CourseSource最新文献

The Flight Physics Concept Inventory: Reliably Evaluating Aerodynamic Lift, Drag and Associated (Naïve) Concepts of Flight in Class and In-Game 飞行物理概念清单:可靠地评估空气动力升力，阻力和相关(Naïve)飞行的概念在课堂上和游戏内

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.27

Florian Genz, André Bresges, Kathleen A. Falconer

引用次数: 0

Real World Scenarios in Non-Majors Biology 非专业生物学的真实世界场景

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.5

J. Sabel, Anna Bess Sorin

引用次数: 0

Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website. 让学生参与药物遗传学:使用PharmGKB网站进行患者案例研究。

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.10

Andrea M Mosquera, Lauren M Aleksunes

{"title":"Engaging Students in Pharmacogenetics: Patient Case Studies Using the PharmGKB Website.","authors":"Andrea M Mosquera, Lauren M Aleksunes","doi":"10.24918/cs.2023.10","DOIUrl":"https://doi.org/10.24918/cs.2023.10","url":null,"abstract":"Cytochrome P450 (CYP) enzymes are important regulators of drug efficacy and toxicity. Genetic variation in CYP isoforms can impact how well patients respond to medications or experience unwanted toxicities. PharmGKB is an online pharmacogenomics resource that collates the latest data and clinical guidelines on genetic variation and drug responses. The purpose of this lesson was to develop an interactive, case-based activity that demonstrated how pharmacogenetics can be used to influence the prescribing of medications. This lesson was provided to 71 students during a two-hour online interactive session. The lesson consisted of 1) a didactic lecture on pharmacogenetic principles, 2) an overview of the PharmGKB website by the instructor, and 3) patient cases that used the PharmGKB website to answer questions and make recommendations about drug therapy. Patient cases explored the impact of genetic variation in CYP enzymes on patients prescribed medications for different diseases including depression (citalopram, CYP2C19), pain (codeine, CYP2D6), organ transplantation (tacrolimus, CYP3A5), and viral infection (efavirenz, CYP2B6). Four additional cases are included in this lesson. Students reviewed the patient cases in small groups, used PharmGKB to answer questions and design treatment plans, and presented their recommendations to instructors and other students. Based on pre-/post-lesson assessment questions and student feedback, we conclude that an interactive, group-based activity can be used to teach basic principles of pharmacogenetics and connect students to online resources for drug dosing.","PeriodicalId":72713,"journal":{"name":"CourseSource","volume":"10 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10357923/pdf/nihms-1888552.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9855105","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1

Defining and Understanding Pathogenic Disease: An Engaging Activity That Connects Students’ Lived Experiences With Their Academic Studies 定义和理解致病性疾病:一项将学生的生活经历与学术研究联系起来的引人入胜的活动

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.18

Peggy L Brady

引用次数: 0

Fatty Acid Induction of Lipid Droplets in Cancer Cells 脂肪酸对癌细胞脂滴的诱导作用

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.19

Jacob J. Adler

引用次数: 1

Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples 尊重遗传学的复杂性:用现实世界的例子探索基因和环境的作用

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.2

Kelly M. Schmid, Jennifer Avena, L. Hobbie, Pam Kalas, Tamara L Kelly, Amy L. Klocko, Iglika V. Pavlova, G. Radick, Lauren Edris Snow, Michelle K. Smith

{"title":"Honoring the Complexity of Genetics: Exploring the Role of Genes and the Environment Using Real World Examples","authors":"Kelly M. Schmid, Jennifer Avena, L. Hobbie, Pam Kalas, Tamara L Kelly, Amy L. Klocko, Iglika V. Pavlova, G. Radick, Lauren Edris Snow, Michelle K. Smith","doi":"10.24918/cs.2023.2","DOIUrl":"https://doi.org/10.24918/cs.2023.2","url":null,"abstract":"Historically, undergraduate genetics courses have disproportionately focused on the impact of genes on phenotypes, rather than multifactorial concepts which consider how a combination of genes, the environment, and gene-by-environment interactions impacts traits. Updating the curriculum to include multifactorial concepts is important to align course materials to current understanding of genetics, and potentially reduce deterministic thinking, which is the belief that traits are solely controlled by genes. Currently there are few resources to help undergraduate biology instructors incorporate multifactorial concepts into their genetics courses, so we designed this lesson that centers on familiar, real-world examples. During this lesson, students learn how to distinguish between genetic and environmental sources of variation, and examine and interpret examples of how phenotypic variation can result from a combination of gene and environmental variation and interactions. This lesson, which is designed for both in-person and online classrooms, engages students in small group and large group discussion, figure interpretation, and provides questions that can be used for both formative and summative assessments. Results from assessment questions suggest that students found working through models depicting the interactions between genotypes and environments beneficial for their understanding of these complex topics.","PeriodicalId":72713,"journal":{"name":"CourseSource","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69329593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Learning How to Make “Good Enough” Estimations 学习如何做出“足够好”的评估

