Continence (Amsterdam, Netherlands)最新文献

{"title":"Urethral lesion by the cuff of the artificial urinary sphincter: A systematic review of optimal management at time of explantation","authors":"Lukas Costa de Salles,&nbsp;Carlos Arturo Levi D’Ancona,&nbsp;Juliano Cesar Moro,&nbsp;Arthur Degani Ottaiano","doi":"10.1016/j.cont.2025.101899","DOIUrl":"10.1016/j.cont.2025.101899","url":null,"abstract":"<div><h3>Introduction and Objective</h3><div>: Artificial Urinary Sphincter (AUS) is the gold standard for Stress urinary incontinence (SUI) surgical treatment. This systematic review pursues the optimal course of action during AUS cuff explantation due to urethral cuff erosion, the device’s main complication.</div></div><div><h3>Methods:</h3><div>Systematic review of Medline, Embase, Cochrane Library, and Scielo databases following the PRISMA statement, from January 2014 to April 2024. The risk of bias was assessed using the “Newcastle–Ottawa Scale for cohorts” and “Critical Appraisal Checklist for Case Series”. Our primary outcome was the stricture rate after treatment. There was no external funding for this review.</div></div><div><h3>Results</h3><div>: Of 362 initial studies, six were included, with 277 patients. There were five retrospective single-center studies and one multicentric study. Pelvic irradiation was a risk factor for cuff erosion and stricture formation. Severe lesions (larger than 33% of the urethra) are at higher risk for stricture development and present poor results when treated conservatively. Mild lesions (smaller than 33%) showed no difference between urinary diversion and surgical repair.</div></div><div><h3>Conclusions:</h3><div>Mild lesions should be addressed with urethral catheterization for 3-6 weeks associated with a suprapubic tube. Severe erosions should receive surgical correction. Prospective, randomized studies are needed.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"15 ","pages":"Article 101899"},"PeriodicalIF":0.0,"publicationDate":"2025-05-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144167365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ketamine-induced uropathy","authors":"Hann-Chorng Kuo","doi":"10.1016/j.cont.2025.101907","DOIUrl":"10.1016/j.cont.2025.101907","url":null,"abstract":"<div><div>Ketamine induced uropathy has become a new bladder pain syndrome affecting the bladder, kidney, and quality of life in ketamine abusers. Ketamine-associated cystitis (KC) is an emerging public health concern, particularly among young adults who abuse ketamine recreationally and, to a lesser extent, in patients receiving ketamine therapeutically for depression. Although currently rare in clinical psychiatry, the incidence of KC might rise as ketamine-based therapies become more prevalent. This manuscript reviews recent knowledge in the ketamine induced uropathy and potential clinical implications.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"15 ","pages":"Article 101907"},"PeriodicalIF":0.0,"publicationDate":"2025-05-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144178257","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In how many patients urodynamics should be omitted? Data from a single-centre database on the basis of the upstream trial","authors":"Eleonora Rosato ,&nbsp;Maria Cristina Mancini ,&nbsp;Giorgio Cerrelli ,&nbsp;Francesco Di Rocco ,&nbsp;Luca Orecchia ,&nbsp;Giuseppe Farullo ,&nbsp;Andrea Turbanti ,&nbsp;Simone Pletto ,&nbsp;Yuri Cavaleri ,&nbsp;Enrico Finazzi Agrò","doi":"10.1016/j.cont.2025.101903","DOIUrl":"10.1016/j.cont.2025.101903","url":null,"abstract":"<div><h3>Objective:</h3><div>The role of invasive urodynamics (iUDS) before surgery for benign prostatic obstruction (BPO) is debated. The UPSTREAM trial showed that adding iUDS to routine care does not decrease the number of patients who will undergo surgery nor ensure better outcomes after surgery. Ito and coworkers showed that patients could be divided into two categories according to certain parameters. The primary aim of this study was to determine the proportion of patients with BPO undergoing iUDS who exhibit characteristics predictive of good surgical outcome.