Current genetic medicine reports最新文献_第6页

Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch? 向胃病倾斜：宿主-病原体基因组不匹配？

Current genetic medicine reports Pub Date : 2018-12-01 Epub Date: 2018-10-10 DOI: 10.1007/s40142-018-0153-x

Gloria Tavera, Douglas R Morgan, Scott M Williams

{"title":"Tipping the Scale Toward Gastric Disease: A Host-Pathogen Genomic Mismatch?","authors":"Gloria Tavera, Douglas R Morgan, Scott M Williams","doi":"10.1007/s40142-018-0153-x","DOIUrl":"10.1007/s40142-018-0153-x","url":null,"abstract":"Purpose of review: Chronic infection with Helicobacter pylori infection is necessary but not sufficient to initiate development of intestinal-type gastric adenocarcinoma. It is not clear what additional factors tip the scale from commensal bacteria towards a pathogen that facilitates development of gastric cancer. Genetic variants in both the pathogen and host have been implicated, but neither alone explains a substantial portion of disease risk.Recent findings: In this review, we consider studies that address the important role of human and bacterial genetics, ancestry and their interactions in determining gastric disease risk. We observe gaps in the current literature that should guide future work to confirm the hypothesis of the interacting roles of host and bacterial genetics that will be necessary to translate these findings into clinically relevant information.Summary: We summarize genetic risk factors for gastric disease in both H. pylori and human hosts. However, genetic variation of one or the other organism in isolation insufficiently explains gastric disease risk. The most promising models of gastric disease risk simultaneously consider the genetic variation of both the H. pylori and human host, under a co-evolution model.","PeriodicalId":72731,"journal":{"name":"Current genetic medicine reports","volume":"6 4","pages":"199-207"},"PeriodicalIF":0.0,"publicationDate":"2018-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40142-018-0153-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"36976646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Admixture, Genetics and Complex Diseases in Latin Americans and US Hispanics 拉丁美洲人和西班牙裔美国人的混合、遗传和复杂疾病

IF 2.1

Current genetic medicine reports Pub Date : 2018-09-29 DOI: 10.1007/s40142-018-0151-z

G. Soares-Souza, V. Borda, F. Kehdy, E. Tarazona-Santos

引用次数: 8

Micronuclei and What They Can Tell Us in Cytogenetic Diagnostics 微核及其在细胞遗传学诊断中的作用

IF 2.1

Current genetic medicine reports Pub Date : 2018-09-27 DOI: 10.1007/s40142-018-0149-6

G. Hovhannisyan, T. Harutyunyan, R. Aroutiounian

引用次数: 3

Towards Cultural Competence in the Genomic Age: a Review of Current Health Care Provider Educational Trainings and Interventions 基因组时代的文化能力:当前卫生保健提供者教育培训和干预措施的回顾

IF 2.1

Current genetic medicine reports Pub Date : 2018-09-26 DOI: 10.1007/s40142-018-0150-0

Molly A McGinniss, Amelia Tahmassi, Erica Ramos

引用次数: 6

Conventional Cytogenetic Approaches—Useful and Indispensable Tools in Discovering Fish Biodiversity 常规细胞遗传学方法——发现鱼类生物多样性的有用和不可或缺的工具

IF 2.1

Current genetic medicine reports Pub Date : 2018-09-25 DOI: 10.1007/s40142-018-0148-7

M. Bello Cioffi, O. Moreira-Filho, P. Ráb, A. Sember, W. F. Molina, L. Bertollo

引用次数: 20

Fragile Sites as Drivers of Gene and Genome Evolution 脆弱位点作为基因和基因组进化的驱动因素

IF 2.1

Current genetic medicine reports Pub Date : 2018-09-25 DOI: 10.1007/s40142-018-0154-9

K. Wilhelm, Constanze Pentzold, Sandra Schoener, A. Arakelyan, A. Hakobyan, K. Mrasek, A. Weise

引用次数: 6

Human Molecular Neurocytogenetics 人类分子神经细胞遗传学

IF 2.1

Current genetic medicine reports Pub Date : 2018-09-19 DOI: 10.1007/s40142-018-0152-y

Y. Yurov, S. Vorsanova, I. Iourov

引用次数: 11

Significance of Cytogenetics in Leukemia Diagnostics 细胞遗传学在白血病诊断中的意义

IF 2.1

Current genetic medicine reports Pub Date : 2018-09-18 DOI: 10.1007/s40142-018-0147-8

T. S. Wan, Eleanor K C Hui, M. Ng

引用次数: 1

Genetics of Subclinical Coronary Atherosclerosis. 亚临床冠状动脉粥样硬化的遗传学。

Current genetic medicine reports Pub Date : 2018-09-01 Epub Date: 2018-07-13 DOI: 10.1007/s40142-018-0145-x

Lawrence F Bielak, Patricia A Peyser

{"title":"Genetics of Subclinical Coronary Atherosclerosis.","authors":"Lawrence F Bielak, Patricia A Peyser","doi":"10.1007/s40142-018-0145-x","DOIUrl":"https://doi.org/10.1007/s40142-018-0145-x","url":null,"abstract":"Purpose of review: This review highlights recent findings regarding genetics of coronary artery calcification (CAC), a marker of subclinical atherosclerosis burden, that is a precursor of clinical coronary artery disease.Recent findings: CAC quantity is heritable. Genome wide association studies of common single nucleotide polymorphisms have identified genomic regions explaining ~2.4% of CAC heritability. Low frequency and rare variants explain additional variation in CAC. Evidence suggests that there may be different genetic etiologies for variation in CAC progression than for cross-sectional measures of CAC. Studies integrating multiple -omics data are providing new insights into the pathobiology of subclinical coronary atherosclerosis.Summary: The future is promising for innovative studies utilizing whole genome sequencing data as well as other -omics such as epigenomic modifications of genes and gene expression. These studies may provide multiple sources of data pointing to the same gene or pathway, thus providing greater confidence in findings.","PeriodicalId":72731,"journal":{"name":"Current genetic medicine reports","volume":"6 3","pages":"116-123"},"PeriodicalIF":0.0,"publicationDate":"2018-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1007/s40142-018-0145-x","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"37041256","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Genetic and Epigenetic Regulations of Post-prandial Lipemia 餐后血脂的遗传和表观遗传调控

IF 2.1

Current genetic medicine reports Pub Date : 2018-07-09 DOI: 10.1007/s40142-018-0146-9

Huichun Xu

引用次数: 0