Die Ophthalmologie最新文献_第9页

Erratum zu: Bilaterale fibrinöse Iridozyklitis mit ausgeprägter Myopisierung. 勘误：双侧纤维蛋白性虹膜睫状体炎伴明显近视。

Die Ophthalmologie Pub Date : 2025-01-01 DOI: 10.1007/s00347-024-02112-7

Peter Werkl, Gerald Seidel, Christoph Singer, Hrvoje Tomasic, Tobias Peschaut, Astrid Heidinger, Katharina Valentin, Michael Sommer

引用次数: 0

Erratum zu: Retinitis bei Rickettsiose. 勘误：立克次体病中的视网膜炎。

Die Ophthalmologie Pub Date : 2025-01-01 DOI: 10.1007/s00347-024-02099-1

Marvin Lucas Biller, Klemens Paul Kaiser, Johanna Kessel, Julia Koepsell, Silke Besier, Ninel Kenikstul, Julian Bucur, Michael Müller, Thomas Kohnen

引用次数: 0

Retinal OCT biomarkers and their association with cognitive function-clinical and AI approaches. 视网膜 OCT 生物标记及其与认知功能的关联--临床和人工智能方法。

Die Ophthalmologie Pub Date : 2025-01-01 Epub Date: 2024-02-21 DOI: 10.1007/s00347-024-01988-9

Franziska G Rauscher, Rui Bernardes

{"title":"Retinal OCT biomarkers and their association with cognitive function-clinical and AI approaches.","authors":"Franziska G Rauscher, Rui Bernardes","doi":"10.1007/s00347-024-01988-9","DOIUrl":"10.1007/s00347-024-01988-9","url":null,"abstract":"Retinal optical coherence tomography (OCT) biomarkers have the potential to serve as early, noninvasive, and cost-effective markers for identifying individuals at risk for cognitive impairments and neurodegenerative diseases. They may also aid in monitoring disease progression and evaluating the effectiveness of interventions targeting cognitive decline. The association between retinal OCT biomarkers and cognitive performance has been demonstrated in several studies, and their importance in cognitive assessment is increasingly being recognized. Machine learning (ML) is a branch of artificial intelligence (AI) with an exponential number of applications in the medical field, particularly its deep learning (DL) subset, which is widely used for the analysis of medical images. These techniques efficiently deal with novel biomarkers when their outcome for the applications of interest is unclear, e.g., for diagnosis, prognosis prediction, disease staging, or any other relevance to clinical practice. However, using AI-based tools for medical purposes must be approached with caution, despite the many efforts to address the black-box nature of such approaches, especially due to the general underperformance in datasets other than those used for their development. Retinal OCT biomarkers are promising as potential indicators for decline in cognitive function. The underlying mechanisms are currently being explored to gain deeper insights into this relationship linking retinal health and cognitive function. Insights from neurovascular coupling and retinal microvascular changes play an important role. Further research is needed to establish the validity and utility of retinal OCT biomarkers as early indicators of cognitive decline and neurodegenerative diseases in routine clinical practice. Retinal OCT biomarkers could then provide a new avenue for early detection, monitoring and intervention in cognitive impairment with the potential to improve patient care and outcomes.","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"20-28"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139914212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Anterior ischemic optic neuropathy (AION) : S1 guidelines of the German Society of Ophthalmology (DOG) and the German Professional Association of Ophthalmologists (BVA). Version: 30.08.2024]. [前部缺血性视神经病变（AION）：德国眼科学会 (DOG) 和德国眼科医生专业协会 (BVA) 的 S1 指南。版本：30.08.2024]。

Die Ophthalmologie Pub Date : 2025-01-01 Epub Date: 2024-10-24 DOI: 10.1007/s00347-024-02128-z

引用次数: 0

[MiHUBx: a digital progress hub for the use of intersectoral clinical data sets using the example of diabetic macular edema]. [MiHUBx：以糖尿病性黄斑水肿为例，使用跨部门临床数据集的数字进展中心]。

Die Ophthalmologie Pub Date : 2024-12-18 DOI: 10.1007/s00347-024-02146-x

Gabriel Stolze, Vinodh Kakkassery, Danny Kowerko, Martin Bartos, Katja Hoffmann, Martin Sedlmayr, Katrin Engelmann

{"title":"[MiHUBx: a digital progress hub for the use of intersectoral clinical data sets using the example of diabetic macular edema].","authors":"Gabriel Stolze, Vinodh Kakkassery, Danny Kowerko, Martin Bartos, Katja Hoffmann, Martin Sedlmayr, Katrin Engelmann","doi":"10.1007/s00347-024-02146-x","DOIUrl":"https://doi.org/10.1007/s00347-024-02146-x","url":null,"abstract":"Background: Evidence-based treatment recommendations are helpful in the corresponding discipline-specific treatment but can hardly take data from real-world care into account. In order to make better use of this in everyday clinical practice, including with respect to predictive statements about disease development or treatment success, models with data from treatment must be developed in order to use them for the development of assistive artificial intelligence.Goal: The aim of the Use Case 1 of the medical informatics hub in Saxony (MiHUBx) is the development of a model based on treatment and research data for a treatment algorithm supported by biomarkers and also the development of the necessary digital infrastructure.Material and methods: Step by step, the necessary partners in hospitals and practices will be brought together technically or through research questions within Use Case 1 \"Ophthalmology meets Diabetology\", a regional digital progress hub in health, the medical informatics hub in Saxony (MiHUBx ) of the nationwide medical informatics initiative (MII).Results: Based on joint studies with diabetologists, robust serological and imaging biomarkers were selected that provide evidence of the development of diabetic macular edema (DME). In the future, these and other scientifically proven prognostic markers will be incorporated into a treatment algorithm that is supported by artificial intelligence (AI). For this purpose, model procedures are being developed together with medical informatics specialists. At the same time, a data integration center (DIZ) was established.Conclusion: In addition to the structured and technical combination of the previously disseminated and partially heterogeneous treatment data, the Use Case 1 defines the chances and hurdles for using such real-world data to develop artificial intelligence.","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142848483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Bilateral choroidal detachment and hypotension under treatment with checkpoint inhibitors]. [使用检查点抑制剂治疗时出现双侧脉络膜脱离和低血压］