</div></div><div><h3>Methods:</h3><div>This retrospective study included consecutive male patients with BPO and lower urinary tract symptoms (LUTS) who underwent iUDS at our centre between January 2013 and March 2024. Patients were categorized based on UPSTREAM trial criteria for good surgical outcomes (IPSS &gt; 16, IPSS QoL &gt; 4, <span><math><msub><mrow><mi>Q</mi></mrow><mrow><mi>max</mi></mrow></msub></math></span> &lt; 9.8 mL/s, age <span><math><mo>≤</mo></math></span> 74 years). Further analysis examined bladder outlet obstruction index (BOOI <span><math><mo>≥</mo></math></span> 48) and bladder contractility index (BCI <span><math><mo>≥</mo></math></span> 123).</div></div><div><h3>Results:</h3><div>Among 212 patients analysed, 38.2% met all criteria for good surgical outcomes, while 61.8% exhibited at least one unfavourable criterion. In particular, 90/131 patients had one unfavourable criterion, 32/131 had two, and 9/131 had three. Among these patients, concerning BOOI and BCI analysis, 74% had a BCI &lt; 123, 48.1% had a BOOI &lt; 48, and 45% had both a BCI &lt; 123 and BOOI &lt; 48.</div></div><div><h3>Conclusion:</h3><div>Our findings suggest that fewer than 40% of patients undergoing iUDS before potential BPO surgery have a good prognosis based on clinical characteristics. Among those with ‘unfavourable criteria’, given the high prevalence of detrusor underactivity (DU) and non-obstructive profiles, urodynamics may refine and optimize surgical selection.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101903"},"PeriodicalIF":0.0,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacovigilance of lower urinary tract adverse events among commonly prescribed medications: A FAERS database analysis","authors":"Robert Adler,&nbsp;Michael Kozlov,&nbsp;Mark M. Shimanov ,&nbsp;Dylan S. Davie ,&nbsp;Benjamin Mishail ,&nbsp;David Musheyev,&nbsp;Jeffrey P. Weiss","doi":"10.1016/j.cont.2025.101902","DOIUrl":"10.1016/j.cont.2025.101902","url":null,"abstract":"<div><h3>Background:</h3><div>Lower urinary tract symptoms (LUTS) are a diverse group of urologic conditions characterized by dysfunction in storage, voiding, and post-micturition control. Previous studies estimate that medications account for 10% of LUTS in men. Pharmacovigilance studies, such as those using the Food and Drug Administration (FDA) Adverse Events Reporting System (FAERS), aid physicians in identifying adverse reactions and potential mechanisms to improve clinical practice. Our study sought to identify drugs that are potentially associated with LUTS and investigate the relationship between a variety of commonly prescribed medications and various LUTS.</div></div><div><h3>Methods:</h3><div>The FAERS Database was queried for a list of 17 Reaction Terms. Proportion of drug reactions to total and proportional reporting ratios were calculated for each drug. FDALabel was used to determine whether any LUTS were within the side effect profile of a drug.</div></div><div><h3>Results:</h3><div>LUTS accounted for .8% of total adverse reactions. Mirabegron (14.39) had the highest proportion of LUTS events compared to all adverse events, followed by Tolterodine Tartrate (10.95) Fesoterodine Fumarate (7.20), Tamsulosin Hydrochloride (7.07), and Warfarin Sodium (6.46). Other classes such as immunotherapeutics, proton pump inhibitors, and various psychiatric medications reported LUTS that were not within the FDALabel.</div></div><div><h3>Conclusion:</h3><div>Medications causing LUTS encompass a wide variety of classes. We discovered several medications for which FDA labels were inconsistent with reporting of adverse events. Physicians should be aware of potential medications that have not been previously reported to cause LUTS or do not contain specific LUTS within their FDA label.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101902"},"PeriodicalIF":0.0,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144116972","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Undiagnosed neurologic disease in refractory chronic pelvic pain: High yield in screen-positive patients","authors":"Talia Denis ,&nbsp;Dyer Pettijohn ,&nbsp;Elise J.B. De ,&nbsp;Charles E. Argoff","doi":"10.1016/j.cont.2025.101900","DOIUrl":"10.1016/j.cont.2025.101900","url":null,"abstract":"<div><h3>Introduction:</h3><div>Primary management of chronic pelvic pain depends on identifying and addressing its underlying etiologies. The prevalence of neurological conditions in the setting of chronic pelvic pain is poorly documented. In this study, we actively screened patients with chronic pelvic pain within our combined Urology/Urogynecology/Neurology Pain Management specialty clinics for multidisciplinary pelvic symptomatology, including neurologic, and, if present, facilitated multidisciplinary assessment of the patient.