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Review—Systematic Review on Electrochemical Biosensing of Breast Cancer miRNAs to Develop Alternative DCIS Diagnostic Tool 综述-乳腺癌症miRNA电化学生物传感开发替代DCIS诊断工具的系统综述
ECS sensors plus Pub Date : 2022-06-03 DOI: 10.1149/2754-2726/ac75c5
S. Sornambikai, H. Amir, G. Bhuvaneshwari, N. Ponpandian, C. Viswanathan
{"title":"Review—Systematic Review on Electrochemical Biosensing of Breast Cancer miRNAs to Develop Alternative DCIS Diagnostic Tool","authors":"S. Sornambikai, H. Amir, G. Bhuvaneshwari, N. Ponpandian, C. Viswanathan","doi":"10.1149/2754-2726/ac75c5","DOIUrl":"https://doi.org/10.1149/2754-2726/ac75c5","url":null,"abstract":"Till date, no systematic review is conducted on electrochemical biosensing of multiplexed breast cancer miRNAs to identify their suitability as an alternative diagnostic tool for ductal carcinoma in situ (DCIS). Original articles published in English from PUBMED, Science Direct, Scopus, MEDLINE, Cochrane Library, National Centre for Biotechnology Information, and Google scholar during Jan 2012–Feb 2022 were searched using set inclusion criteria. The Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) 2020 guidelines was followed to report this review. Methodological quality of the included studies was evaluated using Risk of Bias (ROB) assessment criteria. Out of 1973 screened articles, 17 studies were eligible and included in this review wherein, 1 study (5.88%) involving generic neutravidin modified nanolabel probe using biotintylated molecular beacons immobilized metal nanoparticles prepared using one pot assay to detect miRNAs 21 and 141 had low ROB and 16 studies (94.12%) had medium ROB. Medium ROB of majority of the included studies reveals its limited evidence to conclude its suitability for diagnosing DCIS using miRNAs. High quality studies with inter assays and validation are extensively needed for the development of diagnostic tool for DCIS via miRNAs.","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44476858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Perspective— Powerful Micro/Nano-Scale Heat Engine: Thermoelectric Converter on Chip 展望-强大的微/纳米级热机:芯片上的热电转换器
ECS sensors plus Pub Date : 2022-06-01 DOI: 10.1149/2754-2726/ac7534
Zhenhua Wu, Zhiyu Hu
{"title":"Perspective— Powerful Micro/Nano-Scale Heat Engine: Thermoelectric Converter on Chip","authors":"Zhenhua Wu, Zhiyu Hu","doi":"10.1149/2754-2726/ac7534","DOIUrl":"https://doi.org/10.1149/2754-2726/ac7534","url":null,"abstract":"As heat engines, thermoelectric converters can utilize a large amount of free low-grade thermal energy in the environment to generate electricity cleanly and quietly, contributing to a sustainable low-carbon life. They can also act as refrigerators and sensors based on their special ability to reversibly convert heat to electricity. Attractively, thermoelectric converters fabricated by microelectromechanical system technology exhibit more powerful potential when reaching the micro/nano-scale owing to the characteristics of electrons and phonons transport, with cost-effective mass manufacturing advantages. Thermoelectric converters will play an increasingly important role in extensive fields with a bright future.","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45033181","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Review—Lab-in-a-Mouth and Advanced Point-of-Care Sensing Systems: Detecting Bioinformation from the Oral Cavity and Saliva 口腔实验室和先进的护理点传感系统:从口腔和唾液中检测生物信息
ECS sensors plus Pub Date : 2022-06-01 DOI: 10.1149/2754-2726/ac7533
Chochanon Moonla, Don Hui Lee, Dinesh Rokaya, Natcha Rasitanon, G. Kathayat, Won-Yong Lee, Jayoung Kim, Itthipon Jeerapan
{"title":"Review—Lab-in-a-Mouth and Advanced Point-of-Care Sensing Systems: Detecting Bioinformation from the Oral Cavity and Saliva","authors":"Chochanon Moonla, Don Hui Lee, Dinesh Rokaya, Natcha Rasitanon, G. Kathayat, Won-Yong Lee, Jayoung Kim, Itthipon Jeerapan","doi":"10.1149/2754-2726/ac7533","DOIUrl":"https://doi.org/10.1149/2754-2726/ac7533","url":null,"abstract":"Cavitas sensors and point-of-need sensors capable of providing physical and biochemical information from the oral cavity and saliva have attracted great attention because they offer remarkable advantages for noninvasive sensing systems. Herein, we introduce the basic anatomy and physiology of important body cavities to understand their characteristics as it is a pivotal foundation for the successful development of in-mouth devices. Next, the advanced development in lab-in-a-mouth sensors and point-of-need sensors for analyzing saliva are explained. In addition, we discuss the integrations of artificial intelligence and electronic technologies in smart sensing networks for healthcare systems. This review ends with a discussion of the challenges, future research trends, and opportunities in relevant disciplines. Mouthguard-based sensors and conventional salivary sensing devices will continue to be significant for the progress in the next-generation sensing technologies and smart healthcare systems.","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48710578","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 16
