Current pediatrics reports最新文献

Health Benefits of Video Games in Adolescents and Young Adults. 电子游戏对青少年和年轻人的健康益处。

IF 2.8

Current pediatrics reports Pub Date : 2026-01-01 Epub Date: 2026-02-26 DOI: 10.1007/s40124-026-00376-y

Jason M Nagata, Sahana Nayak, William Choi, Char Potes, Alexander Heuer, Zain Memon, Jonanne Talebloo, Elizabeth J Li, Kevin Bao, Christiane K Helmer, Megan A Moreno, Jason M Lavender

{"title":"Health Benefits of Video Games in Adolescents and Young Adults.","authors":"Jason M Nagata, Sahana Nayak, William Choi, Char Potes, Alexander Heuer, Zain Memon, Jonanne Talebloo, Elizabeth J Li, Kevin Bao, Christiane K Helmer, Megan A Moreno, Jason M Lavender","doi":"10.1007/s40124-026-00376-y","DOIUrl":"https://doi.org/10.1007/s40124-026-00376-y","url":null,"abstract":"Purpose of review: Although studies of outcomes associated with video gaming in adolescence and young adulthood largely focus on potential harms, video game use may also promote certain health benefits. This review synthesizes the positive health outcomes associated with video gaming, while providing recommendations to clinicians for considering and evaluating both beneficial and adverse effects.Recent findings: Recent evidence suggests that video gaming may strengthen the development of cognitive and executive functioning in adolescents and young adults. Moreover, video game use may also contribute positively to social connection and personal identity formation.Summary: Clinicians should engage in open, nonjudgmental dialogue with youth to better explore the context and patterns of their video gaming. The American Academy of Pediatrics' 5 Cs framework and Family Media Plan offer evidence-based frameworks that can be referenced to facilitate thoughtful discussions about video game use.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"14 1","pages":"2"},"PeriodicalIF":2.8,"publicationDate":"2026-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12945946/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147328388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pediatric Hypertriglyceridemia: Lipoprotein Metabolism, Etiology, and Management. 儿童高甘油三酯血症：脂蛋白代谢，病因学和管理。

IF 2.8

Current pediatrics reports Pub Date : 2025-12-01 Epub Date: 2025-06-28 DOI: 10.1007/s40124-025-00349-7

Hidenori Moriyama, J Nina Ham

{"title":"Pediatric Hypertriglyceridemia: Lipoprotein Metabolism, Etiology, and Management.","authors":"Hidenori Moriyama, J Nina Ham","doi":"10.1007/s40124-025-00349-7","DOIUrl":"10.1007/s40124-025-00349-7","url":null,"abstract":"Purpose of review: Hypertriglyceridemia increases the risk of both atherosclerotic cardiovascular disease and acute pancreatitis. While management of dyslipidemia has long been a focus in the care of adult patients, relatively recent recommendations for universal pediatric lipid screening have facilitated earlier and more widespread diagnoses of dyslipidemia in youth. This review highlights lipoprotein metabolism, etiologic classifications, and management strategies to guide clinicians in identifying and treating hypertriglyceridemia in children and adolescents.Recent findings: Novel therapies targeting lipoprotein pathways, particularly angiopoietin-like 3 and apolipoprotein C-III inhibitors, show promise in reducing triglyceride levels among patients with inherited or treatment-refractory conditions. These agents build upon established options (fibrates, omega-3 fatty acid preparations, and statins) that have been adapted from adult practice for pediatric use.Summary: A comprehensive approach to pediatric hypertriglyceridemia integrates lifestyle interventions with pharmacotherapy for those whose levels remain elevated. Timely identification of underlying etiologies, such as obesity, medication-induced hypertriglyceridemia, and rare genetic mutations, is vital. Intervention for extremely high triglyceride levels can mitigate acute pancreatitis risk, while even modest reductions may improve long-term cardiovascular outcomes. By combining appropriate screening, prompt evaluation, and individualized therapies, clinicians can reduce both immediate and long-term complications, thereby improving overall cardiometabolic health in children and adolescents.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"13 ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12524095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145310100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Latest Updates in Prevention and Screening of Type 1 Diabetes Mellitus. 预防及筛查1型糖尿病的最新进展。

IF 2.8

Current pediatrics reports Pub Date : 2025-12-01 Epub Date: 2025-07-03 DOI: 10.1007/s40124-025-00351-z

