Energy & Environmental Science最新文献_第2页

Characterization of the B cell receptor repertoire in melanoma 黑色素瘤中 B 细胞受体谱系的特征

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-11-04 DOI: 10.1038/s41568-024-00770-y

Jisu Chae, Junho Chung

引用次数: 0

Midkine crisis fuels age-related tumorigenesis Midkine 危机助长了与年龄有关的肿瘤发生

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-31 DOI: 10.1038/s41568-024-00771-x

Gabrielle Brewer

引用次数: 0

The present and future of the Cancer Dependency Map 癌症依赖地图的现状与未来

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-28 DOI: 10.1038/s41568-024-00763-x

Rand Arafeh, Tsukasa Shibue, Joshua M. Dempster, William C. Hahn, Francisca Vazquez

{"title":"The present and future of the Cancer Dependency Map","authors":"Rand Arafeh, Tsukasa Shibue, Joshua M. Dempster, William C. Hahn, Francisca Vazquez","doi":"10.1038/s41568-024-00763-x","DOIUrl":"https://doi.org/10.1038/s41568-024-00763-x","url":null,"abstract":"Despite tremendous progress in the past decade, the complex and heterogeneous nature of cancer complicates efforts to identify new therapies and therapeutic combinations that achieve durable responses in most patients. Further advances in cancer therapy will rely, in part, on the development of targeted therapeutics matched with the genetic and molecular characteristics of cancer. The Cancer Dependency Map (DepMap) is a large-scale data repository and research platform, aiming to systematically reveal the landscape of cancer vulnerabilities in thousands of genetically and molecularly annotated cancer models. DepMap is used routinely by cancer researchers and translational scientists and has facilitated the identification of several novel and selective therapeutic strategies for multiple cancer types that are being tested in the clinic. However, it is also clear that the current version of DepMap is not yet comprehensive. In this Perspective, we review (1) the impact and current uses of DepMap, (2) the opportunities to enhance DepMap to overcome its current limitations, and (3) the ongoing efforts to further improve and expand DepMap.","PeriodicalId":72,"journal":{"name":"Energy & Environmental Science","volume":"96 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142519250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Stemness in solid malignancies: coping with immune attack 实体恶性肿瘤中的干细胞：应对免疫攻击

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-25 DOI: 10.1038/s41568-024-00760-0

Judith Agudo, Yuxuan Miao

{"title":"Stemness in solid malignancies: coping with immune attack","authors":"Judith Agudo, Yuxuan Miao","doi":"10.1038/s41568-024-00760-0","DOIUrl":"https://doi.org/10.1038/s41568-024-00760-0","url":null,"abstract":"Immunotherapy has become a key new pillar of cancer treatment, and this has sparked interest in understanding mechanisms of cancer immune evasion. It has long been appreciated that cancers are constituted by heterogeneous populations of tumour cells. This feature is often fuelled by specialized cells that have molecular programs resembling tissue stem cells. Although these cancer stem cells (CSCs) have capacity for unlimited self-renewal and differentiation, it is increasingly evident that some CSCs are capable of achieving remarkable immune resistance. Given that most immunotherapy regiments have overlooked CSC-specific immune-evasive mechanisms, many current treatment strategies often lead to cancer relapse. This Review focuses on advancements in understanding how CSCs in solid tumours achieve their unique immune-evasive properties, enabling them to drive tumour regrowth. Moreover, as cancers often arise from tissue stem cells that acquired oncogenic mutations, we discuss how tissue stem cells undergoing malignant transformation activate intrinsic immune-evasive mechanisms and establish close interactions with suppressive immune cells to escape immune surveillance. In addition, we summarize how in advanced disease stages, CSCs often hijack features of normal stem cells to resist antitumour immunity. Finally, we provide insights in how to design a new generation of cancer immunotherapies to ensure elimination of CSCs.","PeriodicalId":72,"journal":{"name":"Energy & Environmental Science","volume":"15 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142489808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Convergent inducers and effectors of T cell paralysis in the tumour microenvironment 肿瘤微环境中T细胞瘫痪的趋同诱导因子和效应因子

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-24 DOI: 10.1038/s41568-024-00761-z

Douglas Hanahan, Olivier Michielin, Mikael J. Pittet

{"title":"Convergent inducers and effectors of T cell paralysis in the tumour microenvironment","authors":"Douglas Hanahan, Olivier Michielin, Mikael J. Pittet","doi":"10.1038/s41568-024-00761-z","DOIUrl":"https://doi.org/10.1038/s41568-024-00761-z","url":null,"abstract":"Tumorigenesis embodies the formation of a heterotypic tumour microenvironment (TME) that, among its many functions, enables the evasion of T cell-mediated immune responses. Remarkably, most TME cell types, including cancer cells, fibroblasts, myeloid cells, vascular endothelial cells and pericytes, can be stimulated to deploy immunoregulatory programmes. These programmes involve regulatory inducers (signals-in) and functional effectors (signals-out) that impair CD8+ and CD4+ T cell activity through cytokines, growth factors, immune checkpoints and metabolites. Some signals target specific cell types, whereas others, such as transforming growth factor-β (TGFβ) and prostaglandin E2 (PGE2), exert broad, pleiotropic effects; as signals-in, they trigger immunosuppressive programmes in most TME cell types, and as signals-out, they directly inhibit T cells and also modulate other cells to reinforce immunosuppression. This functional diversity and redundancy pose a challenge for therapeutic targeting of the immune-evasive TME. Fundamentally, the commonality of regulatory programmes aimed at abrogating T cell activity, along with paracrine signalling between cells of the TME, suggests that many normal cell types are hard-wired with latent functions that can be triggered to prevent inappropriate immune attack. This intrinsic capability is evidently co-opted throughout the TME, enabling tumours to evade immune destruction.","PeriodicalId":72,"journal":{"name":"Energy & Environmental Science","volume":"63 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2024-10-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

