Continence (Amsterdam, Netherlands)最新文献

{"title":"Sensation kinetics identifies novel bladder sensation-capacity curve shapes during urodynamics in patients with urinary urgency","authors":"John E. Speich ,&nbsp;Annapoorani Narayanan ,&nbsp;Mrudula Bandaru ,&nbsp;Nyasia Jones ,&nbsp;Devina Thapa ,&nbsp;Rui Li ,&nbsp;Zachary E. Cullingsworth ,&nbsp;Anna S. Nagle ,&nbsp;Andrew F. Colhoun ,&nbsp;Adam P. Klausner","doi":"10.1016/j.cont.2025.102291","DOIUrl":"10.1016/j.cont.2025.102291","url":null,"abstract":"<div><h3>Objective</h3><div>Overactive bladder (<strong>OAB</strong>) is characterized by urinary urgency. To better characterize the relationship between bladder sensation and urgency, a tablet-based “Sensation Meter” was developed to enable construction of bladder sensation-capacity curves. The objective of this study was to correlate sensation-capacity curve shapes during urodynamics (<strong>UDS</strong>) with urgency severity and bother.</div></div><div><h3>Methods</h3><div>Individuals with moderate-to-severe urgency presenting for clinically indicated UDS were prospectively enrolled after urgency characterization using the International Consultation on Incontinence OAB questionnaire (<strong>ICIq-OAB</strong>). Throughout UDS filling, participants recorded sensation of bladder fullness (0–100 %) using the Sensation Meter. Sensation-capacity curves were constructed and area-under-the-curve (<strong>AUC</strong>) analysis was implemented to differentiate between three curve-shape patterns defined as r, l, and j-shape. Curve shapes were correlated categorically to urgency severity and bother, UDS capacity, and the presence/absence of DO.</div></div><div><h3>Findings</h3><div>The study included 69 participants (52F, 17M). The distribution of sensation-capacity curve shapes was 7 (10 %) r-shape, 43 (62 %) l-shape, and 19 (28 %) j-shape. A j-shaped curve was significantly associated with severe urgency and with high urgency bother, but not with bladder capacity or DO.</div></div><div><h3>Conclusions</h3><div>The key finding was the association between a j-shaped sensation-capacity curve, demonstrating a rapid acceleration of sensation near the end of filling, with both urgency symptom severity and bother. Curve shapes were not associated with bladder capacity or DO, suggesting that a j-shaped curve may potentially identify a separate driver of urinary urgency. Additional studies are needed to determine whether sensation-capacity curves can be used to identify novel OAB/urgency phenotypes or guide therapy.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102291"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145320655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bladder antimuscarinics in older adults: as bad as portrayed?","authors":"Adrian Wagg","doi":"10.1016/j.cont.2025.102304","DOIUrl":"10.1016/j.cont.2025.102304","url":null,"abstract":"<div><div>The use of antimuscarinics for overactive bladder in older adults has been affected by the results of epidemiological cross-sectional studies which have found an association between their use and the risk of an incident dementia diagnosis. Since the publication of earlier studies with high media exposure, later reports have resulted in conflicting findings, some shedding doubt upon initial results. This expert update reviews some of these conflicts and the results of studies which have assessed cognition in older adults, both with and without cognitive impairment. There is a need for a re-evaluation of current clinical guidelines in the light of these newer, and in some cases older, but ignored, studies.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102304"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145571348","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Choosing the optimal urethral Catheter: A computational comparison","authors":"James Fox ,&nbsp;Silje Ekroll Jahren ,&nbsp;Marcus J. Drake ,&nbsp;Francesco Clavica","doi":"10.1016/j.cont.2025.102297","DOIUrl":"10.1016/j.cont.2025.102297","url":null,"abstract":"<div><h3>Introduction</h3><div>Indwelling urinary catheters, particularly Foley catheters, are commonly used in clinical care but remain associated with several complications, including bladder tissue damage, risk of infection, poor emptying speeds and urethral trauma. Despite ongoing design innovations, objective comparisons between catheter types are limited. This study aimed to develop a computational framework to quantitatively assess and compare the performance of three urinary catheter designs (Foley, Optitip, and Flume) across metrics linked to patient outcomes.