Kate Citron-Zafrin, Rachelle Gandica, Natasha Leibel

{"title":"Latest Updates in Prevention and Screening of Type 1 Diabetes Mellitus.","authors":"Kate Citron-Zafrin, Rachelle Gandica, Natasha Leibel","doi":"10.1007/s40124-025-00351-z","DOIUrl":"10.1007/s40124-025-00351-z","url":null,"abstract":"Purpose of review: We describe the latest guidelines for classification of stages of type 1 diabetes (T1D) and updates regarding screening and prevention of T1D in the pediatric population.Recent findings: Preclinical diabetes is now staged and there are both completed and ongoing trials that have identified therapeutic targets to potentially delay the onset of clinical T1D and the need for insulin therapy. The approval of teplizumab as the first FDA approved pharmacologic agent to delay progression of T1D, makes screening increasingly important.Summary: Type 1 diabetes (T1D) is a chronic disease caused by autoimmune destruction of pancreatic beta cells, resulting in insulin deficiency. Screening for T1D is offered in clinical trials for high-risk individuals, such as family members of those with T1D. Advantages to screening for T1D include prevention of life-threatening diabetic ketoacidosis (DKA) and reduction in the risk of associated morbidity and mortality. T1D is now classified in stages that are defined by the presence of pancreatic autoantibodies and dysglycemia. Teplizumab is a humanized anti-CD3 monoclonal antibody and is the first pharmacologic agent approved by the US Food and Drug Administration (FDA) to delay progression of T1D. Additionally, there have been many trials aimed at identifying additional therapeutic targets to delay onset of clinical T1D and the need for insulin therapy.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"13 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12599897/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145497212","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Body Image, Disordered Eating, and Eating Disorders in Gender Diverse Youth. 性别差异青年的身体意象、饮食失调和饮食失调。

IF 2.8

Current pediatrics reports Pub Date : 2025-12-01 Epub Date: 2025-01-24 DOI: 10.1007/s40124-025-00341-1

Alexandra Allam, Samuel B Seidman, Blair Uniacke

{"title":"Body Image, Disordered Eating, and Eating Disorders in Gender Diverse Youth.","authors":"Alexandra Allam, Samuel B Seidman, Blair Uniacke","doi":"10.1007/s40124-025-00341-1","DOIUrl":"10.1007/s40124-025-00341-1","url":null,"abstract":"Purpose of review: We examine the prevalence of body image disturbance, disordered eating, and eating disorders (EDs) among gender diverse youth, and discuss implications and recommendations for providers encountering these intersecting issues in their practice.Recent findings: Increasing evidence demonstrates that transgender and non-binary youth experience greater rates of body image issues, as well as disordered eating and EDs. Gender dysphoria in combination with these body, shape, weight, and food concerns are associated with elevated rates of other comorbid psychiatric problems, each of which place gender diverse youth at risk for adverse outcomes. Routine assessment of gender dysphoria and EDs is necessary for earlier and therefore more successful interventions. Likewise, targeting symptoms of both gender dysphoria and EDs concurrently is critical for optimal results.Summary: Body dissatisfaction, disordered eating and EDs are often related to and comorbid with gender dysphoria, all of which are prevalent among gender diverse youth. Such symptoms are associated with additional psychiatric issues, including depression, anxiety, and suicidal ideation in this population. For earlier intervention and better outcomes, routine screening in primary care settings is necessary, as are referrals to providers who are equipped to treat both gender- and eating-related problems simultaneously.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"13 1","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12494176/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145234455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Implications of Childhood Cancer. 儿童癌症的代谢影响

IF 2.8

Current pediatrics reports Pub Date : 2025-01-01 Epub Date: 2025-06-26 DOI: 10.1007/s40124-025-00348-8

