F&S reviews最新文献

{"title":"Effects of assisted reproductive techniques on offspring gonadal function: a systematic review and meta-analysis","authors":"Andrea Crafa M.D.,&nbsp;Rossella Cannarella M.D., Ph.D.,&nbsp;Federica Barbagallo M.D.,&nbsp;Sandro La Vignera M.D., Ph.D.,&nbsp;Rosita A. Condorelli M.D., Ph.D.,&nbsp;Aldo E. Calogero M.D.","doi":"10.1016/j.xfnr.2023.03.001","DOIUrl":"https://doi.org/10.1016/j.xfnr.2023.03.001","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate whether the use of assisted reproductive techniques (ARTs) affected the gonadal function of the offspring. Numerous concerns have emerged over the years about the use of ARTs and their effects on the health of the offspring.</p></div><div><h3>Evidence Review</h3><p>Data were extracted through extensive searches in the PubMed and Scopus databases from their establishment until August 2022. Meta-analysis was performed following the Preferred Reporting Items for Systematic Review and Meta-Analysis Protocols guidelines. All eligible studies were selected according to the Population, Exposure, Comparison/Comparator, Outcomes, Study design model. All studies that analyzed pubertal development and testicular and ovarian function of offspring conceived using ARTs were included. The quality of the studies was assessed using the Cambridge Quality Checklists. For the different outcomes, the standardized mean difference (SMD), the mean difference, and the odds ratio were evaluated. Cochran-Q and I² statistics were used to evaluate statistical heterogeneity. Differences in pubertal development, hormone levels, and sperm function in ART-conceived subjects compared with spontaneously conceived (SC) control subjects.</p></div><div><h3>Results</h3><p>Children conceived using ART do not appear to have impaired pubertal development or achievement of pubertal milestones. From an endocrine point of view, ART-conceived males showed lower sex hormone-binding globulin levels than the control group (SMD = −0.25 [−0.44, −0.05]; I² = 29%) and a tendency to lower testosterone levels (SMD = −0.16 [−0.32, 0.01]; I² = 0). Lower levels of inhibin B, on the other hand, were present only in intracytoplasmic sperm injection-born males compared with the control group (SMD = −0.24 [−0.44, −0.04]; I² = 0). In females, higher luteinizing hormone levels were found in the ART group than in the control group (SMD = 0.33 [0.06, 0.59]; I² = 17%). In contrast, lower levels of 17ß-estradiol were observed only in the intracytoplasmic sperm injection group compared with girls with SC (SMD = −0.39 [−0.74, −0.03]; I² = 0). However, no definitive conclusions can be drawn considering the heterogeneity of hormonal assessments in females. Finally, young adults born from ART had a reduced sperm concentration (SMD = −0.34 [−0.57, −0.11]; I² = 0), total sperm count (SMD = −0.28 [−0.51, −0.05]; I² = 0), and normal sperm morphology (SMD = −0.35 [−0.58, −0.13]; I² = 0) compared with those SC.</p></div><div><h3>Conclusion</h3><p>A slight alteration in the function of the male germinal epithelium appears to be associated with the use of ART, as shown by the reduced levels of inhibin B and the altered sperm parameters.</p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204245","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy and utility of blood and urine biomarkers for the noninvasive diagnosis of endometriosis: a systematic literature review and meta-analysis","authors":"Wioletta Dolińska B.Sc. ,&nbsp;Hannah Draper M.B.Ch.B. M.Phil. ,&nbsp;Lara Othman M.B.Ch.B. ,&nbsp;Chloe Thompson B.Sc. ,&nbsp;Samantha Girvan M.Phil ,&nbsp;Keith Cunningham M.D. ,&nbsp;Jane Allen M.B.Ch.B. ,&nbsp;Alan Rigby M.Sc. ,&nbsp;Kevin Phillips M.B.Ch.B. ,&nbsp;Barbara-ann Guinn Ph.D.","doi":"10.1016/j.xfnr.2022.12.001","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.12.001","url":null,"abstract":"<div><h3>Objective</h3><p>Endometriosis is a chronic, incurable condition associated with debilitating pain and subfertility affecting over 190 million women worldwide, which has no reliable noninvasive diagnostic tool. We aimed to determine the state-of-the-art in noninvasive liquid biopsy biomarker detection and predict the most promising biomarkers for endometriosis detection.