Genetics of Subclinical Coronary Atherosclerosis.

IF 1.4 Q4 GENETICS & HEREDITY

Current genetic medicine reports Pub Date : 2018-09-01 Epub Date: 2018-07-13 DOI:10.1007/s40142-018-0145-x

Lawrence F Bielak, Patricia A Peyser

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引用次数: 3

Abstract

Purpose of review: This review highlights recent findings regarding genetics of coronary artery calcification (CAC), a marker of subclinical atherosclerosis burden, that is a precursor of clinical coronary artery disease.

Recent findings: CAC quantity is heritable. Genome wide association studies of common single nucleotide polymorphisms have identified genomic regions explaining ~2.4% of CAC heritability. Low frequency and rare variants explain additional variation in CAC. Evidence suggests that there may be different genetic etiologies for variation in CAC progression than for cross-sectional measures of CAC. Studies integrating multiple -omics data are providing new insights into the pathobiology of subclinical coronary atherosclerosis.

Summary: The future is promising for innovative studies utilizing whole genome sequencing data as well as other -omics such as epigenomic modifications of genes and gene expression. These studies may provide multiple sources of data pointing to the same gene or pathway, thus providing greater confidence in findings.

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亚临床冠状动脉粥样硬化的遗传学。

综述目的:本综述重点介绍了冠状动脉钙化(CAC)遗传学的最新发现，CAC是亚临床动脉粥样硬化负担的标志，是临床冠状动脉疾病的前兆。最近发现:CAC数量具有遗传性。对常见单核苷酸多态性的全基因组关联研究已经确定了能够解释约2.4% CAC遗传率的基因组区域。低频率和罕见的变异解释了CAC的其他变异。有证据表明，与CAC的横截面测量相比，CAC进展的变异可能存在不同的遗传病因。整合多组学数据的研究为亚临床冠状动脉粥样硬化的病理生物学提供了新的见解。摘要:利用全基因组测序数据以及其他组学如基因的表观基因组修饰和基因表达的创新研究前景广阔。这些研究可能提供指向同一基因或途径的多个数据来源，从而为研究结果提供更大的信心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Current genetic medicine reports

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