Jia Tan, Byourak Shabane, Etan Orgel, Steven D Mittelman

{"title":"Metabolic Implications of Childhood Cancer.","authors":"Jia Tan, Byourak Shabane, Etan Orgel, Steven D Mittelman","doi":"10.1007/s40124-025-00348-8","DOIUrl":"10.1007/s40124-025-00348-8","url":null,"abstract":"Purpose of review: Childhood cancer patients and survivors often suffer from obesity and metabolic syndrome. The purpose of this review is to evaluate the available data on how body composition and metabolism are affected by childhood cancer and its treatment.Recent findings: Though severity varies among cancers and treatments, childhood cancer patients often exhibit acute changes in metabolism and body composition during the induction of therapy. Particularly prevalent is a decrease in lean mass accompanied by excess adiposity, often called sarcopenic obesity. These metabolic burdens can last for decades after therapy and contribute to future morbidity and mortality. A few promising studies show that dietary and physical activity interventions may reduce these outcomes.Summary: Body composition and metabolic effects occur during cancer treatment and can increase the risk of chronic disease in survivors. More studies are needed to best plan monitoring and intervention strategies to prevent metabolic syndrome and its sequelae in childhood cancer survivors. the course of the disease.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"13 ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12890196/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146168120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metabolic Implications of PCOS. 多囊卵巢综合征的代谢影响。

IF 2.8

Current pediatrics reports Pub Date : 2025-01-01 Epub Date: 2025-11-19 DOI: 10.1007/s40124-025-00364-8

Amna Naveed, Rachana Shah, Angelina Bernier, Valeriia Muradova, Eray Savgan Gurol, Melanie Cree, Rachel Whooten

引用次数: 0

Supporting Adolescents Bereaved by Sibling Suicide: A Review of Needs, Gaps, and Opportunities. 支持因兄弟姐妹自杀而失去亲人的青少年：需求、差距和机会的回顾。

IF 2.8

Current pediatrics reports Pub Date : 2025-01-01 Epub Date: 2025-09-24 DOI: 10.1007/s40124-025-00363-9

Sarah Danzo, Yomna Anan, Kacie Kidd, Gina Sequeira, Nicole F Kahn

{"title":"Supporting Adolescents Bereaved by Sibling Suicide: A Review of Needs, Gaps, and Opportunities.","authors":"Sarah Danzo, Yomna Anan, Kacie Kidd, Gina Sequeira, Nicole F Kahn","doi":"10.1007/s40124-025-00363-9","DOIUrl":"10.1007/s40124-025-00363-9","url":null,"abstract":"Purpose of review: Suicide is a leading cause of death among adolescents. However, while there is a growing focus on suicide prevention efforts, there has been very little research on how to support young people bereaved by suicide, particularly adolescent siblings. Given the impact of suicide on the entire family, as well as the increased risk of mental health problems and suicidal behaviors during adolescence, we sought to review the current literature through a family systems lens to identify what is known, current gaps, and needs for future work to be able to better support adolescents bereaved by sibling suicide.Recent findings: Overall, very few studies have examined the impact of sibling suicide on adolescents, and even fewer examine interventions for adolescents who have lost a sibling to suicide.Summary: Findings highlight a critical need for more work focused on developing and rigorously evaluating interventions for adolescents bereaved by sibling suicide. Additional program development and research in this area is critical to improve long term outcomes for adolescents and their families, and to ultimately reduce suicide risk among surviving adolescent siblings.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"13 1","pages":"26"},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12460479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145187745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Building Strong Foundations: Bone Health in Pediatric Patients with Diabetes. 建立坚实的基础：儿童糖尿病患者的骨骼健康。

IF 2.8

Current pediatrics reports Pub Date : 2025-01-01 Epub Date: 2025-12-13 DOI: 10.1007/s40124-025-00365-7

Cara V Tillotson, Melissa D Garganta

{"title":"Building Strong Foundations: Bone Health in Pediatric Patients with Diabetes.","authors":"Cara V Tillotson, Melissa D Garganta","doi":"10.1007/s40124-025-00365-7","DOIUrl":"10.1007/s40124-025-00365-7","url":null,"abstract":"Purpose of review: Skeletal development begins in childhood with all bone accrual complete by early adulthood, making bone health an important topic in pediatric medicine. This is especially true for patients with diabetes as these and other chronic conditions are associated with increased lifelong risk of fracture. The purpose of this review is to give a broad overview of bone health in diabetes including etiology, pathogenesis, and current recommendations for management.Recent findings: Studies continue to demonstrate lifelong increased risk of osteoporotic fractures in patients with diabetes. Like all diabetes complications, tight glycemic control, nutrition, and exercise play crucial roles in the prevention of this diabetes complication. Bisphosphonate therapy for osteoporosis in pediatrics is limited to those with a history of fragility fractures.Opinion statement: Pediatricians should promote lifestyle modifications to optimize bone health for all patients with diabetes, including ensuring adequate nutrition (vitamin D and calcium intake), exercise, and glycemic control. Dual-energy x-ray absorptiometry (DXA) scan should be considered for any patient with diabetes and a history of clinically significant fracture (vertebral fracture, low impact long-bone fracture, or multiple fractures). Referral to an endocrinologist with experience in osteoporosis treatment is appropriate for any patient with diabetes and a history of pathologic fracture.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"13 ","pages":""},"PeriodicalIF":2.8,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12904259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146203985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Narrative Synthesis Review of Legislation Banning Gender-Affirming Care. 禁止性别肯定护理立法的叙述综合审查。

