md. Helal Uddin Chowdhury, Shaikh Bokhtear Uddin, Mohammad Omar Faruque

{"title":"Untangling the biological efficacy and chemical composition of different solvent extractives from Brownlowia elata Roxb. leaves","authors":"Md. Helal Uddin Chowdhury, Shaikh Bokhtear Uddin, Mohammad Omar Faruque","doi":"10.1016/j.focha.2025.101160","DOIUrl":"10.1016/j.focha.2025.101160","url":null,"abstract":"<div><div>Traditionally, <em>Brownlowia elata</em> Roxb. is employed to treat syphilis and diarrhea; henceforth bioactive potential of this remains unexplored. Its effectiveness in treating helminthic and bacterial-mediated diarrhea alongside antioxidant and cytotoxic potential unfolds for the first time. Among solvent extractives, BuOH BEL contains a broad spectrum of total bioactive contents. These same extracts had paramount total antioxidant capacity and exhibited an IC<sub>50</sub> of 26.3µg/ml in the DPPH assay, as well as a lower cytotoxicity of 38.9µg/ml LC<sub>50</sub> value. These bioefficiencies are positively correlated with the total bioactive contents present in this plant, as evidenced by the Pearson correlation and PCA analysis. Similarly, 16.5 and 15 mm furthest inhibitory zones were noted with the same BuOH BEL extract, along with taking 0.823 and 1.64 min lower time for paralysis and death, respectively, comparable to levamisole in an anthelmintic assay. GC-MS analysis of this extract uncovered six fatty acyl, prenol lipids, benzene, and steroid derivative compounds. Among them, dodecyl-phthalate and (25S)-3beta-Hydroxycholest-5-en-26-oic acid methyl ester showed prominent binding efficacy against each of the disease-linked receptors, aiming for potent drug-likeness attributes. To this extent, these findings corroborated the plant’s significant anthelmintic and antibacterial activity, which connects to alleviating diarrhea alongside having antioxidative potential.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101160"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

GC–MS analysis, molecular docking and pharmacokinetic evaluation of phytocompounds from Lagerstroemia speciosa (L.) pers. bark and their effect on inflammation target proteins 紫薇植物化合物的GC-MS分析、分子对接及药动学评价。树皮及其对炎症靶蛋白的影响

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-11-24 DOI: 10.1016/j.focha.2025.101172

Shahnaz Parvin Sweety , Tahsin Ahmed Rupok , Mst. Sadia Afroz Shoily , Mst. Shahnaj Parvin , Jaytirmoy Barmon , Md. Ekramul Islam

{"title":"GC–MS analysis, molecular docking and pharmacokinetic evaluation of phytocompounds from Lagerstroemia speciosa (L.) pers. bark and their effect on inflammation target proteins","authors":"Shahnaz Parvin Sweety , Tahsin Ahmed Rupok , Mst. Sadia Afroz Shoily , Mst. Shahnaj Parvin , Jaytirmoy Barmon , Md. Ekramul Islam","doi":"10.1016/j.focha.2025.101172","DOIUrl":"10.1016/j.focha.2025.101172","url":null,"abstract":"<div><div><em>Lagerstroemia speciosa</em> (L.) Pers., traditionally used for various ailments, was investigated for its anti-inflammatory potential using integrated <em>in vitro, in vivo</em>, and <em>in silico</em> approaches. The methanolic bark extract was fractionated. The chloroform fraction (CHF) showed the highest <em>in vitro</em> activity, significantly protecting against hemolysis induced by heat (71.83%), hypotonicity (62.17%), and AAPH (59.17%) at 400 µg/mL. <em>In vivo</em>, CHF reduced carrageenan-induced paw edema in mice by 55.02% at 400 mg/kg (<em>P</em> < 0.01). GC–MS identified six major compounds, of which three—9-methoxybicyclo[6.1.0]nona-2,4,6-triene, hexadecenoic acid methyl ester, and 1,2-benzenedicarboxylic acid ester exhibited strong COX-2 binding. Molecular dynamics simulations confirmed the stability of these interactions, with favorable RMSD and binding free energies. ADME and drug-likeness analysis suggested good oral bioavailability. These findings support L. <em>speciosa</em> bark as a promising source of plant-derived COX-2 inhibitors for anti-inflammatory drug development.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101172"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying marker compounds for elevated storage temperature in orange juice using untargeted LC-Orbitrap analysis 用非靶向LC-Orbitrap分析鉴定橙汁中贮藏温度升高的标记化合物