Thermally-Driven Micro-Walled Nano-Composite Microfluidic Platform for Controlled Localized Surface Plasmonic Detection of Bovine Growth Hormones 牛生长激素受控局部表面等离子体检测的热驱动微壁纳米复合微流控平台
ECS sensors plus Pub Date : 2022-05-25 DOI: 10.1149/2754-2726/ac733a
J. Ozhikandathil, S. Badilescu, M. Packirisamy
{"title":"Thermally-Driven Micro-Walled Nano-Composite Microfluidic Platform for Controlled Localized Surface Plasmonic Detection of Bovine Growth Hormones","authors":"J. Ozhikandathil, S. Badilescu, M. Packirisamy","doi":"10.1149/2754-2726/ac733a","DOIUrl":"https://doi.org/10.1149/2754-2726/ac733a","url":null,"abstract":"A novel method of integration of a silver-polydimethylsiloxane (PDMS) nanocomposite in a microfluidic channel for the realization of a lab-on-a-chip is reported in this work. By using a silver nitrate aqueous precursor solution, silver nanostructures are formed on, and under the surface of PDMS, by in situ reduction. The silver aggregates formed by reduction have a wide absorbance plasmon band in the UV–Visible range. Separated silver nano-islands, having narrow absorbance bands are formed by using the post-reduction annealing process. The plasmonic property of the silver nanostructures is used for the detection of bovine growth hormone. Subsequently, the nanocomposite was integrated into a specially fabricated micro-wall in the channel which is the actual sensing area in the microfluidic environment. The experiments confirmed that the nanocomposite can be integrated into the microfluidic device in order to enhance the detection sensitivity.","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43548063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Review—An Overview on Recent Progress in Screen-Printed Electroanalytical (Bio)Sensors 丝网印刷电分析(生物)传感器研究进展综述
ECS sensors plus Pub Date : 2022-05-18 DOI: 10.1149/2754-2726/ac70e2
S. Singh, Joseph Wang, S. Cinti
{"title":"Review—An Overview on Recent Progress in Screen-Printed Electroanalytical (Bio)Sensors","authors":"S. Singh, Joseph Wang, S. Cinti","doi":"10.1149/2754-2726/ac70e2","DOIUrl":"https://doi.org/10.1149/2754-2726/ac70e2","url":null,"abstract":"Portability is one of the essential keys in the development of modern analytical devices. Screen printing technology is an established technology for both chemical and biosensor development. Screen printing technology has been used to generate a variety of electronic sensors that are rapid, cost-effective, on-site, real-time, inexpensive, and practical for use in healthcare, environmental monitoring, industrial monitoring, and agricultural monitoring. This review aims to describe recent research progress related to the development and improvement of screen-printed electrodes (SPEs). We also demonstrate the wide range of applications, also highlighting the market directions and the need for novel devices to be used by non-specialists. Finally, we conclude and provide an overview of the constraints and future opportunities of SPEs in biosensor application.","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46217188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 49
DC Sputtered Ultralow Loading Gold Nanofilm Electrodes for Detection of As (III) in Water 直流溅射超低负载金纳米膜电极检测水中As（III）
ECS sensors plus Pub Date : 2022-05-06 DOI: 10.1149/2754-2726/ac6d67
Tybur Q. Casuse, Angelica D. Benavidez, John B. Plumley, L. Tsui, Abdulmehdi Ali, J. Cerrato, F. Garzon
