Current medical issues最新文献_第10页

Magnetic resonance imaging downstaging, pathological response, and microsatellite instability status in patients with signet-ring cell carcinoma rectum undergoing preoperative long-course chemoradiation 直肠印戒细胞癌术前长期放化疗患者的磁共振成像降分期、病理反应和微卫星不稳定状态

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_23_22

B. Rajkrishna, Saikat Das, D. Masih, Tharani Putta, R. Raghunath, T. Ram

{"title":"Magnetic resonance imaging downstaging, pathological response, and microsatellite instability status in patients with signet-ring cell carcinoma rectum undergoing preoperative long-course chemoradiation","authors":"B. Rajkrishna, Saikat Das, D. Masih, Tharani Putta, R. Raghunath, T. Ram","doi":"10.4103/cmi.cmi_23_22","DOIUrl":"https://doi.org/10.4103/cmi.cmi_23_22","url":null,"abstract":"Aim and Objective: To assess the magnetic resonance imaging (MRI) downstaging, pathological response, and the relationship between microsatellite instability (MSI) and radiotherapy response in signet-ring cell carcinoma rectum. Materials and Methods: Twenty two patients were recruited prospectively and retrospectively in this observational study. Six weeks following radiotherapy, the response was assessed using an MRI pelvis, and patients who were operable underwent total mesorectal excision followed by adjuvant chemotherapy. The outcome of radiotherapy was correlated with post radiation MRI downstaging, pathological response, and MSI status. Results: The post radiotherapy response assessment MRI showed tumor regression grading (TRG) 5 in 5 patients. TRG 4 seen in 12, TRG 3 in 3, and TRG 2 in 1 patient. Fifteen patients were operable and post-operativ histopathology showed that 40% had pathological complete response (pCR) and 26.7% had near-complete response. Even those who had no response in MRI had pCR. MSI done 17 patients were stable. Of the 6 patients who had complete pathological response, two were MRI TRG 5, three were MRI TRG 4, and one was MRI TRG 3. The median survival was 23 months. The 2-year and 3-year disease-free survival was 46% and 38%, respectively. Conclusion: The predictive value of MRI downstaging in these tumors following neoadjuvant long-course chemoradiation therapy is not often in concurrence with the histopathological response and needs to be interpreted carefully. Even though the pCR rate seen in this cohort is encouraging, this needs to be evaluated in studies with large cohorts.","PeriodicalId":72734,"journal":{"name":"Current medical issues","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85353264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of COVID-19 pandemic on caustic ingestion at a tertiary care center in South India COVID-19大流行对印度南部三级保健中心腐蚀性摄入的影响

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_118_21

N. Rao, E. Simon

{"title":"The impact of COVID-19 pandemic on caustic ingestion at a tertiary care center in South India","authors":"N. Rao, E. Simon","doi":"10.4103/cmi.cmi_118_21","DOIUrl":"https://doi.org/10.4103/cmi.cmi_118_21","url":null,"abstract":"Background: The COVID-19 pandemic has had a significant impact on the mental health of individuals which has sometimes led to attempts at deliberate self-harm including the ingestion of caustic substances. This study was aimed to compare the rates of caustic substance ingestion during the pandemic to a similar period in the preceding year at our center. Methodology: We carried out a retrospective analysis, in which patients' details (demographic, clinical, endoscopic, and outcomes) were collected and compared between April 2019 and December 2019 (pre-COVID-19 pandemic) and from April 2020 to December 2020 (during the COVID-19 pandemic). Results: A total of 41 patients were included in this study, 26 (63.4%) in the pandemic period and 15 (36.5%) in the prepandemic period. The majority were female in both the prepandemic (60%) and pandemic periods (53.9%). More adolescents (<18 years of age) were seen in the pandemic period (15.3%) than in the prepandemic period (6.7%). The proportion of patients admitted with caustic substance ingestion in the pandemic period (3.53%) was significantly higher than in the prepandemic period (1.57%) (P = 0.0094). Conclusion: Caustic substance ingestion almost doubled in our center during the COVID-19 pandemic highlighting the burden of mental health issues during a pandemic.","PeriodicalId":72734,"journal":{"name":"Current medical issues","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78022388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dimethoate self-poisoning–Induced severe hypotension 乐果自中毒引起的严重低血压

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_12_22

Anand M Tiwari, K. Zirpe, R. Wadia, S. Gurav, A. Deshmukh

引用次数: 1

Experiential learning: How pedagogy is changing in medical education 体验式学习:医学教育中教学法的变化

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_35_22

Debkumar Pal, M. Taywade, Kumbha Gopi

引用次数: 1

Physiotherapy and behavioral techniques in management of posttraumatic stress disorder in health-care workers amid COVID pandemic COVID大流行期间卫生保健工作者创伤后应激障碍的物理治疗和行为技术管理

