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PTH Signaling and Epigenetic Control of Bone Remodeling. PTH信号传导与骨重塑的表观遗传调控。
Current molecular biology reports Pub Date : 2016-03-01 Epub Date: 2016-02-03 DOI: 10.1007/s40610-016-0033-7
Florante Ricarte, Teruyo Nakatani, Nicola Partridge
{"title":"PTH Signaling and Epigenetic Control of Bone Remodeling.","authors":"Florante Ricarte,&nbsp;Teruyo Nakatani,&nbsp;Nicola Partridge","doi":"10.1007/s40610-016-0033-7","DOIUrl":"https://doi.org/10.1007/s40610-016-0033-7","url":null,"abstract":"<p><p>As our understanding of the mechanisms that govern bone development advance, the role of epigenetic modifications in these processes become increasingly evident. Interestingly, in parathyroid hormone (PTH)-induced bone metabolism and remodeling, recent evidence shows that PTH signaling employs a particular facet of the epigenetic machinery to elicit its desired effects. In this review, we briefly discuss the known epigenetic events occurring in cells of the osteoblast lineage. More specifically, we elaborate on current findings that reveal the utilization of histone deacetylating enzymes (HDACs) in PTH-regulated modulation of gene expression in bone.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"55-61"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0033-7","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34459658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 4
Systemic Control of Bone Homeostasis by FGF23 Signaling. FGF23信号传导对骨稳态的系统控制。
Current molecular biology reports Pub Date : 2016-03-01 Epub Date: 2016-02-03 DOI: 10.1007/s40610-016-0035-5
Erica L Clinkenbeard, Kenneth E White
{"title":"Systemic Control of Bone Homeostasis by FGF23 Signaling.","authors":"Erica L Clinkenbeard,&nbsp;Kenneth E White","doi":"10.1007/s40610-016-0035-5","DOIUrl":"https://doi.org/10.1007/s40610-016-0035-5","url":null,"abstract":"<p><p>The regulation of phosphate metabolism as an influence on bone homeostasis is profound. Recent advances in understanding the systemic control of Fibroblast growth factor-23 (FGF23) has uncovered novel effectors of endocrine feedback loops for calcium, phosphate, and vitamin D balance that interact with 'traditional' feedback loops for mineral metabolism. Not only are these findings re-shaping research studying phosphate handling and skeletal interactions, they have provided new therapeutic interventions. Emerging data support that the control of FGF23 production in bone and its circulating concentrations is a multi-layered process, with some influences affecting FGF23 transcription and some post-translational modification of the secreted, bioactive protein. Additionally, the actions of FGF23 on its target tissues via its co-receptor αKlotho, are subject to regulatory events just coming to light. The recent findings of systemic influences on circulating FGF23 and the downstream manifestations on bone homeostasis will be reviewed herein.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"62-71"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0035-5","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34350083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex. 细胞机械敏感性是由LINC核复合物实现的。
Current molecular biology reports Pub Date : 2016-03-01 Epub Date: 2016-02-01 DOI: 10.1007/s40610-016-0032-8
Gunes Uzer, Clinton T Rubin, Janet Rubin
{"title":"Cell Mechanosensitivity is Enabled by the LINC Nuclear Complex.","authors":"Gunes Uzer,&nbsp;Clinton T Rubin,&nbsp;Janet Rubin","doi":"10.1007/s40610-016-0032-8","DOIUrl":"https://doi.org/10.1007/s40610-016-0032-8","url":null,"abstract":"<p><p>Mechanoresponses in mesenchymal stem cells (MSCs) guide both differentiation and function. In this review, we focus on advances in0 our understanding of how the cytoplasmic cytoskeleton, nuclear envelope and nucleoskeleton, which are connected via LINC (<i>Linker of Nucleoskeleton and Cytoskeleton</i>) complexes, are emerging as an integrated dynamic signaling platform to regulate MSC mechanobiology. This dynamic interconnectivity affects mechanical signaling and transfer of signals into the nucleus. In this way, nuclear and LINC-mediated cytoskeletal connectivity play a critical role in maintaining mechanical signaling that affects MSC fate by serving as both mechanosensory and mechanoresponsive structures. We review disease and age related compromises of LINC complexes and nucleoskeleton that contribute to the etiology of musculoskeletal diseases. Finally we invite the idea that acquired dysfunctions of LINC might be a contributing factor to conditions such as aging, microgravity and osteoporosis and discuss potential mechanical strategies to modulate LINC connectivity to combat these conditions.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"36-47"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0032-8","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34596943","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 39