{"title":"DC Sputtered Ultralow Loading Gold Nanofilm Electrodes for Detection of As (III) in Water","authors":"Tybur Q. Casuse, Angelica D. Benavidez, John B. Plumley, L. Tsui, Abdulmehdi Ali, J. Cerrato, F. Garzon","doi":"10.1149/2754-2726/ac6d67","DOIUrl":"https://doi.org/10.1149/2754-2726/ac6d67","url":null,"abstract":"This study investigates the use of DC sputtering, physical vapor deposition as a facile method for creating ultralow loading, Au/C electrodes for use in the detection of As (III) in water. The sputtered nanofilm electrodes on carbon papers, substantially reduces the amount of Au consumed per electrode, <10 μg cm−2, compared to use of wire, foil, or screen-printed electrodes. Linear stripping voltammetry (LSV) was chosen for analytical simplicity and ease of automation. Electrodes using Au nanoparticles supported on Vulcan XC 72 R carbon were also investigated but were not viable for LSV analysis due to capacitive current charging of the high surface area carbon. The DC sputtered, Au nanofilm electrodes were used to create calibration curves for concentrations of As (III) between 5 and 50 μg l−1 and the standard addition method was used in a surface water sample with 5.5 μg l−1 total As. Peak areas plotted against concentration displayed strong linear correlation with meaningful detection below the USEPA maximum contaminant level (MCL) of 10 μg l−1. To our knowledge, this is the first study which utilizes the facile and mass manufacturable DC sputtering method to produce As (III) sensing electrodes. The results of this study have implications for the development of single use, low-cost nanofilm electrodes for field As (III) electroanalysis.","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45085978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Total Internal Reflection of Two Lasers in a Single Planar Optical Waveguide 单平面光波导中两个激光器的全内反射
ECS sensors plus Pub Date : 2022-04-07 DOI: 10.1149/2754-2726/ac6523
Philip A. Kocheril, Kiersten D. Lenz, H. Mukundan
{"title":"Total Internal Reflection of Two Lasers in a Single Planar Optical Waveguide","authors":"Philip A. Kocheril, Kiersten D. Lenz, H. Mukundan","doi":"10.1149/2754-2726/ac6523","DOIUrl":"https://doi.org/10.1149/2754-2726/ac6523","url":null,"abstract":"Multiplex biomarker quantitation is ideal for tracking the progression of a disease, but sensitive, specific, and quantitative multiplex biosensing remains challenging. We achieved total internal reflection with two lasers in a single planar optical waveguide by coupling 532 nm laser light into the diffraction grating of a waveguide and 635 nm laser light directly into the thin film of the same waveguide. We confirmed that the evanescent fields generated in the waveguide can excite two fluorescent dyes (Alexa Fluor 532 and Alexa Fluor 647) held to the surface of the waveguide through biotin-streptavidin chemistry. This sensing concept holds significant potential as a platform for multiplex biomarker detection.","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42218183","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
ECS Sensors Plus–An Electrochemical Society Journal ECS传感器+——电化学学会杂志
ECS sensors plus Pub Date : 2022-04-05 DOI: 10.1149/2754-2726/ac6431
A. Khosla
{"title":"ECS Sensors Plus–An Electrochemical Society Journal","authors":"A. Khosla","doi":"10.1149/2754-2726/ac6431","DOIUrl":"https://doi.org/10.1149/2754-2726/ac6431","url":null,"abstract":"","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41412123","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Improved Toluene Response of Mixed-Potential Type YSZ-Based Gas Sensors Using CeO2-Added Au Electrodes 使用添加CeO2的Au电极改善混合电位型YSZ基气体传感器的甲苯响应
ECS sensors plus Pub Date : 2022-04-04 DOI: 10.1149/2754-2726/ac63d2
T. Ueda, Nobumitsu Oide, K. Kamada, T. Hyodo, Y. Shimizu
{"title":"Improved Toluene Response of Mixed-Potential Type YSZ-Based Gas Sensors Using CeO2-Added Au Electrodes","authors":"T. Ueda, Nobumitsu Oide, K. Kamada, T. Hyodo, Y. Shimizu","doi":"10.1149/2754-2726/ac63d2","DOIUrl":"https://doi.org/10.1149/2754-2726/ac63d2","url":null,"abstract":"","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48193383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 13
Polypyrrole Based Molecularly Imprinted Polymer Platform for Klebsiella pneumoniae Detection 基于聚吡咯的分子印迹聚合物平台检测肺炎克雷伯菌
ECS sensors plus Pub Date : 2022-03-25 DOI: 10.1149/2754-2726/ac612c
Roshani Sharma, G. Lakshmi, Ajay Kumar, P. Solanki
{"title":"Polypyrrole Based Molecularly Imprinted Polymer Platform for Klebsiella pneumoniae Detection","authors":"Roshani Sharma, G. Lakshmi, Ajay Kumar, P. Solanki","doi":"10.1149/2754-2726/ac612c","DOIUrl":"https://doi.org/10.1149/2754-2726/ac612c","url":null,"abstract":"","PeriodicalId":72870,"journal":{"name":"ECS sensors plus","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47264436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 20
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