Critical care science最新文献

{"title":"Beyond survival: the imperative, innovation, and implementation of long-term intensive care unit follow-up.","authors":"José Mário Meira Teles, João Gabriel Rosa Ramos, David Pilcher","doi":"10.62675/2965-2774.20260479","DOIUrl":"10.62675/2965-2774.20260479","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260479"},"PeriodicalIF":0.0,"publicationDate":"2026-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149119452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intensive care unit admission among adults with tuberculosis: a systematic review of clinical characteristics.","authors":"Marjorie Fairuzy Stolarz, Melissa Ferrari Gomes, Gabriel Pavinati, Matheus Cordeiro Marchiotti, Francisco Beraldi de Magalhães, Gabriela Tavares Magnabosco","doi":"10.62675/2965-2774.20260018","DOIUrl":"10.62675/2965-2774.20260018","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260018"},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042172","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prolonged capillary refill time is associated with intolerance to enteral nutrition in critically ill patients.","authors":"Lucas Vieira de Souza, Magno Tauceda Borges, Gilberto Friedman, Rafael Barberena Moraes","doi":"10.62675/2965-2774.20260017","DOIUrl":"10.62675/2965-2774.20260017","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260017"},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Characterization of weaning practices in intensive care units in Global South countries: a clinical practice survey.","authors":"Roque Basoalto Escobar, Aline Braz Pereira, Glauco Adrieno Westphal, Madiha Hashmi, Santiago Lucas Napoli, Senthilkumar Rajagopal, Bharath Kumar Tirupakuzhi Vijayaraghavan, Moses Siaw-Frimpong, Cornelius Sendagire, Mohd Shahnaz Hasan, Chun Pan, Jing-Chao Luo, Nicolas Nin, Miguel Ibarra-Estrada, Carlos Alberto Lescano-Alva, Luis Felipe Reyes, Ignacio Granda Luna, Diptesh Aryal, Alejandro Bruhn, Gustavo Adolfo Ospina-Tascón, Eduardo Kattan, Alexandre Biasi Cavalcanti","doi":"10.62675/2965-2774.20260112","DOIUrl":"10.62675/2965-2774.20260112","url":null,"abstract":"<p><strong>Objective: </strong>To characterize current practices and protocols for mechanical ventilation weaning in intensive care units in Global South countries, describing practice variability and identifying opportunities for standardization that may reduce extubation failure.</p><p><strong>Methods: </strong>We conducted an international, multicenter electronic survey of healthcare professionals working in intensive care units across Global South countries. A structured questionnaire collected data on current weaning practices, including weaning protocols, spontaneous breathing trials, extubation criteria, post-extubation respiratory support, and management of high-risk patients. Descriptive analyses were used to summarize institutional characteristics and clinical practices.</p><p><strong>Results: </strong>Of 1,098 responses, 738 participants from Global South intensive care units were included (Latin America: 427, Asia: 278, and Africa: 33). Most respondents were physicians working in mixed medical-surgical units, with a median of 16 intensive care unit beds and substantial variability in staffing ratios across regions. Overall, 74% of intensive care units reported a weaning protocol. The spontaneous breathing trial was the most common method to assess extubation readiness, predominantly using pressure support with positive end-expiratory pressure in high-risk patients, although marked regional variation was observed. Return to mechanical ventilation for 1 hour after a successful spontaneous breathing trial was reported in 20% of cases. Post-extubation respiratory support also varied widely, with non-invasive ventilation more frequently used in Asia and Brazil and high-flow nasal cannula in Africa and China.</p><p><strong>Conclusion: </strong>Weaning practices in Global South intensive care units are highly heterogeneous. Despite widespread use of key evidence-based strategies, variability in spontaneous breathing trial techniques and post-extubation support highlights the need for context-adapted guidelines and targeted research to improve extubation outcomes.</p>","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260112"},"PeriodicalIF":0.0,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149042205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HbA1c-based personalization of glucose management in critical illness: a target trial emulation.","authors":"Joseph Furler, Frank M Gao, Aniket Nadkarni, Meg Stevens, Dinesh Pandey, Hossein Jahanabadi, Ary Serpa Neto","doi":"10.62675/2965-2774.20260001","DOIUrl":"10.62675/2965-2774.20260001","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the effect of HbA1c-guided glycaemic control on 30-day intensive care unit mortality in intensive care unit patients.