Genetic, Social, and Lifestyle Drivers of Healthy Aging and Longevity.

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2022-09-01 Epub Date: 2022-09-26 DOI:10.1007/s40142-022-00205-w

Patricia Alejandra Castruita, Stefanie Danielle Piña-Escudero, Miguel E Rentería, Jennifer S Yokoyama

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引用次数: 0

Abstract

Purpose of review: "Healthy aging" is the state of the aging process in which a person can maintain physical, social, mental, and spiritual wellness. This literature review presents an overview of recent studies that explore how biological, social, and environmental factors contribute to healthy aging.

Recent findings: A number of genome-wide association studies have been conducted recently for traits related to healthy aging, such as frailty index, healthspan, muscle strength, and parental longevity, leading to the discovery of dozens of genetic variants associated with these traits. In parallel, associations between healthy aging measures and multiple non-biological environmental elements have been identified as key moderators of the aging process, indirectly influencing day-to-day homeostatic processes.

Summary: Individual variations in lifespan and healthspan are influenced by genetic factors, with a heritability of ~ 25% in developed countries. Non-genetic risk variance is explained in part by social, cultural, and lifestyle conditions. Altogether, these factors contribute to a multifaceted state of wellness over time, shaping individual risk to frailty and resilience during the aging process. Notably, "Blue Zone" populations, which are characterized by an abundance in healthy lifestyles across generations, share some commonalities regarding determinants of health.

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健康老龄化和长寿的遗传、社会和生活方式驱动因素

综述目的:“健康衰老”是指一个人在衰老过程中能够保持身体、社会、心理和精神健康的状态。这篇文献综述概述了最近的研究，探讨了生物、社会和环境因素如何促进健康老龄化。最近的发现:一些全基因组关联研究最近已经进行了一些与健康衰老相关的特征，如脆弱指数、健康寿命、肌肉力量和父母寿命，导致发现了几十个与这些特征相关的遗传变异。与此同时，健康衰老措施与多种非生物环境因素之间的关联已被确定为衰老过程的关键调节因子，间接影响日常的稳态过程。摘要:寿命和健康寿命的个体差异受遗传因素的影响，在发达国家遗传率约为25%。非遗传风险差异部分可以由社会、文化和生活方式条件解释。总之，随着时间的推移，这些因素有助于形成多方面的健康状态，在衰老过程中形成个体脆弱和恢复能力的风险。值得注意的是，"蓝区"人口的特点是几代人都有丰富的健康生活方式，在健康决定因素方面有一些共同之处。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.