Electroencephalography and clinical neurophysiology最新文献

{"title":"Multiparameter flow cytometry and ClonoSEQ correlation to evaluate precursor B-lymphoblastic leukemia measurable residual disease.","authors":"Nouran Momen, Joseph Tario, Kai Fu, You-Wen Qian","doi":"10.1007/s12308-023-00544-9","DOIUrl":"10.1007/s12308-023-00544-9","url":null,"abstract":"<p><p>Measurable residual disease (MRD) detection for precursor B-lymphoblastic leukemia (B-ALL) has become the standard of care. However, the testing methodology has not been standardized. We aim to correlate COG multiparameter flow cytometry (MFC) and ClonoSEQ techniques to assess the test characteristics, to study abnormal immunophenotype for B-ALL MRD, and to observe B-ALL clonal evolution and the impact of blinatumomab therapy on MFC testing. MFC and molecular reports were retrieved from electronic medical records and data was reviewed. Included in this study were 74 bone marrow samples collected from 31 B-ALL patients at our institution between January 2021 and March 2022. COG MFC and ClonoSEQ results were concordant in 59/74 samples (80%) with positive concordant results in 12 samples (16%) and negative concordant results in 47 samples (64%). Discordant results were seen in 15/74 samples (20%), with 14 samples (19%) showing ClonoSEQ + /MFC- results and only 1 sample (1%) showing MFC + /ClonoSEQ- result. ClonoSEQ + /MFC- cases had MRD values ranging from 1 to 1400 cells/million nucleated cells with 86% of cases showing MRD values of < 100 cells/million nucleated cells. Newly identified dominant sequences were detected using ClonoSEQ in 2/31 patients (6%) during follow-up. All 14 bone marrow samples from 8 patients, who had gone through blinatumomab immunotherapy, were MRD negative by MFC, but 3 cases were MRD positive by ClonoSEQ. Our results show strong correlation between COG MFC and ClonoSEQ (r = 0.96), and both methods are complementary. Clonal evolution may occur, and blinatumomab immunotherapy may impact MFC B-ALL MRD evaluation.</p>","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"103 1","pages":"85-94"},"PeriodicalIF":0.6,"publicationDate":"2023-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77673985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deterioration from healthy to mild cognitive impairment and Alzheimer's disease mirrored in corresponding loss of centrality in directed brain networks.","authors":"Sinan Zhao, D Rangaprakash, Peipeng Liang, Gopikrishna Deshpande","doi":"10.1186/s40708-019-0101-x","DOIUrl":"10.1186/s40708-019-0101-x","url":null,"abstract":"<p><strong>Objective: </strong>It is important to identify brain-based biomarkers that progressively deteriorate from healthy to mild cognitive impairment (MCI) to Alzheimer's disease (AD). Cortical thickness, amyloid-ß deposition, and graph measures derived from functional connectivity (FC) networks obtained using functional MRI (fMRI) have been previously identified as potential biomarkers. Specifically, in the latter case, betweenness centrality (BC), a nodal graph measure quantifying information flow, is reduced in both AD and MCI. However, all such reports have utilized BC calculated from undirected networks that characterize synchronization rather than information flow, which is better characterized using directed networks.</p><p><strong>Methods: </strong>Therefore, we estimated BC from directed networks using Granger causality (GC) on resting-state fMRI data (N = 132) to compare the following populations (p < 0.05, FDR corrected for multiple comparisons): normal control (NC), early MCI (EMCI), late MCI (LMCI) and AD. We used an additional metric called middleman power (MP), which not only characterizes nodal information flow as in BC, but also measures nodal power critical for information flow in the entire network.</p><p><strong>Results: </strong>MP detected more brain regions than BC that progressively deteriorated from NC to EMCI to LMCI to AD, as well as exhibited significant associations with behavioral measures. Additionally, graph measures obtained from conventional FC networks could not identify a single node, underscoring the relevance of GC.</p><p><strong>Conclusion: </strong>Our findings demonstrate the superiority of MP over BC as well as GC over FC in our case. MP obtained from GC networks could serve as a potential biomarker for progressive deterioration of MCI and AD.