Current genetic medicine reports最新文献

Al-Accelerated Human Genetic Discrimination: Implications of UNGPs 加速人类基因歧视：联合国全球契约的影响

IF 2.1

Current genetic medicine reports Pub Date : 2024-02-27 DOI: 10.1007/s40142-023-00208-1

Leifan Wang, Xiaohui Liang

引用次数: 0

Addressing Gene Modified Technology for Emerging Risks Through Regional Networks 通过区域网络解决基因改造技术应对新出现的风险

Current genetic medicine reports Pub Date : 2023-09-18 DOI: 10.1007/s40142-023-00207-2

Geoffrey Otim, Sandra Matinyi, Ian Peter Busuulwa, Perez Mweine, Erikan Baluku, George Peter Magoola, Ivy S. G. Chimulwa, Stephen Mukuze, Peace Proscovia Aber, Peter Ahabwe Babigumira, Alex Katumba, Stephen Obol Opiyo

引用次数: 0

Meet the New Editor-in-Chief 认识新主编

IF 2.1

Current genetic medicine reports Pub Date : 2022-12-01 DOI: 10.1007/s40142-023-00206-3

Una Fairbrother

引用次数: 0

Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity. 健康老龄化和长寿的遗传、社会和生活方式驱动因素

IF 1.4

Current genetic medicine reports Pub Date : 2022-09-01 Epub Date: 2022-09-26 DOI: 10.1007/s40142-022-00205-w

Patricia Alejandra Castruita, Stefanie Danielle Piña-Escudero, Miguel E Rentería, Jennifer S Yokoyama

{"title":"Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity.","authors":"Patricia Alejandra Castruita, Stefanie Danielle Piña-Escudero, Miguel E Rentería, Jennifer S Yokoyama","doi":"10.1007/s40142-022-00205-w","DOIUrl":"10.1007/s40142-022-00205-w","url":null,"abstract":"Purpose of review: \"Healthy aging\" is the state of the aging process in which a person can maintain physical, social, mental, and spiritual wellness. This literature review presents an overview of recent studies that explore how biological, social, and environmental factors contribute to healthy aging.Recent findings: A number of genome-wide association studies have been conducted recently for traits related to healthy aging, such as frailty index, healthspan, muscle strength, and parental longevity, leading to the discovery of dozens of genetic variants associated with these traits. In parallel, associations between healthy aging measures and multiple non-biological environmental elements have been identified as key moderators of the aging process, indirectly influencing day-to-day homeostatic processes.Summary: Individual variations in lifespan and healthspan are influenced by genetic factors, with a heritability of ~ 25% in developed countries. Non-genetic risk variance is explained in part by social, cultural, and lifestyle conditions. Altogether, these factors contribute to a multifaceted state of wellness over time, shaping individual risk to frailty and resilience during the aging process. Notably, \"Blue Zone\" populations, which are characterized by an abundance in healthy lifestyles across generations, share some commonalities regarding determinants of health.","PeriodicalId":72731,"journal":{"name":"Current genetic medicine reports","volume":null,"pages":null},"PeriodicalIF":1.4,"publicationDate":"2022-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10686287/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44371953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Why, Who and How We Should Screen for Melanoma 为什么，谁以及如何筛查黑色素瘤

IF 2.1

Current genetic medicine reports Pub Date : 2022-06-01 DOI: 10.1007/s40142-022-00204-x

Karlijn L J Clarysse, K. Lacy

引用次数: 0

Genodermatoses - Opportunities for Early Detection and Cancer Prevention. 遗传性皮肤病-早期发现和癌症预防的机会。

Current genetic medicine reports Pub Date : 2022-01-01 Epub Date: 2022-10-04 DOI: 10.1007/s40142-022-00203-y