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-11-09 DOI: 10.1016/j.focha.2025.101163

Patrick Casey, Ciarán Beirne, Damian McNeely, Finbarr Murphy

{"title":"Identifying marker compounds for elevated storage temperature in orange juice using untargeted LC-Orbitrap analysis","authors":"Patrick Casey, Ciarán Beirne, Damian McNeely, Finbarr Murphy","doi":"10.1016/j.focha.2025.101163","DOIUrl":"10.1016/j.focha.2025.101163","url":null,"abstract":"<div><div>In this study Untargeted LC<img>Orbitrap analysis is used to identify marker compounds which can be used to identify when orange juice beverages have been stored at elevated temperature. Orange juice (OJ) products, with varying levels of Concentrate % and Pulp %, were held at 40 °C for one week to replicate the effects of improper storage. Using untargeted analysis, it was found that this temperature results in a significant increase of flavonoids tangeretin and nobiletin in all sample types measured. Further analysis shows that the increase in flavonoid concentration is closely correlated to the % of orange juice concentrate in the beverage. Further discussion details how these results support and enhance previous studies which have proposed a mechanism for the release of phenolic compounds during heating. It is also shown that the flavonoid compounds hesperidin and naringin did not exhibit repeatable changes following 40 °C storage, in comparison to control samples stored at 4 °C. The contrasting behaviour of hesperidin and naringin compared to tangeretin and nobiletin is also discussed. Potential benefits for using tangeretin and nobiletin as analytical markers for elevated storage temperature, along with the effectiveness of LC<img>Orbitrap for untargeted analysis are also discussed.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101163"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of the addition of fresh cactus (nopal) on the production of enriched maize flour and tortillas 鲜仙人掌对浓缩玉米粉和玉米饼生产的影响

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-08-13 DOI: 10.1016/j.focha.2025.101087

Carlos M. Enríquez-Castro , Brenda Contreras-Jiménez , Mario E. Rodríguez-García

引用次数: 0

Optimizing spray-drying conditions to improve the nutritional value of plant-based complementary foods: A study on egg yolk powders 优化喷雾干燥条件提高植物性辅食的营养价值——以蛋黄粉为研究对象

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-09-13 DOI: 10.1016/j.focha.2025.101108

Keyre Amdala, Erkihun Masresha, Haileeyesus Gebrehiwot, Helen Weldemichael

{"title":"Optimizing spray-drying conditions to improve the nutritional value of plant-based complementary foods: A study on egg yolk powders","authors":"Keyre Amdala, Erkihun Masresha, Haileeyesus Gebrehiwot, Helen Weldemichael","doi":"10.1016/j.focha.2025.101108","DOIUrl":"10.1016/j.focha.2025.101108","url":null,"abstract":"<div><div>Locally available complementary foods are high in carbohydrates and little protein, made of cereal or starchy root crops. The purpose of this study to optimize spray drying conditions for egg yolk powder and evaluate the effect of incorporating egg yolk powder into plant-based complementary foods on the macro-nutritional content in comparison with commercially available complementary foods. Addressing infant under nutrition requires attention to the quantity and quality of foods introduced during infancy. Spray-drier was used to convert liquid egg yolk into powder, by varying processing conditions (inlet-temperature, feed rate, and dilution rate). These parameters were selected to optimize the moisture content of egg powder by using response surface methodology. Parameters such as physicochemical, water activity, bulk density, and sensorial attributes were evaluated to assess the overall quality and acceptability of the products. Standard official procedures were used to determine the macronutrient composition of developed foods and ingredients, and there was a significant difference between developed and commercial complementary foods in all macronutrient compositions. Egg yolk powder increases the protein content of bulla from 1.45 to 14.72 % and mitin-Aja from 11.11 to 18.74 %. In this study, the energy density of 3.8 kcal/g from egg yolk powder blended with Mitin-aja and Bulla can fulfill the requirements in 53, 81, and 144 g/day for 6–8, 9–11, and 12–23 month-old children, respectively. Incorporating animal source foods into complementary food formulations can serve as a potential strategy to overcome malnutrition. In general, the formulated diets were better than commercially available complementary foods.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101108"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced functional and antioxidant properties of rice bran protein through solid-state fermentation 通过固态发酵提高米糠蛋白的功能和抗氧化性能

