COVID最新文献

{"title":"Housing Status and COVID-19 Prevention Recommendations among People Who Use Drugs","authors":"Izza Zaidi, Ashly E. Jordan, Lauren Jessell, Leonardo Dominguez Gomez, Alex Harocopos, Michelle Nolan","doi":"10.3390/covid3100110","DOIUrl":"https://doi.org/10.3390/covid3100110","url":null,"abstract":"Housing conditions can increase health risks for people who use opioids (PWUO). Little research documents the influence of housing on PWUO’s ability to practice disease prevention methods. This study examines associations between housing status of PWUO in NYC and their ability to practice COVID-19 prevention recommendations during the initial wave of the pandemic. Participants were recruited via convenience sampling and administered a survey. Eligibility required age ≥18 years, using opioids ≥3times in the prior 30 days, and accessing a health-related service in the prior year. Descriptive and bivariate statistics assessed relationships between housing and the ability to practice social distancing, access soap and running water or hand sanitizer (soap), and access face masks. Multivariable Poisson regression was used to examine relationships between housing and the potential to practice COVID-19 prevention recommendations. The 329 participants were grouped into stable housing (34.3%), unstable/shelter housing (31.9%), and street homeless (33.7%) categories. Street homeless PWUO were significantly less likely to have access to soap and face masks than those stably housed. There were no significant differences between PWUO experiencing unstable and stable housing. PWUO experiencing street homelessness may have had increased vulnerability to COVID-19. Providing low-threshold health-related resources and increasing linkages to housing opportunities could promote health of PWUO experiencing street homelessness during future emergencies.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"495 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135993402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in Lifestyle Habits in Individuals with Diabetes during the COVID-19 Pandemic: The ELSA-Brasil Cohort Study","authors":"William Jones Dartora, Maria Inês Schmidt, Rosane Harter Griep, Bruce B. Duncan","doi":"10.3390/covid3100109","DOIUrl":"https://doi.org/10.3390/covid3100109","url":null,"abstract":"The COVID-19 pandemic and society’s response to it may have constrained the ability of those with diabetes to achieve a healthy lifestyle. We conducted a longitudinal study to assess the frequency and magnitude of sedentary habits, physical activity, sleep, alcohol consumption, weight, and smoking from July 2020 to February 2021 and compared these levels to those before the pandemic (2017–2019) in 1082 participants of the ELSA-Brasil study with known diabetes. Our results showed that inappropriate sleep duration was common (649, 68.9%) before the pandemic. Many (447, 31.1%) with this problem achieved an adequate sleep duration during the pandemic. Significant increases occurred in time in front of screens (1.3; 95%CI 0.66–2.11 h/day) and time sitting or reclining (1.4, 95%CI 0.8–2.3 h/day). Physical activity decreased (270, 95%CI 243–298 MET-min/wk). Alcohol consumption decreased without statistical significance (−19.6, 95%CI −51.1–11.9 g/w). In general, changes were similar between diabetics and non-diabetics, except that screen time in-creased less (−0.18, −0.35–−0.01 h/day) for those with diabetes. Sleep duration improved, but the frequency of sedentary habits increased, and physical activity decreased during the pandemic. Understanding changes brought on by the pandemic is essential to facilitate the implementation of quality health care for those with diabetes in moments of social stress.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"10 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135969469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2: An Update on the Biological Interplay with the Human Host","authors":"Giuseppe Lippi, Fabian Sanchis-Gomar, Camilla Mattiuzzi, Brandon M. Henry","doi":"10.3390/covid3100108","DOIUrl":"https://doi.org/10.3390/covid3100108","url":null,"abstract":"Coronavirus Disease 2019 (COVID-19) is an infectious respiratory illness caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The disease, first identified in the Chinese city of Wuhan in November 2019, has since spread worldwide, is the latest human pandemic and has officially infected over 800 million people and has caused nearly seven million deaths to date. Although SARS-CoV-2 belongs to the large family of coronaviruses, it has some unique biological characteristics in its interplay with the human host. Therefore, this narrative review aims to provide an up-to-date overview of the structure of the virus, incubation and shedding in the human host, infectivity and biological evolution over time, as well as the main mechanisms for invading human host cells and replicating within. We also proffer that ongoing epidemiological surveillance of newly emerged variants must always be accompanied by biological studies aimed at deciphering new advantageous traits that may contribute to increasing virulence and pathogenicity, such that the most appropriate strategies for establishing a (relatively) safe coexistence with the human host can be implemented.