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Role of Sonic Hedgehog Signaling Pathway in Intervertebral Disc Formation and Maintenance. Sonic Hedgehog信号通路在椎间盘形成和维持中的作用。
Current molecular biology reports Pub Date : 2018-12-01 Epub Date: 2018-10-24 DOI: 10.1007/s40610-018-0107-9
Diviya Rajesh, Chitra Lekha Dahia
{"title":"Role of Sonic Hedgehog Signaling Pathway in Intervertebral Disc Formation and Maintenance.","authors":"Diviya Rajesh,&nbsp;Chitra Lekha Dahia","doi":"10.1007/s40610-018-0107-9","DOIUrl":"https://doi.org/10.1007/s40610-018-0107-9","url":null,"abstract":"<p><strong>A purpose of review: </strong>The intervertebral discs (IVD) are an essential component of the spine. Degeneration of the discs, commonly due to age or injury, is a leading cause of chronic lower back pain. Despite its high prevalence, there is no effective treatment for disc disease due to limited understanding of disc at the cellular and molecular level.</p><p><strong>B recent findings: </strong>Recent research has demonstrated the importance of the intracellular developmental pathway sonic hedgehog (Shh) during the formation and postnatal maintenance of the IVD. Recent studies corroborate that the down-regulation of SHH expression is associated with pathological changes in the IVDs and demonstrate the reactivation of the hedgehog pathway as a promising avenue for rescuing health disc structure and function.</p><p><strong>C summary: </strong>Understanding the role of developmental signaling pathways that regulate disc formation and maintenance may help develop strategies to recapitulate the same mechanism for disc treatment and hence improve the quality and longevity of patient lives.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 4","pages":"173-179"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0107-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36901303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
IVD Development: Nucleus pulposus development and sclerotome specification. IVD发育：髓核发育和硬皮刀规格。
Current molecular biology reports Pub Date : 2018-09-01 Epub Date: 2018-07-13 DOI: 10.1007/s40610-018-0100-3
Bashar Alkhatib, Ga I Ban, Sade Williams, Rosa Serra
{"title":"IVD Development: Nucleus pulposus development and sclerotome specification.","authors":"Bashar Alkhatib,&nbsp;Ga I Ban,&nbsp;Sade Williams,&nbsp;Rosa Serra","doi":"10.1007/s40610-018-0100-3","DOIUrl":"10.1007/s40610-018-0100-3","url":null,"abstract":"<p><strong>Purpose of review: </strong>Intervertebral discs (IVD) are derived from embryonic notochord and sclerotome. The nucleus pulposus is derived from notochord while other connective tissues of the spine are derived from sclerotome. This manuscript will review the past 5 years of research into IVD development.</p><p><strong>Recent findings: </strong>Over the past several years, advances in understanding the step-wise process that govern development of the nucleus pulposus and the annulus fibrosus have been made. Generation of tissues from induced or embryonic stem cells into nucleus pulposus and paraxial mesoderm derived tissues has been accomplished <i>in vitro</i> using pathways identified in normal development. A balance between BMP and TGF-β signaling as well as transcription factors including Pax1/Pax9, Mkx and Nkx3.2 appear to be very important for cell fate decisions generating tissues of the IVD.</p><p><strong>Summary: </strong>Understanding how the IVD develops will provide the foundation for future repair, regeneration, and tissue engineering strategies for IVD disease.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 3","pages":"132-141"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0100-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9297692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 17
Bone Marrow “Yellow” and “Red” Adipocytes”: Good or Bad Cells? 骨髓“黄”和“红”脂肪细胞:好细胞还是坏细胞?