</p></div><div><h3>Evidence Review</h3><p>A systematic review of the literature following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines was conducted using the PubMed, MEDLINE, Scopus, and Cochrane Library databases. Primary research studies examining blood or urine biomarkers in humans published in English up until August 2022 were included. Studies with more than 10 patients with clear methodology and surgical staging of endometriosis were included, whereas studies that included gynecological malignancies or who did not perform laparoscopy in the control group were excluded. The articles were assessed for the risk of bias using the Quality Assessment of Diagnostic Accuracy Studies-2 tool. One investigator extracted the data, and 2 investigators checked the accuracy. Extracted data were analyzed descriptively, the box plots of pooled data were calculated using RStudio, and the likelihood ratios were determined.</p></div><div><h3>Results</h3><p>A total of 8,244 and 3,619 manuscripts for blood and urine biomarkers were identified. After screening on the basis of the title, abstract, full text, and quality assurance, 18 of these studies assessing blood biomarkers and 15 examining urine biomarkers were eligible for data extraction. However, there were inconsistencies in the results indicating that standardized techniques would be essential for direct comparisons to be made in the future. In 4 of the eligible studies, the urine biomarkers were juxtaposed with blood markers; however, in most cases, the combination of blood and urine biomarkers resulted in an increase in the area under the curve value, sensitivity, and specificity. One study presented biomarkers with a likelihood ratio of &gt;10. However, currently, none of the biomarkers have been shown to be clinically useful, and further research is necessary to determine their utility in clinical practice.</p></div><div><h3>Conclusion</h3><p>Multiple biomarkers described here provide exciting avenues for further study particularly as part of diagnostic panels, including the endometrial antigens tropomyosin 3, stomatin-like protein 2, and tropomodulin 3, microribonucleic acids, and interleukins. There is a need for standardized protocols to be used to achieve consistent, reproducible results that will facilitate the development of a clinically applicable noninvasive test for endometriosis.</p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50204244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Aberrant microribonucleic acid expression patterns in recurrent implantation failure: a review","authors":"Zahra Khosravizadeh Ph.D. ,&nbsp;Zahra Rashidi Ph.D. ,&nbsp;Maral Daneshyan B.S. ,&nbsp;Kajal Khodamoradi Ph.D. ,&nbsp;Ali Talebi Ph.D.","doi":"10.1016/j.xfnr.2022.11.003","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.11.003","url":null,"abstract":"<div><p><span><span>Implantation failure is the most common cause of pregnancy loss after in vitro fertilization and embryo transfer. Recurrent implantation failure (RIF) after in vitro fertilization has devastating consequences for some patients with infertility. Recent studies have reported that microribonucleic acids (miRNAs) can regulate </span>embryo implantation<span><span> events and may be involved in RIF. MiRNAs are small, single-stranded, noncoding ribonucleic acids that can regulate gene expression in a posttranscriptional manner through degradation or suppression of messenger ribonucleic acids. MiRNAs are generated as long primary miRNA transcripts that are processed by a nuclear </span>RNase<span> III enzyme into precursor miRNAs. After transport to the cytoplasm, the precursor miRNAs are processed into functional miRNAs. MiRNAs have a critical role in normal development and are involved in several biologic processes, including cell proliferation<span><span>, apoptosis, and differentiation, as well as embryo implantation. MiRNAs also have a role in the down-regulation of several cell cycle genes in the epithelium of the secretory-phase </span>endometrium. This review aimed to discuss the possible roles of miRNAs in RIF. According to published data, miRNAs secreted by the endometrium and embryos can contribute to regulating embryo-endometrium cross talk and impact embryo implantation </span></span></span></span>in patients<span> with RIF. An improved understanding of molecular mechanisms underlying RIF may help to advance diagnosis and treatment of this clinical condition. Although several studies have provided evidence that miRNAs play important roles in RIF, further research is essential to evaluate the function of miRNAs and their target genes and understand the mechanisms by which miRNAs control the molecular events involved in RIF.