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Advances in biochemical psychopharmacology最新文献

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Peripheral-type benzodiazepine receptors in blood cells of anxious patients. 焦虑患者外周血中外周型苯二氮卓受体的研究。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
P Rocca, L Ravizza, G Maina, B Bergamasco, P Ferrero
{"title":"Peripheral-type benzodiazepine receptors in blood cells of anxious patients.","authors":"P Rocca, L Ravizza, G Maina, B Bergamasco, P Ferrero","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499006","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The action of the general anesthetic propofol on GABAA receptors. 全麻异丙酚对GABAA受体的作用。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
A Concas, G Santoro, M P Mascia, M Serra, E Sanna, G Biggio
{"title":"The action of the general anesthetic propofol on GABAA receptors.","authors":"A Concas, G Santoro, M P Mascia, M Serra, E Sanna, G Biggio","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of GABAergic transmission by ethanol. 乙醇对gaba能传输的调节。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
M K Ticku, M Mhatre, A K Mehta
{"title":"Modulation of GABAergic transmission by ethanol.","authors":"M K Ticku, M Mhatre, A K Mehta","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12553092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Suppression of voluntary alcohol intake in rats and alcoholics by gamma-hydroxybutyric acid: a non-GABAergic mechanism. -羟基丁酸抑制大鼠和酗酒者的自愿酒精摄入:一种非氨基丁酸能机制。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
G Biggio, M Cibin, M Diana, F Fadda, S D Ferrara, L Gallimberti, G L Gessa, G P Mereu, Z L Rossetti, M Serra
{"title":"Suppression of voluntary alcohol intake in rats and alcoholics by gamma-hydroxybutyric acid: a non-GABAergic mechanism.","authors":"G Biggio, M Cibin, M Diana, F Fadda, S D Ferrara, L Gallimberti, G L Gessa, G P Mereu, Z L Rossetti, M Serra","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12679057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modulation of GABAA-gated C1- currents in nigral neurons in slices. gabaa门控C1-电流在神经元切片中的调制作用。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
G Mereu, E Costa, C T Livsey, S Vicini
{"title":"Modulation of GABAA-gated C1- currents in nigral neurons in slices.","authors":"G Mereu, E Costa, C T Livsey, S Vicini","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12553091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroid therapy in Huntington's disease. 亨廷顿舞蹈病的类固醇治疗。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
U Bonuccelli, A Nuti, C Maremmani, R Ceravolo, A Muratorio
{"title":"Steroid therapy in Huntington's disease.","authors":"U Bonuccelli, A Nuti, C Maremmani, R Ceravolo, A Muratorio","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12559635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Acute effects of ethanol on GABAA receptor function: molecular and physiological determinants. 乙醇对GABAA受体功能的急性影响:分子和生理决定因素。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
N J Leidenheimer, R A Harris
{"title":"Acute effects of ethanol on GABAA receptor function: molecular and physiological determinants.","authors":"N J Leidenheimer, R A Harris","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499008","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Partial agonists of benzodiazepine receptors for the treatment of epilepsy, sleep, and anxiety disorders. 苯二氮卓类受体的部分激动剂用于治疗癫痫、睡眠和焦虑症。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
W Haefely, M Facklam, P Schoch, J R Martin, E P Bonetti, J L Moreau, F Jenck, J G Richards
{"title":"Partial agonists of benzodiazepine receptors for the treatment of epilepsy, sleep, and anxiety disorders.","authors":"W Haefely,&nbsp;M Facklam,&nbsp;P Schoch,&nbsp;J R Martin,&nbsp;E P Bonetti,&nbsp;J L Moreau,&nbsp;F Jenck,&nbsp;J G Richards","doi":"","DOIUrl":"","url":null,"abstract":"<p><p>The classic benzodiazepines produce anxiolytic, anticonvulsant, sedative and myorelaxant effects at overlapping dose ranges. Efforts to reduce the sedative/myorelaxant component of this profile has a long history. Two rational approaches might theoretically lead to the desired drugs. One is based on the combination of partial (low efficacy) agonists of the benzodiazepine receptor with different receptor reserves in neurons subversing various functions. The other approach is based on the existence of GABAA-benzodiazepine receptor polymorphism and assumes that distinct receptor variants may be more prevalent on neurons involved in various CNS functions. Results are presented that were obtained with the partial agonist bretazenil and three other ligands in vitro as well as in vivo. Curves relating fractional receptor occupancy and various effects (potentiation of GABA-induced chloride flux, anticonvulsant, anticonflict and sedative effects) are fully consistent with the view that the particular profile of activity of bretazenil is the result of partial agonism. Comparison of fractional receptor occupancy required for the various effects of both full and partial agonists confirm earlier suggestions that receptor reserves for the individual effects differ with the same order. Clinical aspects of partial benzodiazepine receptor agonists are discussed on the basis of the preliminary information available to date.</p>","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12499015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
What are the differences between abecarnil and conventional benzodiazepine anxiolytics? 阿贝卡尔尼与传统的苯二氮卓类抗焦虑药有什么区别?
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
D N Stephens, L Turski, M Hillman, J D Turner, H H Schneider, M Yamaguchi
{"title":"What are the differences between abecarnil and conventional benzodiazepine anxiolytics?","authors":"D N Stephens,&nbsp;L Turski,&nbsp;M Hillman,&nbsp;J D Turner,&nbsp;H H Schneider,&nbsp;M Yamaguchi","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12527618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Steroid modulation of amino acid neurotransmitter receptors. 氨基酸神经递质受体的类固醇调节。
Advances in biochemical psychopharmacology Pub Date : 1992-01-01
D H Farb, T T Gibbs, F S Wu, M Gyenes, L Friedman, S J Russek
{"title":"Steroid modulation of amino acid neurotransmitter receptors.","authors":"D H Farb,&nbsp;T T Gibbs,&nbsp;F S Wu,&nbsp;M Gyenes,&nbsp;L Friedman,&nbsp;S J Russek","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":7274,"journal":{"name":"Advances in biochemical psychopharmacology","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"1992-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"12498997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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