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.23

Jon D. H. Gaffney

引用次数: 0

Teaching the Photoelectric Effect Using an Open-Source Interactive Simulation 利用开源交互仿真教学光电效应

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.34

C. Wieman

{"title":"Teaching the Photoelectric Effect Using an Open-Source Interactive Simulation","authors":"C. Wieman","doi":"10.24918/cs.2023.34","DOIUrl":"https://doi.org/10.24918/cs.2023.34","url":null,"abstract":"The photoelectric effect is one of the fundamental experiments that established the basis of quantum mechanics. Students studying this experiment in modern physics courses struggle to understand what it actually measured and why it is significant. This lesson is built around the PhET interactive simulation of this experiment. The activity involves the use of this open-source online simulation to carry out simulated experiments exploring the emission of electrons from metal surfaces when light is shone on them, and to compare those results with the predictions of the classical theory of light and its interactions with matter. This shows why Einstein’s quantum interpretation is needed to explain the observed behavior. Students complete a worksheet that guides them through the simulated experiment and comparison of observations with predictions of the classical theory of light and matter interactions. Then they are given the quantum interpretation, including exploring analogies to help develop their understanding. This presentation is supported by having students answer and discuss a set of questions in small groups. This lesson has achieved greatly improved student mastery of this fundamental experiment and how it shaped physics.","PeriodicalId":72713,"journal":{"name":"CourseSource","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"69329975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Go Extinct! An Award-Winning Evolution Game That Teaches Tree-Thinking as Students Pursue the Winning Strategy 灭绝!一个屡获殊荣的进化游戏，在学生追求获胜策略的过程中教授树思维

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.9

Ariel E. Marcy

引用次数: 0

Science “Fails”: A Bank of Historical Examples for Learning From Failure in Science 科学“失败”:从科学失败中学习的历史案例库

CourseSource Pub Date : 2023-01-01 DOI: 10.24918/cs.2023.39

Christina Makkar, Maria Dasios, Nicole Laliberté, Fiona Rawle

{"title":"Science “Fails”: A Bank of Historical Examples for Learning From Failure in Science","authors":"Christina Makkar, Maria Dasios, Nicole Laliberté, Fiona Rawle","doi":"10.24918/cs.2023.39","DOIUrl":"https://doi.org/10.24918/cs.2023.39","url":null,"abstract":"Learning from failure is critically important to the processes of scientific inquiry, discovery, and invention. However, students are not routinely taught how to reflect on, learn from, and ultimately embrace failure, and relatively few curricular examples and teaching tools exist for reflecting on failure and its relationship to discovery. In fact, many science textbooks are stories of past successes in science and often neglect the failures or missteps that led to major discoveries. Yet examples of failures, errors, setbacks, and accidents that led to innovation and discovery abound for use in instruction. Moreover, research suggests that students benefit when failure is openly discussed and reframed as integral to learning. We have curated a bank of examples as a teaching tool to encourage and guide discussions about learning from failure. We highlight systemic barriers to embracing failure and note resources (time, funding, security, cultural capital) that facilitate second chances; we cannot encourage students to embrace failure without acknowledging these needs. Nevertheless, reflecting on failure in science courses can hone the evaluative and creative capacities of students, aid in the development of procedural and metacognitive knowledge, and invite improvement in many science process skills including research, analysis, and experimental design and implementation. Importantly, reflecting on failure can also decrease stigma, promote resilience, and positively impact student wellbeing.","PeriodicalId":72713,"journal":{"name":"CourseSource","volume":"306 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"134980927","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0