Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference最新文献

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Distal radius bone mineral density estimation using the filling factor of trabecular bone in the x-ray image. 基于x线图像中骨小梁填充因子的桡骨远端骨密度估计。
Sooyeul Lee, Ji-Wook Jeong, Jeong Won Lee, Done-Sik Yoo, Seunghwan Kim
{"title":"Distal radius bone mineral density estimation using the filling factor of trabecular bone in the x-ray image.","authors":"Sooyeul Lee,&nbsp;Ji-Wook Jeong,&nbsp;Jeong Won Lee,&nbsp;Done-Sik Yoo,&nbsp;Seunghwan Kim","doi":"10.1109/IEMBS.2006.259910","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.259910","url":null,"abstract":"<p><p>Osteoporosis is characterized by an abnormal loss of bone mineral content, which leads to a tendency to non-traumatic bone fractures or to structural deformations of bone. Thus, bone density measurement has been considered as a most reliable method to assess bone fracture risk due to osteoporosis. In past decades, X-ray images have been studied in connection with the bone mineral density estimation. However, the estimated bone mineral density from the X-ray image can undergo a relatively large accuracy or precision error. The most relevant origin of the accuracy or precision error may be unstable X-ray image acquisition condition. Thus, we focus our attentions on finding a bone mineral density estimation method that is relatively insensitive to the X-ray image acquisition condition. In this paper, we develop a simple technique for distal radius bone mineral density estimation using the trabecular bone filling factor in the X-ray image and apply the technique to the wrist X-ray images of 20 women. Estimated bone mineral density shows a high linear correlation with a dual-energy X-ray absorptiometry (r=0.87).</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"1980-2"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.259910","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 6
Modelling and simulation of the TLR4 pathway with coloured petri nets. 用彩色petri网对TLR4通路进行建模和仿真。
C Täubner, B Mathiak, A Kupfer, N Fleischer, S Eckstein
{"title":"Modelling and simulation of the TLR4 pathway with coloured petri nets.","authors":"C Täubner,&nbsp;B Mathiak,&nbsp;A Kupfer,&nbsp;N Fleischer,&nbsp;S Eckstein","doi":"10.1109/IEMBS.2006.259902","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.259902","url":null,"abstract":"<p><p>This paper demonstrates the first steps of an automation process to develop models of signal transduction pathways using discrete modelling languages. The whole approach consists of modelling, validation, animation, linking databases to simulation tools and also the qualitative analysis of the data. In this paper, we detail the modelling and simulation of the TLR4 pathway with a coloured petri net simulation tool and the validation of this model against the semantic and mechanistic map from a biological database. These graphical maps contain all necessary reactions as a figure. We start with an UML class diagram to understand the static structure of molecules involved in the TLR4 pathway. Afterwards we model and simulate each \"pathway step reaction\" - one after another - to get the behaviour of the final system. The result is a model of the pathway which can be used in simulations, derived solely from basic chemical reactions in the database. Also, it is a lesson on critical points where human decision-making is needed, because not all the required information is stored directly in the database.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"2009-12"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.259902","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055676","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 30
Computation intelligent for eukaryotic cell-cycle gene network. 真核细胞周期基因网络的智能计算。
Shinq-Jen Wu, Cheng-Tao Wu, Tsu-Tian Lee
{"title":"Computation intelligent for eukaryotic cell-cycle gene network.","authors":"Shinq-Jen Wu,&nbsp;Cheng-Tao Wu,&nbsp;Tsu-Tian Lee","doi":"10.1109/IEMBS.2006.260339","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.260339","url":null,"abstract":"<p><p>Computational intelligent approaches is adopted to construct the S-system of eukaryotic cell cycle for further analysis of genetic regulatory networks. A highly nonlinear power-law differential equation is constructed to describe the transcriptional regulation of gene network from the time-courses dataset. Global artificial algorithm, based on hybrid differential evolution, can achieve global optimization for the highly nonlinear differential gene network modeling. The constructed gene regulatory networks will be a reference for researchers to realize the inhibitory and activatory operator for genes synthesis and decomposition in Eukaryotic cell cycle.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"2017-20"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.260339","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
The maternal ECG suppression algorithm for efficient extraction of the fetal ECG from abdominal signal. 采用母体心电抑制算法从胎儿腹部信号中有效提取胎儿心电信号。
A Matonia, J Jezewski, K Horoba, A Gacek, P Labaj