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"178 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136358389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychotherapy Incorporating Equine Interaction as a Complementary Therapeutic Intervention for Young Adults in a Residential Treatment Program during the COVID-19 Pandemic","authors":"Katie Holtcamp, Molly C. Nicodemus, Tommy Phillips, David Christiansen, Brian J. Rude, Peter L. Ryan, Karen Galarneau","doi":"10.3390/covid3100107","DOIUrl":"https://doi.org/10.3390/covid3100107","url":null,"abstract":"Substance use disorder has become an epidemic in the young adult population across the United States, and these numbers rose during the COVID-19 pandemic. Psychotherapy incorporating equine interaction has emerged to show promise in the mental health community as a complementary form of therapy for this age group and offered a viable treatment option during the pandemic due to the outdoor nature of the treatment environment. However, research concerning its use within a residential treatment program was lacking. The objective of this study was to evaluate the efficacy of psychotherapy incorporating equine interaction in a residential treatment program during the COVID-19 pandemic for developing an emotionally safe environment for learning for young adults. Participants (ages 18–25 years) were those in a substance abuse residential treatment program utilizing psychotherapy incorporating equine interaction during the COVID-19 pandemic. Participants were involved in weekly equine therapy for 2–7 weeks. Participants were divided according to length of stay at the residential facility and participation level with equine interactive activities. Assessment of emotional safety and long-term memory development was performed at the beginning and end of the treatment program. The development of memories centered around equine information that was covered during the treatment program. Semantic memory was assessed using a self-reporting knowledge exam and procedural memory was assessed using a skill evaluation. Emotional safety was determined using a self-reporting survey instrument. Paired t-tests determined significant improvement in emotional safety (p = 0.02) and semantic (p = 0.01) and procedural (p = 0.00) memory for all participants by the end of the program. The one-way analysis of variance indicated length of stay and participation level were not significant indicators of emotional safety (length of stay: p = 0.91, participation level: p = 0.98) and semantic (length of stay: p = 0.09, participation level: p = 0.60) and procedural (length of stay: p = 0.25, participation level: p = 0.09) memory development. These results suggest psychotherapy incorporating equine interaction was an efficient complementary therapeutic intervention for developing emotional safety and encouraging learning in a young-adult residential addiction treatment program during the COVID-19 pandemic.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"66 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135548351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The rs2228145 Variant of the Interleukin-6 Receptor (IL-6R) Gene Impacts on In Vitro Cellular Responses to SARS-CoV-2 VOC B1.1.7 Recombinant Spike Protein","authors":"Saira Sarwar, Rebecca Aicheler, Lee Butcher, Katie Rees, Stephen Potter, Richard Rowlands, Richard Webb","doi":"10.3390/covid3100106","DOIUrl":"https://doi.org/10.3390/covid3100106","url":null,"abstract":"Given the variability in inflammatory responses to SARS-CoV-2 infection observed within human populations, we aimed to develop an in vitro model system (based on monocyte-macrophages, a key relevant cell type) that could yield insights regarding the impact of rs2228145, a clinically relevant polymorphism within the coding region of a key inflammatory gene in the body’s response to SARS-CoV-2 infection: the interleukin-6 receptor (IL-6R) gene. Three monocyte-macrophage cell-lines (U937, THP-1, MM6) were shown to exhibit AA, AC and CC rs2228145 genotypes, respectively, and to exhibit an MM6 > THP-1 > U937 pattern regarding basal levels of soluble IL-6R (sIL-6R) release. Similar MM6 > THP-1 > U937 patterns were seen regarding the extents to which (i) circulating levels of the IL-6/sIL-6R ‘active complex’ increased and (ii) phosphorylation of the downstream transcription-factor STAT3 occurred, following treatment with SARS-CoV-2 spike protein (SP). Moreover, a blocking antibody for the ACE-2 entry receptor for SARS-CoV-2 suppressed effects (i) and (ii), suggesting that interaction between SP and ACE-2 is the initial event that triggers IL-6/IL-6R signalling in our system. Production of IL-8 occurred to greater extents in A549 lung epithelial cells treated with tissue-culture supernatants from SP-treated MM6 cultures than SP-treated THP-1 or U937 cultures. Our data indicate that the rs2228145 genotype significantly impacts upon SP-associated IL-6/sIL-6R signalling in vitro, suggesting that it may influence in vivo risk of developing severe COVID-19 and/or long-COVID symptoms following infection by SARS-CoV-2. Thus, the rs2228145 genotype may have potential as a biomarker that differentiates between patients at risk of developing severe and/or prolonged symptoms following infection by SARS-CoV-2 and those who are at less risk.