Prenatal Maternal Stress and Epigenetics: Review of the Human Research 产前母亲压力与表观遗传学:人类研究综述
Current molecular biology reports Pub Date : 2016-02-17 DOI: 10.1007/s40610-016-0030-x
L. Cao-Lei, D. Laplante, S. King
{"title":"Prenatal Maternal Stress and Epigenetics: Review of the Human Research","authors":"L. Cao-Lei, D. Laplante, S. King","doi":"10.1007/s40610-016-0030-x","DOIUrl":"https://doi.org/10.1007/s40610-016-0030-x","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"60 1","pages":"16 - 25"},"PeriodicalIF":0.0,"publicationDate":"2016-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0030-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52666800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 51
Histone Modifications in Ageing and Lifespan Regulation 衰老和寿命调节中的组蛋白修饰
Current molecular biology reports Pub Date : 2016-02-13 DOI: 10.1007/s40610-016-0031-9
M. Maleszewska, Julia S. P. Mawer, Peter Tessarz
{"title":"Histone Modifications in Ageing and Lifespan Regulation","authors":"M. Maleszewska, Julia S. P. Mawer, Peter Tessarz","doi":"10.1007/s40610-016-0031-9","DOIUrl":"https://doi.org/10.1007/s40610-016-0031-9","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"26 - 35"},"PeriodicalIF":0.0,"publicationDate":"2016-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0031-9","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52666922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 32
Mitotic Bookmarking: Maintaining Post-Mitotic Reprogramming of Transcription Reactivation 有丝分裂书签:维持有丝分裂后转录再激活的重编程
Current molecular biology reports Pub Date : 2016-02-05 DOI: 10.1007/s40610-016-0029-3
N. Lodhi, Yingbiao Ji, A. Tulin
{"title":"Mitotic Bookmarking: Maintaining Post-Mitotic Reprogramming of Transcription Reactivation","authors":"N. Lodhi, Yingbiao Ji, A. Tulin","doi":"10.1007/s40610-016-0029-3","DOIUrl":"https://doi.org/10.1007/s40610-016-0029-3","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"10 - 15"},"PeriodicalIF":0.0,"publicationDate":"2016-02-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0029-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52666681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 24
Spatial Organization of Epigenomes 表观基因组的空间组织
Current molecular biology reports Pub Date : 2016-02-04 DOI: 10.1007/s40610-016-0028-4
J. Dubé, X. Q. Wang, J. Dostie
{"title":"Spatial Organization of Epigenomes","authors":"J. Dubé, X. Q. Wang, J. Dostie","doi":"10.1007/s40610-016-0028-4","DOIUrl":"https://doi.org/10.1007/s40610-016-0028-4","url":null,"abstract":"","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"1 - 9"},"PeriodicalIF":0.0,"publicationDate":"2016-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0028-4","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52666227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren's Disease). 结缔组织变性:掌筋膜变性(Dupuytren病)的机制。
Current molecular biology reports Pub Date : 2016-01-01 Epub Date: 2016-07-14 DOI: 10.1007/s40610-016-0045-3
S Karkampouna, M Kreulen, M C Obdeijn, P Kloen, A L Dorjée, F Rivellese, A Chojnowski, I Clark, Marianna Kruithof-de Julio