</span></p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49889735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of vitamin D and endometriosis: role in pathophysiology, diagnosis, treatment, and prevention","authors":"Bhavjeet Kaur Kahlon M.B.B.S. ,&nbsp;Mackenzie Simon-Collins ,&nbsp;Elisabeth Nylander M.Sc. ,&nbsp;James Segars M.D. ,&nbsp;Bhuchitra Singh M.D., M.P.H., M.S., M.B.A.","doi":"10.1016/j.xfnr.2022.11.005","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.11.005","url":null,"abstract":"<div><h3>Objective</h3><p><span>To assess the current literature evaluating the role of vitamin D in </span>endometriosis in humans.</p></div><div><h3>Evidence Review</h3><p>A systematic review<span> was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines within PubMed, Embase, the Cochrane Library, the Web of Science, and Scopus. A comprehensive search strategy was developed by a data informationist. Observational and interventional studies assessing endometriosis and vitamin D association in humans published in English up to March 10, 2022, were included. Two reviewers independently screened studies evaluating the role of vitamin D in endometriosis. The risk of bias was assessed using the Cochrane Risk of Bias 2.0 tool, Newcastle-Ottawa scale, and Strengthening the Reporting of Observational Studies in Epidemiology. Extracted data were analyzed descriptively.</span></p></div><div><h3>Results</h3><p><span><span><span>Of 1,921 studies identified, 29 met the eligibility criteria after screening the titles, abstracts, and full texts and were included in this systematic review. Of these, 13 were clinical studies, 12 were preclinical studies, and 4 had components of both preclinical and clinical studies. Eight of the 11 clinical studies evaluating the vitamin D levels reported that low vitamin D levels were associated with endometriosis, whereas a study found higher vitamin D levels in endometriosis, and the rest did not report an association. Experimental studies found that vitamin D played an important role in multiple pathogenetic processes, such as cell proliferation, invasion, degradation, and inflammation, by regulation of cytokines, including interleukin-6 and interleukin-8, </span>prostaglandin activity, and </span>matrix metalloproteinases. The expressions of important genes, such as </span><em>EGFR</em>, <em>MDGF</em>, <em>PDGFB</em>, 1α-OHase, and <span><em>CYP24A1</em></span><span>, involved in the development of endometriosis were found to be influenced by vitamin D. Only 1 of 9 studies evaluating the polymorphism of the vitamin D receptor gene found an association of endometriosis with the </span><em>Bsm</em>I variant of the <em>VDR</em><span><span> gene. Two studies reported the diagnostic accuracy of the urinary<span> vitamin D binding protein as an isolated biomarker of endometriosis to be limited. </span></span>Clinical trials studying the efficacy of vitamin D in treating the symptoms of endometriosis were equivocal.</span></p></div><div><h3>Conclusion</h3><p>Data were strongly supportive of a correlation between low vitamin D levels and endometriosis in most studies. Studies suggesting the role of vitamin D in the regulation of important cellular and signaling pathways involving gene expressions and cytokines in endometriosis have been consistent. Further studies evaluating the therapeutic efficacy of vitamin D in endometriosis are required because the data were equivocal.","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49889733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How does adenomyosis impact endometrial receptivity? An updated systematic review of clinical and molecular insights","authors":"Takehiro Hiraoka M.D., Ph.D.,&nbsp;Yasushi Hirota M.D., Ph.D.,&nbsp;Yutaka Osuga M.D., Ph.D.","doi":"10.1016/j.xfnr.2022.11.004","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.11.004","url":null,"abstract":"<div><h3>Objective</h3><p><span>To summarize current knowledge regarding the outcomes of assisted reproductive technology (ART) </span>in patients<span> with adenomyosis, offer insights into the defects in the regulation of endometrial receptivity, and discuss the implications for the clinical management of adenomyosis and infertility.