Current problems in cancer. Case reports最新文献_第3页

Activity of pemetrexed in recurrent, metastatic sacral chordoma: A case report 培美曲塞治疗复发性、转移性骶脊索瘤1例

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-11-22 DOI: 10.1016/j.cpccr.2024.100340

Dominique G. Celestino , Lara E. Davis , Santosh Kesari

{"title":"Activity of pemetrexed in recurrent, metastatic sacral chordoma: A case report","authors":"Dominique G. Celestino , Lara E. Davis , Santosh Kesari","doi":"10.1016/j.cpccr.2024.100340","DOIUrl":"10.1016/j.cpccr.2024.100340","url":null,"abstract":"<div><div>Chordomas are a rare slow growing tumor with a high recurrence rate that originate from residual embryonic notochord cells, primarily affecting the axial skeleton. Currently limited treatment options exist beyond surgery and radiation, and systemic chemotherapy has shown limited efficacy. The majority of chordomas exhibit negative thymidylate synthase (TS) expression, implying a potential responsiveness to the antifolate agent pemetrexed. We present a case report of a 78-year-old patient with recurrent, metastatic sacral chordoma who showed clinical and radiological improvement with pemetrexed treatment. The patient received 12 cycles of pemetrexed which resulted in a decrease in the size of liver and lung lesions. Moreover, the patient experienced resolution of debilitating symptoms, including right leg weakness, and unsteady gait. This case report highlights the use of pemetrexed as a therapeutic option for recurrent and metastatic chordoma. Further research is warranted to explore the optimal use of pemetrexed in chordoma management and identify predictive biomarkers for treatment response.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"17 ","pages":"Article 100340"},"PeriodicalIF":0.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Larotrectinib in NTRK3 fusion–positive metastatic secretory carcinoma of the breast: A case study

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-11-22 DOI: 10.1016/j.cpccr.2024.100334

Martin Dietrich , Michel Velez

引用次数: 0

Administration of trastuzumab deruxtecan in metastatic breast cancer patients with severe hepatic impairment 对肝功能严重受损的转移性乳腺癌患者使用曲妥珠单抗德鲁司坦

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-11-22 DOI: 10.1016/j.cpccr.2024.100337

Laura Sun , Gaybrielle Moore , Annalise Labatut , Jane Meisel , Kevin Kalinsky , Kristina Byers

引用次数: 0

Cytokine release syndrome in non- small cell lung cancer patient receiving immune checkpoint inhibitors: A case report 接受免疫检查点抑制剂的非小细胞肺癌患者的细胞因子释放综合征：1例报告

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-11-22 DOI: 10.1016/j.cpccr.2024.100339

Ana Geltar , Assist Urska Janzic

{"title":"Cytokine release syndrome in non- small cell lung cancer patient receiving immune checkpoint inhibitors: A case report","authors":"Ana Geltar , Assist Urska Janzic","doi":"10.1016/j.cpccr.2024.100339","DOIUrl":"10.1016/j.cpccr.2024.100339","url":null,"abstract":"<div><div>Cytokine release syndrome (CRS) is a well-described immune-related adverse event following chimeric antigen receptor T-cell therapy (CAR-T) but has rarely been reported following therapy with immune checkpoint inhibitors (ICI).</div><div>We present a clinical case of severe CRS after ICI therapy for advanced non-small-cell lung cancer (NSCLC). After the third cycle of ipilimumab and nivolumab the patient presented with fever, hypotension and somnolence, leading to acute respiratory failure, acute kidney and hepatic failure, capillary leak syndrome, requiring ICU (intensive care unit) care. She recovered after receiving tocilizumab and steroid therapy.</div><div>Subsequently, we found 17 clinical cases of advanced NSCLC patients in peer review, experiencing CRS as an adverse event of treatment with ICI. We review those cases in detail and compare the similarities and outcomes.</div><div>Conclusion: CRS is a serious, life-threatening complication that is rare after ICI therapy for solid cancers but becoming increasingly frequent since ICI therapies are broadening indications. When presented with clinical symptoms, considering CRS is crucial, as early recognition is key to timely intervention and favorable outcome for the patient.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"17 ","pages":"Article 100339"},"PeriodicalIF":0.2,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the Whipple procedure in chondrosarcoma metastasis to the pancreas 再次探讨胰腺软骨肉瘤转移的惠普尔手术

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-11-16 DOI: 10.1016/j.cpccr.2024.100333

Joseph S Lim , Daniel Zeter , Paul Murdock , Joseph Saad , Houssam Osman , Joseph Buell , Dhiresh Rohan Jeyarajah