</div></div><div><h3>Methods:</h3><div>A standardized, systematic neurological history and physical was conducted when screening suggested a structural or functional nervous system disorder. Subsequent neurological testing was tailored to the clinical findings.</div></div><div><h3>Results:</h3><div>Of 188 patients who screened positive for neurological symptoms and signs and initiated combined evaluation, 126 (67%) completed recommended neurological evaluation and testing. Of the 126 who completed workup, 92 (73%) were found to have objective evidence of a neurological disorder, of which 77 (84%) were new diagnoses. The most common diagnoses included small fiber neuropathy, large fiber neuropathy, lumbosacral radiculopathy, and severe spinal stenosis.</div></div><div><h3>Conclusion:</h3><div>Neurologic disease is prevalent in people with chronic pelvic pain who have neurologic symptoms and signs. Most of the neurologic diagnoses in this study were previously unidentified; thus, many patients had experienced neurodiagnostic delay. Screening for neurologic symptomatology is recommended in patients with chronic pelvic pain to facilitate diagnostic accuracy.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101900"},"PeriodicalIF":0.0,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Soluble vascular endothelial growth factor receptor 1 (VEGFR1): A possible biomarker in BPS/IC?","authors":"Pedro Abreu-Mendes ,&nbsp;Rui Almeida Pinto ,&nbsp;Diogo Dias ,&nbsp;Francisco Cruz ,&nbsp;Ana Charrua","doi":"10.1016/j.cont.2025.101898","DOIUrl":"10.1016/j.cont.2025.101898","url":null,"abstract":"<div><h3>Introduction:</h3><div>Interstitial cystitis/bladder pain syndrome (IC/BPS) pathophysiology is not fully understood. Vascular endothelial growth factor (VEGF) has been implicated in bladder vasculature alterations and nociception, but the role of its soluble receptor, VEGFR1, remains poorly explored. This study aimed to determine whether urinary VEGF and VEGFR1 levels could be biomarkers for IC/BPS. As a post hoc analysis, we also examined VEGFR1 variation and its relationship with the clinical characteristics of IC/BPS patients and urinary serotonin levels.</div></div><div><h3>Material and Methods:</h3><div>An observational cross-sectional pilot study was conducted after clearance from the ethics committee. Eighteen female IC/BPS patients and 19 healthy age-matched females without past urological conditions were included. ESSIC criteria were used to phenotype. The patient’s symptoms evaluated were bladder pain, urinary frequency, and life quality. Patients during flare episodes or taking antidepressant drugs were excluded. Urine samples from patients and healthy subjects were used to measure VEGF, VEGFR1, and serotonin urinary levels. The relation of VEGFR1 with serotonin and clinical parameters was assessed.</div></div><div><h3>Results:</h3><div>Patients and healthy volunteers had a similar median age. No statistical differences in VEGF were detected. Urinary VEGFR1 was significantly lower in patients. Soluble VEGFR1 did not correlate to serotonin levels or clinical parameters. The urinary serotonin levels were similar between groups.</div></div><div><h3>Conclusion:</h3><div>Urinary VEGFR1, but not urinary VEGF, might be a useful IC/BPS biomarker. Further investigation is necessary to confirm the present observation and validate the relationship of VEGFR1 with clinical parameters and serotonin.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101898"},"PeriodicalIF":0.0,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144069806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A deeper exploration of functional connectivity of brain regions regulating bladder function in healthy adults","authors":"Arda Bayer ,&nbsp;Kris Hoffman ,&nbsp;Betsy Salazar ,&nbsp;Behnaam Aazhang ,&nbsp;Rose Khavari","doi":"10.1016/j.cont.2025.101897","DOIUrl":"10.1016/j.cont.2025.101897","url":null,"abstract":"<div><div>Functional magnetic resonance imaging (fMRI) has been the primary tool in human research for studying and advancing our understanding of neural control of the bladder. Although the current working model identifies several brain regions involved in bladder storage, there are unknowns regarding the full extent of collaboration among these regions. This study analyzes the changes in the resting state