</div></div><div><h3>Methods</h3><div>A female lower urinary tract (LUT) model was constructed using standard anatomical dimensions. Each catheter was assessed using geometrical analysis, computational fluid dynamics (CFD), and finite element analysis (FEA). Simulations were performed at two catheter positions (bladder centre and bladder neck) and under two bladder pressures (4 and 20 cmH₂O). Quantified metrics include residual urine volume, catheter height (protrusion into the bladder), immersed surface area, wall shear stress, urine flow rate, and von Mises stress in bladder tissue.</div></div><div><h3>Results</h3><div>The Foley catheter consistently underperformed across all metrics, showing high residual volumes, low shear stress near the side holes, and high von Mises stress in the bladder tissue (factors linked to infection, blockage, and trauma). In contrast, the Flume and Optitip catheters demonstrated improved flow dynamics, reduced catheter height, and lower immersed surface area.</div></div><div><h3>Conclusions</h3><div>This study presents a novel modelling approach to assess urinary catheter design. Findings support the clinical need to move beyond traditional Foley designs and adopt better-performing alternatives to reduce complications and improve patient safety and comfort.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102297"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Variation in catheter management and predictors of trial without catheter success in men with AUR: results from the AUR-SNAPSHOT study","authors":"Nadine Arina Maria van Merode ,&nbsp;P.Y. Hermans ,&nbsp;T. de Jong ,&nbsp;B.M.A. Schout ,&nbsp;C. Cobussen ,&nbsp;J.P.A. van Basten ,&nbsp;R. de Jongh ,&nbsp;S. Mekke ,&nbsp;H. Roshani ,&nbsp;M.M. Nijenhuis ,&nbsp;J.I.M. van Uhm ,&nbsp;R.R. Kikkert ,&nbsp;S. Tilli ,&nbsp;J.F.A. Heesakkers ,&nbsp;M. Duijn ,&nbsp;E.P. van Haarst ,&nbsp;A.M. Tijans ,&nbsp;A. Noordzij ,&nbsp;L. van Eerten-Koops ,&nbsp;I. Bleumer ,&nbsp;L.P.W. Witte","doi":"10.1016/j.cont.2025.102295","DOIUrl":"10.1016/j.cont.2025.102295","url":null,"abstract":"<div><h3>Background and objective</h3><div>This study aimed to assess practice variation in the timing and management of trial without catheter (TWOC) following acute urinary retention (AUR) in Dutch hospitals. Secondary objectives were to identify clinical predictors of TWOC success and evaluate catheter-related complications.</div></div><div><h3>Methods</h3><div>We conducted a retrospective cross-sectional observational study across multiple Dutch hospitals. Male patients aged ≥18 years with a single episode of spontaneous AUR were identified using electronic health record queries. Data collected included catheter duration, alpha-blocker use, TWOC outcomes, predictors of success, and complications. TWOC success was defined as spontaneous voiding with acceptable post-void residual, as judged by the local clinician. Predictors were determined with multivariable binomial logistic regression.</div></div><div><h3>Key findings and limitations</h3><div>A total of 299 men (mean age 73.1 ± 9.4 years) were included from January 2022 to June 2022. Median drained volume was 1000 mL (IQR 750–1500 mL), and median catheter duration was 15 days (IQR 6–23 days). TWOC success varied across hospitals (14–55 %). Catheter duration and alpha-blocker were not significant predictors. Older age (OR 0.93, <em>p</em> = 0.001) and larger drained volume (OR 0.99, <em>p</em> &lt; 0.001) were associated with lower success, while alcohol consumption increased success odds (OR 3.54, <em>p</em> = 0.016). The study is limited by the retrospective design, lack of standard definition for TWOC success, and observational nature.</div></div><div><h3>Conclusion</h3><div>Substantial variation exists in catheter duration and TWOC management across Dutch hospitals. Age, drained volume, and alcohol use were significant predictors of TWOC outcome. However, the association with alcohol should be interpreted as an indication that non-BOO causes of AUR may resolve spontaneously. Findings highlight the need for standardised protocols and support future multicenter randomized trials to optimize care, reduce complications, and improve patient quality of life.