COVID最新文献

{"title":"Gene-Level Analyses of Novel Olfactory-Related Signal from Severe SARS-CoV-2 GWAS Reveal Association with Disease Mortality.","authors":"Yu Chen Zhao, Xinan Wang, Yujia Lu, Rounak Dey, Yuchen Liu, Francesca Giacona, Elizabeth A Abe, Emma White, Li Su, Qingyi Wei, Xihong Lin, Lorelei A Mucci, Jehan Alladina, David C Christiani","doi":"10.3390/covid5120206","DOIUrl":"10.3390/covid5120206","url":null,"abstract":"<p><strong>Importance: </strong>The coronavirus disease 2019 (COVID-19) was the third leading cause of mortality in the United States for three years in a row. The genetic contributions to disease severity remain unclear and many previously identified single nucleotide polymorphisms (SNPs) have not been replicated nor linked with functional significance.</p><p><strong>Objective: </strong>To identify SNPs associated with mortality among hospitalized COVID-19 patients supplemented by expression quantitative trait loci (eQTL) evidence to infer plausible functional mechanisms related to COVID-19 severity.</p><p><strong>Design: </strong>A quality-controlled genome-wide association study (GWAS) supported by robust gene-level omnibus kernel association tests (SKAT-O), functional prediction, and eQTL analyses of the top GWAS signal.</p><p><strong>Setting: </strong>Massachusetts General Hospital (MGH).</p><p><strong>Participants: </strong>370 adult ICU patients with SARS-CoV-2 infection and acute hypoxemic respiratory failure and floor patients with mild hypoxemia managed with supplemental oxygen consecutively admitted to MGH between March and June 2020 (Surge 1), and January and March 2021 (Surge 2) with baseline clinical characteristics and demographics collected.</p><p><strong>Exposures: </strong>Low-pass genotyped SNPs from whole blood and aggregated SNP-sets of potential disease susceptibility loci with ±500 kb flanking regions.</p><p><strong>Main outcomes & measures: </strong>Genome-wide individual SNP associations and SNP-set associations with mortality outcomes from 370 severe COVID-19 cases.</p><p><strong>Results: </strong>After LD pruning (<0.8) and false discovery rate adjustment (<0.05), we identified rs7420371 G>A of the receptor transporter protein 5 (<i>RTP5</i>) gene as the top independent signal significantly associated with 30- and 60-day mortality among severe COVID-19 patients (OR, 2.32; 95% CI, 1.59-3.39; <i>p</i> = 4.92 × 10^-9 and OR, 2.06; 95% CI, 1.43-2.97; <i>p</i> = 5.43 × 10^-8, respectively). SKAT-O analyses on the <i>RTP5</i> SNP-set showed associations with both mortality outcomes (<i>p</i> = 5.90 × 10^-5 and 6.17 × 10^-5, respectively). eQTL analysis showed rs7420371 A allele significantly upregulated the mRNA expression of <i>RTP5</i> in 266 cerebellum tissues, in 277 cerebellar hemisphere tissues, and in 270 cerebral cortex samples.</p><p><strong>Conclusions & relevance: </strong>We discovered a novel, independent, and potentially functional SNP <i>RTP5</i> rs7420371 G>A to be significantly associated with COVID-19 mortality. The A allele is significantly associated with elevated mRNA expression of <i>RTP5</i> in the brain, an important protein coding gene that modulates olfactory binding and taste perceptions in response to SARS-CoV-2 infection.</p>","PeriodicalId":72714,"journal":{"name":"COVID","volume":"5 12","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12981488/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147470455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk of SARS-CoV-2 Infection Among Hospital-Based Healthcare Workers in Thailand at Myanmar Border, 2022.","authors":"Narumol Sawanpanyalert, Nuttagarn Chuenchom, Meng-Yu Chen, Peangpim Tantilipikara, Suchin Chunwimaleung, Tussanee Nuankum, Yuthana Samanmit, Brett W Petersen, James D Heffelfinger, Emily Bloss, Somsak Thamthitiwat, Woradee Lurchachaiwong","doi":"10.3390/covid5080115","DOIUrl":"10.3390/covid5080115","url":null,"abstract":"<p><strong>Background: </strong>This study examined risk factors for syndrome novel coronavirus 2 virus (SARS-CoV-2) infection and self-reported adherence to infection prevention and control (IPC) measures among healthcare workers (HCWs) at a hospital in Thailand near the Myanmar border.