IF 2.8

Current pediatrics reports Pub Date : 2024-09-01 Epub Date: 2024-06-27 DOI: 10.1007/s40124-024-00320-y

Jessie Melina Garcia Gutiérrez, Emerson Dusic, Audren J K Bambilla, Arjee Javellana Restar

{"title":"A Narrative Synthesis Review of Legislation Banning Gender-Affirming Care.","authors":"Jessie Melina Garcia Gutiérrez, Emerson Dusic, Audren J K Bambilla, Arjee Javellana Restar","doi":"10.1007/s40124-024-00320-y","DOIUrl":"10.1007/s40124-024-00320-y","url":null,"abstract":"Purpose of review: In recent years, there has been a drastic increase in legislation across US states that aims to ban gender-affirming care (GAC) for transgender and nonbinary (trans) youth. We synthesized the literature on bans on GAC, its impacts on medical and mental health providers, trans communities, particularly trans youth and their caregivers (e.g., parents/families), and provided recommendations for future research and advocacy.Recent findings: We highlight several adverse impacts of legislation banning GAC, including: an increase in professional tensions for medical and mental health providers that work with trans youth and worse mental health outcomes for trans youth and their caregivers due to loss of autonomy in accessing evidence-based GAC.Summary: Bans on GAC undermine evidenced-based practices and are resulting in negative health effects for trans communities and youth. Research evidence highlights the need to examine effects of bans at the intersections of gender identity, socioeconomic status, race, and ethnicity.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"12 3","pages":"44-51"},"PeriodicalIF":2.8,"publicationDate":"2024-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11935454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143722866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Norovirus on Children and Adolescents: Implications for Ongoing Vaccine Development. 诺如病毒对儿童和青少年的影响：对正在进行的疫苗开发的影响。

IF 2.8

Current pediatrics reports Pub Date : 2024-01-01 Epub Date: 2025-08-13 DOI: 10.1007/s40124-025-00355-9

Ming Tan

{"title":"The Impact of Norovirus on Children and Adolescents: Implications for Ongoing Vaccine Development.","authors":"Ming Tan","doi":"10.1007/s40124-025-00355-9","DOIUrl":"10.1007/s40124-025-00355-9","url":null,"abstract":"Purpose of review: This article highlights the heightened vulnerability of children and adolescents to norovirus infection and discusses the implications for ongoing vaccine development efforts.Recent findings: Young children remain highly vulnerable to norovirus infections and are at an increased risk of severe disease. However, a recent Phase 2b clinical trial in infants failed to demonstrate meaningful protection or other clinical benefits. Similarly, low protective efficacy was observed in adults in a separate Phase 2b clinical evaluation, raising concerns about the complexity of norovirus vaccine development, particularly for young children.Summary: Norovirus continues to pose a significant global health threat, affecting individuals of all ages and contributing to considerable morbidity, mortality, and socioeconomic burden. Children and adolescents are especially vulnerable, as they often spend time in closed or semi-closed environments such as daycare centers and schools, settings commonly associated with norovirus outbreaks. The lack of an FDA-approved norovirus vaccine underscores the urgent need for effective preventive strategies. Several vaccine candidates, utilizing diverse platforms, have advanced to Phase 2 clinical trials and beyond, targeting various age groups. While some have shown promise in adults, a recent Phase 2b clinical trial of a VLP-based vaccine in infants failed to demonstrate sufficient efficacy, and another Phase 2b study of an adenovirus-vectored vaccine reported low efficacy in adults. These findings suggest that novel approaches and strategies may be required to overcome the current challenges in norovirus vaccine development.","PeriodicalId":72740,"journal":{"name":"Current pediatrics reports","volume":"13 1","pages":"21"},"PeriodicalIF":2.8,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12350415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0