{"title":"The maternal ECG suppression algorithm for efficient extraction of the fetal ECG from abdominal signal.","authors":"A Matonia,&nbsp;J Jezewski,&nbsp;K Horoba,&nbsp;A Gacek,&nbsp;P Labaj","doi":"10.1109/IEMBS.2006.260221","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.260221","url":null,"abstract":"<p><p>At present, noninvasive recording of abdominal fetal electrocardiogram and analysis of the fetal heart rate variability seems to be the most promising method to detect the fetal hypoxia. The main problem is to obtain a good quality fetal ECG, which is strongly distorted by maternal component of dominating energy. The paper presents the new method of maternal electrocardiogram recognition and suppression relying on determination of template maternal PQRST complex and its subtraction during consecutive maternal cardiac cycles. The efficiency of the developed method was evaluated and related to three other selected methods for maternal ECG suppression using dedicated coefficients created for this comparison.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"3106-9"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.260221","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055688","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 38
Tailoring magnetic field gradient design to magnet cryostat geometry. 剪裁磁场梯度设计磁铁低温恒温器几何。
A Trakic, F Liu, H S Lopez, H Wang, S Crozier
{"title":"Tailoring magnetic field gradient design to magnet cryostat geometry.","authors":"A Trakic,&nbsp;F Liu,&nbsp;H S Lopez,&nbsp;H Wang,&nbsp;S Crozier","doi":"10.1109/IEMBS.2006.259223","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.259223","url":null,"abstract":"<p><p>Eddy currents induced within a magnetic resonance imaging (MRI) cryostat bore during pulsing of gradient coils can be applied constructively together with the gradient currents that generate them, to obtain good quality gradient uniformities within a specified imaging volume over time. This can be achieved by simultaneously optimizing the spatial distribution and temporal pre-emphasis of the gradient coil current, to account for the spatial and temporal variation of the secondary magnetic fields due to the induced eddy currents. This method allows the tailored design of gradient coil/magnet configurations and consequent engineering trade-offs. To compute the transient eddy currents within a realistic cryostat vessel, a low-frequency finite-difference time-domain (FDTD) method using total-field scattered-field (TFSF) scheme has been performed and validated.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"268-71"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.259223","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Discrete Laplacian recordings of the electroenterogram from abdominal surface in humans. 人类腹部表面肠电图的离散拉普拉斯记录。
Gema Prats-Boluda, José L Martinez-de-Juan, Javier Garcia-Casado, José L Guardiola, José L Ponce
{"title":"Discrete Laplacian recordings of the electroenterogram from abdominal surface in humans.","authors":"Gema Prats-Boluda,&nbsp;José L Martinez-de-Juan,&nbsp;Javier Garcia-Casado,&nbsp;José L Guardiola,&nbsp;José L Ponce","doi":"10.1109/IEMBS.2006.260007","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.260007","url":null,"abstract":"<p><p>The first aim of this study was to obtain the discrete Laplacian of the myoelectric small intestine signal (electroenterogram, EEnG) from bipolar recordings on the abdominal surface in humans. In addition, the objective was to identify the slow wave (SW) component of the EEnG in the estimated Laplacian, as well as to compare this signal with the bipolar surface recordings. It was carried out 8 recording sessions in 6 healthy volunteers. The discrete Laplacian of the surface potential was performed using Hjorth's Laplacian estimation method. In order to identify the SW component of the EEnG, an adaptive filter, which removes breath interference from abdominal surface recordings, was designed. After that, periodograms and their dominant frequency were obtained. The results show that this frequency, in all surface recording channels and in their corresponding Laplacian, ranges from 0.12 to 0.16 Hz (7.3 to 9.8 cycles per minute) inside of the SW frequency range, whereas the frequencies of the respiration ranges from 0.21 to 0.31 Hz (12.9-18.4 cpm). Furthermore abdominal surface Laplacian potential contains averaged SW, information unless any bipolar surface channel do not record properly this signal. Consequently EEnG surface recordings can become a low cost technique to study bowel motility non-invasively.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"6080-3"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.260007","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055771","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of the slow wave of bowel myoelectrical surface recording by empirical mode decomposition. 用经验模态分解识别肠肌电表面记录慢波。
Yiyao Ye, J Garcia-Casado, J L Martinez-de-Juan, J L Guardiola, J L Ponce
{"title":"Identification of the slow wave of bowel myoelectrical surface recording by empirical mode decomposition.","authors":"Yiyao Ye,&nbsp;J Garcia-Casado,&nbsp;J L Martinez-de-Juan,&nbsp;J L Guardiola,&nbsp;J L Ponce","doi":"10.1109/IEMBS.2006.260123","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.260123","url":null,"abstract":"<p><p>Surface electroenterogram (EEnG) is a non-invasive method to study bowel myoelectrical activity. Nevertheless, surface recorded EEnG is contaminated by respiratory, motion artifacts, and other interferences. The goal of this paper is to remove the respiration artifact and ultra-low frequency components from surface EEnG by means of empirical mode decomposition (EMD). Seven recording sessions on abdominal surface of three Beagle dogs were conducted. Power percentages of interferences and of fundamental slow wave were calculated before and after the application of the method. The results show that the interference power is significantly reduced (23 +/- 16% vs. 5 +/- 4%), and fundamental slow wave power is significantly increased (59 +/- 17% vs. 76 +/- 13%). Therefore, the EMD method can be helpful to remove respiration and ultra-low frequency components from the external EEnG recordings.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"6165-8"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.260123","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 5
