Complex psychiatry最新文献_第7页

Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson's Disease. 重度抑郁症与帕金森病趋同机制的研究。

Complex psychiatry Pub Date : 2021-02-01 DOI: 10.1159/000512657

Angela A Tran, Myra De Smet, Gary D Grant, Tien K Khoo, Dean L Pountney

{"title":"Investigating the Convergent Mechanisms between Major Depressive Disorder and Parkinson's Disease.","authors":"Angela A Tran, Myra De Smet, Gary D Grant, Tien K Khoo, Dean L Pountney","doi":"10.1159/000512657","DOIUrl":"https://doi.org/10.1159/000512657","url":null,"abstract":"Major depressive disorder (MDD) affects more than cognition, having a temporal relationship with neuroinflammatory pathways of Parkinson's disease (PD). Although this association is supported by epidemiological and clinical studies, the underlying mechanisms are unclear. Microglia and astrocytes play crucial roles in the pathophysiology of both MDD and PD. In PD, these cells can be activated by misfolded forms of the protein α-synuclein to release cytokines that can interact with multiple different physiological processes to produce depressive symptoms, including monoamine transport and availability, the hypothalamus-pituitary axis, and neurogenesis. In MDD, glial cell activation can be induced by peripheral inflammatory agents that cross the blood-brain barrier and/or c-Fos signalling from neurons. The resulting neuroinflammation can cause neurodegeneration due to oxidative stress and glutamate excitotoxicity, contributing to PD pathology. Astrocytes are another major link due to their recognized role in the glymphatic clearance mechanism. Research suggesting that MDD causes astrocytic destruction or structural atrophy highlights the possibility that accumulation of α-synuclein in the brain is facilitated as the brain cannot adequately clear the protein aggregates. This review examines research into the overlapping pathophysiology of MDD and PD with particular focus on the roles of glial cells and neuroinflammation.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":"6 3-4","pages":"47-61"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000512657","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9974830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 11

Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version. 药物依赖与酒精中毒半结构化评估(SSADDA)中文版的诊断信度与效度。

Complex psychiatry Pub Date : 2021-02-01 Epub Date: 2020-09-16 DOI: 10.1159/000511606

Bao-Zhu Yang, Liang-Jen Wang, Ming-Chyi Huang, Sheng-Chang Wang, Meng-Chang Tsai, Yu-Chi Huang, Yaira Z Nuñez, Mei-Hing Ng, Henry R Kranzler, Joel Gelernter, Chih-Ken Chen

{"title":"Diagnostic Reliability and Validity of the Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) Chinese Version.","authors":"Bao-Zhu Yang, Liang-Jen Wang, Ming-Chyi Huang, Sheng-Chang Wang, Meng-Chang Tsai, Yu-Chi Huang, Yaira Z Nuñez, Mei-Hing Ng, Henry R Kranzler, Joel Gelernter, Chih-Ken Chen","doi":"10.1159/000511606","DOIUrl":"https://doi.org/10.1159/000511606","url":null,"abstract":"The Semi-Structured Assessment for Drug Dependence and Alcoholism (SSADDA) is a polydiagnostic instrument for substance use and psychiatric disorders. We translated the SSADDA English version into Chinese (SSADDA-Chinese) and report here our examination of the diagnostic reliability and validity of DSM-IV substance dependence (SD) diagnoses in a Mandarin-speaking sample in Taiwan. We recruited 125 subjects who underwent an assessment of lifetime SD diagnoses using both the SSADDA-Chinese and the Structured Clinical Interview for DSM-IV, Clinician Version (SCID-Chinese). Thirty-one subjects were retested with the SSADDA-Chinese. Cohen's κ statistic, which measures chance-corrected agreement, was used to measure the test-retest reliability and concurrent validity of the individual SD diagnoses. There was a high degree of concordance between SD diagnoses made using the SSADDA-Chinese and the SCID-Chinese, including those for dependence on alcohol (κ = 0.83), ketamine (κ = 0.97), methamphetamine (κ = 0.93), and opioids (κ = 0.95). The test-retest reliability of dependence diagnoses for ketamine (κ = 0.95), methamphetamine (κ = 0.80), and opioids (κ = 1.00) obtained using the SSADDA-Chinese was excellent, while that for alcohol dependence (κ = 0.63) and nicotine dependence (κ = 0.65) was good. We conclude that the SSADDA-Chinese is a reliable and valid instrument for the diagnosis of major SD traits in Mandarin-speaking populations.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"62-67"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000511606","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39707015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Front & Back Matter 正面和背面

