Advances in applied microbiology最新文献

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Microalgae for biofuel production. 用于生物燃料生产的微藻。
2区 生物学
Advances in applied microbiology Pub Date : 2019-10-25 DOI: 10.1016/bs.aambs.2019.10.001
D James Gilmour
{"title":"Microalgae for biofuel production.","authors":"D James Gilmour","doi":"10.1016/bs.aambs.2019.10.001","DOIUrl":"https://doi.org/10.1016/bs.aambs.2019.10.001","url":null,"abstract":"<p>Microalgae have been used commercially since the 1950s and 1960s, particularly in the Far East for human health foods and in the United States for wastewater treatment. Initial attempts to produce bulk chemicals such as biofuels from microalgae were not successful, despite commercially favorable conditions during the 1970s oil crisis. However, research initiatives at this time, many using extremophilic microalgae and cyanobacteria (e.g., <em>Dunaliella</em> and <em>Spirulina</em>), did solve many problems and clearly identified biomass productivity and harvesting as the two main constraints stopping microalgae producing bulk chemicals, such as biofuels, on a large scale. In response to the growing unease around global warming, induced by anthropogenic CO<sub>2</sub> emissions, microalgae were again suggested as a carbon neutral process to produce biofuels. This recent phase of microalgae biofuels research can be thought to have started around 2007, when a very highly cited review by Chisti was published. Since 2007, a large body of scientific publications have appeared on all aspects of microalgae biotechnology, but with a clear emphasis on neutral lipid (triacylglycerol) synthesis and the use of neutral lipids as precursors for biodiesel production. In this review, the key research on microalgal biotechnology that took place prior to 2007 will be summarized and then the research trends post 2007 will be examined emphasizing the research into producing biodiesel from microalgae.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Advances in yeast alcoholic fermentations for the production of bioethanol, beer and wine. 酵母酒精发酵生产生物乙醇、啤酒和葡萄酒的研究进展。
2区 生物学
Advances in applied microbiology Pub Date : 2019-10-25 DOI: 10.1016/bs.aambs.2019.10.002
Kevy Pontes Eliodório,Gabriel Caetano de Gois E Cunha,Caroline Müller,Ana Carolina Lucaroni,Reinaldo Giudici,Graeme Maxwell Walker,Sérgio Luiz Alves,Thiago Olitta Basso
{"title":"Advances in yeast alcoholic fermentations for the production of bioethanol, beer and wine.","authors":"Kevy Pontes Eliodório,Gabriel Caetano de Gois E Cunha,Caroline Müller,Ana Carolina Lucaroni,Reinaldo Giudici,Graeme Maxwell Walker,Sérgio Luiz Alves,Thiago Olitta Basso","doi":"10.1016/bs.aambs.2019.10.002","DOIUrl":"https://doi.org/10.1016/bs.aambs.2019.10.002","url":null,"abstract":"<p>Yeasts have a long-standing relationship with humankind that has widened in recent years to encompass production of diverse foods, beverages, fuels and medicines. Here, key advances in the field of yeast fermentation applied to alcohol production, which represents the predominant product of industrial biotechnology, will be presented. More specifically, we have selected industries focused in producing bioethanol, beer and wine. In these bioprocesses, yeasts from the genus <em>Saccharomyces</em> are still the main players, with <em>Saccharomyces cerevisiae</em> recognized as the preeminent industrial ethanologen. However, the growing demand for new products has opened the door to diverse yeasts, including non-<em>Saccharomyces</em> strains. Furthermore, the development of synthetic media that successfully simulate industrial fermentation medium will be discussed along with a general overview of yeast fermentation modeling.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 31
Research progress on the basic helix-loop-helix transcription factors of Aspergillus species. 曲霉属基本螺旋-环-螺旋转录因子的研究进展。
2区 生物学
Advances in applied microbiology Pub Date : 2019-10-22 DOI: 10.1016/bs.aambs.2019.09.001
Bao-Teng Wang,Xing-Ye Yu,Yun-Jia Zhu,Miao Zhuang,Zhi-Min Zhang,Long Jin,Feng-Jie Jin