{"title":"Revisiting the Whipple procedure in chondrosarcoma metastasis to the pancreas","authors":"Joseph S Lim , Daniel Zeter , Paul Murdock , Joseph Saad , Houssam Osman , Joseph Buell , Dhiresh Rohan Jeyarajah","doi":"10.1016/j.cpccr.2024.100333","DOIUrl":"10.1016/j.cpccr.2024.100333","url":null,"abstract":"<div><h3>Introduction</h3><div>Chondrosarcoma is the second most common primary bone cancer with the lungs being the primary site of metastasis. Pancreatic metastases can occur, but their rarity makes management challenging.</div></div><div><h3>Presentation of case</h3><div>A 27-year-old female with a past medical history of childhood chondrosarcoma of her left tibia presented with metastatic chondrosarcoma of the pancreas five years later. The patient underwent an upfront Whipple procedure with positive margins. Upon recovery, her oncology team recommended watchful waiting. One year later, she presented to the emergency department with coffee ground emesis and diffuse abdominal pain. A computed tomography scan showed a large recurrent mass at the pancreatic remnant concerning for local recurrence. Upper endoscopy found active bleeding near the gastrojejunostomy anastomosis with no ulcers as well as portal hypertensive gastropathy. After discussing these findings, the patient ultimately declined any further treatment, and she was discharged to hospice.</div></div><div><h3>Discussion</h3><div>This is the second reported case of a Whipple procedure for metastatic chondrosarcoma, and first with positive margins (R1). It appears that chondrosarcoma metastasis to the pancreas requiring Whipple procedure is associated with poor outcomes. This unfortunate result is further compounded by the lack of neoadjuvant or adjuvant chemotherapy or radiation in the setting of R1 resection.</div></div><div><h3>Conclusion</h3><div>Upfront Whipple procedure in metastatic chondrosarcoma at high risk for R1 resection should be considered with neoadjuvant radiation Adjuvant radiation can be considered if there are positive margins.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"17 ","pages":"Article 100333"},"PeriodicalIF":0.2,"publicationDate":"2024-11-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142744469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Atypical presentation of lung adenocarcinoma as cardiac tamponade and venous thromboembolism: A case report

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-11-13 DOI: 10.1016/j.cpccr.2024.100331

Amit Kumar, Sandeep Garg, Praveen Bharti, Manidipa Mondal

引用次数: 0

Acquired lipodystrophy following use of pembrolizumab 使用 Pembrolizumab 后获得性脂肪营养不良

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-10-31 DOI: 10.1016/j.cpccr.2024.100332

Maya Weitzen , Marcus DaSilva Goncalves , Shaheer Khan , Alexander Barbaro , Richard Carvajal , Keyur Thakar

{"title":"Acquired lipodystrophy following use of pembrolizumab","authors":"Maya Weitzen , Marcus DaSilva Goncalves , Shaheer Khan , Alexander Barbaro , Richard Carvajal , Keyur Thakar","doi":"10.1016/j.cpccr.2024.100332","DOIUrl":"10.1016/j.cpccr.2024.100332","url":null,"abstract":"<div><div>This case report details a 65-year-old female with Hashimoto's hypothyroidism and stage III melanoma who developed acquired generalized lipodystrophy (AGL), a rare immune-mediated adverse event, following pembrolizumab treatment. The patient was initially treated with nivolumab but was switched to pembrolizumab after developing optic neuritis. After starting pembrolizumab, the patient experienced significant weight loss and lipoatrophy in the face, thighs, and buttocks, alongside hypertrophy of the fat pads in her axillae, supraclavicular, and suprapubic areas. The patient also exhibited symptoms of marked insulin resistance and hypertriglyceridemia, indicative of AGL. Pembrolizumab treatment was discontinued after the patient developed additional side effects including hepatitis, hypophysitis, and thyroiditis, and the patient was commenced on steroid therapy. The patients insulin resistance and hypertriglyceridemia subsequently improved. Genetic sequencing excluded a genetic cause for her lipodystrophy. This is the fourth case of a patient developing AGL following administration of pembrolizumab, and the third for advanced melanoma. Since pembrolizumab administration for treatment of advanced melanoma is becoming more common, it necessitates clinician awareness to potential, rare complications not commonly defined in initial clinical trials.</div></div>","PeriodicalId":72741,"journal":{"name":"Current problems in cancer. Case reports","volume":"16 ","pages":"Article 100332"},"PeriodicalIF":0.2,"publicationDate":"2024-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142658942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adeno-squamous carcinoma of bartholin gland: Challenges in diagnosis and management of a less known vulvar cancer – A case report 巴氏腺鳞癌：鲜为人知的外阴癌的诊断和治疗难题 - 病例报告

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-10-18 DOI: 10.1016/j.cpccr.2024.100330

Sarita Kumari , Ruchi Rathore , Abhinav Singhal , Haritha Maddirala , Sandeep Mathur , Neerja Bhatla

引用次数: 0

Prolonged survival in postoperative recurrent EGFR-L858R NSCLC: A 24-year case report 延长 EGFR-L858R NSCLC 术后复发患者的生存期：长达 24 年的病例报告

IF 0.2

Current problems in cancer. Case reports Pub Date : 2024-10-18 DOI: 10.1016/j.cpccr.2024.100329

Yoshihiro Go , Chinatsu Yoshizaki , Yuki Yoshida , Shiho Nohmi , Rui Kusakado , Yuichiro Saito , Kensuke Izumizaki , Takafumi Ogawa , Takashi Suzuki , Fumihiro Yamaguchi

引用次数: 0

Refractory chronic lymphocytic leukemia with concomitant extramedullary multiple myeloma with lymph node involvement 难治性慢性淋巴细胞白血病合并淋巴结受累的髓外多发性骨髓瘤

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Current problems in cancer. Case reports Pub Date : 2024-10-18 DOI: 10.1016/j.cpccr.2024.100324

Piotr Jachimowski , Łukasz Ciulkiewicz , Bogna Ziarkiewicz-Wróblewska , Laretta Grabowska-Derlatka , Grzegorz Basak , Mateusz Ziarkiewicz

引用次数: 0