</p><p><strong>Design: </strong>Target trial emulation using the parametric g-formula. Setting: A single tertiary academic hospital intensive care unit in Melbourne, Australia. Patients: All adults admitted between January 2019 and December 2023 with an admission HbA1c measurement and complete intensive care unit admission/discharge data. Interventions: Three glucose control strategies were compared: natural course (usual care), NICE-SUGAR target (8 - 10mmol/L), and personalised HbA1c-guided target (usual glycaemia ± 0.8mmol/L).</p><p><strong>Results: </strong>Among 3,541 patients (64% male, median age 68 years), mortality was 6.46% (95%CI 4.16% - 8.83%) under the natural course, 6.52% (95%CI 4.40% - 8.82%) with NICE-SUGAR, and 6.56% (95%CI 4.40% - 8.85%) with HbA1c-guided targets. Absolute risk differences versus usual care was 0.10% (95%CI -0.26% - 0.93) for HbA1c-guided strategy. Subgroup analyses by diabetes status, admission type, illness severity, and septic shock showed no survival benefit.</p><p><strong>Conclusion: </strong>In this large single-centre target trial emulation, personalising glycaemic targets based on admission HbA1c did not improve 30-day intensive care unit mortality compared with either usual care or NICE-SUGAR targets. These findings suggest that HbA1c-guided glucose control is unlikely to confer meaningful survival benefit under current implementation approaches.</p>","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260001"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690041/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To: Diagnostic accuracy of lung ultrasound in children with respiratory pathology admitted in a pediatric intensive care unit of a low-resource setting: a single-center experience.","authors":"Mohd Saif Khan, Anis Chaari","doi":"10.62675/2965-2774.20260154","DOIUrl":"10.62675/2965-2774.20260154","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260154"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To: What's the best strategy for biomarker-guided antibiotic therapy in sepsis.","authors":"Vanessa Soares Lanziotti, Roberto Jabornisky, Saraswati Kache","doi":"10.62675/2965-2774.20260185-2","DOIUrl":"10.62675/2965-2774.20260185-2","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e202601852"},"PeriodicalIF":0.0,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690023/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148992684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antifungal use with and without fungal diagnoses among patients with septic shock in a retrospective multicenter cohort.","authors":"Robert J Flick, Li Yan, Nicholas A Bosch, Anica C Law, Khyzer B Aziz, Chad H Hochberg, Joseph Levy, Theodore J Iwashyna","doi":"10.62675/2965-2774.20260094","DOIUrl":"10.62675/2965-2774.20260094","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260094"},"PeriodicalIF":0.0,"publicationDate":"2026-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13690028/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"To: The efficacy of high-flow nasal cannula versus non-invasive mechanical ventilation in preventing reintubation in patients at high risk of extubation failure: systematic review and meta-analysis with trial sequential analysis.","authors":"Yeşim Şerife Bayraktar","doi":"10.62675/2965-2774.20260223","DOIUrl":"10.62675/2965-2774.20260223","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e20260223"},"PeriodicalIF":0.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518003/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889458","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond bed counts: equity and access to adult intensive care in middle-income countries, the Brazilian case.","authors":"Ederlon Rezende, Cristiano Augusto Franke, Patrícia Machado Veiga de Carvalho Mello, Jorge Ibrain Figueira Salluh, Rui Moreno","doi":"10.62675/2965-2774.20260158-2","DOIUrl":"10.62675/2965-2774.20260158-2","url":null,"abstract":"","PeriodicalId":72721,"journal":{"name":"Critical care science","volume":"38 ","pages":"e202601582"},"PeriodicalIF":0.0,"publicationDate":"2026-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13518004/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148889308","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}