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-11-25 DOI: 10.1016/j.focha.2025.101183

Warathep Buasum , Raintong Singanusong , Monthana Weerawatanakorn , Sirilux Chaijamrus , Tipawan Thongsook

{"title":"Enhanced functional and antioxidant properties of rice bran protein through solid-state fermentation","authors":"Warathep Buasum , Raintong Singanusong , Monthana Weerawatanakorn , Sirilux Chaijamrus , Tipawan Thongsook","doi":"10.1016/j.focha.2025.101183","DOIUrl":"10.1016/j.focha.2025.101183","url":null,"abstract":"<div><div>This study successfully extracted protein from defatted rice bran, a by-product of the rice bran oil industry, using solid-state fermentation (SSF) with a mixed Koji starter, composed of a mixed microbial culture. The fermentation process significantly produced cellulase, amylase, and both neutral and alkaline protease activity, resulting in a high protein extraction yield of 64.70 % after 48 h of fermentation. The resulting rice bran protein concentrate (RBPC), obtained by spray-drying the extract, contained approximately 50 % protein, with dietary fiber as the second most abundant component. Compared to both rice protein (RP) and alkaline-extracted defatted rice bran protein (A-DRBP), RBPC demonstrated significantly improved functional and antioxidant properties. RBPC exhibited superior solubility (69.32 % at pH 9), foam stability (121.67–136.67 %), and emulsion stability (38.64 min). These improvements are attributed to its peptide rich composition and increased soluble dietary fiber. While its water absorption was lower, its oil absorption was comparable to the other samples. Furthermore, RBPC showed notably higher antioxidant activity. Its DPPH and ABTS radical scavenging capacities were 17.25 and 32.46 mg eq Trolox/g dry sample, respectively, and it had a high total phenolic content (34.30 mg GAE/g dry sample). The amino acid profile of the RBPC was consistent with those reported for rice bran protein in the literatures. The composition of RBPC primarily consisted of short peptides, ranging from 8 to 46 amino acids. These findings demonstrate that RBPC is a highly versatile and promising ingredient for the food industry.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101183"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Computational analysis of azadirachta indica-derived phytochemicals targeting α-amylase and α-glucosidase for antidiabetic activity 针对α-淀粉酶和α-葡萄糖苷酶的印楝衍生植物化学物质抗糖尿病活性的计算分析

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-10-10 DOI: 10.1016/j.focha.2025.101132

Ali Mohamod Wasaf Hasan , Md. Sakib Al Hasan , Emon Mia , Mohammed Burhan Uddin , Sumaya Akter Bithi , Noshin Tasnim Yana , Imam Hossen Rakib , Md. Arif Hossain , Muhammad Torequl Islam

