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[New systemic treatment approaches for conjunctival melanoma]. 结膜黑色素瘤的新系统治疗方法
Die Ophthalmologie Pub Date : 2025-05-01 Epub Date: 2025-03-11 DOI: 10.1007/s00347-025-02207-9
Florian T Steinberg, Michael Simon, Philomena A Wawer-Matos Reimer, Alexander C Rokohl, Ludwig M Heindl
{"title":"[New systemic treatment approaches for conjunctival melanoma].","authors":"Florian T Steinberg, Michael Simon, Philomena A Wawer-Matos Reimer, Alexander C Rokohl, Ludwig M Heindl","doi":"10.1007/s00347-025-02207-9","DOIUrl":"10.1007/s00347-025-02207-9","url":null,"abstract":"<p><p>Conjunctival melanoma is a rare disease that nevertheless has a high tumor-associated mortality rate. A resection in sano with adjuvant local treatment currently represents the therapeutic gold standard and systemic treatment is used for metastasized conjunctival melanoma and/or very advanced nonresectable local findings. New knowledge on molecular changes in conjunctival melanoma shows a clear similarity to those of cutaneous melanoma. Therefore, many findings on new systemic forms of treatment for cutaneous melanoma can be transferred to conjunctival melanoma. In the clinical application BRAF/MEK inhibitors and immune checkpoint inhibitors are already in use and good response rates have been shown in small retrospective studies and case reports. Due to the rarity of conjunctival melanoma, there are no larger prospective studies comparing different systemic therapeutic agents. In a nonrandomized retrospective comparison, a better overall survival was shown for a combination of BRAF/MEK inhibitors (progression-free 1‑year survival probability of 54.7%; overall survival of 29.1 months) compared to a combination of PD1/CTLA4 antibodies (progression-free 1‑year survival probability of 42%; overall survival of 18 months). The current recommendation is to perform genomic profiling for every conjunctival melanoma, particularly to investigate a BRAF mutation. If a BRAF mutation is present, BRAF/MEK inhibitor treatment should preferably be initiated. Treatment with immune checkpoint inhibitors can be used in the case of BRAF-negative mutation status or treatment failure with BRAF/MEK inhibitors. Monotherapy with the CTLA4 antibody ipilimumab is not recommended due to its inferiority to PD1 antibodies. New knowledge in the genomic profiling of conjunctival melanoma could enable further targeted treatment options in the future.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"349-356"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143607330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Cataract in childhood-Part 1 : Diagnostics and preoperative management]. [儿童白内障-第1部分：诊断和术前管理]。
Die Ophthalmologie Pub Date : 2025-05-01 Epub Date: 2025-04-30 DOI: 10.1007/s00347-025-02242-6
Claudia Kuhli-Hattenbach, Yaroslava Wenner, Maria Fronius, Petra Dávidová, Thomas Kohnen
{"title":"[Cataract in childhood-Part 1 : Diagnostics and preoperative management].","authors":"Claudia Kuhli-Hattenbach, Yaroslava Wenner, Maria Fronius, Petra Dávidová, Thomas Kohnen","doi":"10.1007/s00347-025-02242-6","DOIUrl":"https://doi.org/10.1007/s00347-025-02242-6","url":null,"abstract":"<p><p>Cataract in childhood can be associated with a high amblyogenic risk depending on the age at onset, extent of lens opacity and cataract laterality and accompanying ocular diseases. Early diagnosis and initiation of adequate treatment of a cataract in childhood are essential for a favorable long-term development of visual acuity. The decision for or against surgical treatment is essentially dependent on the estimation of the individual amblyogenic risk. This article provides an overview of relevant publications and own research data and therefore the current state of research on the topics etiology, symptoms, amblyogenic risk and diagnostics of pediatric cataract. This article focuses on conspicuous symptoms and the importance and performance of diagnostic methods including the Bruckner test, funduscopy without pupil dilation and adequate visual acuity testing in preverbal children. The assessment of the individual risk of amblyopia and possible long-term functional and morphological results represent the basis for treatment planning of cataract in childhood.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":"122 5","pages":"410-418"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144047517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Pachychoroid as parameter for the course of juvenile placoid chorioretinopathy]. [厚脉络膜作为青少年类placoid脉络膜视网膜病变病程的参数]。
Die Ophthalmologie Pub Date : 2025-05-01 Epub Date: 2025-02-19 DOI: 10.1007/s00347-025-02193-y
V Wittwer, A Scheider