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"87 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135739293","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perceived Stress and Coping among University Students Amidst COVID-19 Pandemic","authors":"Coral L. Shuster, Marie C. Tate, Christina T. Schulz, Cheyenne T. Reyes, Megan M. Drohan, Angela G. Astorini, Amy L. Stamates, Manshu Yang, Mark L. Robbins","doi":"10.3390/covid3100105","DOIUrl":"https://doi.org/10.3390/covid3100105","url":null,"abstract":"University students may have experienced heightened levels of stress during the COVID-19 pandemic; however, less is known about coping mechanisms (i.e., approach and avoidance) that were used to manage such stress. Further, there is a need to identify groups of students who may have been at elevated risk for stress. The present study examined the association between coping and perceived stress and whether there were differences in stress based on sociodemographic factors and COVID-19-related changes in employment, housing, and income. Data were collected from 150 university students between the ages of 18 and 25 years (M = 20.68; SD = 1.73). Results indicated that those who endorsed more approach coping skills had lower levels of stress and those who endorsed more avoidance coping skills had higher levels of stress. Additionally, females, those who lost income, and non-heterosexual individuals endorsed higher levels of stress. The results demonstrate the importance of targeted discussions with university students regarding stressors and coping mechanisms.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"21 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135246202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of COVID-19 Vaccination on Transmission: A Systematic Review","authors":"Anouk Oordt-Speets, Julia Spinardi, Carlos Mendoza, Jingyan Yang, Graciela Morales, John M. McLaughlin, Moe H. Kyaw","doi":"10.3390/covid3100103","DOIUrl":"https://doi.org/10.3390/covid3100103","url":null,"abstract":"Vaccination against infectious disease affords direct protection from vaccine-induced immunity and additional indirect protection for unvaccinated persons. A systematic review was conducted to estimate the indirect effect of COVID-19 vaccination. From PubMed and Embase, 31 studies were included describing the impact of original wild-type COVID-19 vaccines on disease transmission or viral load. Overall, study results showed the effectiveness of COVID-19 vaccination against SARS-CoV-2 transmission (range 16–95%), regardless of vaccine type or number of doses. The effect was apparent, but less pronounced against omicron (range 24–95% for pre-omicron variants versus 16–31% for omicron). Results from viral load studies were supportive, showing SARS-CoV-2 infections in vaccinated individuals had higher Ct values, suggesting lower viral load, compared to infections among the unvaccinated. Based on these findings, well-timed vaccination programs may help reduce SARS-CoV-2 transmission—even in the omicron era. Whether better-matched vaccines can improve effectiveness against transmission in the omicron era needs further study.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"31 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Staff COVID-19 Pandemic Survey-Results from the Prevention and Early Treatment of Acute Lung Injury (PETAL) Network","authors":"Jasreen Kaur Gill, Andrew Bissonette, Aaron A. Cook, Anja Kathrin Jaehne, Jacqueline Day, Sheri Renaud, Gordon Jacobsen, Kristine Nelson, Lori-Ann Kozikowski, Namita Jayaprakash, Jayna Gardner-Gray, Jennifer Swiderek, Cathryn F. Oldmixon, Nancy J. Ringwood, Robert L. Sherwin, Mark D. Williams, Arielle Hodari Gupta, Nicholas J. Johnson, Robert C. Hyzy, Pauline K. Park, Emanuel P. Rivers","doi":"10.3390/covid3100104","DOIUrl":"https://doi.org/10.3390/covid3100104","url":null,"abstract":"Objectives: There is a lack of knowledge about the challenges of researchers who continued in-person research during the early phases of the COVID-19 pandemic. Design: Electronic survey assessing work-related exposure to COVID-19, logistical challenges, and procedural changes during the first year of the COVID-19 pandemic on clinical research. Setting: National Heart, Lung, and Blood Institute-sponsored Prevention and Early Treatment of Acute Lung Injury Clinical Trial Network Centers. Subjects: Research staff at research Network Sites. Measurements and Main Results: The 37-question survey was completed by 277 individuals from 24 states between 29 September 2020, and 12 December 2020, yielding a response rate of 37.7%. Most respondents (91.5%) indicated that non-COVID-19 