Extracellular vesicles and circulating nucleic acids最新文献_第6页

Leveraging biomimetic synthesis strategy for next-generation dendritic cell nanovaccines. 利用仿生合成策略制备下一代树突状细胞纳米疫苗。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-10-08 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.35

Yutian Xia, Jianzhong Zhang

引用次数: 0

Extracellular vesicles in reproduction and pregnancy. 生殖和妊娠中的细胞外囊泡。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-09-30 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.27

Tahlia I Smith, Ashley E Russell

{"title":"Extracellular vesicles in reproduction and pregnancy.","authors":"Tahlia I Smith, Ashley E Russell","doi":"10.20517/evcna.2022.27","DOIUrl":"10.20517/evcna.2022.27","url":null,"abstract":"Extracellular vesicles (EVs) are small, lipid-bound packages that are secreted by all cell types and have been implicated in many diseases, such as cancer and neurodegenerative disorders. Though limited, an exciting new area of EV research focuses on their role in the reproductive system and pregnancy. In males, EVs have been implicated in sperm production and maturation. In females, EVs play a vital role in maintaining reproductive organ homeostasis and pregnancy, including the regulation of folliculogenesis, ovulation, and embryo implantation. During the development and maintenance of a pregnancy, the placenta is the main form of communication between the mother and the developing fetus. To support the developing fetus, the placenta will act as numerous vital organs until birth, and release EVs into the maternal and fetal bloodstream. EVs play an important role in cell-to-cell communication and may mediate the pathophysiology of pregnancy-related disorders such as preeclampsia, gestational diabetes mellitus, preterm birth, and intrauterine growth restriction, and potentially serve as noninvasive biomarkers for these conditions. In addition, EVs may also mediate processes involved in both male and female infertility. Together, the EVs secreted by both the male and female reproductive tracts work to promote reproductive fertility and play vital roles in mediating maternal-fetal crosstalk and pregnancy maintenance.","PeriodicalId":73008,"journal":{"name":"Extracellular vesicles and circulating nucleic acids","volume":"33 1","pages":"292-317"},"PeriodicalIF":0.0,"publicationDate":"2022-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89789591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Liquid biopsy for monitoring medulloblastoma. 液体活检监测成神经管细胞瘤。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-09-28 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.36

Robert H Eibl, Markus Schneemann

{"title":"Liquid biopsy for monitoring medulloblastoma.","authors":"Robert H Eibl, Markus Schneemann","doi":"10.20517/evcna.2022.36","DOIUrl":"10.20517/evcna.2022.36","url":null,"abstract":"Despite recent progress in molecular diagnostics defining four distinct medulloblastoma groups, the clinical management of these malignant childhood tumors of the cerebellum remains challenging. After surgical removal of the tumor, both cytotoxic chemotherapy and irradiation can offer additional curative benefits, but they also include a significant risk of long-term damage. Early molecular profiling aims to predict the outcome of such aggressive therapies. This prevents unnecessary damage to patients who may not need it and helps to identify those patients with remaining tumor cells who may benefit from more aggressive treatment with the intent to cure. Monitoring tumor evolution in real time allows personalized precision medicine with an immediate clinical response resulting in a better outcome. Liquid biopsy includes various methodologies already applied in numerous studies and clinical trials for common cancers including brain tumors, but information on medulloblastomas is limited. This review summarizes the recent developments of how liquid biopsy can support or even replace the standard monitoring of medulloblastomas by medical imaging or cytology and discusses what will be needed to make liquid biopsy a new gold standard in diagnosis, therapy, and follow-up of medulloblastomas for the benefit of the patients.","PeriodicalId":73008,"journal":{"name":"Extracellular vesicles and circulating nucleic acids","volume":"94 1","pages":"280-291"},"PeriodicalIF":0.0,"publicationDate":"2022-09-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648495/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75645476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Towards responsible ctDNA-based multi-cancer screening: a preliminary exploration and discussion of ethically relevant aspects. 面向负责任的基于ctdna的多癌筛查：伦理相关方面的初步探索与讨论。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-08-16 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.23

Wybo Dondorp, Guido de Wert

{"title":"Towards responsible ctDNA-based multi-cancer screening: a preliminary exploration and discussion of ethically relevant aspects.","authors":"Wybo Dondorp, Guido de Wert","doi":"10.20517/evcna.2022.23","DOIUrl":"10.20517/evcna.2022.23","url":null,"abstract":"While testing for easily accessible biomarkers in the circulation (\"liquid biopsy\") has found its way to clinical cancer care, a further expected development is its use as a \"universal\" early detection test in population screening for cancer. A promising marker for such screening is circulating cell-free fragments of tumor DNA, shed into the circulation during tumor cell turnover. Several blood-based \"multicancer early detection (MCED) tests\" have recently been developed - but still need validation in large-scale studies involving non-patient populations. In this paper, we proactively explore the ethical aspects of this development. We refer to an often quoted synthesis of the internationally accepted framework of principles for responsible screening as first drawn up for the World Health Organisation (WHO) by Wilson and Junger 50 years ago and further developed and fine-tuned ever since. As our analysis suggests, some specific ethical issues and concerns about potential MCED screening connect to the fact that cancer is not just one disease. As a consequence, not all findings will have the same clinical utility. We discuss this against the background of earlier debates pertaining to broad scope forms of screening in other contexts, specifically newborn and reproductive genetic screening. We highlight the guidance provided by some of the criteria from the screening framework that seems most relevant in this connection: the need for screening objectives to be defined at the outset, the need for mechanisms to minimize potential risks, and the requirement that, for those participating in the screening, the overall benefits outweigh the harm.","PeriodicalId":73008,"journal":{"name":"Extracellular vesicles and circulating nucleic acids","volume":"20 1","pages":"235-243"},"PeriodicalIF":0.0,"publicationDate":"2022-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74777617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanded knowledge of cell-free DNA biology: potential to broaden the clinical utility. 扩展无细胞DNA生物学的知识：扩大临床应用的潜力。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-08-10 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.21

