{"title":"INFLUENCE OF HYPOXIC PRECONDITIONING ON THE MECHANISMS OF BLOOD OXYGEN TRANSPORT AND OXIDATIVE DAMAGES\u0000DURING HEPATIC ISCHEMIA-REPERFUSION IN RABBITS.","authors":"M N Khodosovsky","doi":"10.15407/fz62.03.039","DOIUrl":"https://doi.org/10.15407/fz62.03.039","url":null,"abstract":"<p><p>The effect of hypoxic preconditioning (HP) on the blood\u0000oxygen-binding properties and liver oxidative damages was\u0000determine during hepatic ischemia-reperfusion (HIR) in rabbits.\u0000Animals were randomized into two experimental groups:\u00001st (HIR) - hepatic ischemia (30 min by Pringle maneuver) and\u0000reperfusion (120 min); 2nd (HP+HIR) – before HIR the rabbits\u0000were passed through hypoxic chamber at 3500 m altitude during\u00001 hr/day (3 times day after day). The parameters of blood\u0000oxygen transport (р50, рСО2, рО2, рН, HCO3\u0000-, ABE and ect.),\u0000lipid peroxidation products (conjugated dienes, Schiff bases)\u0000and blood hepatic markers (ALT, AST) were detected. It’s\u0000found that HIR leads to decline in hemoglobin oxygen affinity,\u0000activation of lipid peroxidation processes and elevation of ALT\u0000and AST activities in the 1st group. Hypoxic preconditioning\u0000(2nd group) markedly increased hemoglobin oxygen affinity,\u0000reduced the lipid peroxidation processes and ALT and AST\u0000activities in the blood during HIR. Thus, HP has a protective\u0000effect during HIR through elevation of hemoglobin oxygen\u0000affinity and declining hepatic oxidative damages.</p>","PeriodicalId":73031,"journal":{"name":"Fiziolohichnyi zhurnal (Kiev, Ukraine : 1994)","volume":"62 3","pages":"39-47"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"35939520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}