Complex psychiatry Pub Date : 2021-02-01 DOI: 10.1159/000515240

引用次数: 0

Transcriptomic Deconvolution of Dorsal Striata Reveals Increased Monocyte Fractions in Bipolar Disorder. 背纹状体转录组反褶积显示双相情感障碍中单核细胞比例增加。

Complex psychiatry Pub Date : 2021-02-01 Epub Date: 2020-10-01 DOI: 10.1159/000511887

Sai Batchu

{"title":"Transcriptomic Deconvolution of Dorsal Striata Reveals Increased Monocyte Fractions in Bipolar Disorder.","authors":"Sai Batchu","doi":"10.1159/000511887","DOIUrl":"https://doi.org/10.1159/000511887","url":null,"abstract":"Introduction: Accumulating evidence suggests a relationship between the immune system, neuroinflammation, and mood disorders such as bipolar disorder (BD). However, the immunological landscape of critical brain structures implicated with BD, such as the dorsal striatum, has yet to be characterized. This study sought to investigate the immunological composition of dorsal striata in patients with BD.Methods: CIBERSORTx, an established RNA deconvolution algorithm, was applied on RNA-sequencing data developed from dorsal striata of 18 BD patients and 17 controls. A validated gene signature matrix for 22 human hematopoietic cell subsets was used to infer the relative proportions of immune cells that were present in the original brain tissue.Results: Deconvolution of the bulk gene expression data showed that dorsal striata from BD subjects had a significantly greater relative abundance of monocytes compared to control samples.Conclusion: Monocytes may play a role in the pathogenesis of BD in dorsal striata. Further studies are warranted to confirm the computational results presented herein.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000511887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Vol. 6, 2020 第6卷，2020

Complex psychiatry Pub Date : 2021-02-01 DOI: 10.1159/000514820

引用次数: 0

Emergence 出现

Complex psychiatry Pub Date : 2021-01-06 DOI: 10.1002/cplx.10009

H. Morowitz

引用次数: 0

Introducing Complex Psychiatry. 介绍复杂精神病学。

Complex psychiatry Pub Date : 2020-10-01 DOI: 10.1159/000508645

Joel Gelernter, Renato Polimanti

引用次数: 0

Genomic Chaos Begets Psychiatric Disorder. 基因组混乱导致精神失常

Complex psychiatry Pub Date : 2020-10-01 Epub Date: 2020-04-21 DOI: 10.1159/000507988

Donard S Dwyer

{"title":"Genomic Chaos Begets Psychiatric Disorder.","authors":"Donard S Dwyer","doi":"10.1159/000507988","DOIUrl":"10.1159/000507988","url":null,"abstract":"The processes that created the primordial genome are inextricably linked to current day vulnerability to developing a psychiatric disorder as summarized in this review article. Chaos and dynamic forces including duplication, transposition, and recombination generated the protogenome. To survive early stages of genome evolution, self-organization emerged to curb chaos. Eventually, the human genome evolved through a delicate balance of chaos/instability and organization/stability. However, recombination coldspots, silencing of transposable elements, and other measures to limit chaos also led to retention of variants that increase risk for disease. Moreover, ongoing dynamics in the genome creates various new mutations that determine liability for psychiatric disorders. Homologous recombination, long-range gene regulation, and gene interactions were all guided by spooky action-at-a-distance, which increased variability in the system. A probabilistic system of life was required to deal with a changing environment. This ensured the generation of outliers in the population, which enhanced the probability that some members would survive unfavorable environmental impacts. Some of the outliers produced through this process in man are ill suited to cope with the complex demands of modern life. Genomic chaos and mental distress from the psychological challenges of modern living will inevitably converge to produce psychiatric disorders in man.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"20-29"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673594/pdf/cxp-0006-0020.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Brain Microvascular Endothelial Cell and Blood-Brain Barrier Dysfunction in Schizophrenia. 脑微血管内皮细胞和血脑屏障功能障碍在精神分裂症中的作用