{"title":"Connective Tissue Degeneration: Mechanisms of Palmar Fascia Degeneration (Dupuytren's Disease).","authors":"S Karkampouna, M Kreulen, M C Obdeijn, P Kloen, A L Dorjée, F Rivellese, A Chojnowski, I Clark, Marianna Kruithof-de Julio","doi":"10.1007/s40610-016-0045-3","DOIUrl":"10.1007/s40610-016-0045-3","url":null,"abstract":"<p><p>Dupuytren's disease is a connective tissue disorder of the hand causing excessive palmar fascial fibrosis with associated finger contracture and disability. The aetiology of the disease is heterogeneous, with both genetic and environmental components. The connective tissue is abnormally infiltrated by myofibroblasts that deposit collagen and other extracellular matrix proteins. We describe the clinical profile of Dupuytren's disease along with current therapeutic schemes. Recent findings on molecular and cellular parameters that are dysregulated in Dupuytren's disease, which may contribute to the onset of the disease, and the role of resident inflammation promoting fibrosis, are highlighted. We review recent literature focusing on non-myofibroblast cell types (stem cell-like cells), their pro-inflammatory and pro-fibrotic role that may account for abnormal wound healing response.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"133-140"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0045-3","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52667703","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 12
Paracrine Signaling by Extracellular Vesicles via Osteoblasts. 细胞外囊泡经成骨细胞传递旁分泌信号。
Current molecular biology reports Pub Date : 2016-01-01 Epub Date: 2016-02-23 DOI: 10.1007/s40610-016-0034-6
Jess Morhayim, Resti Rudjito, Johannes P van Leeuwen, Marjolein van Driel
{"title":"Paracrine Signaling by Extracellular Vesicles via Osteoblasts.","authors":"Jess Morhayim,&nbsp;Resti Rudjito,&nbsp;Johannes P van Leeuwen,&nbsp;Marjolein van Driel","doi":"10.1007/s40610-016-0034-6","DOIUrl":"https://doi.org/10.1007/s40610-016-0034-6","url":null,"abstract":"<p><p>Extracellular vesicles (EVs), spherical bilayered proteolipids, behave as paracrine effectors since they are released from cells to deliver signals to other cells. They control a diverse range of biological processes by transferring proteins, lipids, and nucleic acids between cells and are secreted by a wide spectrum of cell types and are found in various biological fluids. EVs are formed at the plasma membrane or in endosomes and are heterogeneous in size and composition. Increasing understanding of the working mechanisms is promising for therapeutic and diagnostic opportunities. In this review, we will focus on the recent developments in this emerging field with special emphasis on the role of EVs in the bone microenvironment, with a central role for the osteoblasts in the communication with a diversity of cells, including bone metastases.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 ","pages":"48-55"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40610-016-0034-6","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"34679116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 26
Strategies and First Advances in the Development of Prevascularized Bone Implants. 血管前骨植入物的开发策略和初步进展。
Current molecular biology reports Pub Date : 2016-01-01 Epub Date: 2016-08-15 DOI: 10.1007/s40610-016-0046-2
Christoph Rücker, Holger Kirch, Oliver Pullig, Heike Walles
{"title":"Strategies and First Advances in the Development of Prevascularized Bone Implants.","authors":"Christoph Rücker, Holger Kirch, Oliver Pullig, Heike Walles","doi":"10.1007/s40610-016-0046-2","DOIUrl":"10.1007/s40610-016-0046-2","url":null,"abstract":"<p><p>Despite the great regenerative potential of human bone, large bone defects are a serious condition. Commonly, large defects are caused by trauma, bone disease, malignant tumor removal, and infection or medication-related osteonecrosis. Large defects necessitate clinical treatment in the form of autologous bone transplantation or implantation of biomaterials as well as the application of other available methods that enhance bone defect repair. The development and application of prevascularized bone implants are closely related to the development animal models and require dedicated methods in order to reliably predict possible clinical outcomes and the efficacy of implants. Cell sheet engineering, 3D-printing, arteriovenous loops, and naturally derived decellularized scaffolds and their respective testings in animal models are presented as alternative to the autologous bone graft in this article.</p>","PeriodicalId":72737,"journal":{"name":"Current molecular biology reports","volume":"2 1","pages":"149-157"},"PeriodicalIF":0.0,"publicationDate":"2016-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4996880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"52667823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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