</p><p><strong>Methods: </strong>From March to July 2022, HCWs aged ≥ 18 with COVID-19 exposure at Mae Sot General Hospital completed a questionnaire on IPC adherence, training, and COVID-19 knowledge. Nasopharyngeal samples were collected bi-weekly for SARS-CoV-2 testing. A mobile application was used for real-time monitoring of daily symptoms and exposure risks. Chi-square, Fisher's exact tests, and log-binomial regression were performed to investigate association.</p><p><strong>Results: </strong>Out of 289 (96.3%) participants, 27 (9.9%) tested positive for SARS-CoV-2, with cough reported by 85.2% of cases. Nurse assistants (NAs) had a higher risk of infection (adjusted relative risk [aRR] 3.87; 95% CI: 0.96-15.6). Working in inpatient departments (aRR 2.37; 95% CI: 1.09-5.15) and COVID-19 wards (aRR 5.97; 95% CI: 1.32-26.9) was also associated with increased risk. While 81.7% reported consistent hand hygiene, 37% indicated inadequate IPC knowledge.</p><p><strong>Conclusions: </strong>HCWs, especially NAs and those in high-risk departments, should receive enhanced IPC training. Real-time digital monitoring tools can enhance data collection and HCW safety and are likely to be useful tools for supporting surveillance and data collection efforts.</p>","PeriodicalId":72714,"journal":{"name":"COVID","volume":"5 8","pages":"115"},"PeriodicalIF":1.0,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13047749/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147624195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mortality and Predictors of Mortality Among COVID-19 Patients in Kiambu County, Kenya.","authors":"Teresia Njoki Kimani, Nyamai Mutono, Anita Makori, Patricia Mumbua Wambua, Patrick Nyaga, Jesse Gitaka, Omu Anzala, Samuel M Thumbi","doi":"10.3390/covid5060076","DOIUrl":"https://doi.org/10.3390/covid5060076","url":null,"abstract":"<p><p>SARS-CoV-2 continues to circulate with new variants of uncertain transmissibility and virulence arising over time and resulting in varying morbidity and mortality between and within countries. This study aimed to identify the predictors of mortality among hospitalized COVID-19 patients across the first five waves of the pandemic. We conducted a retrospective cohort study at Tigoni Level 4 Hospital in Kenya. The study included patients admitted between June 2020 to August 2022 who tested positive for SARS-CoV-2. Sociodemographic and clinical data were abstracted from patient records at the time of admission and throughout their hospital stay. We employed Cox proportional hazard regression analysis to estimate the time to event (discharge or death) and identify predictors of mortality. Both time-varying and non-time-varying covariates were included in the models. A total of 1985 patients were admitted, of whom 557 (28%) died. The median hospital stay was 4 (1.0-8.0) days and 9 (5.0-13.0) days for patients who died and those who were discharged alive, respectively. Compared to patients admitted during wave 1, those admitted during the subsequent waves had high risk of death estimated at adjusted HR: 1.66 (95% CI 1.2, 2.54), 5.17 (95% CI 3.55, 7.53), 2.62 (95% CI 1.87, 3.67), and 2.17 (95% CI 1.51, 3.11) for waves 2, 3, 4, and 5, respectively. A proportion of patients presented with persistent chest pain, cough, and hypoxia and continued oxygen therapy for more than two months. In addition, patients who had persistent fever, hypoxia, cough, and fatigue had a significant mortality risk (adjusted HR: 3.00; 95% CI: 1.81-4.98; HR: 1.97; 95% CI: 1.73-2.26; HR: 1.47; 95% CI: 1.24-1.75; HR: 1.64; 95% CI: 1.05-2.54). Conversely, patients who had low oxygen saturation and received oxygen at admission had a 76% (HR: 0.24; 95% CI: 0.13-0.42) reduction in mortality risk and in addition patients whose treatment was altered had a 49% reduction in mortality risk (HR: 0.51; CI: 0.45-0.58). Our study highlights the benefits of oxygen therapy on the outcome of COVID-19 patients and justifies the need to increase investments in oxygen especially in low-and-middle-income countries. It also confirms the need to analyze the pandemic by the different waves.</p>","PeriodicalId":72714,"journal":{"name":"COVID","volume":"5 6","pages":""},"PeriodicalIF":1.