research was affected by COVID-19 research studies. In response to the COVID-19 pandemic, 20% of respondents were reassigned to different roles at their institution. Many survey takers were exposed to COVID-19 (56%), with more than 50% of researchers requiring a COVID-19 test and 8% testing positive. The fear of infection was 2.7-times higher compared to pre-COVID-19 times. Shortages of personal protective equipment were encountered by 34% of respondents, primarily due to lack of access to N95 masks, followed by gowns and protective eyewear. Personal protective equipment reallocation from research to clinical use was reported by 31% of respondents. Most of the respondents (88.5%), despite these logistical challenges, indicated their willingness to enroll COVID-19 patients. Conclusions: During the first year of the COVID-19 pandemic, members of the research network were engaged in COVID-19 research despite logistical challenges, limited access to personal protective equipment, and fear of exposure. The research network’s survey experience can inform ongoing policy discussions to create research enterprises that can dexterously refocus research to address the knowledge gaps associated with novel public health emergencies while mitigating the effect of pandemics on existing research projects and research personnel.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135966102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Learning from Latin America: Coordinating Policy Responses across National and Subnational Levels to Combat COVID-19","authors":"Michael M. Touchton, Felicia Marie Knaul, Hector Arreola-Ornelas, Renzo Calderon-Anyosa, Silvia Otero-Bahamón, Calla Hummel, Pedro Pérez-Cruz, Thalia Porteny, Fausto Patino, Patricia J. Garcia, Jorge Insua, Oscar Mendez, Carew Boulding, Jami Nelson-Nuñez, V. Ximena Velasco Guachalla","doi":"10.3390/covid3090102","DOIUrl":"https://doi.org/10.3390/covid3090102","url":null,"abstract":"We provide policy lessons for governments across Latin America by drawing on an original dataset of daily national and subnational non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic for eight Latin American countries: Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, Mexico, and Peru. Our analysis offers lessons for health system decision-making at various levels of government and highlights the impact of subnational policy implementation for responding to health crises. However, subnational responses cannot replace coordinated national policy; governments should emphasize the vertical integration of evidence-based policy from national to local levels while tailoring local policies to local conditions as they evolve. Horizontal policy integration across sectors and jurisdictions will also improve coordination at each level of government. The Latin American experiences with policy and politics during the COVID-19 pandemic project glocal health policy recommendations that connect global considerations with local needs.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"38 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"136236440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosocial and Economic Risks of Institutional Quarantine in a Low-Resource Setting: Experiences of Affected Persons during the COVID-19 Pandemic in Uganda","authors":"Esther K. Nanfuka, Agatha Kafuko, Rita Nakanjako, James T. Ssenfuuma, Florence Turyomurugyendo, Jingo Kasule","doi":"10.3390/covid3090101","DOIUrl":"https://doi.org/10.3390/covid3090101","url":null,"abstract":"Institutional quarantine was one of the key public health measures used to control the spread of the Corona Virus Disease 2019 (COVID-19). Institutional quarantine has been associated with several psychosocial and economic risks. However, little is known about the psychosocial and economic risks it poses to affected persons in low-resource countries since it is a relatively new strategy for controlling disease spread in these settings. This article provides insights into the economic and psychosocial risks encountered by affected persons in a low-resource context. Narrative interviews were conducted with 20 adults placed under institutional quarantine to contain the COVID-19 pandemic in Uganda. Individuals confined in institutional quarantine experienced an intricate range of economic and psychosocial risks including loss of livelihood and/or income, financial distress, fear, worry, anger, loneliness, and stigma. The experience of specific risks was shaped by an intersection between individual and contextual factors. However, disregard for economic and social issues and shortcomings in the implementation of institutional quarantine contributed profoundly to the occurrence of risks. Safety nets to address the emergent financial insecurities of quarantined individuals and their families and bridging gaps in the implementation of institutional quarantine may help to minimise the associated economic and psychosocial risks in Uganda and similar contexts.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135207533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}