真核细胞周期基因网络的智能计算。

Shinq-Jen Wu, Cheng-Tao Wu, Tsu-Tian Lee
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引用次数: 5

摘要

采用计算智能方法构建真核细胞周期s系统,进一步分析遗传调控网络。利用时间序列数据构建了一个高度非线性的幂律微分方程来描述基因网络的转录调控。基于混合差分进化的全局人工算法可以对高度非线性的差分基因网络建模实现全局优化。构建的基因调控网络将为研究人员实现真核细胞周期中基因合成和分解的抑制和激活操作符提供参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Computation intelligent for eukaryotic cell-cycle gene network.

Computational intelligent approaches is adopted to construct the S-system of eukaryotic cell cycle for further analysis of genetic regulatory networks. A highly nonlinear power-law differential equation is constructed to describe the transcriptional regulation of gene network from the time-courses dataset. Global artificial algorithm, based on hybrid differential evolution, can achieve global optimization for the highly nonlinear differential gene network modeling. The constructed gene regulatory networks will be a reference for researchers to realize the inhibitory and activatory operator for genes synthesis and decomposition in Eukaryotic cell cycle.

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