Die Ophthalmologie Pub Date : 2024-12-01 Epub Date: 2024-09-30 DOI: 10.1007/s00347-024-02114-5

Jonathan Meinke, Maike S Adamson, Marlene Saßmannshausen, Thomas Ach, Frank G Holz, Matthias M Mauschitz

引用次数: 0

[Electrophysiology in ophthalmology]. [眼科电生理学]。

Die Ophthalmologie Pub Date : 2024-12-01 Epub Date: 2024-11-15 DOI: 10.1007/s00347-024-02134-1

Laura Kühlewein, Katarina Stingl

引用次数: 0

[The "oncological trace": circulating tumor DNA in uveal melanomas]. [肿瘤踪迹：葡萄膜黑色素瘤中的循环肿瘤 DNA]。

Die Ophthalmologie Pub Date : 2024-12-01 Epub Date: 2024-11-11 DOI: 10.1007/s00347-024-02139-w

C H D Le Guin, N Barwinski, M Zeschnigk, N E Bechrakis

{"title":"[The \"oncological trace\": circulating tumor DNA in uveal melanomas].","authors":"C H D Le Guin, N Barwinski, M Zeschnigk, N E Bechrakis","doi":"10.1007/s00347-024-02139-w","DOIUrl":"10.1007/s00347-024-02139-w","url":null,"abstract":"Background: Cell-free DNA (cfDNA) and the tumor DNA it contains can be detected in various body fluids and can be obtained in a minimally invasive manner using a liquid biopsy. The fragmented cell-free tumor DNA (ctDNA) serves as a marker for the presence of tumor cells in the body and its analysis enables genetic tumor characteristics to be determined. For some nonocular tumors ctDNA is already approved as a predictive or prognostic marker.Methods: This literature review article describes examples of the use of ctDNA as a biomarker in nonocular tumors and the current status of ctDNA analysis in cases of uveal melanomas. For this purpose, a selective literature search was carried out via PubMed.Results: Uveal melanomas are nowadays usually treated by eye-preserving therapy. In these cases, there is usually no tumor tissue available for further diagnostic testing. Alternatively, molecular characteristics of the tumor can be determined by the genetic analysis of ctDNA. In uveal melanomas the presence of ctDNA in the plasma at the time of the primary diagnosis is controversial; however, an increase in the amount of ctDNA, which can be used to investigate diagnostically and prognostically relevant genetic changes, was detected during irradiation therapy of the primary tumor in some patients. In the later course of the disease, the amount of ctDNA in the plasma is a suitable marker for metastatic progression. In some cases, an increase in ctDNA levels could be recognized several months before the clinical detection of metastases.Conclusion: The analysis of cfDNA in patients with a uveal melanoma is a promising and minimally invasive method for obtaining information about the tumor or the course of the disease. It is currently being investigated which patients could benefit from it in the future. Several issues related to standardization and technical validation must be addressed for its routine clinical application.","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"963-968"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Circulating tumor cells in uveal melanoma : "The needle in the haystack"]. [葡萄膜黑色素瘤中的循环肿瘤细胞："大海捞针"]。

Die Ophthalmologie Pub Date : 2024-12-01 Epub Date: 2024-11-23 DOI: 10.1007/s00347-024-02136-z

Salvatore Grisanti, S R Sonntag, S A Tura

{"title":"[Circulating tumor cells in uveal melanoma : \"The needle in the haystack\"].","authors":"Salvatore Grisanti, S R Sonntag, S A Tura","doi":"10.1007/s00347-024-02136-z","DOIUrl":"10.1007/s00347-024-02136-z","url":null,"abstract":"Background: A fundamental prerequisite for the development of clinically manifested metastases in uveal melanoma (UM) is the hematogenous dissemination of melanoma cells, which circulate in the systemic circulation, deposit in organs and can subsequently colonize the organs.Material and methods: This article presents a review of the literature on the detection of circulating tumor cells (CTC) from UM and their relevance for the clinical and pathophysiological aspects of the malignancy.Results: Since the first description of CTC in UM patients 20 years ago, only 20 articles have been published on the detection of intact CTCs in UM. Besides demonstrating the presence of CTCs in the systemic circulation, these articles give insights into the pathophysiology and chronology of CTC dissemination, the diagnostics and risk stratification of UM.Conclusion: The detection of CTC in UM has proved to be beneficial in many ways. The early time of cell dissemination and also the associated factors should lead to a rethinking in the clinical routine in the context of the fatal danger of metastases.","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"954-962"},"PeriodicalIF":0.0,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142696069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

[Pronounced ocular findings due to an unexpected systemic cause]. [由于意外的系统性原因导致的明显眼部症状]。

Die Ophthalmologie Pub Date : 2024-12-01 Epub Date: 2024-10-17 DOI: 10.1007/s00347-024-02124-3

Clemens N Rudolph, Karl T Boden, Peter Szurman, Philip Wakili

引用次数: 0