Molecular differences between subtypes of bone marrow adipocytes.

Current molecular biology reports Pub Date : 2018-03-01 Epub Date: 2018-02-15
Clarissa S Craft, Ziru Li, Ormond A MacDougald, Erica L Scheller
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Abstract

Purpose of review: Bone marrow adipocytes (BMAs) have distinct molecular properties and physiologic responses depending on their location within the skeleton.

Recent findings: This concept was introduced in the 1970s and validated more recently in the contexts of cold exposure, sympathetic tone, hematopoiesis, diabetes, lactation, fasting and caloric restriction.

Summary: In this brief review, we discuss the concept of regulated vs constitutive BMAs, explore their evolutionary and microenvironmental origins, define the site-specific molecular features of BMAs, and discuss the translational implications of the dual bone marrow adipose tissue hypothesis.

Abstract Image

骨髓脂肪细胞亚型之间的分子差异。
综述的目的:骨髓脂肪细胞(BMAs)因其在骨骼中的位置不同而具有不同的分子特性和生理反应:摘要:在这篇简短的综述中,我们讨论了调控型与组成型骨髓脂肪组织的概念,探讨了它们的进化和微环境起源,定义了骨髓脂肪组织的特定部位分子特征,并讨论了双重骨髓脂肪组织假说的转化意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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