Critical care science最新文献

The clinical significance of intracranial pressure waveform analysis in brain-injured patients. 颅脑损伤患者颅内压波形分析的临床意义。

Critical care science Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260081

Sérgio Brasil, Fabio Silvio Taccone

引用次数: 0

The intensive care unit balancing act: integrated staffing models for better patient ratios. 重症监护室平衡行为：综合人员配置模式，以提高患者比例。

Critical care science Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260088

Nicole M Thomasian, Hayley B Gershengorn, Hannah Wunsch

引用次数: 0

Towards a common core dataset for critical care: a registry-centered vision for global improvement. 迈向重症监护的共同核心数据集：以注册中心为中心的全球改进愿景。

Critical care science Pub Date : 2026-04-17 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260338

Vrindha Pari, David Pilcher, Luigi Pisani

引用次数: 0

Distinct venous thrombotic phenotypes exist in the critically ill. 在危重病人中存在不同的静脉血栓表型。

Critical care science Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260044

Nicole P Juffermans, Marieke J H A Kruip, Henrik Endeman

引用次数: 0

Adaptation of the Spanish model of organ donation: experience from a public hospital in Argentina. 西班牙器官捐献模式的适应：阿根廷一家公立医院的经验。

Critical care science Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260264

Nicolás Sebastián Rocchetti, Julián Pablo Juárez, Ender Azuaje, Pablo Centeno

引用次数: 0

Five things the intensivist cannot forget in the management of invasive candidiasis. 在处理侵袭性念珠菌病时，强化医生不能忘记的五件事。

Critical care science Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260217

José-Artur Paiva, Cidália Pina-Vaz, José Manuel Pereira

引用次数: 0

Sleep fragmentation, impaired glymphatic clearance, and long-term cognitive impairment after critical illness. 危重疾病后的睡眠片段化、淋巴清除受损和长期认知障碍。

Critical care science Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260042

Fawaz Alshammari, Samantha A Keil, Mary Elizabeth Wilcox

{"title":"Sleep fragmentation, impaired glymphatic clearance, and long-term cognitive impairment after critical illness.","authors":"Fawaz Alshammari, Samantha A Keil, Mary Elizabeth Wilcox","doi":"10.62675/2965-2774.20260042","DOIUrl":"10.62675/2965-2774.20260042","url":null,"abstract":"Sleep disruption is nearly universal during critical illness and is increasingly linked to long-term cognitive impairment among intensive care unit survivors. Advances in neuroscience have highlighted the glymphatic system - a brain-wide perivascular network that clears metabolic waste such as β-amyloid and phosphorylated tau - as a plausible mechanism connecting sleep disturbance to adverse neurocognitive outcomes. Glymphatic transport is highly state-dependent, functioning optimally during slow-wave sleep and diminishing with wakefulness or fragmented sleep. This invited review synthesizes preclinical and human evidence showing that sleep fragmentation and loss of slow-wave sleep impair cerebrospinal fluid-interstitial fluid exchange, promote accumulation and spread of tau and other neurotoxic proteins, and may accelerate neurodegenerative trajectories. We discuss how commonly used sedatives may induce unconsciousness without reproducing the coordinated neuromodulatory and neurovascular conditions of natural slow-wave sleep, creating \"pseudo-sleep\" that may fail to support metabolic clearance. We propose glymphatic dysfunction as an integrative pathway linking intensive care unit sleep disruption, inflammation, and sedative exposure to persistent deficits in memory, attention, and executive function after critical illness.","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260042"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13124093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Planning for predictable emergency admissions to improve patient access and flow. 规划可预测的急诊入院，以改善病人的访问和流量。

Critical care science Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260175

Airton Leonardo de Oliveira Manoel, Kathryn Chalklin, Elizabeth Butorac, Mary Copeland, Sandro B Rizoli, Sonya Canzian, Andrew Baker

{"title":"Planning for predictable emergency admissions to improve patient access and flow.","authors":"Airton Leonardo de Oliveira Manoel, Kathryn Chalklin, Elizabeth Butorac, Mary Copeland, Sandro B Rizoli, Sonya Canzian, Andrew Baker","doi":"10.62675/2965-2774.20260175","DOIUrl":"10.62675/2965-2774.20260175","url":null,"abstract":"Objective: To implement and evaluate a new inpatient flow process designed to reduce overnight transfers, decrease Emergency Department length of stay, and improve overall hospital throughput.Methods: A two-phase quality improvement initiative was conducted using the DMAIC (Define, Measure, Analyze, Improve, Control) framework. In Phase 1, \"flow beds\" were introduced to minimize overnight patient transfers and enhance staff and patient experiences. Phase 2 implemented an early morning transfer process from the trauma and neurosurgery intensive care unit to the trauma and neurosurgery inpatient ward, aligning intensive care unit capacity with anticipated daily demand. The effectiveness of the interventions was assessed using a before-and-after study design.Results: Flow beds were successfully created in over 85% of eligible cases, reducing overnight transfers to alternate units by more than 50%. Emergency Department length of stay and decision-to-admit times improved by 25% and 43%, respectively, at the 90th percentile (p < 0.05). Total inpatient length of stay decreased by 11% (approximately 1 day). In Phase 2, early trauma and neurosurgery intensive care unit discharges occurred in 50% of cases, eliminating surgical cancellations due to intensive care unit bed shortages during the study period.Conclusion: Proactive inpatient flow strategies focused on demand-capacity alignment significantly improved Emergency Department and inpatient metrics, while reducing intensive care unit-related surgical delays.","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260175"},"PeriodicalIF":0.0,"publicationDate":"2026-03-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12977223/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147596522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A critical use of peripherally inserted central catheters in the intensive care unit. 外周插入中心导管在重症监护病房的关键应用。

Critical care science Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260237

Viviane Cordeiro Veiga, Pedro Henrique Rigotti Soares, André Kalil, Pedro Póvoa

引用次数: 0

International collaboration in critical care research: a 5-year bibliometric analysis of disparities between critical care studies in developed in high- and middle-/low-income countries. 重症监护研究的国际合作：高、中/低收入发达国家重症监护研究差异的5年文献计量分析

Critical care science Pub Date : 2026-03-30 eCollection Date: 2026-01-01 DOI: 10.62675/2965-2774.20260420

Renato Daltro-Oliveira, Victor Hugo Ferreira, Amanda Quintairos, Filipe Sousa Amado, Laura Inez de Oliveira Santos, Jorge Ibrain Figueira Salluh, Antonio Paulo Nassar Júnior

引用次数: 0