Helena Carley, Anjana Kulkarni

{"title":"Genodermatoses - Opportunities for Early Detection and Cancer Prevention.","authors":"Helena Carley, Anjana Kulkarni","doi":"10.1007/s40142-022-00203-y","DOIUrl":"https://doi.org/10.1007/s40142-022-00203-y","url":null,"abstract":"Purpose of review: This review describes the clinical features of the major adult-onset genodermatosis-associated hereditary cancer predisposition syndromes. Diagnosis of these conditions can be challenging due to a wide range of clinical features, varied presentations within families and the involvement of multiple medical specialities.Recent findings: By emphasising the cutaneous and other non-malignant features, we aim to alert clinicians from all specialities to clues in the clinical history which should prompt consideration of a genodermatosis-associated hereditary cancer predisposition syndrome. In recognition of the move towards remote (telephone or video) appointments since the Covid-19 pandemic, we propose criteria which could be used by Cancer Genetics services to triage patients for in-person consultations in order to examine for signs of genodermatosis.Summary: Although individually rare, familiarity with these conditions amongst genetic and non-genetic clinicians is important as early diagnosis provides an opportunity to implement risk-reduction measures prior to a cancer diagnosis.","PeriodicalId":72731,"journal":{"name":"Current genetic medicine reports","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9531856/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"33495997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Considerations in Management for Trans and Gender Diverse Patients with Inherited Cancer Risk 癌症遗传风险跨性别患者的管理思考

IF 2.1

Current genetic medicine reports Pub Date : 2021-09-27 DOI: 10.1007/s40142-021-00201-6

Bethany M. Coad, Josephine Giblin, R. Walsh, Oliwia Kuczkowska, Alexander M von Vaupel-Klein, A. Berner

引用次数: 3

The Role of RNA-Sequencing as a New Genetic Diagnosis Tool RNA测序作为一种新的遗传诊断工具的作用

IF 2.1

Current genetic medicine reports Pub Date : 2021-04-23 DOI: 10.1007/s40142-021-00199-x

Philippa D. K. Curry, Krystyna L. Broda, C. Carroll

引用次数: 10

The Therapeutic Potential of Epigenome-Modifying Drugs in Cardiometabolic Disease 表观基因组修饰药物治疗心脏代谢疾病的潜力

IF 2.1

Current genetic medicine reports Pub Date : 2021-03-18 DOI: 10.1007/s40142-021-00198-y

M. Berjawi, C. Bell

引用次数: 0

Horizon Scanning in Cancer Genomics: How Advances in Genomic Medicine Will Change Cancer Care Over the Next Decade. 癌症基因组学的地平线扫描：基因组医学的进步将如何改变未来十年的癌症治疗》（Horizon Scanning in Cancer Genomics: How Advances in Genomic Medicine Will Change Cancer Care Over the Future Decade）。

IF 2.1

Current genetic medicine reports Pub Date : 2021-01-01 Epub Date: 2021-07-15 DOI: 10.1007/s40142-021-00200-7

Lydia M Seed

{"title":"Horizon Scanning in Cancer Genomics: How Advances in Genomic Medicine Will Change Cancer Care Over the Next Decade.","authors":"Lydia M Seed","doi":"10.1007/s40142-021-00200-7","DOIUrl":"10.1007/s40142-021-00200-7","url":null,"abstract":"Purpose of review: Advances in genomic medicine have the potential to revolutionise cancer patient care by driving forwards the clinical practice of precision oncology. This review aims to outline how genomic medicine advances may alter the care of cancer patients and their families over the next 10 years.Recent findings: The translation of oncogenomic advances into the clinical environment will likely be facilitated by the increasing availability of next-generation sequencing technologies and the increasing genomic literacy of healthcare professionals. The implementation of the centralised, nationwide NHS Genomic Medicine Service promises to improve equity of cancer care and to facilitate personalisation of almost every stage of the care pathway, from informing population screening and how we diagnose cancer to delivering prognoses and surveillance. Advances in cancer pharmacogenomics, and other \"omics\" technologies, have a tremendous potential to optimise patient care. Genomic medicine advances will also enhance the care offered to cancer patients' families.Summary: Genomic medicine advances are likely to transform almost every aspect of a cancer patient's care pathway. Cancer care will profoundly improve over the next decade, increasing UK cancer survival rates and improving patient outcomes.","PeriodicalId":72731,"journal":{"name":"Current genetic medicine reports","volume":null,"pages":null},"PeriodicalIF":2.1,"publicationDate":"2021-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8280651/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39220540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0