{"title":"Research progress on the basic helix-loop-helix transcription factors of Aspergillus species.","authors":"Bao-Teng Wang,Xing-Ye Yu,Yun-Jia Zhu,Miao Zhuang,Zhi-Min Zhang,Long Jin,Feng-Jie Jin","doi":"10.1016/bs.aambs.2019.09.001","DOIUrl":"https://doi.org/10.1016/bs.aambs.2019.09.001","url":null,"abstract":"<p>Basic helix-loop-helix (bHLH) proteins belong to a superfamily of transcription factors, and they are widely distributed in eukaryotic organisms. Members of the bHLH protein family can form homodimers or heterodimers with themselves or other family members, and they often play bifunctional roles as activators and repressors to uniquely regulate the transcription of downstream target genes. The bHLH transcription factors are usually involved in developmental processes, including cellular proliferation and differentiation. Therefore, these transcription factors often play crucial roles in regulating growth, development, and differentiation in eukaryotes. <em>Aspergillus</em> species fungi are widely distributed in the environment, and they play important roles not only in the decomposition of organic matter as an important environmental microorganism but also in the fermentation and the food processing industry. Furthermore, some pathogenic fungi, such as <em>Aspergillus flavus</em> and <em>Aspergillus fumigatus</em>, affect the environment and human health in important ways. Recent research has shown that some <em>Aspergillus</em> bHLH proteins are significantly involved in the regulation of asexual and sexual reproduction, secondary metabolite production, carbohydrate metabolism, conidial and sclerotial production, among other processes. Here, we review the regulatory mechanisms and biological functions of the bHLH transcription factors of the <em>Aspergillus</em> genus to provide a theoretical reference for further study on the growth and development of <em>Aspergillus</em> and the functions of bHLHs.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Azotobacters as biofertilizer. 作为生物肥料的固氮细菌。
2区 生物学
Advances in applied microbiology Pub Date : 2019-08-28 DOI: 10.1016/bs.aambs.2019.07.001
Hirendra Kumar Das
{"title":"Azotobacters as biofertilizer.","authors":"Hirendra Kumar Das","doi":"10.1016/bs.aambs.2019.07.001","DOIUrl":"https://doi.org/10.1016/bs.aambs.2019.07.001","url":null,"abstract":"<p><em>Azotobacters</em> have been used as biofertilizer since more than a century. <em>Azotobacters</em> fix nitrogen aerobically, elaborate plant hormones, solubilize phosphates and also suppress phytopathogens or reduce their deleterious effect. Application of wild type <em>Azotobacters</em> results in better yield of cereals like corn, wheat, oat, barley, rice, pearl millet and sorghum, of oil seeds like mustard and sunflower, of vegetable crops like tomato, eggplant, carrot, chillies, onion, potato, beans and sugar beet, of fruits like mango and sugar cane, of fiber crops like jute and cotton and of tree like oak. In addition to the structural genes of the enzyme nitrogenase and of other accessory proteins, <em>A. vinelandii</em> chromosomes contain the regulatory genes <em>nifL</em> and <em>nifA</em>. NifA must bind upstream of the promoters of all <em>nif</em> operons for enabling their expression. NifL on activation by oxygen or ammonium, interacts with NifA and neutralizes it. Nitrogen fixation has been enhanced by deletion of <em>nifL</em> and by bringing <em>nifA</em> under the control of a constitutive promoter, resulting in a strain that continues to fix nitrogen in presence of urea fertilizer. Additional copies of <em>nifH</em> (the gene for the Fe-protein of nitrogenase) have been introduced into <em>A. vinelandii</em>, thereby augmenting nitrogen fixation. The urease gene complex <em>ureABC</em> has been deleted, the ammonia transport gene <em>amtB</em> has been disrupted and the expression of the glutamine synthase gene has been regulated to enhance urea and ammonia excretion. Gluconic acid has been produced by introducing the glucose dehydrogenase gene, resulting in enhanced solubilization of phosphate.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508746","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
The role of microorganisms in soy sauce production. 微生物在酱油生产中的作用。
2区 生物学
Advances in applied microbiology Pub Date : 2019-08-27 DOI: 10.1016/bs.aambs.2019.07.002
Desmond K O'toole
{"title":"The role of microorganisms in soy sauce production.","authors":"Desmond K O'toole","doi":"10.1016/bs.aambs.2019.07.002","DOIUrl":"https://doi.org/10.1016/bs.aambs.2019.07.002","url":null,"abstract":"<p>Soy sauce is a salty condiment commonly used in Eastern Asia that is made from soy beans with varying amounts of wheat or no wheat at all. It is known as <em>shoyu</em> in Japan, <em>chiang-yu</em> (or -yi) in China, <em>kecup</em> in Indonesia, <em>kunjang</em> in Korea, <em>toyo</em> in The Philippines, and <em>see-ieu</em> in Thailand (Beuchat, 1985; Djien, 1982; Fukushima, 1989). It provides flavor in an otherwise bland diet, and nutritionally it provides salt (NaCl) and predigested proteins in a diet that is traditionally protein poor. It has been made for centuries on a small scale in many towns and villages in Asia, but since 1950, particularly in Japan, the manufacturing process has been studied and modernized so that its manufacture is now concentrated in large factories using modern, controlled methods of production (Sasaki &amp; Nunomura, 1993). In Japan, soy sauce fermentation is a major food manufacturing activity. More than 1.1 million kiloliters of soy sauce was produced in 1986 by 3000 producers, and the Kikkoman Company supplied 30% of the market (Fukushima, 1989). By 1990 there were 2871 manufacturers, 5 of which produced about 50% of the total production (Sasaki &amp; Nunomura, 1993). While modern methods are used for most of the soy sauce produced in Japan, and factory production in other Asian countries is growing, soy sauce is still produced by methods involving no modern technological inputs (Röling, Prasetyo, Timotius, Stouthamer, &amp; van Verseveld, 1994).</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 23