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12931959/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147313023","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of a Multiplex Immunoassay Platform to Investigate Multifaceted Antibody Responses in SARS-CoV-2 Vaccinees with and Without Prior Infection.","authors":"Troy Odo, Brien K Haun, Caitlin A Williams, Aquena Ball, Albert To, Teri Ann S Wong, Lauren Ching, Eileen Nakano, Alex Van Ry, Laurent Pessaint, Hanne Andersen, Oreola Donini, Vivek R Nerurkar, Axel T Lehrer","doi":"10.3390/covid5040044","DOIUrl":"10.3390/covid5040044","url":null,"abstract":"<p><p>The emergence of COVID-19 necessitated the rapid development of vaccines. While highly effective at reducing severe disease and death, breakthrough infections remain a problem as the virus continues to mutate. To help address this issue, we show the utility of a multiplex immunoassay in measuring multiple aspects of the antibody response generated by SARS-CoV-2 vaccines. We use a multiplex immunoassay platform to measure spike-specific IgG concentration, avidity, and receptor-binding inhibition. In addition, we correlate results from an ACE-2 receptor-binding inhibition assay with corresponding data from a SARS-CoV-2 microneutralization assay to establish this inhibitory assay as a potential predictor of virus neutralization. We studied these antibody responses in SARS-CoV-2-naïve and -convalescent vaccinees. Our results showed increased IgG concentrations, avidity, and inhibition following vaccination in both groups. We were also able to differentiate the immune response between the two groups using the multiplex immunoassay platform to look at antibody diversity. The receptor-binding inhibition assay has strong correlations with a cell-based pseudovirus neutralization assay as well as with WT SARS-CoV-2 Washington and Delta variant PRNT₅₀ assays. This suggests that the inhibition assay may be able to simultaneously predict virus neutralization of different SARS-CoV-2 variants. Overall, we show that the developed custom multiplex immunoassay with several experimental variations is a powerful tool in assessing multiple aspects of the SARS-CoV-2 antibody response in vaccinated individuals.</p>","PeriodicalId":72714,"journal":{"name":"COVID","volume":"5 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of the COVID-19 Pandemic on Influenza Vaccination Coverage Among Young U.S. Children: A Socioeconomic Analysis.","authors":"Tawny Saleh, Mina Shirazi, Mary C Cambou, Karin Nielsen-Saines","doi":"10.3390/covid5020020","DOIUrl":"10.3390/covid5020020","url":null,"abstract":"<p><p>The COVID-19 pandemic disrupted healthcare delivery across the United States (U.S.), including childhood vaccine administration. This study analyzed data from the National Health Interview Survey (NHIS), a nationally representative survey of the U.S. population, assessing trends and predictors of influenza vaccination uptake among children ≤ 5 years before and amid the COVID-19 pandemic. Influenza vaccination coverage declined significantly, from 56% in 2019 to 46% in 2022 (<i>p</i> < 0.001). Age-specific declines were notable, with rates dropping among one-year-olds from 68% to 53%, two-year-olds from 63% to 49%, and infants from 31% to 24% (<i>p</i> < 0.001). Logistic regression revealed African American children had lower odds of vaccination compared to non-Hispanic White children (OR = 0.70, <i>p</i> < 0.001), while Asian children had higher odds (OR = 1.32, <i>p</i> = 0.018). Uninsured children were less likely to be vaccinated than insured children (OR = 0.71, <i>p</i> = 0.022). Regional analysis showed the Northeast had the highest vaccination rates (60% in 2019, 56% in 2022), while the South had the lowest (52% in 2019, 41% in 2022). These findings underscore the need for targeted strategies to address socioeconomic disparities and improve influenza vaccine uptake in young children in the U.S.