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Advances in biochemical psychopharmacology最新文献

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The GABAA-like autoreceptor is a pharmacologically novel GABA receptor. gabaa样自身受体是一种药理学上新颖的GABA受体。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
M C Minchin, C Ennis, N Lattimer, J F White, A C White, G K Lloyd
{"title":"The GABAA-like autoreceptor is a pharmacologically novel GABA receptor.","authors":"M C Minchin, C Ennis, N Lattimer, J F White, A C White, G K Lloyd","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499004","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Studies on the expression of GABAA receptor alpha subunit mRNAs. GABAA受体α亚基mrna表达的研究。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
P Montpied, S M Paul
{"title":"Studies on the expression of GABAA receptor alpha subunit mRNAs.","authors":"P Montpied, S M Paul","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499011","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The pharmacology of cyclopyrrolone derivatives acting at the GABAA/benzodiazepine receptor. 环吡咯酮衍生物作用于GABAA/苯二氮卓类受体的药理学研究。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
A Doble, T Canton, O Piot, J L Zundel, J M Stutzmann, C Cotrel, J C Blanchard
{"title":"The pharmacology of cyclopyrrolone derivatives acting at the GABAA/benzodiazepine receptor.","authors":"A Doble, T Canton, O Piot, J L Zundel, J M Stutzmann, C Cotrel, J C Blanchard","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The actions of endogenous and synthetic pregnane steroids on GABAA receptors. 内源性和合成孕激素对GABAA受体的作用。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
C Hill-Venning, J J Lambert, J A Peters, T G Hales, C Gill, H Callachan, N C Sturgess
{"title":"The actions of endogenous and synthetic pregnane steroids on GABAA receptors.","authors":"C Hill-Venning, J J Lambert, J A Peters, T G Hales, C Gill, H Callachan, N C Sturgess","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499022","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
"Peripheral" benzodiazepine recognition sites may be involved in the rapid tolerance to the sedative effects of benzodiazepines in rats. “外周”苯二氮卓类药物识别位点可能参与了大鼠对苯二氮卓类药物镇静作用的快速耐受。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
C Ambrosio, C De Luca, M Massotti
{"title":"\"Peripheral\" benzodiazepine recognition sites may be involved in the rapid tolerance to the sedative effects of benzodiazepines in rats.","authors":"C Ambrosio, C De Luca, M Massotti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12527615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GABAA and NMDA receptor function during chronic administration of ethanol. 慢性给药乙醇对GABAA和NMDA受体的影响。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
E Sanna, M Serra, A Cossu, G Colombo, P Follesa, G Biggio
{"title":"GABAA and NMDA receptor function during chronic administration of ethanol.","authors":"E Sanna, M Serra, A Cossu, G Colombo, P Follesa, G Biggio","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12553093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Structural variety of GABAA receptors and specificity of benzodiazepines pharmacological profiles. GABAA受体的结构变化及苯二氮卓类药物的特异性。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
P Giusti, E Romeo, J Auta, A Guidotti
{"title":"Structural variety of GABAA receptors and specificity of benzodiazepines pharmacological profiles.","authors":"P Giusti, E Romeo, J Auta, A Guidotti","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
GABAA-receptor subtypes differing in alpha-subunit composition display unique pharmacological properties. 不同α亚基组成的gabaa受体亚型表现出独特的药理学特性。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
H Mohler, D Benke, S Mertens, J M Fritschy
{"title":"GABAA-receptor subtypes differing in alpha-subunit composition display unique pharmacological properties.","authors":"H Mohler,&nbsp;D Benke,&nbsp;S Mertens,&nbsp;J M Fritschy","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>GABAA-receptor subtypes in rat brain were characterized using anti-peptide antisera specific for the alpha 1-, alpha 3- and alpha 5-subunits. While a high abundance of alpha 1-containing receptors was demonstrated by immunoprecipitation (80-90% of receptors), the receptors precipitated with the alpha 3- and the alpha 5-antiserum were less frequent (18-25% and 10-23%, respectively). The three receptor populations displayed unique pharmacological properties as shown by radioligand binding. Diazepam, flumazenil and flunitrazepam displayed similar displacing potencies in [3H]-flumazenil binding. However, the affinities of CL 218872, beta CCM and zolpidem were up to 10-fold lower in the alpha 3- than the alpha 1-receptor population while intermediate values were found for the alpha 5-receptor population. In many brain areas, a neuron-specific expression of receptors containing either alpha 1- or alpha 3-subunits could be visualized immunohistochemically. It will be of major interest to determine, whether ligands with differential affinities for receptor subtypes in situ will provide novel therapeutic profiles.</p>","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biochemical, immunological, and pharmacological characterization of GABAA-benzodiazepine receptor subtypes. gabaa -苯二氮卓受体亚型的生化、免疫学和药理学特征。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
W Sieghart, K Fuchs, J Zezula, A Buchstaller, F Zimprich, H Lassmann
{"title":"Biochemical, immunological, and pharmacological characterization of GABAA-benzodiazepine receptor subtypes.","authors":"W Sieghart,&nbsp;K Fuchs,&nbsp;J Zezula,&nbsp;A Buchstaller,&nbsp;F Zimprich,&nbsp;H Lassmann","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular determinants in GABAA/BZ receptor subtypes. GABAA/BZ受体亚型的分子决定因素。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
H A Wieland, H Lüddens, P H Seeburg
{"title":"Molecular determinants in GABAA/BZ receptor subtypes.","authors":"H A Wieland,&nbsp;H Lüddens,&nbsp;P H Seeburg","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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