Digital medicine最新文献_第7页

Precision medicine: Rare diseases and community genetics 精准医学:罕见病和社区遗传学

Digital medicine Pub Date : 2019-10-01 DOI: 10.4103/digm.digm_29_19

A. Bittles

{"title":"Precision medicine: Rare diseases and community genetics","authors":"A. Bittles","doi":"10.4103/digm.digm_29_19","DOIUrl":"https://doi.org/10.4103/digm.digm_29_19","url":null,"abstract":"Precision medicine is based on the premise that genomic analysis radically changes the nature and scope of therapeutic medicine. While genome sequencing has revolutionized the study of human disease, to date progress in translating genomic knowledge into treatments for inherited disorders has been less apparent. However, increasing attention on the relationship(s) between rare diseases (RDs) and precision medicine should significantly accelerate this process, as evidenced by the increasing numbers of molecular therapies receiving approval from the U.S. Food and Drug Administration. There are an estimated 7000 RDs, a majority of which affect <1/million people; but, collectively, it has been calculated that in high-income countries ≥1/17 persons have a RD. RDs represent both a significant health challenge and a major economic burden for many affected individuals and their families, and although many are life-threatening, they often remain undiagnosed or misdiagnosed. Unfortunately, global progress in resolving these issues has been hindered by basic problems such as differing national and regional definitions, from a RD prevalence of 1 to 5/10,000 affected persons in Europe and Australia to 1/500,000 in China. There also has been failure to recognize that many RDs originated as founder mutations and are community-specific, an especially important consideration in populations where community endogamy is the rule and close-kin marriage is traditional. The near-global transition from a communicable to a predominantly noncommunicable disease profile has, however, served to highlight the importance of genetics in medicine, and resulted in a rapidly growing focus on RDs. Against this background, collaborative international programs to facilitate the prevention and curative treatment of RDs merit urgent adoption and support.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"5 1","pages":"154 - 161"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48504477","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Understanding the design rules for a nonintrusive, textile, heart rate monitoring system 了解非侵入式纺织心率监测系统的设计规则

Digital medicine Pub Date : 2019-10-01 DOI: 10.4103/digm.digm_27_19

Theodore Hughes‐Riley, F. Hill-Casey, Carlos Oliveira, Arash M. Shahidi, W. Hurley, T. Dias

{"title":"Understanding the design rules for a nonintrusive, textile, heart rate monitoring system","authors":"Theodore Hughes‐Riley, F. Hill-Casey, Carlos Oliveira, Arash M. Shahidi, W. Hurley, T. Dias","doi":"10.4103/digm.digm_27_19","DOIUrl":"https://doi.org/10.4103/digm.digm_27_19","url":null,"abstract":"Background and Objectives: Nonintrusive heart rate (HR) monitoring can be a useful tool for health monitoring. By creating capacitively coupled textile electrodes, a comfortable monitoring system can be integrated into seating or bedding that can monitor HR through clothing. This work empirically studied two factors for a system of this type: the electrode size and the material worn by the subject. Materials and Methods: HR measurements were taken using six different sizes of the rectangular textile electrode with four subjects and the signal-to-noise ratio (SNR) of the signals were analyzed. A further set of experiments were conducted with a single subject and a fixed electrode size where different materials were worn. Results: Electrode size was seen to have a statistically insignificant effect on the collected signal quality. The SNR was also largely unaffected by the worn material type. Conclusion: This study provided empirical data relating to two important factors for nonintrusive, textile, and HR monitoring systems. This data will be helpful for designing a seat-based HR monitoring system or to understand the operational limitations of a system of this type.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"5 1","pages":"162 - 169"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41727247","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Hospitals of the future as economic development hubs Guiqian International General Hospital Launch 未来医院作为经济发展的枢纽，贵迁国际综合医院启动

Digital medicine Pub Date : 2019-10-01 DOI: 10.4103/digm.digm_25_19

David Wortley

引用次数: 1

Systematic drug repurposing to enable precision medicine: A case study in breast cancer 系统药物再利用以实现精准医疗：癌症的一个案例研究