</span></p></div><div><h3>Evidence Review</h3><p>We conducted a comprehensive literature search of PubMed for original and review articles published in English up to June 2022 in the following areas: adenomyosis and infertility; ART; endometrial receptivity; and embryo implantation.</p></div><div><h3>Results</h3><p><span><span>Adenomyosis may have a negative impact on endometrial receptivity, reducing the probability of conception by ART. The severity of adenomyosis seems to be associated with the severity of the impairment in receptivity, and before treatment with a gonadotropin-releasing hormone agonist before frozen-thawed </span>embryo transfer<span> may restore endometrial receptivity. Molecular analyses demonstrated that genes associated with endometrial receptivity are aberrantly expressed in the eutopic endometria of women with infertility with adenomyosis. Hyperproliferation of the endometrial epithelium, impaired </span></span>decidualization<span>, progesterone<span> resistance, altered expression of adhesion molecules<span><span>, a hyperinflammatory microenvironment, chronic </span>endometritis<span>, and abnormal uterine contractility seem to be involved in the impairment of endometrial receptivity.</span></span></span></span></p></div><div><h3>Conclusion</h3><p>Uterine adenomyosis reduces endometrial receptivity via several mechanisms. In addition, data suggest that the etiologic mechanism of adenomyosis is responsible for impaired endometrial receptivity. Before treatment with a gonadotropin-releasing hormone agonist before frozen-thawed embryo transfer may ameliorate the defects in the uterine environment, probably by restoring the expression of genes that are essential for embryo implantation. Further research using animal models should aim to additionally clarify the relationship between adenomyosis and infertility to refine the treatment strategies for women with infertility with adenomyosis.</p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49889734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modifiable socioeconomic and lifestyle risk factors for female infertility in Asia: a systematic review from the population health perspective","authors":"Ling-Jun Li Ph.D. ,&nbsp;Ashley Chow B.Sc. ,&nbsp;Audrey J. Gaskins Ph.D. ,&nbsp;Jie Ning Jovin Lee B.Sc. ,&nbsp;Mahesh Choolani Ph.D. ,&nbsp;Brian K. Kennedy Ph.D. ,&nbsp;Zhongwei Huang Ph.D. ,&nbsp;Yap Seng Chong M.D. ,&nbsp;Cuilin Zhang Ph.D.","doi":"10.1016/j.xfnr.2022.09.001","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.09.001","url":null,"abstract":"<div><h3>Objective</h3><p>To pinpoint the knowledge gaps and systematically identify modifiable infertility-related socioeconomic and lifestyle risk factors in Asian women, since most studies on female infertility-related risk factors were conducted in the Western populations. This review pinpointed the knowledge gaps and aimed to systematically identify modifiable infertility-related socioeconomic and lifestyle risk factors in Asian women.</p></div><div><h3>Evidence Review</h3><p>We performed a systematic literature search according to the Preferred Reporting Items for Systematic Reviews<span> and Meta-Analyses checklist from January 1, 1990, to October 31, 2021, in PubMed, the Web of Science, Embase, and Scopus, using a set of keywords related to our schemes, such as socioeconomics, lifestyle, infertility, and time to pregnancy. We shortlisted a combination of available full texts, English publications, original research articles, human subjects, and nonpregnant women of childbearing age with the intent of conceiving without medical assistance as the population of interest for further screening.</span></p></div><div><h3>Results</h3><p>We included 43 Asian studies that reported modifiable socioeconomic and lifestyle risk factors with the following outcomes: time to pregnancy; pregnancy rate; or infertility rate. Similar to the Western populations, female infertility in Asian women was associated with advanced age at marriage, sexual dysfunction, elevated stress levels, and greater adiposity. Interestingly, a higher socioeconomic status in Asian women was positively associated with female infertility, whereas a higher socioeconomic status in their male partners was inversely associated with couple infertility. Regrettably, few publications reported lifestyle risk factors, such as physical activity, dietary food groups, sleep disorders, and substance use.