Critical care science最新文献

{"title":"Reply to: Death by community-based methicillin-resistant Staphylococcus aureus: case report.","authors":"Julia Lima Vieira, Tais Sica da Rocha, Francisco Bruno, Ruy Pezzi de Alencastro, Jefferson Pedro Piva","doi":"10.62675/2965-2774.20240155-en","DOIUrl":"10.62675/2965-2774.20240155-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240155en"},"PeriodicalIF":0.0,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11634237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741549","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognostic significance of gastrointestinal dysfunction in critically ill patients with COVID-19.","authors":"Ricardo Antônio Correia Lima, Annika Reintam Blaser, Júlia Falconiere Paredes Ramalho, Barbara Cristina de Almeida Campos Lacerda, Gabriela Sadigurschi, Paula Fonseca Aarestrup, Rafael Aguilar Sales, João Mansur Filho, Roberto Muniz Ferreira","doi":"10.62675/2965-2774.20240020-en","DOIUrl":"10.62675/2965-2774.20240020-en","url":null,"abstract":"<p><strong>Objective: </strong>To analyze in-hospital and 1-year morbidity and mortality associated with acute gastrointestinal dysfunction in critically ill patients with COVID-19 via a prespecified scoring system.</p><p><strong>Methods: </strong>Between March and July 2020, consecutive hospitalized patients with COVID-19 from a single institution were retrospectively analyzed by medical chart review. Only those who remained in the intensive care unit for more than 24 hours were included. Gastrointestinal dysfunction was assessed according to a predefined 5-point progressive gastrointestinal injury scoring system, considering the first 7 days of hospitalization. Laboratory data, comorbidities, the need for mechanical ventilation, the duration of intensive care unit stay, and subsequent in-hospital and 1-year mortality rates were also recorded.</p><p><strong>Results: </strong>Among 230 patients who were screened, 215 were included in the analysis. The median age was 68 years (54 - 82), and 57.7% were male. The total gastrointestinal dysfunction scores were 0 (79.1%), I (15.3%), II (4.7%), III (0.9%), and IV (0%). Any manifestation of gastrointestinal dysfunction was present in 20.9% of all patients and was associated with longer lengths of stay (20 days [11 - 33] versus 7 days [4 - 16]; p < 0.001] and higher C-reactive protein levels on admission (12.8mg/mL [6.4 - 18.4] versus 5.7mg/mL [3.2 - 13.4]; p < 0.001). The gastrointestinal dysfunction score was significantly associated with mortality (OR 2.8; 95%CI 1.7 - 4.8; p < 0.001) and the need for mechanical ventilation (OR 2.8; 95%CI 1.7 - 4.6; p < 0.001). Both in-hospital and 1-year death rates progressively increased as gastrointestinal dysfunction scores increased.</p><p><strong>Conclusion: </strong>In the current series of intensive care unit patients with COVID-19, gastrointestinal dysfunction severity, as defined by a prespecified scoring system, was predictive of adverse in-hospital and 1-year outcomes.</p>","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240020en"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554297/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reply to: Critical COVID-19 and neurological dysfunction - a direct comparative analysis between SARS-CoV-2 and other infectious pathogens.","authors":"Ana Teixeira-Vaz, José Artur Paiva","doi":"10.62675/2965-2774.20240180-en","DOIUrl":"10.62675/2965-2774.20240180-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240180en"},"PeriodicalIF":0.0,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142633658","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Optimization of antibiotic use in the intensive care unit: how we do it.","authors":"Patrícia Moniz, João Fustiga, Marta Maio Herculano, Pedro Póvoa","doi":"10.62675/2965-2774.20240017-en","DOIUrl":"10.62675/2965-2774.20240017-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240017en"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554294/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Andexanet alfa for the management of severe bleeding: what should critical care physicians know about it?","authors":"Felicio Savioli, Julyana Maiolino, Leonardo Rocha","doi":"10.62675/2965-2774.20240178-en","DOIUrl":"10.62675/2965-2774.20240178-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240178en"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463985/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity of illness scores in the pediatric intensive care unit: a practical guide.","authors":"María Del Pilar Arias López, Arnaldo Prata-Barbosa, Fernanda