Die Ophthalmologie最新文献

{"title":"[Uveal effusion syndrome due to immune-mediated reaction to pembrolizumab].","authors":"V Schöneberger, J Schätzel, L Kinzel, F Schaub, T A Fuchsluger, C Brockmann","doi":"10.1007/s00347-025-02215-9","DOIUrl":"10.1007/s00347-025-02215-9","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"548-551"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143756289","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Stellate cataract].","authors":"Colya N Englisch, Claus Englisch","doi":"10.1007/s00347-025-02244-4","DOIUrl":"10.1007/s00347-025-02244-4","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"499"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Patient- and donor-dependent factors in descemet membrane endothelial keratoplasty and their impact on visual acuity and quality of life].","authors":"Thomas Hammer, P Wieland, J Horn, A Viestenz, A Viestenz","doi":"10.1007/s00347-025-02238-2","DOIUrl":"10.1007/s00347-025-02238-2","url":null,"abstract":"<p><strong>Background: </strong>Descemet membrane endothelial keratoplasty (DMEK) is the gold standard for the treatment of endothelial corneal decompensation. The rapid postoperative improvement in visual acuity and the lower rejection rate of this minimally invasive procedure compared to penetrating keratoplasty justify the high acceptance of DMEK.</p><p><strong>Objective: </strong>The aim of this study was to analyse the general conditions for an optimal visual outcome after DMEK by recording patient- and graft-dependent factors.</p><p><strong>Study design and methods: </strong>A total of 72 eyes were retrospectively analysed in which Fuchs' endothelial dystrophy was treated by DMEK at the University Eye Hospital in Halle in 2019 and 2020. The data at the following timepoints were collected: preoperative graft examination, examination prior to surgery and one examination within the first 6 months postoperatively and one in the second postoperative year. In particular, the best corrected visual acuity (BCVA) and endothelial cell density were compared. A patient survey was used to evaluate the subjectively perceived success of the therapy. The main focus was on reduction in symptoms and the regained independence and participation in social life.</p><p><strong>Results: </strong>The BCVA increased from 0.37 ± 0.15 (logMAR 0.43 ± 0.82) preoperatively to 0.65 ± 0.18 (logMAR 0.19 ± 0.74) in the second postoperative year. The endothelial cell density of the transplant decreased from 2503 ± 206 cells/mm² preoperatively to 1441 ± 516 cells/mm² in the second postoperative year and thus decreased on average by 42%. The corneal thickness decreased from 599 ± 58 µm preoperatively to 521 ± 48 µm in the second postoperative year and decreased on average by 78 ± 71 µm. More than 70% of the patients surveyed complained of sensitivity to light (n = 66), blurred vision (n = 64) and reduced colour perception (n = 59). 57% (n = 50) reported symptoms of glare. 50% of patients (n = 50) felt that their vision was better at the time of the survey than preoperatively and 40% (n = 40) felt that it was optimal. Of those surveyed 84% (n = 84) described their quality of life postoperatively as better or even optimal.</p><p><strong>Conclusion: </strong>DMEK is an effective and safe procedure. The visual outcome can be influenced by various patient- and graft-dependent factors. Patients who had previously undergone other eye operations or had other eye diseases achieved a lower average postoperative increase in visual acuity. In addition, a correlation between donor gender and the decrease in endothelial cell density can be recognised. The endothelial cell loss in female donors is greater than in male donors.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"524-532"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144035981","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Epidemiology in patient counseling].","authors":"Robert P Finger, Alexander K Schuster, Caroline Brandl","doi":"10.1007/s00347-025-02264-0","DOIUrl":"https://doi.org/10.1007/s00347-025-02264-0","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":"122 7","pages":"501-502"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144546402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Spontaneous visual improvement after DMEK despite transplant dislocation].","authors":"Broder Poschkamp, Andreas Stahl, Marie-Christine Bründer","doi":"10.1007/s00347-025-02214-w","DOIUrl":"10.1007/s00347-025-02214-w","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"552-557"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143702354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Screening recommendations for glaucoma, age-related macular degeneration and diabetic eye diseases].","authors":"Lukas Schloesser, Focke Ziemssen, Alexander K Schuster, Somar Hasan, Robert P Finger","doi":"10.1007/s00347-025-02250-6","DOIUrl":"10.1007/s00347-025-02250-6","url":null,"abstract":"<p><strong>Background: </strong>The main causes of blindness, age-related macular degeneration (AMD), glaucoma and diabetic eye diseases (DED), are becoming increasingly more important in terms of health economics due to the demographic developments.</p><p><strong>Objective: </strong>The current screening recommendations for these diseases and the underlying evidence are presented.</p><p><strong>Material and methods: </strong>A detailed literature search was conducted and the recommendations of the relevant guidelines of the Association of the Scientific Medical Societies in Germany (AWMF) were summarized.</p><p><strong>Results: </strong>There are current screening recommendations for glaucoma and DED but there is still no consensus with respect to AMD. Screening for DED is financed by the statutory health insurance (SHI) and offered as part of routine care. Glaucoma screening is only covered by the SHI if certain risk factors are present and is not yet implemented across the board.</p><p><strong>Conclusion: </strong>There are established screening programs for DED that are financed by the SHI; however, there are AWMF recommendations for glaucoma but no SHI-financed screening programs and there are still no AWMF screening recommendations for AMD. Whether and to what extent screening programs are used by the respective target populations should be further investigated in studies.