</p></div><div><h3>Conclusion</h3><p>Asian women may have more infertility-related cultural and dietary diversity, and it is worthy of future research efforts. It is also critical and more effective to tackle the infertility problem in both women and men. Hence, we discussed the imperative need for research efforts in Asian couples.</p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The impact of obesity and subsequent weight loss through bariatric surgery on male fertility","authors":"Sally F. Vitez M.D. ,&nbsp;Bestoun H. Ahmed M.D., F.A.C.S. ,&nbsp;Miguel Brieño-Enríquez M.D., Ph.D. ,&nbsp;Kathleen Hwang M.D.","doi":"10.1016/j.xfnr.2022.11.002","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.11.002","url":null,"abstract":"<div><p><span>This is a comprehensive review evaluating current literature published on the impact of obesity and subsequent weight loss on male factor infertility. The prevalence of obesity is increasing worldwide, and it is projected that by 2030, &gt;50% of all adults in the United States will be obese. Obesity, with excess adipose tissue<span>, leads to a proinflammatory state with higher reactive oxygen species<span> production, dysfunction of the hypothalamic-pituitary-gonadal axis, and subsequent alterations in spermatogenesis. There is growing evidence to support the negative impact of obesity on male </span></span></span>factor fertility<span><span><span>, specifically manifesting as reduced semen parameters. However, the male contribution to fertility goes beyond the standard semen analysis<span>. As a result, in-depth molecular studies through metabolomics<span>, proteomics, and </span></span></span>epigenomics have been described to better understand male factor infertility and the impact of obesity on subfecundity. Given the obesity epidemic, there has been an increase in medically supervised weight loss programs and surgical intervention for weight loss. </span>Bariatric surgery<span><span> has become the mainstay of treatment for obesity. Early case reports documented a harmful impact of bariatric surgery on semen parameters; however, more recent </span>prospective cohort studies identify no change in standard semen parameters after significant weight loss after bariatric surgery. Nonetheless, the clinical impact of bariatric surgery on fertility and ongoing clinical pregnancy when performed for obese male partners remains undetermined and an area for further study.</span></span></p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometrial receptivity, to test or not to test: the evidence on contemporary assays","authors":"Elizabeth Clain M.D. ,&nbsp;Kate Devine M.D.","doi":"10.1016/j.xfnr.2022.11.001","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.11.001","url":null,"abstract":"<div><p>Despite improvements in in vitro fertilization success over the last 2 decades, the live birth rates do not exceed 65% even after transfer of a preimplantation genetic testing for aneuploidy<span><span> normal blastocyst<span> to a sonographically optimal endometrium<span>. Consequently, there has been a search for more subtle endometrial factors that may deter sustained implantation and for treatments to mitigate these factors. Assays evaluating the window of implantation, markers of inflammation, normal vs. abnormal </span></span></span>microbiome<span><span>, and variations in the expression of endometrial proteins thought to be associated with implantation are commercially available and sought out by patients. The Endometrial Receptivity Assay aims to individualize embryo transfer timing but lacks sufficient data to support its use. Chronic </span>endometritis may be associated with poor reproductive outcomes in some patients; however, accurate diagnosis is a challenge, and there is no high-quality evidence supporting routine assessment. Assessment of the uterine microbiome, ReceptivaDx, and the endometrial function test similarly do not have sufficient data to recommend routine testing in either the general infertility population or those who have experienced unsuccessful embryo transfer. Additional studies are needed to evaluate the endometrial contribution to implantation failure and what population, if any, may benefit from additional endometrial testing.