Digital medicine Pub Date : 2019-10-01 DOI: 10.4103/digm.digm_28_19

K. Taylor, Sayoni Das, M. Pearson, J. Kozubek, M. Strivens, Steve Gardner

{"title":"Systematic drug repurposing to enable precision medicine: A case study in breast cancer","authors":"K. Taylor, Sayoni Das, M. Pearson, J. Kozubek, M. Strivens, Steve Gardner","doi":"10.4103/digm.digm_28_19","DOIUrl":"https://doi.org/10.4103/digm.digm_28_19","url":null,"abstract":"Background and Objectives: Precision medicine and drug repurposing provide an opportunity to ameliorate the challenges of declining pharmaceutical R&D productivity, rising costs of new drugs, and poor patient response rates to existing medications. Multifactorial “disease signatures” provide unique insights into the architecture of complex disease populations that can be used to better stratify patient groups, aiding the delivery of precision medicine. Methods: Analysis of a complex disease (breast cancer) population was undertaken to identify the combinations of single-nucleotide polymorphisms that are associated with different disease subgroups. Target genes associated with the disease risk of these subgroups were examined, followed by identification and evaluation of existing active chemical leads as drug repurposing candidates. Results: One hundred and seventy-five disease-associated gene targets relevant to different subpopulations of breast cancer patients were identified. Twenty-three of these genes were prioritized as both promising novel drug targets and repurposing candidates. Two targets, P4HA2 and TGM2, have high repurposing potential and a strong mechanistic link to breast cancer. Conclusions: This study showed that detailed analysis of combinatorial genomic (and other) features can be used to accurately stratify patient populations and identify highly plausible drug repurposing candidates systematically across all disease-associated targets.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"5 1","pages":"180 - 186"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49400678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Knowledge, attitude, and willingness to use and pay for smartphone applications for physical activity among pregnant women 孕妇使用智能手机应用进行体育锻炼的知识、态度和意愿

Digital medicine Pub Date : 2019-10-01 DOI: 10.4103/digm.digm_3_20

C. Mbada, Oluwaseun Omole, C. Igwe, David Olakorede, C. Fatoye, O. Akinwande, Comfort Sanuade, A. Odole, F. Fatoye

{"title":"Knowledge, attitude, and willingness to use and pay for smartphone applications for physical activity among pregnant women","authors":"C. Mbada, Oluwaseun Omole, C. Igwe, David Olakorede, C. Fatoye, O. Akinwande, Comfort Sanuade, A. Odole, F. Fatoye","doi":"10.4103/digm.digm_3_20","DOIUrl":"https://doi.org/10.4103/digm.digm_3_20","url":null,"abstract":"Background: A decline in physical activity (PA) during pregnancy, despite its benefits to the mother and fetus, invites concerns for innovative platforms for its implementation. This cross-sectional study assessed knowledge, attitude, and “willingness to use” and “willingness to pay” for smartphone applications (apps) for PA. Materials and Methods: A total of 196 consenting pregnant women participated in this study. Eligible respondents were pregnant women who were 18 years and older, on at least a second antenatal visit and uses a mobile phone. Three purposively selected antenatal care facilities were surveyed. A self-developed questionnaire pilot tested for face and content validity was used as the research tool. Results: The mean age of the respondents was 27.5 ± 3.42 years, and 52% of them were occasionally engaged in PA. The point prevalence for smartphone use for general purpose and the usability rate of smartphone app were 72.4% and 84.2%, respectively. The rates for willingness to use PA apps for pregnancy and willingness to pay for the apps were 64.3% and 63.8%, respectively. There was a significant association between the attitude of respondents toward smartphone apps use for PA and number of parity (χ2 = 7.119; P = 0.028). There was no significant association between knowledge of the use of smartphone apps for PA in pregnancy and each of the educational qualification (χ2 = 13.046; P = 0.523), income (χ2 = 11.086; P = 0.679), age (χ2 = 4.552; P = 0.804), gravidity status (χ2 = 5.302; P = 0.506), and number of parity (χ2 = 1.878; P = 0.758). Conclusion: Nigerian pregnant women have good knowledge, positive attitude, and willingness to use smartphone apps for PA in pregnancy. There was a significant association between the number of parity and each of the attitude and knowledge of the use of smartphone apps for PA.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"5 1","pages":"170 - 179"},"PeriodicalIF":0.0,"publicationDate":"2019-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44374664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Input data for computational models of blood flows 为血流计算模型输入数据

Digital medicine Pub Date : 2019-10-01 DOI: 10.4103/digm.digm_24_19

M. Thiriet

引用次数: 0

Personalized three-dimensional printed models assist presurgical planning and treatment of complex congenital heart disease 个性化的三维打印模型有助于复杂先天性心脏病的术前规划和治疗

Digital medicine Pub Date : 2019-10-01 DOI: 10.4103/digm.digm_23_19

Zhonghua Sun, S. Aldosari

引用次数: 0

Assessment of psychological stress during sleep using digital devices and its clinical relevance to future occupational health practice 使用数字设备评估睡眠期间的心理压力及其与未来职业卫生实践的临床相关性