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102295"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nocturia and SGLT2 inhibitors: A review of pathophysiology, clinical evidence, and therapeutic implications","authors":"Matthew Antonellis ,&nbsp;Robert Adler ,&nbsp;Michael Kozlov ,&nbsp;Jason Lazar ,&nbsp;Jeffrey P. Weiss","doi":"10.1016/j.cont.2025.102299","DOIUrl":"10.1016/j.cont.2025.102299","url":null,"abstract":"<div><h3>Background</h3><div>Sodium-glucose cotransporter-2 (SGLT2) inhibitors are widely used in patients with diabetes, heart failure, and chronic kidney disease, all of whom are at elevated risk for nocturia. These agents affect renal glucose and sodium handling, potentially influencing nocturnal urine production. However, their overall impact on nocturia remains poorly defined.</div></div><div><h3>Methods</h3><div>A systematic review was conducted according to PRISMA 2020 guidelines. PubMed, Embase, and Web of Science were searched through May 2025 for studies reporting nocturia-related outcomes among SGLT2 inhibitor users. Eligible study designs included randomized controlled trials, observational studies, and post-marketing analyses. Additionally, disproportionality analysis using the FDA Adverse Event Reporting System (FAERS) was performed to assess urinary adverse event signals across individual agents.</div></div><div><h3>Results</h3><div>Forty-six studies met inclusion criteria. Trial data suggest a modest increase in urinary frequency and nocturia, though few studies employed validated symptom measures. Pharmacovigilance analysis revealed elevated reporting rates of nocturia, particularly with canagliflozin. In contrast, shorter half-life agents such as tofogliflozin demonstrated lower nocturia prevalence. Morning dosing and individualized agent selection may mitigate symptom burden.</div></div><div><h3>Conclusions</h3><div>SGLT2 inhibitors are associated with a small but clinically meaningful increase in nocturia, especially during early treatment. The effect varies by agent pharmacokinetics and patient characteristics. Prospective studies using standardized outcome measures are needed to guide personalized prescribing and symptom management.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102299"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Editorial Comment: LUTD in rare pediatric neurological conditions: A joint report by the neurourology promotion committee and children and young adults committee","authors":"Cagri Akin Sekerci ,&nbsp;Selcuk Yucel ,&nbsp;Tufan Tarcan","doi":"10.1016/j.cont.2025.102301","DOIUrl":"10.1016/j.cont.2025.102301","url":null,"abstract":"","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102301"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145617674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Urinary incontinence in Africa: Experiences of women and healthcare workers in Nigeria and Kenya and opportunities for expanding care","authors":"Laura E. Keyser ,&nbsp;Fatimat Akinlusi ,&nbsp;Oliver Muchiri ,&nbsp;Eliud Luutsa ,&nbsp;Michael Ngigi ,&nbsp;Michelle Angwenyi ,&nbsp;Jessica L. McKinney","doi":"10.1016/j.cont.2025.102290","DOIUrl":"10.1016/j.cont.2025.102290","url":null,"abstract":"<div><h3>Rationale</h3><div>Urinary incontinence (UI) is prevalent among women worldwide, however perspectives from African women with UI and healthcare workers (HCWs) involved in their care are lacking.</div></div><div><h3>Objective</h3><div>To understand UI in Africa through the perspectives of women with UI and HCWs to inform effective, accessible, and patient-centered treatment.</div></div><div><h3>Findings</h3><div>A total of 175 participants were interviewed August–September 2023 about the healthcare environment, digital health, and UI care, management, and treatment options in this qualitative study: 88 women with UI (37 Nigerian, 51 Kenyan) and 87 HCWs (29 Nigerian, 58 Kenyan). All participants provided written informed consent; the study was approved by institutional and national ethics’ committees in Nigeria and Kenya.</div><div>Amongst women:</div><div>• Health literacy, cultural and religious beliefs, and healthcare system interactions influence healthcare decision-making.