functional connectivity (rsFC) network involving regions of the brain, brainstem, and cerebellum in healthy adults with respect to conventional pairwise rsFC and four rsFC global network statistics. Healthy adult males and females (n=15), ages 22–33, were asked to consume 472–750 mL of water, empty their bladder, and enter the fMRI scanner, after which the “control” resting-state fMRI (rs-fMRI) scans were obtained. Participants remained in the scanner until they indicated a feeling of strong desire to void, or until 10 min had elapsed, at which point “strong desire to void” rs-fMRI scans were acquired. Functional connectivity (FC) analysis was performed using 19 <em>a priori</em> regions of interest (ROIs) in the brain, specifically incorporating the brainstem and cerebellum from previous studies. Statistical significance was gauged via t-tests with Bonferroni correction for multiple hypothesis testing. Our results revealed significance, p&lt;0.05, in the rsFC network, where the average rsFC during the strong sensation state was higher than in the control state. The pontine micturition center and cerebellum were associated with this significant increase in the average degree of 19 ROIs. The contrasts in network statistics were more substantial than the contrasts in pairwise rsFC.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101897"},"PeriodicalIF":0.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143941705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors contributing to bladder fibrosis","authors":"Karl Swärd ,&nbsp;Karl-Erik Andersson ,&nbsp;Bengt Uvelius","doi":"10.1016/j.cont.2025.101763","DOIUrl":"10.1016/j.cont.2025.101763","url":null,"abstract":"<div><h3>Background:</h3><div>Bladder outlet obstruction, commonly resulting from benign prostatic hyperplasia or congenital urethral valves, is a prevalent cause of voiding dysfunction. This condition induces significant bladder hypertrophy, alters excitability, and increases residual urine. Obstruction has been extensively studied in experimental animal models using surgical obstruction. A frequent pathological endpoint is bladder fibrosis, characterized by structural and functional deterioration of the bladder wall</div></div><div><h3>Objective:</h3><div>This article examines the pathophysiological mechanisms linking bladder outlet obstruction to fibrosis, with particular attention to bladder wall overstretch, compromised perfusion, and neural impairment</div></div><div><h3>Methods:</h3><div>We conducted a targeted literature review, employing search terms including urinary bladder, obstruction, hypoxia, and fibrosis. In addition, we analysed a bank of electron micrographs and publicly available microarray datasets derived from obstructed rat bladders to support our synthesis of experimental findings</div></div><div><h3>Key Findings:</h3><div>Our analysis underscores the intricate interplay among mechanical forces, neural input, and molecular signalling in the pathogenesis of bladder fibrosis secondary to outlet obstruction. We present a flow chart that models fibrosis progression in obstructed rat bladders. This algorithm synthesizes experimental data and incorporates key parameters such as bladder wall tension, hemodynamics, inflammatory cytokine levels, leading to expression of fibrosis-driving proteins.</div></div><div><h3>Conclusions:</h3><div>The proposed model offers a conceptual and analytical framework for studying fibrosis in the context of bladder outlet obstruction. It holds promise for guiding future research and informing the development of targeted therapeutic strategies aimed at interrupting the progression of bladder dysfunction driven by ischemia, oxidative stress, and chronic inflammation.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101763"},"PeriodicalIF":0.0,"publicationDate":"2025-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143904195","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of water-filled and air-charged catheters in urodynamic studies for women with stress urinary incontinence","authors":"Nikita Kazakov,&nbsp;George Kasyan,&nbsp;Igor Gritskov,&nbsp;Roman Stroganov,&nbsp;Bagrat Grigoryan,&nbsp;Arman Sarukhanian,&nbsp;Dmitry Pushkar","doi":"10.1016/j.cont.2025.101766","DOIUrl":"10.1016/j.cont.2025.101766","url":null,"abstract":"<div><h3>Objective:</h3><div>This study aimed to compare pressure measurements obtained using water-filled catheters (WFC) and air-charged catheters (ACC) during comprehensive urodynamic studies (UDS) in women with stress urinary incontinence (SUI).