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"518-523"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144121588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Open-angle glaucoma: Who is affected and what are the risk factors?]","authors":"Anna M Welzel, Somar Hasan, Julia V Stingl, Esther M Hoffmann, Alexander K Schuster","doi":"10.1007/s00347-025-02255-1","DOIUrl":"10.1007/s00347-025-02255-1","url":null,"abstract":"<p><p>Open-angle glaucoma is one of the main causes of visual impairment and blindness worldwide and also in Germany. Because open-angle glaucoma involves the irreversible loss of retinal ganglion cells and their axons, which results in irreversible visual field and visual acuity impairments, early detection of the disease is crucial. This article presents and evaluates the epidemiology and risk factors for open-angle glaucoma.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"503-509"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144227835","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Retreatment after keratorefractive lenticule extraction (KLEx) : Results of various methods and influence of the recommendations of the Committee for Refractive Surgery (KRC) on the incidence of retreatment].","authors":"Anika Förster, Ziad Muqbel, Samer Alkarkoukly, H Burkhard Dick, Suphi Taneri","doi":"10.1007/s00347-025-02239-1","DOIUrl":"10.1007/s00347-025-02239-1","url":null,"abstract":"<p><strong>Background: </strong>Keratorefractive lenticule extraction (KLEx) has been shown to be safe and effective for the correction of myopia and myopic astigmatism. Residual refractive errors reduce the uncorrected postoperative visual acuity leading to patient dissatisfaction and increased retreatment rates.</p><p><strong>Aim of the study: </strong>The aim was to assess the potential influence of the recommendations of the Committee for Refractive Surgery (KRC) on the likelihood of retreatment and to compare the results of various methods for retreatment after KLEx for myopia.</p><p><strong>Methods: </strong>Retrospective study of eyes with myopia and myopic astigmatism in which KLEx (SMILE, Visumax 500, Carl Zeiss Meditec, Jena, Germany) was performed between April 2015 and December 2022.</p><p><strong>Results: </strong>A total of 2462 eyes from 1278 patients were analyzed. Of the eyes 3.05% (n = 75) were retreated within 24 months. Eyes in the recommended treatment range (corrections up to -8.0 dpt in the stronger main section) had a 50% lower risk of retreatment than eyes within the borderline range (corrections between -8.0 dpt and -10.0 dpt in the stronger main section). Retreatment was predominantly performed using the advanced surface ablation (ASA n = 44) or the Circle program (transformation of a SMILE cap into a flap, n = 29). The postoperative results of both methods after 3 months were comparably safe and effective; however, visual recovery was significantly faster with Circle. A second KLEx treatment in two eyes (one patient) resulted in a residual refractive error, which impaired the uncorrected visual acuity even 1.7 years later.</p><p><strong>Conclusion: </strong>There was a significantly lower retreatment rate in the recommended treatment range than in the borderline range according to the KRC recommendations. In addition, the ASA and Circle proved to be equally predictable but with different healing processes. These results can help with the education and selection of patients.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"533-543"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144043998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Risk factors for age-related macular degeneration : Lessons learned from current data].","authors":"Caroline Brandl, Iris M Heid, H Helbig, Frank G Holz, Robert P Finger, Matthias M Mauschitz","doi":"10.1007/s00347-025-02257-z","DOIUrl":"10.1007/s00347-025-02257-z","url":null,"abstract":"<p><strong>Background: </strong>Identifying risk factors for age-related macular degeneration (AMD) is crucial for patient counseling and the development of potential prevention strategies.</p><p><strong>Objectives: </strong>This study summarizes the current epidemiological evidence on AMD risk factors, analyzes their clinical relevance, and discusses potential preventive measures.</p><p><strong>Materials and methods: </strong>A systematic literature review was conducted to assess demographic, genetic, and modifiable risk factors for AMD, including smoking, diet, and physical activity.</p><p><strong>Results: </strong>Age is the strongest risk factor for early and advanced AMD. Genetic predisposition also plays a critical role, particularly from genetic variants in the complement and lipid metabolism pathways and extracellular matrix. Modifiable factors such as smoking, dietary habits, and physical activity significantly influence the risk of AMD. Recent studies further suggest a potentially beneficial effect of medication intake, such as metformin and statins.</p><p><strong>Conclusion: </strong>Epidemiological data indicate that smoking cessation, adherence to a Mediterranean diet, and regular physical activity are associated with a reduced risk of AMD over time. These factors should be integral to patient counseling. The continued extension of longitudinal study data will be key to refining individual risk profiles and optimizing prevention strategies.</p>","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":"510-517"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144287424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"[Exacerbation of granular corneal dystrophy type 2 after laser in situ keratomileusis (LASIK)].","authors":"Tim Berger, Albéric Sneyers, Stefan Weber, Berthold Seitz","doi":"10.1007/s00347-025-02280-0","DOIUrl":"https://doi.org/10.1007/s00347-025-02280-0","url":null,"abstract":"","PeriodicalId":72808,"journal":{"name":"Die Ophthalmologie","volume":" ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}