Application of model systems to study adaptive responses of Mycobacterium tuberculosis during infection and disease. 应用模型系统研究结核分枝杆菌在感染和发病期间的适应性反应。
2区 生物学
Advances in applied microbiology Pub Date : 2019-08-26 DOI: 10.1016/bs.aambs.2019.08.001
Bhavna Gowan Gordhan,Julian Peters,Bavesh Davandra Kana
{"title":"Application of model systems to study adaptive responses of Mycobacterium tuberculosis during infection and disease.","authors":"Bhavna Gowan Gordhan,Julian Peters,Bavesh Davandra Kana","doi":"10.1016/bs.aambs.2019.08.001","DOIUrl":"https://doi.org/10.1016/bs.aambs.2019.08.001","url":null,"abstract":"<p>Tuberculosis (TB) claims more human lives than any other infectious organism. The lethal synergy between TB-HIV infection and the rapid emergence of drug resistant strains has created a global public health threat that requires urgent attention. <em>Mycobacterium tuberculosis</em>, the causative agent of TB is an exquisitely well-adapted human pathogen, displaying the ability to promptly remodel metabolism when encountering stressful environments during pathogenesis. A careful study of the mechanisms that enable this adaptation will enhance the understanding of key aspects related to the microbiology of TB disease. However, these efforts require microbiological model systems that mimic host conditions in the laboratory. Herein, we describe several in vitro model systems that generate non-replicating and differentially culturable mycobacteria. The changes that occur in the metabolism of <em>M. tuberculosis</em> in some of these models and how these relate to those reported for human TB disease are discussed. We describe mechanisms that tubercle bacteria use to resuscitate from these non-replicating conditions, together with phenotypic heterogeneity in terms of culturabiliy of <em>M. tuberculosis</em> in sputum. Transcriptional changes in <em>M. tuberculosis</em> that allow for adaptation of the organism to the lung environment are also summarized. Finally, given the emerging importance of the microbiome in various infectious diseases, we provide a description of how the lung and gut microbiome affect susceptibility to TB infection and response to treatment. Consideration of these collective aspects will enhance the understanding of basic metabolism, physiology, drug tolerance and persistence in <em>M. tuberculosis</em> to enable development of new therapeutic interventions.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-08-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138508736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Bacterial spores, from ecology to biotechnology. 细菌孢子,从生态学到生物技术。
2区 生物学
Advances in applied microbiology Pub Date : 2019-01-01 Epub Date: 2018-11-27 DOI: 10.1016/bs.aambs.2018.10.002
Christophe Paul, Sevasti Filippidou, Isha Jamil, Wafa Kooli, Geoffrey L House, Aislinn Estoppey, Mathilda Hayoz, Thomas Junier, Fabio Palmieri, Tina Wunderlin, Anael Lehmann, Saskia Bindschedler, Torsten Vennemann, Patrick S G Chain, Pilar Junier
{"title":"Bacterial spores, from ecology to biotechnology.","authors":"Christophe Paul,&nbsp;Sevasti Filippidou,&nbsp;Isha Jamil,&nbsp;Wafa Kooli,&nbsp;Geoffrey L House,&nbsp;Aislinn Estoppey,&nbsp;Mathilda Hayoz,&nbsp;Thomas Junier,&nbsp;Fabio Palmieri,&nbsp;Tina Wunderlin,&nbsp;Anael Lehmann,&nbsp;Saskia Bindschedler,&nbsp;Torsten Vennemann,&nbsp;Patrick S G Chain,&nbsp;Pilar Junier","doi":"10.1016/bs.aambs.2018.10.002","DOIUrl":"https://doi.org/10.1016/bs.aambs.2018.10.002","url":null,"abstract":"<p><p>The production of a highly specialized cell structure called a spore is a remarkable example of a survival strategy displayed by bacteria in response to challenging environmental conditions. The detailed analysis and description of the process of sporulation in selected model organisms have generated a solid background to understand the cellular processes leading to the formation of this specialized cell. However, much less is known regarding the ecology of spore-formers. This research gap needs to be filled as the feature of resistance has important implications not only on the survival of spore-formers and their ecology, but also on the use of spores for environmental prospection and biotechnological applications.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aambs.2018.10.002","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36994088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 28