Huiwen Che, Kate Stanley, Tatjana Jatsenko, Bernard Thienpont, Joris Robert Vermeesch

引用次数: 0

Cell-free DNA as a biomarker in cancer. 无细胞DNA作为癌症的生物标志物。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-08-02 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.20

Robert H Eibl, Markus Schneemann

引用次数: 0

Meeting report of the 2nd Lugano ExoDay: extracellular vesicles as next-generation clinical biomarkers and therapeutic agents. 第二届Lugano ExoDay会议报告：细胞外囊泡作为下一代临床生物标志物和治疗剂。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-07-29 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.17

Carolina Balbi, Marina Cretich, Lucio Barile

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Meeting Abstracts of the first meeting of the American Society for Intercellular Communication 2021. 2021年美国细胞间通信学会第一次会议摘要。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-07-19 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.10

Gurudutt Pendyala, Ashley E Russell, Shilpa Buch, Susmita Sil, Emeli Chatterjee, Bojan Losic, Alissa M Weaver, Tsuneya Ikezu, Randy Schekman, Xiaoli Yu

引用次数: 0

New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery. 工程植物外泌体样纳米囊泡作为治疗和药物传递的纳米平台的新见解。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-06-29 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2021.25

Shafiu A Umar Shinge, Yin Xiao, Jiang Xia, Yujie Liang, Li Duan

{"title":"New insights of engineering plant exosome-like nanovesicles as a nanoplatform for therapeutics and drug delivery.","authors":"Shafiu A Umar Shinge, Yin Xiao, Jiang Xia, Yujie Liang, Li Duan","doi":"10.20517/evcna.2021.25","DOIUrl":"10.20517/evcna.2021.25","url":null,"abstract":"Plant exosome-like nanovesicles (PELNVs) are membrane-encapsulated nanostructures released from cells into their surroundings. PELNVs have an important role in intercellular and interspecies communication in all three domains of life. They act as protective compartments for the long-distance transit of signal molecules like proteins, nucleic acids, lipids, and other metabolites. A range of plants and vegetables can emit PELNVs. The importance of PELNVs in interspecies communication stems from their concentration in biomolecules (lipids, proteins, and miRNAs), lack of toxicity, ease of internalization by cells, and anti-inflammatory, immune-modulatory, and regenerative characteristics. PELNVs derived from numerous fruits and vegetables are biocompatible, biodegradable, and abundant in various plant species. Moreover, their convincing physicochemical characteristics underpin their modulative role in physiological and pathological processes, all of which have fueled speculation that these nanovesicles could be particularly adept at developing future-generation bio-therapeutic platforms. The goal of this review was not only to present an overview of the identified roles of PELNVs in physiology and pathology, but also to provide new insight toward their engineering for effective therapeutics and drug delivery nanoplatforms, a clue for future direction to the ongoing research gaps.","PeriodicalId":73008,"journal":{"name":"Extracellular vesicles and circulating nucleic acids","volume":"75 1","pages":"150-162"},"PeriodicalIF":0.0,"publicationDate":"2022-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648482/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83405570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Strategies to functionalize extracellular vesicles against HER2 for anticancer activity. 细胞外囊泡功能化对抗HER2的抗癌活性策略。

Extracellular vesicles and circulating nucleic acids Pub Date : 2022-04-18 eCollection Date: 2022-01-01 DOI: 10.20517/evcna.2022.07

Elena Gurrieri, Vito Giuseppe D'Agostino

{"title":"Strategies to functionalize extracellular vesicles against HER2 for anticancer activity.","authors":"Elena Gurrieri, Vito Giuseppe D'Agostino","doi":"10.20517/evcna.2022.07","DOIUrl":"10.20517/evcna.2022.07","url":null,"abstract":"Cell-secreted extracellular vesicles (EVs) are membranous particles highly heterogeneous in size and molecular cargo. Comprehensively, released EV sub-populations can show a wide range and selection of different protein, RNA, and lipid species, complementing cell communication signals. Recently, EVs represent a new source for developing targeted delivery systems. EVs are stable in biofluids, intrinsically biocompatible with low immunogenicity, and capable of transferring cargo molecules into \"recipient\" cells. The immune-mediated recognition represents a popular approach to functionalize and direct EVs towards receptor-positive cell populations. The human epidermal growth factor receptor 2 (HER2, also known as neu or ERBB2) is a tyrosine kinase of clinical relevance, targeted by several available antibodies, and a model receptor used to test the biodistribution and anticancer activity of bioformulations, including EVs. Here, we focus on recent strategies adopted for EV functionalization with fusion ligands able to recognize HER2, covering the enhanced expression of membrane-fusion proteins in \"EV-donor\" cells as well as post-isolation EV-surface modifications.","PeriodicalId":73008,"journal":{"name":"Extracellular vesicles and circulating nucleic acids","volume":"136 1","pages":"93-101"},"PeriodicalIF":0.0,"publicationDate":"2022-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11648518/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76442748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0