</p>","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"20 1","pages":"8"},"PeriodicalIF":0.0,"publicationDate":"2019-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6888786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74599038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The utility of radionucleotide imaging in the surgical management of axial neck pain from cervical facet joint arthropathy.","authors":"Christopher D Witiw, Nataliya Tsapenko, Vincent C Traynelis","doi":"10.3171/2019.8.SPINE19806","DOIUrl":"10.3171/2019.8.SPINE19806","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Axial neck pain is common and often debilitating. Diagnosis of the specific pain source can be a challenge, and this confounds effective treatment. Cervical facet arthropathy is implicated in many of these cases. The diagnosis is readily made on conventional cross-sectional imaging modalities, particularly CT imaging. However, this modality falls short in determining if an osteoarthritic facet joint is truly the source of symptoms. Radionucleotide imaging presents a noninvasive radiological adjunct to conventional cross-sectional imaging in the workup of patients with suspected facetogenic pain. Herein, the authors present the patient-reported outcomes (PROs) following posterior instrumented arthrodesis of the subaxial cervical spine from a consecutive case series of patients with a diagnosis of cervical facet joint arthropathy and a concordant positive radionucleotide tracer uptake.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;The clinical case series of patients treated by the senior author at a single tertiary care institution between September 2014 and April 2018 was reviewed. Patients were selected for inclusion if their primary symptom at presentation was axial neck pain without neurological deficits and if CT imaging revealed facet arthropathy of the cervical spine. These patients underwent radionucleotide imaging in the form of a planar 99mTc methylene diphosphonate (99mTc MDP) bone scintigraphy study. Those with a finding of radionucleotide tracer uptake at a location concordant with the facet arthropathy were selected to undergo posterior cervical instrumented arthrodesis of the affected levels. PROs were recorded at the time of surgical consultation (i.e., after nonoperative treatment) and at 6 weeks, 3 months, 6 months, and 1 year following surgery. These included neck and arm pain, the Neck Disability Index (NDI) and the 12-Item Short Form Health Survey responses.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 11 patients were included in this retrospective case series. The average reported neck pain and NDI scores were high at baseline; 7.6 ± 2.3 and 37.1 ± 13.9 respectively. Twelve months after surgical intervention, a significant decrease in reported neck pain of -4.5 (95% CI -6.9, -2.1; p = 0.015) and a significant decrease in NDI of -20.0 (95% CI -29.4, -10.6; p = 0.014) was observed.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusions: &lt;/strong&gt;This case series represents the largest to date of patients undergoing surgical arthrodesis following a finding of facet arthropathy with a concordant positive radioisotope image study. These observations add support to a growing body of evidence that suggests the utility of radioisotope imaging for identification of a facetogenic pain generator in patients with primary axial neck pain and a finding of cervical facet arthropathy. These preliminary data should serve to promote future prospective, controlled studies on the incorporation of radionucleotide imaging into the workup of patients with suspe","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"10 1","pages":"168-173"},"PeriodicalIF":2.9,"publicationDate":"2019-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74594009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical oncology future plan of the Spanish Society of Medical Oncology: challenges and future needs of the Spanish oncologists.","authors":"F Rivera, R Andres, E Felip, R Garcia-Campelo, P Lianes, A Llombart, J M Piera, J Puente, C A Rodriguez, R Vera, J A Virizuela, M Martin, P Garrido","doi":"10.1007/s12094-016-1595-9","DOIUrl":"10.1007/s12094-016-1595-9","url":null,"abstract":"<p><strong>Purpose: </strong>The SEOM Future Plan is aimed at identifying the main challenges, trends and needs of the medical oncology speciality over the next years, including potential oncologist workforce shortages, and proposing recommendations to overcome them.</p><p><strong>Methods: </strong>The estimations of the required medical oncologists workforce are based on an updated Medical Oncologist Register in Spain, Medical Oncology Departments activity data, dedication times and projected cancer incidence. Challenges, needs and future recommendations were drawn from an opinion survey and an advisory board.</p><p><strong>Results: </strong>A shortage of 211 FTE medical oncologist specialists has been established. To maintain an optimal ratio of 158 new cases/FTE, medical oncology workforce should reach 1881 FTE by 2035.</p><p><strong>Conclusions: </strong>Main recommendations to face the growing demand and complexity of oncology services include a yearly growth of 2.5% of medical oncologist's workforce until 2035, and development and application of more accurate quality indicators for cancer care and health outcomes measure.