Complex psychiatry Pub Date : 2020-10-01 Epub Date: 2020-09-14 DOI: 10.1159/000511552

Sovannarath Pong, Rakesh Karmacharya, Marianna Sofman, Jeffrey R Bishop, Paulo Lizano

{"title":"The Role of Brain Microvascular Endothelial Cell and Blood-Brain Barrier Dysfunction in Schizophrenia.","authors":"Sovannarath Pong, Rakesh Karmacharya, Marianna Sofman, Jeffrey R Bishop, Paulo Lizano","doi":"10.1159/000511552","DOIUrl":"10.1159/000511552","url":null,"abstract":"Background: Despite decades of research, little clarity exists regarding pathogenic mechanisms related to schizophrenia. Investigations on the disease biology of schizophrenia have primarily focused on neuronal alterations. However, there is substantial evidence pointing to a significant role for the brain's microvasculature in mediating neuroinflammation in schizophrenia.Summary: Brain microvascular endothelial cells (BMEC) are a central element of the microvasculature that forms the blood-brain barrier (BBB) and shields the brain against toxins and immune cells via paracellular, transcellular, transporter, and extracellular matrix proteins. While evidence for BBB dysfunction exists in brain disorders, including schizophrenia, it is not known if BMEC themselves are functionally compromised and lead to BBB dysfunction.Key messages: Genome-wide association studies, postmortem investigations, and gene expression analyses have provided some insights into the role of the BBB in schizophrenia pathophysiology. However, there is a significant gap in our understanding of the role that BMEC play in BBB dysfunction. Recent advances differentiating human BMEC from induced pluripotent stem cells (iPSC) provide new avenues to examine the role of BMEC in BBB dysfunction in schizophrenia.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"30-46"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673590/pdf/cxp-0006-0030.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability. 突触中的 FMRP 和 CYFIP1 及其在精神病易感性中的作用

Complex psychiatry Pub Date : 2020-10-01 Epub Date: 2020-03-03 DOI: 10.1159/000506858

Nicholas E Clifton, Kerrie L Thomas, Lawrence S Wilkinson, Jeremy Hall, Simon Trent

{"title":"FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability.","authors":"Nicholas E Clifton, Kerrie L Thomas, Lawrence S Wilkinson, Jeremy Hall, Simon Trent","doi":"10.1159/000506858","DOIUrl":"10.1159/000506858","url":null,"abstract":"There is increasing awareness of the role genetic risk variants have in mediating vulnerability to psychiatric disorders such as schizophrenia and autism. Many of these risk variants encode synaptic proteins, influencing biological pathways of the postsynaptic density and, ultimately, synaptic plasticity. Fragile-X mental retardation 1 (FMR1) and cytoplasmic fragile-X mental retardation protein (FMRP)-interacting protein 1 (CYFIP1) contain 2 such examples of highly penetrant risk variants and encode synaptic proteins with shared functional significance. In this review, we discuss the biological actions of FMRP and CYFIP1, including their regulation of (i) protein synthesis and specifically FMRP targets, (ii) dendritic and spine morphology, and (iii) forms of synaptic plasticity such as long-term depression. We draw upon a range of preclinical studies that have used genetic dosage models of FMR1 and CYFIP1 to determine their biological function. In parallel, we discuss how clinical studies of fragile X syndrome or 15q11.2 deletion patients have informed our understanding of FMRP and CYFIP1, and highlight the latest psychiatric genomic findings that continue to implicate FMRP and CYFIP1. Lastly, we assess the current limitations in our understanding of FMRP and CYFIP1 biology and how they must be addressed before mechanism-led therapeutic strategies can be developed for psychiatric disorders.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"5-19"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0