</p>","PeriodicalId":72714,"journal":{"name":"COVID","volume":"5 2","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12269500/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144661153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of Metabolic States on SARS-CoV-2 Vaccine Responses in Mouse Models of Obesity and Diabetes.","authors":"Olivia A Smith, Brent Fujimoto, Teri Ann S Wong, Albert To, Troy Odo, Aquena Ball, Brien K Haun, Hiromi Muramatsu, Ying K Tam, Norbert Pardi, Axel T Lehrer","doi":"10.3390/covid5010002","DOIUrl":"10.3390/covid5010002","url":null,"abstract":"<p><p>The emergence of SARS-CoV-2 has resulted in a significant impact on public health, particularly for individuals with underlying health conditions such as obesity and diabetes. While vaccination efforts have played a crucial role in reducing hospitalizations, it remains unclear whether the effectiveness of these vaccines varies among different population groups. In this study, we investigated the immune responses generated by various SARS-CoV-2 vaccine platforms in mouse models with obesity and diabetes, focusing on both cell-mediated and humoral immune responses. Our findings revealed diminished immune responses in diabetic and obese mice compared to healthy counterparts. After vaccination with adjuvanted subunit or mRNA lipid nanoparticle (LNP) vaccines, both humoral and cell-mediated responses were significantly reduced in diabetic mice. Obese mice also exhibited decreased immunogenicity, albeit to a lesser extent. However, it should be noted that mRNA vaccines demonstrated strong neutralizing responses across all metabolic states, while adjuvanted subunit vaccines elicited higher antibody avidity in mice with type 2 diabetes (T2D) and obesity compared to healthy mice. These results suggest that the impaired humoral and cell-mediated responses observed in altered metabolic states may be linked to chronic inflammation associated with obesity and suboptimal glycemic control in diabetes. Understanding the impact of these metabolic disturbances on vaccine immunogenicity is crucial for developing optimized vaccines that can effectively enhance immune responses and provide long-lasting protection against SARS-CoV-2, even in individuals with obesity and diabetes. By contributing these findings, we support efforts to improve vaccine efficacy in populations affected by metabolic disorders, advancing effective immunization against SARS-CoV-2.</p>","PeriodicalId":72714,"journal":{"name":"COVID","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12097603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"COVID-19 Stress is Associated with Increased Smoking among People with HIV in Western Washington: A Cross-Sectional Survey.","authors":"Anh Tuyet Nguyen, Francis Slaughter, Sarah Smith, David A Katz, Sandeep Prabhu, Liying Wang, Jane M Simoni, Judith I Tsui, Susan M Graham","doi":"10.3390/covid4100112","DOIUrl":"10.3390/covid4100112","url":null,"abstract":"<p><strong>Background: </strong>People living with HIV (PWH) frequently have co-morbid substance use disorders that may have been impacted by the COVID-19 pandemic. This study examined associations between COVID-related stress and increased substance use among PWH in Washington State.</p><p><strong>Methods: </strong>Between August 2020 and March 2021, we conducted an online survey of 397 PWH in Western Washington. Logistic regression was used to analyze associations between a COVID-19 stress score and four self-reported outcomes: increased alcohol use, increased cigarette smoking, increased marijuana use, and increased use of illicit substances.</p><p><strong>Results: </strong>Thirty-five (38.0%) of 92 participants who smoked, 61 (23.4%) of 261 participants who used alcohol, 15 (14.6%) of 103 participants who used marijuana and 35 (33.0%) of 102 participants who used illicit substances reported increased use of these substances. Higher COVID-19 stress scores were associated with higher odds of increased cigarette smoking (adjusted odds ratio [aOR]=1.15, 95% confidence interval [CI]: 1.04-1.27), even after adjustment for anxiety and depressive symptoms (aOR 1.14, 95%CI: 1.03-1.27). COVID-19 stress was not associated with increased use of alcohol, marijuana, or illicit substances.</p><p><strong>Conclusions: </strong>COVID-19-related stress was associated with self-reported increased cigarette smoking among PWH in Western Washington during the pandemic.