</p>","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"41 1","pages":"508-518"},"PeriodicalIF":3.4,"publicationDate":"2017-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s12094-016-1595-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74609500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A central role for calcineurin in protein misfolding neurodegenerative diseases.","authors":"Syed Zahid Ali Shah, Tariq Hussain, Deming Zhao, Lifeng Yang","doi":"10.1007/s00018-016-2379-7","DOIUrl":"10.1007/s00018-016-2379-7","url":null,"abstract":"<p><p>Accumulation of misfolded/unfolded aggregated proteins in the brain is a hallmark of many neurodegenerative diseases affecting humans and animals. Dysregulation of calcium (Ca²⁺) and disruption of fast axonal transport (FAT) are early pathological events that lead to loss of synaptic integrity and axonal degeneration in early stages of neurodegenerative diseases. Dysregulated Ca²⁺ in the brain is triggered by accumulation of misfolded/unfolded aggregated proteins in the endoplasmic reticulum (ER), a major Ca²⁺ storing organelle, ultimately leading to neuronal dysfunction and apoptosis. Calcineurin (CaN), a Ca²⁺/calmodulin-dependent serine/threonine phosphatase, has been implicated in T cells activation through the induction of nuclear factor of activated T cells (NFAT). In addition to the involvement of several other signaling cascades, CaN has been shown to play a role in early synaptic dysfunction and neuronal death. Therefore, inhibiting hyperactivated CaN in early stages of disease might be a promising therapeutic strategy for treating patients with protein misfolding diseases. In this review, we briefly summarize the structure of CaN, inhibition mechanisms by which immunosuppressants inhibit CaN, role of CaN in maintaining neuronal and synaptic integrity and homeostasis and the role played by CaN in protein unfolding/misfolding neurodegenerative diseases.</p>","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"49 1","pages":"1061-1074"},"PeriodicalIF":8.0,"publicationDate":"2017-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11107525/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74612907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Journal of Spine Surgery</i> (<i>JSS</i>) is now indexed in PubMed Central.","authors":"","doi":"10.21037/jss.2016.09.10","DOIUrl":"10.21037/jss.2016.09.10","url":null,"abstract":"","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"99 1","pages":"244"},"PeriodicalIF":0.0,"publicationDate":"2016-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5067272/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74504811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Agomelatine Protection in an LPS-Induced Psychosis-Relevant Behavior Model.","authors":"Sema Inanir, Umit Sertan Copoglu, Hanifi Kokacya, Recep Dokuyucu, Oytun Erbas, Ahmet Inanir","doi":"10.12659/msm.895505","DOIUrl":"10.12659/msm.895505","url":null,"abstract":"<p><p>BACKGROUND The aim of this study was to investigate the effect of agomelatine in a psychosis-relevant behavior model. MATERIAL AND METHODS We used 18 adult male Wistar rats in this study. Twelve rats given LPS for endotoxemia were randomly divided into 2 groups (n=6). Group I was treated with 1 mL/kg 0.9% NaCl i.p. and Group II was treated with 40 mg/kg agomelatine. Six normal rats served as the control group and were not given LPS for endotoxemia. Cylindrical steel cages containing vertical and horizontal metal bars with top cover were used. Rats were put in these cages for the purpose of orientation for 10 min. Apomorphine was given to rats removed from cages, and then they were immediately put back in the cages for the purpose of observing stereotyped conduct. Brain HVA levels and plasma TNF-a levels were evaluated in tissue homogenates using ELISA. The proportion of malondialdehyde (MDA) was measured in samples taken from plasma for detection of lipid peroxidation similar to thiobarbituric acid reactive substances. RESULTS LPS induced-plasma TNF-α, brain TNF-α, and plasma MDA levels were significantly lower in the LPS+agomelatine group compared to the LPS+saline group (p<0.05). HVA levels and stereotype scores were significantly lower in the LPS+agomelatine group compared to the LPS+saline group (p <0.001). CONCLUSIONS Agomelatine reduced TNF-α, HVA, MDA levels, and the stereotype score in relevant models of psychosis. Our results suggest that the anti-inflammatory effect of agomelatine involved oxidant cleansing properties and that its effects on the metabolism of dopamine can play an important role in the model of psychosis. </p>","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"95 1","pages":"3834-9"},"PeriodicalIF":0.0,"publicationDate":"2015-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4677693/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74495171","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Human corneal GlcNac 6-O-sulfotransferase and mouse intestinal GlcNac 6-O-sulfotransferase both