</div><div>• UI symptoms are frustrating; education, treatment and dismantling of stigma are desired.</div><div>• Lack of awareness of UI as a medical condition is pervasive and care-seeking is extremely low.</div><div>Amongst HCWs:</div><div>• Recognition that UI is a burdensome and highly prevalent medical condition that is underdiagnosed and undertreated.</div><div>• Gaps identified, including training needs, prevalence studies and other research, and national guidelines for fistulous and non-fistulous incontinence.</div></div><div><h3>Conclusions</h3><div>This research highlights the pervasive and distressing nature of UI among women in two African countries. Despite high prevalence, low health-seeking behaviors persist. Sensitization efforts focused on pelvic health and UI could improve health literacy. Cultural values of community and collective responsibility could serve as enablers for raising awareness and encouraging treatment-seeking. Expanding research and training in UI management and access to treatment could strengthen healthcare systems in these settings.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102290"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Challenges and advances in offering urinary continence care in Malawi","authors":"Brendan Berry ,&nbsp;Mayur Gami ,&nbsp;Nikesh Thiruchelvam ,&nbsp;Tamsin Greenwell ,&nbsp;Suzie Venn","doi":"10.1016/j.cont.2025.102302","DOIUrl":"10.1016/j.cont.2025.102302","url":null,"abstract":"<div><h3>Background</h3><div>Urinary incontinence (UI) is a highly prevalent condition with profound physical, psychological and social implications. In sub-Saharan Africa, structured pathways for vesicovaginal fistula management exist, however, services for non-fistulae related UI are almost entirely absent. Malawi is a low-income country with severe surgical workforce shortages and therefore lacks basic routine continence services.</div></div><div><h3>Methods</h3><div>This article reports on a Urolink, Meditech and Cambridge Global Health Partnership programme to Kamuzu Central Hospital in Lilongwe in February 2025. The initiative delivered consultant surgical training, urodynamic assessments, outpatient clinics, equipment provision and teaching sessions to urology and gynaecology doctors in training. A mixed methods prospective service implementation and feasibility study was conducted over a one-week programme. Data on procedures, patient assessments, operative outcomes and teaching outcomes were collected.</div></div><div><h3>Results</h3><div>Clinical activity included both major reconstructive surgeries, such clam enterocystoplasty, complex fistulae repair, urethral diverticulectomy, rectus fascial sling and minor procedures including, urethral bulking, cystoscopy assessments, bladder Botox injections and urodynamic studies. Sixteen patients with UI were assessed in urogynecology clinics. Twelve registrars participated in lectures, viva sessions and live surgical teaching. Self-reported confidence improved significantly in all domains including the management of, stress UI, urodynamic assessments, neuropathic bladder and urinary diversion. Collaborative dual consultant operating reinforced the independence of the local consultants.</div></div><div><h3>Discussion</h3><div>Major challenges included theatre inefficiency, sterilisation limitations, shortages of nursing and anaesthetic staff, sociocultural stigma and late patient presentations. Despite these barriers, the program demonstrated the feasibility of introducing basic and advanced continence procedures, sustainable training models and national teaching platforms in a resource-limited setting.</div></div><div><h3>Conclusions</h3><div>Progress in continence surgery in Malawi requires long-term mentorship, infrastructure strengthening, culturally adapted awareness campaigns and national policy support. Global partnerships can act as facilitators for sustainable, context-specific solutions. Short, intensive partnership can build local capacity and initiate a subspecialty service, but long-term outcomes remain unknown.