Peptide-nanoparticle hybrid SERS probe for dynamic detection of active cancer biomarker enzymes. 肽-纳米颗粒复合SERS探针动态检测活性癌症生物标志物酶。
Gang L Liu, F Frank Chen, Jonathan A Ellman, Luke P Lee
{"title":"Peptide-nanoparticle hybrid SERS probe for dynamic detection of active cancer biomarker enzymes.","authors":"Gang L Liu,&nbsp;F Frank Chen,&nbsp;Jonathan A Ellman,&nbsp;Luke P Lee","doi":"10.1109/IEMBS.2006.260259","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.260259","url":null,"abstract":"<p><p>Real-time in situ detection of protease enzymes is crucial for early-stage cancer screening and cell signaling pathway study; however it is difficult to be realized using fluorescence or radioactive probes. Here we devise a hybrid optical probe by incorporating nanocrescent particle and peptides with artificial tag molecules. The peptides have high specificity to PSA, one of the most prominent prostate cancer markers, and a serine protease present in patients' seminal fluid and serum. The extrinsic Raman spectral signal from the tag molecules is enhanced by the nanocrescent and the signal is monitored as the indicator for the peptide digestion in nanomolar PSA concentration and femtoliter reaction volume. Sensitive detection of cancer-related serine protease activity of PSA proteins in low concentrations and small volumes of biofluid is critical to early cancer diagnosis, clinical staging, and therapy. The high reaction specificity of the peptide and the monitored extrinsic Raman signal also minimizes the false detection of other serine proteases and intrinsic Raman signal, which results in a high-fidelity and high-signal-to-noise-ratio cancer nanoprobe. Peptide-conjugated nanocrescents should also be applicable for measuring the intercellular and intracellular activity of other cancer-related proteases and protease activity profiling-enabled cancer cell identification.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"795-8"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.260259","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055778","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 7
An optical fiber photoplethysmographic system for central nervous system tissue. 一种用于中枢神经系统组织的光纤光体积描记系统。
Justin P Phillips, Panayiotis A Kyriacou, Kuriakose J George, John V Priestley, Richard M Langford
{"title":"An optical fiber photoplethysmographic system for central nervous system tissue.","authors":"Justin P Phillips,&nbsp;Panayiotis A Kyriacou,&nbsp;Kuriakose J George,&nbsp;John V Priestley,&nbsp;Richard M Langford","doi":"10.1109/IEMBS.2006.259690","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.259690","url":null,"abstract":"<p><p>A new system for measuring the oxygen saturation of blood within tissue has been developed, for a number of potential patient monitoring applications. This proof of concept project aims to address the unmet need of real-time measurement of oxygen saturation in the central nervous system (CNS) for patients recovering from neurosurgery or trauma, by developing a fiber optic signal acquisition system for internal placement through small apertures. The development and testing of a two-wavelength optical fiber reflectance photoplethysmography (PPG) system is described. It was found that good quality red and near-infrared PPG signals could be consistently obtained from the human fingertip (n=6) and rat spinal cord (n=6) using the fiber optic probe. These findings justify further development and clinical evaluation of this fiber optic system.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"803-6"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.259690","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 11
Analysis of the surgery task for the force feedback amplification in the minimally invasive surgical system. 微创手术系统中力反馈放大的手术任务分析。
Phongsaen Pitakwatchara, Shin-ichi Warisawa, Mamoru Mitsuishi
{"title":"Analysis of the surgery task for the force feedback amplification in the minimally invasive surgical system.","authors":"Phongsaen Pitakwatchara,&nbsp;Shin-ichi Warisawa,&nbsp;Mamoru Mitsuishi","doi":"10.1109/IEMBS.2006.259933","DOIUrl":"https://doi.org/10.1109/IEMBS.2006.259933","url":null,"abstract":"<p><p>This paper presents a new method of amplifying the small reaction force in the minimally invasive surgical system according to the surgeon's intended action. For this purpose, the analysis of the laparoscopic cholecystectomy procedure is first studied. The procedure is broken down and analyzed for the necessary forceps actions based on the degrees of freedom of the surgical tool and the task to be performed. For this system, there are seven necessary forceps actions. Then the concept of the force feedback augmentation has been proposed. It amplifies the small reaction force in specific directions according to the surgeon's intended action. Each action determines how the reaction force should be amplified.</p>","PeriodicalId":72689,"journal":{"name":"Conference proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual Conference","volume":" ","pages":"829-32"},"PeriodicalIF":0.0,"publicationDate":"2006-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1109/IEMBS.2006.259933","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"27055783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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