</div></div><div><h3>Materials and Methods:</h3><div>A prospective comparative study was conducted on 41 female patients with SUI who underwent UDS with simultaneous placement of WFC and ACC between January and May 2024. Intravesical, abdominal, and detrusor pressures were recorded at the end of the bladder filling phase and during voiding, coughing (Pc), and the Valsalva maneuver (Pv). The Shapiro–Wilk test was used to assess the normality of the data, while the Mann–Whitney U test and Student’s t-test were applied for statistical comparison between the two catheter systems. A <span><math><mi>p</mi></math></span>-value of &lt;0.05 was considered statistically significant.</div></div><div><h3>Results:</h3><div>No statistically significant differences were found in intravesical pressure between WFC and ACC at the end of the filling phase (p &gt; 0.05). However, significant differences were observed in abdominal pressure (Pabd), with ACC recording higher values (p &lt; 0.05). No significant differences were noted in maximum detrusor pressure during voiding (p &gt; 0.05). Intravesical pressures during coughing and the Valsalva maneuver were significantly higher with ACC compared to WFC (p &lt; 0.05).</div></div><div><h3>Conclusion:</h3><div>This study demonstrates significant differences between water-filled and air-charged catheters in measuring Pabd, Pc, and Pv. While both systems have their merits, careful consideration is required when interpreting results obtained with ACC. Future research should explore refining standardization protocols to enhance the reliability of urodynamic assessments.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101766"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143851986","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mindfulness and Transcranial Direct Current Stimulation (tDCS) to Attenuate Situational Urgency Urinary Incontinence (UUI): A randomized pilot study","authors":"Cynthia A. Conklin ,&nbsp;Brian Coffman ,&nbsp;Carol M. Greco ,&nbsp;Shachi Tyagi ,&nbsp;Becky D. Clarkson","doi":"10.1016/j.cont.2025.101765","DOIUrl":"10.1016/j.cont.2025.101765","url":null,"abstract":"<div><h3>Introduction:</h3><div>Situational urgency urinary incontinence (UUI), triggered by situations such as approaching the front door and running water, accounts for up to half of all UUI episodes in women. We proposed a behavioral therapy to examine the independent and combined efficacy of mindfulness (MI) and transcranial direct current stimulation (tDCS) of the dorsolateral prefrontal cortex to attenuate reactivity to these scenarios and reduce UUI symptomatology.</div></div><div><h3>Methods:</h3><div>Women aged over 40 reporting regular situationally triggered UUI, with at least two leaks per week, completed a 5-session study with 1-week follow-up. Participants created personal urgency and safe (non-urgency) photographic cues and were randomized to either: MI (n=20), tDCS (n = 18), or MI+tDCS (n = 20) interventions conducted during exposure to personal urgency images over 4 sessions. Pre-post assessments of UUI via bladder diary and questionnaire, reactivity to urgency cues, and attentional bias on a UUI-focused modified Stroop task were collected.</div></div><div><h3>Results:</h3><div>Reactivity to personal cues was significantly reduced in all groups and attentional bias to toileting words was reduced in the MI+tDCS group. Number of leaks decreased in all groups between 0.81 (0.23) and 0.95 (0.23) episodes per day (p &lt; 0.01). Daily urgency decreased significantly in the MI+tDCS group by 1.76 (0.47) episodes (p &lt; 0.01). ICIQ-FLUTS score reduction was clinically meaningful at 1-week follow-up. The interventions demonstrated high feasibility and high rates of acceptability (&gt;80/100) with participant compliance over 90% across groups.</div></div><div><h3>Conclusion:</h3><div>Mindfulness and tDCS offer promising non-invasive therapeutic benefit for reducing UUI symptoms in women with potential for easy dissemination and high adherence without additional pharmaceutical burden.</div></div>","PeriodicalId":72702,"journal":{"name":"Continence (Amsterdam, Netherlands)","volume":"14 ","pages":"Article 101765"},"PeriodicalIF":0.0,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143936131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}