Lima-Setta","doi":"10.62675/2965-2774.20240205-en","DOIUrl":"10.62675/2965-2774.20240205-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240205en"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554295/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of pediatric acute potassium chloride correction infusions on the serum potassium concentration.","authors":"Jade Miller, Alex Dewar, Andrew Wignell, Patrick Davies","doi":"10.62675/2965-2774.20240113-en","DOIUrl":"10.62675/2965-2774.20240113-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240113en"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554296/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the effectiveness of awake-prone positioning and high-flow nasal oxygen in patients with COVID-19-related acute respiratory failure between different waves.","authors":"Mariano Esperatti, Matías Olmos, Marina Busico, Adrian Gallardo, Alejandra Vitali, Jorgelina Quintana, Hiromi Kakisu, Bruno Leonel Ferreyro, Nora Angélica Fuentes, Javier Osatnik, Santiago Nicolas Saavedra, Agustin Matarrese, Greta Dennise Rebaza Niquin, Elizabeth Gisele Wasinger, Giuliana Mast, Facundo Juan Andrada, Ana Inés Lagazio, Nahuel Esteban Romano, Marisol Mariela Laiz, Jose Garcia Urrutia, Mariela Adriana Mogaadouro, Micaela Ruiz Seifert, Emilce Mastroberti, Claudia Navarro Moreno, Anabel Miranda Tirado, María Constanza Viñas, Juan Manuel Pintos, Maria Eugenia Gonzalez, Maite Mateos, Verónica Barbaresi, Ana Elizabeth Grimbeek, Leonel Stein, Ariel Juan Latronico, Silvia Laura Menéndez, Alejandra Dominga Basualdo, Romina Castrillo","doi":"10.62675/2965-2774.20240065-en","DOIUrl":"10.62675/2965-2774.20240065-en","url":null,"abstract":"<p><strong>Objective: </strong>To compare the effectiveness of the awake-prone position on relevant clinical outcomes in patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen between different waves in Argentina.</p><p><strong>Methods: </strong>This multicenter, prospective cohort study included adult patients with COVID-19-related acute respiratory failure requiring high-flow nasal oxygen. The main exposure position was the awake-prone position (≥ 6 hours/day) compared to the non-prone position. The primary outcome was endotracheal intubation, and the secondary outcome was in-hospital mortality. The inverse probability weighting-propensity score was used to adjust the conditional probability of treatment assignment. We then adjusted for contextual variables that varied over time and compared the effectiveness between the first and second waves.</p><p><strong>Results: </strong>A total of 728 patients were included: 360 during the first wave and 368 during the second wave, of whom 195 (54%) and 227 (62%) remained awake-prone for a median (p25 - 75) of 12 (10 - 16) and 14 (8 - 17) hours/day, respectively (Awake-Prone Position Group). The ORs (95%CIs) for endotracheal intubation in the Awake-Prone Position Group were 0.25 (0.13 - 0.46) and 0.19 (0.09 - 0.31) for the first and second waves, respectively (p = 0.41 for comparison between waves). The ORs for in-hospital mortality in the awake-prone position were 0.35 (0.17 - 0.65) and 0.22 (0.12 - 0.43), respectively (p = 0.44 for comparison between waves).</p><p><strong>Conclusion: </strong>The awake-prone position was associated with a reduction in the risk of endotracheal intubation and in-hospital mortality. These effects were independent of the context in which the intervention was applied, and no differences were observed between the different waves.</p>","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240065en"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11484112/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514039","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To: Outcomes of critically ill pregnant COVID-19 patients: a cohort study.","authors":"Josef Finsterer","doi":"10.62675/2965-2774.20240122-en","DOIUrl":"10.62675/2965-2774.20240122-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240122en"},"PeriodicalIF":0.0,"publicationDate":"2024-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11554299/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142514043","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Delirium severity in the intensive care unit.","authors":"Rodrigo Bernardo Serafim, Maria Carolina Paulino, Tarek Sharshar, Bertrand Hermann","doi":"10.62675/2965-2774.20240139-en","DOIUrl":"https://doi.org/10.62675/2965-2774.20240139-en","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"36 ","pages":"e20240139en"},"PeriodicalIF":0.0,"publicationDate":"2024-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11463989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142486069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}