Digital medicine Pub Date : 2019-07-01 DOI: 10.4103/digm.digm_19_19

W. Stipp

{"title":"Assessment of psychological stress during sleep using digital devices and its clinical relevance to future occupational health practice","authors":"W. Stipp","doi":"10.4103/digm.digm_19_19","DOIUrl":"https://doi.org/10.4103/digm.digm_19_19","url":null,"abstract":"Psychophysiological decompensation as a result of occupational stress leads to impairment of occupational performance. Adequate recovery from psychological stress is necessary to maintain occupational performance. It is possible to measure the psychophysiological status and recovery during sleep with health data streamed from biomedical digital devices. Such data, with reference to heart and sleep parameters, could be processed to reflect health status and whether there is a risk of psychophysiological decompensation. This article describes the interpretation of resting heart rate measures, heart rate variability, and actigraphy measures during regular sleep in relation to psychological stress. Interpretation of the health data should be done by informed health-care professionals in combination with clinical history taking. The article does not cover digital measurements while awake and active. The aim of this review article is to provide an evidence-based rationale to health professionals how to interpret digital health data profiles from biomedical devices in appraising psychological stress and recovery. The objective is to prevent the adverse impact of psychological stress on health. Specific lifestyle measures and therapy to manage psychological stress, such as exercise, diet, and cognitive behavioral therapy for insomnia, are not discussed in this article. Applications are especially relevant in the field of occupational health in preventing occupational burnout, achieving a healthy work–life balance, and sustaining a healthy working life. There are future implications with regard to disease prevention as a large proportion of chronic diseases, for example, hypertension, diabetes depression, and ischemic heart disease, are related to chronic psychological stress. Stress monitoring with biomedical devices should occur over periods of work and nonwork days.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"5 1","pages":"102 - 108"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48902112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Evaluating the accuracy of the VitalWellness device 评估VitalWellness设备的准确性

Digital medicine Pub Date : 2019-07-01 DOI: 10.4103/digm.digm_22_19

Nicole Polanco, Sharon Odametey, Seyyedeh Derakshani, M. Khachaturian, Connor Devoe, K. Jethwani, Sujay S Kakarmath

{"title":"Evaluating the accuracy of the VitalWellness device","authors":"Nicole Polanco, Sharon Odametey, Seyyedeh Derakshani, M. Khachaturian, Connor Devoe, K. Jethwani, Sujay S Kakarmath","doi":"10.4103/digm.digm_22_19","DOIUrl":"https://doi.org/10.4103/digm.digm_22_19","url":null,"abstract":"Background and Objective: Portable and readily accessible wellness devices can aid vital sign measuring for those interested in tracking their health. In this diagnostic accuracy study, we evaluated the performance of the VitalWellness device (VW), a wireless, compact, noninvasive device that measures four vital signs (VS) – blood pressure (BP), heart rate (HR), respiratory rate (RR), and body temperature (BT) – using the index finger and forehead. Methods: Adult volunteers with VS that fell both within and outside of the normal physiological range were enrolled to provide BP, HR, RR, and BT measurements using both the VW and Food and Drug Administration-approved reference devices. A subgroup of participants underwent an additional test to analyze the VW's performance on HR and RR outside of normal physiological ranges. Statistical measurements were plotted on scatter and Bland–Altman plots. Sensitivity analyses to evaluate the VW's performance by gender, skin color, finger size, and auxiliary activities were performed. Results: A total of 263 participants completed the study. On an average, systolic BP measured using the VW was 10 mmHg lower than that of the reference device (correlation coefficient r = 0.7), whereas diastolic BP was 3 mmHg lower (r = 0.6), and RR was 2 bpm lower (r = 0.7). VW HR and BT measurements were, on average, 1 bpm and 0.3°F higher than the corresponding reference measurements (r = 0.9 and r = 0.3), respectively. Conclusion: The VW device is well-suited for home-based, nonmedical monitoring of HR, RR, and BP. Further improvement in measurement accuracy is required to enable applications for medical use.","PeriodicalId":72818,"journal":{"name":"Digital medicine","volume":"46 4","pages":"109 - 118"},"PeriodicalIF":0.0,"publicationDate":"2019-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41290299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cloud computing – Securing patient data 云计算——保护患者数据

Digital medicine Pub Date : 2019-07-01 DOI: 10.4103/digm.digm_20_19

D. Amos

引用次数: 0