</p>","PeriodicalId":72714,"journal":{"name":"COVID","volume":"4 10","pages":"1617-1630"},"PeriodicalIF":0.0,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of COVID-19 on Dental Students’ Mental Health Status and Perception of SARS-CoV-2 Vaccine","authors":"Man Hung, Nicole Hablitzel, Sharon Su, Samantha Melnitsky, A. Mohajeri","doi":"10.3390/covid4080078","DOIUrl":"https://doi.org/10.3390/covid4080078","url":null,"abstract":"The COVID-19 pandemic disrupted dental education significantly, forcing adaptations in both didactic and clinical curricula. This study evaluates the impact of COVID-19 on dental students’ mental health and perceptions of the SARS-CoV-2 vaccine. An anonymous online survey was administered to dental students at Roseman University of Health Sciences, focusing on health experiences and vaccination perceptions. Results showed 56.8% of students were concerned about their emotional health, 82.1% felt stressed, and 60.6% felt depressed. About 81.9% received the vaccine, with 75.5% believing it effective, though only 55.3% supported mandatory vaccination. The pandemic negatively impacted students’ emotional health, indicating a need for institutional mental health support. This study was conducted during the COVID-19 pandemic, and findings relate specifically to that period. Further research can focus on investigation of reasonings behind the sentiments.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"49 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141799747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"SARS-CoV-2-Related Parotitis in Children: A Narrative-Focused Review","authors":"Andrea Marino, Giovanni Cacciaguerra, G. Sangiorgio, A. Maniaci, L. La Via, S. Cocuzza, Stefano Stracquadanio, Roberta Leonardi, Serena Spampinato, Bruno Cacopardo, Piero Pavone, Giuseppe Nunnari","doi":"10.3390/covid4080076","DOIUrl":"https://doi.org/10.3390/covid4080076","url":null,"abstract":"The COVID-19 pandemic has revealed a diverse spectrum of clinical manifestations in the pediatric population, including the rare but notable presentation of unilateral parotitis. This comprehensive review explores the complexities surrounding SARS-CoV-2-associated unilateral parotitis in children. It addresses the initial clinical presentation, diagnostic challenges, treatment strategies, and the wider epidemiological impacts of this unusual symptom. The review synthesizes the available literature, providing insights into the pathophysiological mechanisms underlying this atypical manifestation and its implications for pediatric healthcare during the pandemic. Through the rigorous analysis of reported cases, this study underscores the need for increased awareness and a broad differential diagnosis among clinicians. It also emphasizes the importance of continued research to delineate the full clinical spectrum of COVID-19 in children.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"25 13","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141806331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"3Cs: Unleashing Capsule Networks for Robust COVID-19 Detection Using CT Images","authors":"Rawan Alaufi, Felwa A. Abukhodair, Manal Kalkatawi","doi":"10.3390/covid4080077","DOIUrl":"https://doi.org/10.3390/covid4080077","url":null,"abstract":"The COVID-19 pandemic has spread worldwide for over two years. It was considered a significant threat to global health due to its transmissibility and high pathogenicity. The standard test for COVID-19, namely, reverse transcription polymerase chain reaction (RT–PCR), is somehow inaccurate and might have a high false-negative rate (FNR). As a result, an infected person with a negative test result may unknowingly continue to spread the virus, especially if they are infected with an undiscovered COVID-19 strain. Thus, a more accurate diagnostic technique is required. In this study, we propose 3Cs, which is a capsule neural network (CapsNet) used to classify computed tomography (CT) images as novel coronavirus pneumonia (NCP), common pneumonia (CP), or normal lungs. Using 6123 CT images of healthy patients’ lungs and those of patients with CP and NCP, the 3Cs method achieved an accuracy of around 98% and an FNR of about 2%, demonstrating CapNet’s ability to extract features from CT images that distinguish between healthy and infected lungs. This research confirmed that using CapsNet to detect COVID-19 from CT images results in a lower FNR compared to RT–PCR. Thus, it can be used in conjunction with RT–PCR to diagnose COVID-19 regardless of the variant.","PeriodicalId":72714,"journal":{"name":"COVID","volume":"28 11","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141810002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}