Current molecular biology reports Pub Date : 2018-08-09 DOI: 10.1007/s40610-018-0098-6
Domenico Mattiucci, O. Naveiras, A. Poloni
{"title":"Bone Marrow “Yellow” and “Red” Adipocytes”: Good or Bad Cells?","authors":"Domenico Mattiucci, O. Naveiras, A. Poloni","doi":"10.1007/s40610-018-0098-6","DOIUrl":"https://doi.org/10.1007/s40610-018-0098-6","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"46 1","pages":"117 - 122"},"PeriodicalIF":0.0,"publicationDate":"2018-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0098-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52669254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Molecular differences between subtypes of bone marrow adipocytes. 骨髓脂肪细胞亚型之间的分子差异。
Current molecular biology reports Pub Date : 2018-03-01 Epub Date: 2018-02-15
Clarissa S Craft, Ziru Li, Ormond A MacDougald, Erica L Scheller
{"title":"Molecular differences between subtypes of bone marrow adipocytes.","authors":"Clarissa S Craft, Ziru Li, Ormond A MacDougald, Erica L Scheller","doi":"","DOIUrl":"","url":null,"abstract":"<p><strong>Purpose of review: </strong>Bone marrow adipocytes (BMAs) have distinct molecular properties and physiologic responses depending on their location within the skeleton.</p><p><strong>Recent findings: </strong>This concept was introduced in the 1970s and validated more recently in the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting and caloric restriction.</p><p><strong>Summary: </strong>In this brief review, we discuss the concept of regulated <i>vs</i> constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site-specific molecular features of BMAs, and discuss the translational implications of the dual bone marrow adipose tissue hypothesis.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 1","pages":"16-23"},"PeriodicalIF":0.0,"publicationDate":"2018-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6054309/pdf/nihms943570.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36336717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Molecular Differences Between Subtypes of Bone Marrow Adipocytes 骨髓脂肪细胞亚型的分子差异
Current molecular biology reports Pub Date : 2018-02-15 DOI: 10.1007/s40610-018-0087-9
C. Craft, Ziru Li, O. MacDougald, E. Scheller
{"title":"Molecular Differences Between Subtypes of Bone Marrow Adipocytes","authors":"C. Craft, Ziru Li, O. MacDougald, E. Scheller","doi":"10.1007/s40610-018-0087-9","DOIUrl":"https://doi.org/10.1007/s40610-018-0087-9","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 1","pages":"16 - 23"},"PeriodicalIF":0.0,"publicationDate":"2018-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0087-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52668868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 33
Phenotype of Bone Marrow Adipose Tissue: Specificities of the Anatomical Distribution, Secretory Profile, Lipid Content, and Response to Nutritional Status 骨髓脂肪组织的表型:解剖分布、分泌特征、脂质含量和对营养状况的反应的特异性
Current molecular biology reports Pub Date : 2018-02-03 DOI: 10.1007/s40610-018-0086-x
C. Gillet, J. Rasschaert
{"title":"Phenotype of Bone Marrow Adipose Tissue: Specificities of the Anatomical Distribution, Secretory Profile, Lipid Content, and Response to Nutritional Status","authors":"C. Gillet, J. Rasschaert","doi":"10.1007/s40610-018-0086-x","DOIUrl":"https://doi.org/10.1007/s40610-018-0086-x","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 1","pages":"8 - 15"},"PeriodicalIF":0.0,"publicationDate":"2018-02-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0086-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52668646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
Correction to: Male Obesity: Epigenetic Origin and Effects in Sperm and Offspring 更正:男性肥胖:表观遗传起源及其对精子和后代的影响
Current molecular biology reports Pub Date : 2018-01-15 DOI: 10.1007/s40610-017-0084-4
S. Houfflyn, C. Matthys, A. Soubry
{"title":"Correction to: Male Obesity: Epigenetic Origin and Effects in Sperm and Offspring","authors":"S. Houfflyn, C. Matthys, A. Soubry","doi":"10.1007/s40610-017-0084-4","DOIUrl":"https://doi.org/10.1007/s40610-017-0084-4","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 1","pages":"24 - 24"},"PeriodicalIF":0.0,"publicationDate":"2018-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-017-0084-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"47493741","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Correction to: Store-Operated Ca2+ Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives. 更正:存储操作的Ca2+进入作为前列腺癌生物标志物-一个具有视角的谜题。
Current molecular biology reports Pub Date : 2018-01-01 Epub Date: 2018-06-20 DOI: 10.1007/s40610-018-0097-7