{"title":"[Pachychoroid as parameter for the course of juvenile placoid chorioretinopathy].","authors":"V Wittwer, A Scheider","doi":"10.1007/s00347-025-02193-y","DOIUrl":"10.1007/s00347-025-02193-y","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"393-396"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143460994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Intraocular pressure elevation: pseudoexfoliation, masquerade syndrome or anterior uveitis due to CMV infection]. [眼压升高：巨细胞病毒感染引起的假性脱落、假面综合征或前葡萄膜炎]。
Die Ophthalmologie Pub Date : 2025-05-01 Epub Date: 2025-02-27 DOI: 10.1007/s00347-025-02186-x
Jennifer Prues-Hölscher, Piotr Strzalkowski, Gerd Geerling, Alicja Strzalkowska
{"title":"[Intraocular pressure elevation: pseudoexfoliation, masquerade syndrome or anterior uveitis due to CMV infection].","authors":"Jennifer Prues-Hölscher, Piotr Strzalkowski, Gerd Geerling, Alicja Strzalkowska","doi":"10.1007/s00347-025-02186-x","DOIUrl":"10.1007/s00347-025-02186-x","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"401-406"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143517603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Diagnostic value of in vivo confocal microscopy and optical coherence tomography of the anterior segment of the eye in acanthamoeba keratitis]. [眼前段体内共聚焦显微镜和光学相干断层扫描对棘阿米巴角膜炎的诊断价值]。
Die Ophthalmologie Pub Date : 2025-04-28 DOI: 10.1007/s00347-025-02237-3
Albéric Sneyers, Tim Berger, Berthold Seitz, Elias Flockerzi, Yaser Abu Dail, Fidelis Flockerzi, Loay Daas
{"title":"[Diagnostic value of in vivo confocal microscopy and optical coherence tomography of the anterior segment of the eye in acanthamoeba keratitis].","authors":"Albéric Sneyers, Tim Berger, Berthold Seitz, Elias Flockerzi, Yaser Abu Dail, Fidelis Flockerzi, Loay Daas","doi":"10.1007/s00347-025-02237-3","DOIUrl":"https://doi.org/10.1007/s00347-025-02237-3","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Retinal survival of the outer retinal layers after subthreshold micropulse laser therapy for traumatic macular hole]. [阈下微脉冲激光治疗创伤性黄斑孔后视网膜外层视网膜存活]。
Die Ophthalmologie Pub Date : 2025-04-15 DOI: 10.1007/s00347-025-02227-5
Clara E Englisch, Karl T Boden, Peter Szurman, Clemens N Rudolph, Boris V Stanzel, Philip Wakili
{"title":"[Retinal survival of the outer retinal layers after subthreshold micropulse laser therapy for traumatic macular hole].","authors":"Clara E Englisch, Karl T Boden, Peter Szurman, Clemens N Rudolph, Boris V Stanzel, Philip Wakili","doi":"10.1007/s00347-025-02227-5","DOIUrl":"https://doi.org/10.1007/s00347-025-02227-5","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Reversible nyctalopia following bariatric surgery in a young woman in Germany]. [一名德国年轻女性减肥手术后的可逆性夜盲症]。
Die Ophthalmologie Pub Date : 2025-04-11 DOI: 10.1007/s00347-025-02231-9
Mustafa K Hallak, Hermann Krastel, Mirko Otto, Robert P Finger
{"title":"[Reversible nyctalopia following bariatric surgery in a young woman in Germany].","authors":"Mustafa K Hallak, Hermann Krastel, Mirko Otto, Robert P Finger","doi":"10.1007/s00347-025-02231-9","DOIUrl":"https://doi.org/10.1007/s00347-025-02231-9","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Bilateral papilledema and its differential diagnoses: a case report]. [双侧乳头水肿及其鉴别诊断1例]。
Die Ophthalmologie Pub Date : 2025-04-10 DOI: 10.1007/s00347-025-02230-w
Alena Riesmeier, Ekaterina Sokolenko, Carsten Framme
{"title":"[Bilateral papilledema and its differential diagnoses: a case report].","authors":"Alena Riesmeier, Ekaterina Sokolenko, Carsten Framme","doi":"10.1007/s00347-025-02230-w","DOIUrl":"https://doi.org/10.1007/s00347-025-02230-w","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144061133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Masked threat: primary vitreoretinal lymphoma (PVRL)]. [隐性威胁：原发性玻璃体视网膜淋巴瘤（PVRL）]。
Die Ophthalmologie Pub Date : 2025-04-09 DOI: 10.1007/s00347-025-02228-4
Tim Rüterhenke, Lynn Zur Bonsen, Jana Ihlow, Simon Schallenberg, Bert Müller, Uwe Pleyer
{"title":"[Masked threat: primary vitreoretinal lymphoma (PVRL)].","authors":"Tim Rüterhenke, Lynn Zur Bonsen, Jana Ihlow, Simon Schallenberg, Bert Müller, Uwe Pleyer","doi":"10.1007/s00347-025-02228-4","DOIUrl":"https://doi.org/10.1007/s00347-025-02228-4","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144057523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
[Digitalization and artificial intelligence in ophthalmology-Is the matrix not far off?] 数字化与人工智能在眼科的应用——矩阵不远了吗？］
Die Ophthalmologie Pub Date : 2025-04-01 Epub Date: 2025-04-08 DOI: 10.1007/s00347-025-02226-6
Vinodh Kakkassery, Katrin Engelmann
{"title":"[Digitalization and artificial intelligence in ophthalmology-Is the matrix not far off?]","authors":"Vinodh Kakkassery, Katrin Engelmann","doi":"10.1007/s00347-025-02226-6","DOIUrl":"https://doi.org/10.1007/s00347-025-02226-6","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":"122 4","pages":"260-261"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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