Oxalic acid, a molecule at the crossroads of bacterial-fungal interactions. 草酸,一种处于细菌-真菌相互作用十字路口的分子。
2区 生物学
Advances in applied microbiology Pub Date : 2019-01-01 Epub Date: 2018-11-27 DOI: 10.1016/bs.aambs.2018.10.001
Fabio Palmieri, Aislinn Estoppey, Geoffrey L House, Andrea Lohberger, Saskia Bindschedler, Patrick S G Chain, Pilar Junier
{"title":"Oxalic acid, a molecule at the crossroads of bacterial-fungal interactions.","authors":"Fabio Palmieri,&nbsp;Aislinn Estoppey,&nbsp;Geoffrey L House,&nbsp;Andrea Lohberger,&nbsp;Saskia Bindschedler,&nbsp;Patrick S G Chain,&nbsp;Pilar Junier","doi":"10.1016/bs.aambs.2018.10.001","DOIUrl":"https://doi.org/10.1016/bs.aambs.2018.10.001","url":null,"abstract":"<p><p>Oxalic acid is the most ubiquitous and common low molecular weight organic acid produced by living organisms. Oxalic acid is produced by fungi, bacteria, plants, and animals. The aim of this review is to give an overview of current knowledge about the microbial cycling of oxalic acid through ecosystems. Here we review the production and degradation of oxalic acid, as well as its implications in the metabolism for fungi, bacteria, plants, and animals. Indeed, fungi are well known producers of oxalic acid, while bacteria are considered oxalic acid consumers. However, this framework may need to be modified, because the ability of fungi to degrade oxalic acid and the ability of bacteria to produce it, have been poorly investigated. Finally, we will highlight the role of fungi and bacteria in oxalic acid cycling in soil, plant and animal ecosystems.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aambs.2018.10.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36994087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 56
Copyright 版权
2区 生物学
Advances in applied microbiology Pub Date : 2019-01-01 DOI: 10.1016/s0065-2164(19)30031-0
{"title":"Copyright","authors":"","doi":"10.1016/s0065-2164(19)30031-0","DOIUrl":"https://doi.org/10.1016/s0065-2164(19)30031-0","url":null,"abstract":"","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/s0065-2164(19)30031-0","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"55849633","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mucoid switch in Burkholderia cepacia complex bacteria: Triggers, molecular mechanisms and implications in pathogenesis. 洋葱伯克霍尔德菌复合菌的粘液开关:触发、分子机制和发病机制。
2区 生物学
Advances in applied microbiology Pub Date : 2019-01-01 Epub Date: 2019-03-27 DOI: 10.1016/bs.aambs.2019.03.001
Mirela R Ferreira, Sara C Gomes, Leonilde M Moreira
{"title":"Mucoid switch in Burkholderia cepacia complex bacteria: Triggers, molecular mechanisms and implications in pathogenesis.","authors":"Mirela R Ferreira,&nbsp;Sara C Gomes,&nbsp;Leonilde M Moreira","doi":"10.1016/bs.aambs.2019.03.001","DOIUrl":"https://doi.org/10.1016/bs.aambs.2019.03.001","url":null,"abstract":"<p><p>Bacteria produce a vast range of exopolysaccharides (EPSs) to thrive in diverse environmental niches and often display a mucoid phenotype in solid media. One such exopolysaccharide, cepacian, is produced by bacteria of the genus Burkholderia and is of interest due to its role in pathogenesis associated with lung infections in cystic fibrosis (CF) patients. Cepacian is a repeat-unit polymer that has been implicated in biofilm formation, immune system evasion, interaction with host cells, resistance against antimicrobials, and virulence. Its biosynthesis proceeds through the Wzy-dependent polymerization and secretion mechanism, which requires a multienzymatic complex. Key aspects of its structure, genetic organization, and the regulatory network involved in mucoid switch and regulation of cepacian biosynthesis at transcriptional and posttranscriptional levels are reviewed. It is also evaluated the importance of cepacian biosynthesis/regulation key players as evolutionary targets of selection and highlighted the complexity of the regulatory network, which allows cells to coordinate the expression of metabolic functions to the ones of the cell wall, in order to be successful in ever changing environments, including in the interaction with host cells.</p>","PeriodicalId":7298,"journal":{"name":"Advances in applied microbiology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/bs.aambs.2019.03.001","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37273343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
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