</span></span></p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Current options to lower the cost of in vitro fertilization: a comprehensive review","authors":"Austin Gardner M.D. ,&nbsp;Kristen L. Smith M.D. ,&nbsp;Elizabeth Huuki B.S. ,&nbsp;Jacqueline Luizzi M.L.I.S., A.H.I.P. ,&nbsp;Deidre D. Gunn M.D. ,&nbsp;Sukhkamal B. Campbell M.D. ,&nbsp;Bruce D. Pier M.D.","doi":"10.1016/j.xfnr.2022.10.001","DOIUrl":"https://doi.org/10.1016/j.xfnr.2022.10.001","url":null,"abstract":"<div><p><span>Although the first successful in vitro fertilization (IVF) cycle occurred over 40 years ago, the financial cost of IVF remains steep and prevents several patients from pursuing this option for infertility treatment. Institutional coverage for IVF varies widely depending on state or country, and some individuals may ultimately encounter no financial support. In some cases, surgical intervention (instead of or before IVF) could provide a less costly option or optimize IVF success to decrease the number of cycles needed for a successful pregnancy. Alterations in the individual components of the IVF process may cumulatively drive down overall costs. Changing stimulation protocols, medication regimens, or the medications themselves used during IVF could lead to similar pregnancy rates at lower costs. The addition of adjuncts to traditional IVF stimulation may further elevate the success rate. Monitoring of the patient’s response to stimulation medications and the genetic testing of embryos can be applied more judiciously in certain patient populations. Automation in established practices, such as </span>intracytoplasmic sperm injection, may lead to decreased costs if broadly implemented. Patient-specific approaches using demographic and clinical factors to stratify patients on the basis of likelihood of success may enable providers to efficiently counsel patients to better financially plan for an IVF cycle.</p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49906534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro maturation of oocytes for fertility preservation: a comprehensive review","authors":"Michael Grynberg M.D., PhD. ,&nbsp;Nathalie Sermondade M.D., Ph.D. ,&nbsp;Ines Sellami M.D. ,&nbsp;Alexandra Benoit Ph.D. ,&nbsp;Anne Mayeur M.D. ,&nbsp;Charlotte Sonigo M.D., Ph.D.","doi":"10.1016/j.xfnr.2022.07.002","DOIUrl":"10.1016/j.xfnr.2022.07.002","url":null,"abstract":"<div><p><span>The development of oncofertility over the past decade has renewed the interest in in vitro maturation (IVM) because of the specificity of some oncologic situations that may prevent the feasibility of controlled ovarian hyperstimulation. Immature cumulus-oocyte complexes can be recovered from the small </span>antral follicles<span><span> in any phase of the menstrual cycle<span> within a very short time frame, offering the possibility of vitrifying mature oocytes or embryos after IVM in urgent situations or when stimulation is contraindicated. Cumulus-oocyte complexes and immature oocytes can be harvested either transvaginally or directly in the laboratory from extracorporeal ovarian tissue. Although IVM is no longer considered experimental as a result of safety studies, it relies on the extremely complex process of </span></span>oocyte maturation<span>. Despite some live births<span> obtained after IVM in the context of fertility preservation<span><span>, the lower developmental competence of in vitro–matured oocytes demonstrates the need to improve IVM culture systems. Recent advances in IVM systems may improve oocyte competence after IVM, thus tending to reduce the gap between IVM and ovarian stimulation outcomes. Moreover, to optimize the chances of conception in cancer survivors, the combination of IVM and </span>ovarian tissue cryopreservation is the preferred option when ovarian stimulation cannot be performed.</span></span></span></span></p></div>","PeriodicalId":73011,"journal":{"name":"F&S reviews","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124458617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}