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102302"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145519595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The first report of vesicovaginal fistula repair experience in Afghanistan","authors":"Zamari Noori ,&nbsp;Ghulam Rabbani Habibi ,&nbsp;Mohammad Arif Aslami ,&nbsp;Sayed Manan Hashemi ,&nbsp;Lina Naimi ,&nbsp;Mohammad Jawid Nazari ,&nbsp;Hadi Mostafaei ,&nbsp;Helia Mostafaei ,&nbsp;Hanieh Salehi-Pourmehr ,&nbsp;Sakineh Hajebrahimi","doi":"10.1016/j.cont.2025.102289","DOIUrl":"10.1016/j.cont.2025.102289","url":null,"abstract":"<div><h3>Background</h3><div>Vesicovaginal fistulas (VVF) are the most common type of acquired fistula, with various causes, etiologies, and management trends worldwide. We aimed to provide our first report on VVF repair experience in Afghanistan.</div></div><div><h3>Methods</h3><div>A retrospective analysis was conducted on 46 patients who underwent VVF repair between June 2019 and June 2024. Preoperative assessment included physical examination, imaging, and cystoscopy. In cases where the diagnosis was uncertain, a patient-reported pad count (number of pads used per day) was recorded as a supplementary measure of incontinence severity. The surgical procedure involved a transabdominal transvesical approach with circumferential excision of a bladder mucosal cuff around the fistula; the fistulous tract itself was not excised. Closure was performed in two layers, and an interposition flap (peritoneal or omental) was utilized in all cases. Success was defined as the absence of urine leakage one month post-surgery. Postoperative management involved suprapubic catheter drainage for 10–15 days, antibiotics for one week, and antimuscarinics. Complications were classified using the Clavien-Dindo system.</div></div><div><h3>Results</h3><div>All 46 VVFs were of iatrogenic origin: 35 followed total hysterectomy and 11 followed Cesarean section. Seven fistulas were larger than 2.5 cm, and 39 were 1 cm or smaller. The mean follow-up period was 38.43 months. The surgical success rate was 100 %. There were no major complications (Clavien-Dindo class ≥2); five patients had a surgical site infection, and one had a hematoma that required drainage.</div></div><div><h3>Conclusion</h3><div>Transabdominal VVF repair with an interposition flap, utilizing a technique that preserves the fistulous tract, achieved a 100 % success rate in this cohort. This approach is a highly effective management strategy for iatrogenic VVF in a challenging healthcare setting.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102289"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145220853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower urinary tract dysfunction in rare paediatric neurological conditions: A joint report by the neurourology promotion committee and children and young adults committee of the International Continence Society","authors":"Stephanie Kotes ,&nbsp;Danielle Delaney ,&nbsp;Marcus John Drake ,&nbsp;Ashani Couchman ,&nbsp;Thomas Milton ,&nbsp;Kadir Onem ,&nbsp;Katie Brodie ,&nbsp;Sanjay Sinha","doi":"10.1016/j.cont.2025.102296","DOIUrl":"10.1016/j.cont.2025.102296","url":null,"abstract":"<div><div>Neurogenic lower urinary tract dysfunction (NLUTD) is a frequent but under-recognized complication in children with rare neurological disorders. These conditions often interfere with central or peripheral pathways involved in micturition, leading to various clinical presentations including urinary incontinence, urinary retention, and risk to upper tract deterioration. The objective of this joint report by the Neurourology Promotion Committee (NUPC) and the Children and Young Adults Committee (CYAC) of the International Continence Society (ICS) is to describe and summarise rare paediatric neurological conditions associated with NLUTD, with a focus on their pathophysiology, urological sequelae, and implications for clinical management. Included conditions have been categorised into complex anatomical, genetic, neurodevelopmental, metabolic disorders and malignancies. The complex interplay of neurological, anatomical and developmental factors highlights the need for timely, multidisciplinary, and personalized care to protect kidney function, support continence, and enhance quality of life (QoL) in children with complex neurological and developmental conditions.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"16 ","pages":"Article 102296"},"PeriodicalIF":1.2,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145416935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}