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_33_22

Srishti Banerjee

引用次数: 0

Monitoring treatment outcomes among tuberculosis patients: Implications for practice and policy 监测结核病患者的治疗结果:对实践和政策的影响

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_45_22

A. John, H. Avirneni, S. Swaminathan

引用次数: 0

Antimicrobial resistance in India – “A silent pandemic within the pandemic” 印度的抗菌素耐药性——“流行病中的无声流行病”

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_47_22

Karthik Gunasekaran

引用次数: 0

Undergraduate medical education in India during COVID-19 pandemic COVID-19大流行期间印度的本科医学教育

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_38_22

A. Nirupama, Sirshendu Chaudhuri, C. Chittooru, K. Vani, Sravana Chittem

{"title":"Undergraduate medical education in India during COVID-19 pandemic","authors":"A. Nirupama, Sirshendu Chaudhuri, C. Chittooru, K. Vani, Sravana Chittem","doi":"10.4103/cmi.cmi_38_22","DOIUrl":"https://doi.org/10.4103/cmi.cmi_38_22","url":null,"abstract":"Introduction: The COVID-19 pandemic led to the disruption of medical teaching nation-wide and pushed the institutions to explore the probable role of online teaching methods. The aim of this review is to identify the untested perspectives and help in strategizing based on evidence generation for the preparation for future. Methods: We followed the Preferred Reporting Items for Systematic and Meta-Analysis guidelines for reporting the present review. We searched PubMed, Scopus, and Embase databases for the articles published between April 2020 and October 2021 for studies on online medical education in India during the COVID-19 pandemic. Results: We initially screened a total number of 1412 articles and finally recruited 45 articles for the analysis. Majority of the articles were from single institution, and reported the experience of the students and teachers on online teaching. The common teaching platform used such as Zoom and Google Meet were enumerated. Internet connectivity was the most reported challenge of online teaching. None of the selected articles reported on ethical issues related to online teaching. Conclusion: Even though there were some strong points reported for the successful implementation of e-learning, a more sustainable and well-informed plan should be devised for the future on online teaching.","PeriodicalId":72734,"journal":{"name":"Current medical issues","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79715813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence of type 2 diabetes among persons with disabilities in the South-East Asian region: A systematic review and meta-analysis 东南亚地区残疾人2型糖尿病患病率:一项系统综述和荟萃分析

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_27_22

Rajeswaran Thiagesan, V. Gopichandran, S. Subramaniam, Hilaria Soundari, K. Kosalram

{"title":"Prevalence of type 2 diabetes among persons with disabilities in the South-East Asian region: A systematic review and meta-analysis","authors":"Rajeswaran Thiagesan, V. Gopichandran, S. Subramaniam, Hilaria Soundari, K. Kosalram","doi":"10.4103/cmi.cmi_27_22","DOIUrl":"https://doi.org/10.4103/cmi.cmi_27_22","url":null,"abstract":"Background: Type 2 diabetes is a major public health burden in the South-East Asian region. Persons with disabilities have a higher predilection for developing type 2 diabetes. Objective: The objective of this study was to estimate the prevalence of type 2 diabetes among persons with physical, development, sensory, and psychiatric disabilities in the South-East Asian regional countries. Methods: The Medline database was searched through PubMed using a specifically developed search strategy to identify observational studies that looked at the prevalence of type 2 diabetes among persons with various types of disabilities. Specific inclusion–exclusion criteria were used to shortlist the most relevant studies. The AXIS tool was used to assess the risk of bias in the identified studies. Data were extracted from the final list of studies and meta-analyzed using a random-effects model. Forest plot was used to study the pooled estimate and funnel plot was studied to assess publication bias. Subgroup analysis of prevalence of diabetes among persons with psychiatric and physical disabilities was performed. Results: A total of 771 papers were identified for screening. Of them, 740 were excluded and 31 were included in the full-text review. Finally, 12 studies were included in the meta-analysis. The prevalence of type 2 diabetes among persons with disabilities was 12.8% (95% confidence interval [CI]: 8.8%–16.8%). The studies showed a wide heterogeneity. The funnel plot did not show any publication bias. Subgroup analysis showed that while the prevalence of type 2 diabetes in persons with psychiatric disabilities was 14.0% (95% CI: 9%–18.9%), it was 10.6% (95% CI: 3.6%–17.6%) among persons with other forms of physical disabilities. Conclusion: The prevalence of type 2 diabetes is high among persons with disabilities. There is a need for well-conducted systematic studies in the South-East Asian region on prevalence of type 2 diabetes among persons with disabilities.","PeriodicalId":72734,"journal":{"name":"Current medical issues","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72459605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Resolve or refer? A difficult choice in the management of neonatal refractory hypoglycemia 解决还是参考?治疗新生儿难治性低血糖的艰难选择

Current medical issues Pub Date : 2022-07-01 DOI: 10.4103/cmi.cmi_17_22

Vinod Palaparthy, Karen Kiruba, Monica Thapwal

引用次数: 0