produce keratan sulfate.","authors":"T O Akama, J Nakayama, K Nishida, N Hiraoka, M Suzuki, J McAuliffe, O Hindsgaul, M Fukuda, M N Fukuda","doi":"10.1074/jbc.M009995200","DOIUrl":"10.1074/jbc.M009995200","url":null,"abstract":"<p><p>Human corneal N-acetylglucosamine 6-O-sulfotransferase (hCGn6ST) has been identified by the positional candidate approach as the gene responsible for macular corneal dystrophy (MCD). Because of its high homology to carbohydrate sulfotransferases and the presence of mutations of this gene in MCD patients who lack sulfated keratan sulfate in the cornea and serum, hCGn6ST protein is thought to be a sulfotransferase that catalyzes sulfation of GlcNAc in keratan sulfate. In this report, we analyzed the enzymatic activity of hCGn6ST by expressing it in cultured cells. A lysate prepared from HeLa cells transfected with an intact form of hCGn6ST cDNA or culture medium from cells transfected with a secreted form of hCGn6ST cDNA showed an activity of transferring sulfate to C-6 of GlcNAc of synthetic oligosaccharide substrates in vitro. When hCGn6ST was expressed together with human keratan sulfate Gal-6-sulfotransferase (hKSG6ST), HeLa cells produced highly sulfated carbohydrate detected by an anti-keratan sulfate antibody 5D4. These results indicate that hCGn6ST transfers sulfate to C-6 of GlcNAc in keratan sulfate. Amino acid substitutions in hCGn6ST identical to changes resulting from missense mutations found in MCD patients abolished enzymatic activity. Moreover, mouse intestinal GlcNAc 6-O-sulfotransferase had the same activity as hCGn6ST. This observation suggests that mouse intestinal GlcNAc 6-O-sulfotransferase is the orthologue of hCGn6ST and functions as a sulfotransferase to produce keratan sulfate in the cornea.</p>","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"13 1","pages":"16271-8"},"PeriodicalIF":0.0,"publicationDate":"2001-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1074/jbc.M009995200","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74594805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reduction of visual P300 during transient global amnesia.","authors":"H. Bokura, S. Yamaguchi, H. Tsuchiya, K. Yamashita, S. Kobayashi","doi":"10.1093/neucas/6.3.215-a","DOIUrl":"https://doi.org/10.1093/neucas/6.3.215-a","url":null,"abstract":"Transient global amnesia (TGA) is a syndrome of selective loss of recent memory without other neurological deficits. Auditory and visual P300s were recorded during and after TGA to investigate the contribution of the short-term memory system to P300 generation. The auditory P300 during TGA was comparable to that recorded 1 week and 9 months after TGA. In contrast to the auditory modality, the visual target P300 was reduced in amplitude during TGA and at 1 week after the attack. The P300 to novel visual stimuli was also reduced during TGA. Both target and novelty visual P300 recovered by 9 months after TGA. The results support the notion that the neuronal networks responsible for P300 generation are modality dependent and that brain structures perfused by the posterior circulation are involved in visual P300 generation.","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"92 5 1","pages":"422-5"},"PeriodicalIF":0.0,"publicationDate":"2000-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"61063726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From the `EEG age' to a rational scale of brain electric maturation","authors":"J. Wackermann ,&nbsp;M. Matoušek","doi":"10.1016/S0013-4694(98)00090-X","DOIUrl":"10.1016/S0013-4694(98)00090-X","url":null,"abstract":"<div><p>The aim of the present study was to propose an improved method of quantitative assessment of EEG age-related changes. 40 EEG recordings of healthy subjects (aged 0.7–78 years) were analysed. Multidimensional scaling of EEG spectral data indicated a presence of an `age factor' related non-linearly to the chronological age. Relative integrals of FFT spectra in 6 frequency bands were utilized as predictors of age or, alternatively, logarithmized age. Three regression models based on EEG spectral indicators were examined. Regression from logarithmic predictors to logarithm of age performed best in terms of linearity and residual errors. As a result, the Brain Electric Maturation Scale was proposed, being defined by the logarithm of ratio of the age predicted from the EEG data and chronological age. The scale could serve as an objective measure of brain maturation in children, or as an age-independent indicator of slow EEG abnormalities.</p></div>","PeriodicalId":72888,"journal":{"name":"Electroencephalography and clinical neurophysiology","volume":"107 6","pages":"Pages 415-421"},"PeriodicalIF":0.0,"publicationDate":"1998-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1016/S0013-4694(98)00090-X","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"20827870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}