Sven Kappel, Ines Joao Marques, Eugenio Zoni, Paulina Stokłosa, Christine Peinelt, Nadia Mercader, Marianna Kruithof-de Julio, Anna Borgström
{"title":"Correction to: Store-Operated Ca<sup>2+</sup> Entry as a Prostate Cancer Biomarker - a Riddle with Perspectives.","authors":"Sven Kappel,&nbsp;Ines Joao Marques,&nbsp;Eugenio Zoni,&nbsp;Paulina Stokłosa,&nbsp;Christine Peinelt,&nbsp;Nadia Mercader,&nbsp;Marianna Kruithof-de Julio,&nbsp;Anna Borgström","doi":"10.1007/s40610-018-0097-7","DOIUrl":"https://doi.org/10.1007/s40610-018-0097-7","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1007/s40610-017-0072-8.].</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 3","pages":"142"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0097-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37318678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Intervertebral Disc Biology: Genetic Basis of Disc Degeneration. 椎间盘生物学：椎间盘退变的遗传基础。
Current molecular biology reports Pub Date : 2018-01-01 Epub Date: 2018-08-03 DOI: 10.1007/s40610-018-0101-2
Sabrina Munir, Marinko Rade, Juhani H Määttä, Maxim B Freidin, Frances M K Williams
{"title":"Intervertebral Disc Biology: Genetic Basis of Disc Degeneration.","authors":"Sabrina Munir,&nbsp;Marinko Rade,&nbsp;Juhani H Määttä,&nbsp;Maxim B Freidin,&nbsp;Frances M K Williams","doi":"10.1007/s40610-018-0101-2","DOIUrl":"10.1007/s40610-018-0101-2","url":null,"abstract":"<p><strong>Purpose of review: </strong>This review aims to highlight recent advances in understanding the genetic basis of intervertebral disc degeneration (IDD).</p><p><strong>Recent findings: </strong>It has been known for some time that IDD is highly heritable. Recent studies, and in particular the availability of agnostic techniques such as genome-wide association studies, have identified new variants in a variety of genes which contribute to the risk of IDD and to back pain.</p><p><strong>Summary: </strong>A variety of genetic variants are involved in IDD. Some are shared with variants predisposing to back pain, but few have been identified reliably in either phenotype. Further research is required to explain fully the high heritability and how the genetic variants influence cell biology to lead to IDD.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 4","pages":"143-150"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0101-2","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36707215","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Epigenetic Regulation in Prostate Cancer Progression. 前列腺癌进展中的表观遗传调控。
Current molecular biology reports Pub Date : 2018-01-01 Epub Date: 2018-04-18 DOI: 10.1007/s40610-018-0095-9
Katia Ruggero, Sonia Farran-Matas, Adrian Martinez-Tebar, Alvaro Aytes
{"title":"Epigenetic Regulation in Prostate Cancer Progression.","authors":"Katia Ruggero,&nbsp;Sonia Farran-Matas,&nbsp;Adrian Martinez-Tebar,&nbsp;Alvaro Aytes","doi":"10.1007/s40610-018-0095-9","DOIUrl":"https://doi.org/10.1007/s40610-018-0095-9","url":null,"abstract":"<p><strong>Purpose of review: </strong>An important number of newly identified molecular alterations in prostate cancer affect gene encoding master regulators of chromatin biology epigenetic regulation. This review will provide an updated view of the key epigenetic mechanisms underlying prostate cancer progression, therapy resistance, and potential actionable mechanisms and biomarkers.</p><p><strong>Recent findings: </strong>Key players in chromatin biology and epigenetic master regulators has been recently described to be crucially altered in metastatic CRPC and tumors that progress to AR independency. As such, epigenetic dysregulation represents a driving mechanism in the reprograming of prostate cancer cells as they lose AR-imposed identity.</p><p><strong>Summary: </strong>Chromatin integrity and accessibility for transcriptional regulation are key features altered in cancer progression, and particularly relevant in nuclear hormone receptor-driven tumors like prostate cancer. Understanding how chromatin remodeling dictates prostate development and how its deregulation contributes to prostate cancer onset and progression may improve risk stratification and treatment selection for prostate cancer patients.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"4 2","pages":"101-115"},"PeriodicalIF":0.0,"publicationDate":"2018-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-018-0095-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36210903","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 41
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