High-resolution measurement of individual telomere lengths with Telo-seq 利用 Telo-seq 高分辨率测量单个端粒长度

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-22 DOI: 10.1038/s41568-024-00767-7

Carly Tyer

引用次数: 0

Emerging strategies to investigate the biology of early cancer 研究早期癌症生物学的新策略

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-21 DOI: 10.1038/s41568-024-00754-y

Ran Zhou, Xiwen Tang, Yuan Wang

{"title":"Emerging strategies to investigate the biology of early cancer","authors":"Ran Zhou, Xiwen Tang, Yuan Wang","doi":"10.1038/s41568-024-00754-y","DOIUrl":"https://doi.org/10.1038/s41568-024-00754-y","url":null,"abstract":"Early detection and intervention of cancer or precancerous lesions hold great promise to improve patient survival. However, the processes of cancer initiation and the normal–precancer–cancer progression within a non-cancerous tissue context remain poorly understood. This is, in part, due to the scarcity of early-stage clinical samples or suitable models to study early cancer. In this Review, we introduce clinical samples and model systems, such as autochthonous mice and organoid-derived or stem cell-derived models that allow longitudinal analysis of early cancer development. We also present the emerging techniques and computational tools that enhance our understanding of cancer initiation and early progression, including direct imaging, lineage tracing, single-cell and spatial multi-omics, and artificial intelligence models. Together, these models and techniques facilitate a more comprehensive understanding of the poorly characterized early malignant transformation cascade, holding great potential to unveil key drivers and early biomarkers for cancer development. Finally, we discuss how these new insights can potentially be translated into mechanism-based strategies for early cancer detection and prevention.","PeriodicalId":72,"journal":{"name":"Energy & Environmental Science","volume":"79 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142452535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

New horizons in our understanding of precursor multiple myeloma and early interception 我们对多发性骨髓瘤前兆和早期阻断的认识新视野

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-16 DOI: 10.1038/s41568-024-00755-x

David M. Cordas dos Santos, Rosa Toenges, Luca Bertamini, Jean-Baptiste Alberge, Irene M. Ghobrial

{"title":"New horizons in our understanding of precursor multiple myeloma and early interception","authors":"David M. Cordas dos Santos, Rosa Toenges, Luca Bertamini, Jean-Baptiste Alberge, Irene M. Ghobrial","doi":"10.1038/s41568-024-00755-x","DOIUrl":"https://doi.org/10.1038/s41568-024-00755-x","url":null,"abstract":"Multiple myeloma is an incurable plasma cell malignancy that evolves over decades through the selection and malignant transformation of monoclonal plasma cells. The evolution from precursor states to symptomatic disease is characterized by an increasing complexity of genomic alterations within the plasma cells and a remodelling of the microenvironment towards an immunosuppressive state. Notably, in patients with advanced disease, similar mechanisms of tumour escape and immune dysfunction mediate resistance to modern T cell-based therapies, such as T cell-engaging bispecific antibodies and chimeric antigen receptor (CAR)-T cells. Thus, an increasing number of clinical trials are assessing the efficiency and safety of these therapies in individuals with newly diagnosed multiple myeloma and high-risk smoldering multiple myeloma. In this Review, we summarize the current knowledge about tumour intrinsic and extrinsic processes underlying progression from precursor states to symptomatic myeloma and discuss the rationale for early interception including the use of T cell-redirecting therapies.","PeriodicalId":72,"journal":{"name":"Energy & Environmental Science","volume":"72 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenomic heterogeneity as a source of tumour evolution 表观基因组异质性是肿瘤演变的源头

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-16 DOI: 10.1038/s41568-024-00757-9

Marthe Laisné, Mathieu Lupien, Céline Vallot

{"title":"Epigenomic heterogeneity as a source of tumour evolution","authors":"Marthe Laisné, Mathieu Lupien, Céline Vallot","doi":"10.1038/s41568-024-00757-9","DOIUrl":"https://doi.org/10.1038/s41568-024-00757-9","url":null,"abstract":"In the past decade, remarkable progress in cancer medicine has been achieved by the development of treatments that target DNA sequence variants. However, a purely genetic approach to treatment selection is hampered by the fact that diverse cell states can emerge from the same genotype. In multicellular organisms, cell-state heterogeneity is driven by epigenetic processes that regulate DNA-based functions such as transcription; disruption of these processes is a hallmark of cancer that enables the emergence of defective cell states. Advances in single-cell technologies have unlocked our ability to quantify the epigenomic heterogeneity of tumours and understand its mechanisms, thereby transforming our appreciation of how epigenomic changes drive cancer evolution. This Review explores the idea that epigenomic heterogeneity and plasticity act as a reservoir of cell states and therefore as a source of tumour evolution. Best practices to quantify epigenomic heterogeneity and explore its various causes and consequences are discussed, including epigenomic reprogramming, stochastic changes and lasting memory. The design of new therapeutic approaches to restrict epigenomic heterogeneity, with the long-term objective of limiting cancer development and progression, is also addressed.","PeriodicalId":72,"journal":{"name":"Energy & Environmental Science","volume":"6 1","pages":""},"PeriodicalIF":78.5,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunoproteasome as a biomarker for immunotherapy 作为免疫疗法生物标志物的免疫蛋白酶体

IF 78.5 1区材料科学

Energy & Environmental Science Pub Date : 2024-10-15 DOI: 10.1038/s41568-024-00759-7

Radhakrishnan Sabarinathan

引用次数: 0