{"title":"Computational analysis of azadirachta indica-derived phytochemicals targeting α-amylase and α-glucosidase for antidiabetic activity","authors":"Ali Mohamod Wasaf Hasan , Md. Sakib Al Hasan , Emon Mia , Mohammed Burhan Uddin , Sumaya Akter Bithi , Noshin Tasnim Yana , Imam Hossen Rakib , Md. Arif Hossain , Muhammad Torequl Islam","doi":"10.1016/j.focha.2025.101132","DOIUrl":"10.1016/j.focha.2025.101132","url":null,"abstract":"<div><div><em>Azadirachta indica</em> L. (<em>A. indica</em>, neem), has long been used in the treatment of diabetes in numerous countries. This study aims to explore the molecular interactions of bioactive phytochemicals isolated from <em>A. indica</em> with two key enzymes involved in diabetes, human pancreatic α-amylase (4W93) and α-glucosidase (3CTT), using <em>in silico</em> approaches. Molecular docking was conducted with various ligands to evaluate their potential as inhibitors. Molecular docking analyses revealed that 24-methylene cycloartanol (24-MCL), stigmasterol (SML), and β-sitosterol (BSL) exhibited strong binding affinities (‒9.4 kcal/mol) to α-amylase, with SML forming one hydrogen bond (HB) along with multiple hydrophobic interactions. In contrast, montbretin A (MNA) showed a binding energy of ‒8.7 kcal/mol and formed several HBs. For α-glucosidase, gedunin (GN) showed the highest binding energy (‒9.1 kcal/mol), while SML exhibited a binding energy of ‒8.6 kcal/mol with one HB. Drug-likeness assessment using Lipinski’s Rule of 5 indicated that casuarine (CRE), catechin (CTN), and GN complied with the criteria without violations, while 24-MCL, SML, and BSL had one violation. Absorption, distribution, metabolism, excretion, and toxicity (ADMET) predictions highlighted favorable absorption profiles for 24-MCL, GN, and BSL, while MNA exhibited poor pharmacokinetic properties. Additionally, prediction of activity spectra for substances (PASS) prediction results further supported the antidiabetic potential of certain compounds. These findings warrant further <em>in vivo</em> and <em>in vitro</em> validation and clinical trials to assess 24-MCL and GN’s antidiabetic potential, while structural optimization could enhance potency for developing safer, more effective plant-based antidiabetic drugs.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101132"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the bioactive potential of fruit peels: A comprehensive Review 探索果皮的生物活性潜力：综述

Food chemistry advances Pub Date : 2025-12-01 Epub Date: 2025-10-14 DOI: 10.1016/j.focha.2025.101136

Umme Habiba , Rahul Singh , Pankaj B Pathare , Aamir Hussain Dar , Madiya Manzoor , Urba Shafiq Sidiqi , Toiba Majeed

{"title":"Exploring the bioactive potential of fruit peels: A comprehensive Review","authors":"Umme Habiba , Rahul Singh , Pankaj B Pathare , Aamir Hussain Dar , Madiya Manzoor , Urba Shafiq Sidiqi , Toiba Majeed","doi":"10.1016/j.focha.2025.101136","DOIUrl":"10.1016/j.focha.2025.101136","url":null,"abstract":"<div><div>Fruit processing industries generate large quantities of byproducts, particularly fruit peels, which constitute up to 30–50 % of total fruit mass. These peels are rich in bioactive compounds such as polyphenols (e.g., gallic acid and catechins), flavonoids, carotenoids, vitamins (C and E), essential oils, dietary fiber, and pectin. Numerous studies have demonstrated their strong antioxidant capacity (e.g., DPPH scavenging activity >80 %), along with anti-inflammatory, antimicrobial, and anticancer properties. Epidemiological and preclinical data suggest these compounds play roles in supporting cardiovascular function, modulating gut microbiota, improving glycemic control, and promoting bone health.</div><div>This review critically explores the valorization of fruit peels from common fruits such as orange, pomegranate, banana, and mango in the formulation of functional foods, nutraceuticals, and therapeutic agents. Recent advancements in extraction techniques, including ultrasound-assisted, microwave-assisted, and enzyme-assisted extraction, have significantly improved the yield and purity of these bioactives. However, challenges remain in terms of standardization of bioactive content, enhancement of bioavailability (e.g., through nanoencapsulation), and mitigation of potential toxicological risks associated with high-dose or improperly processed extracts.</div><div>Overall, the integration of fruit peel-derived bioactives into commercial applications represents a viable approach to reduce agri-food waste, promote sustainability, and develop cost-effective health-promoting products. Future research should prioritize clinical validation, safety assessment, and regulatory standardization to facilitate large-scale implementation.</div></div>","PeriodicalId":73040,"journal":{"name":"Food chemistry advances","volume":"9 ","pages":"Article 101136"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145333313","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0