Complex psychiatry最新文献_第7页

Transcriptomic Deconvolution of Dorsal Striata Reveals Increased Monocyte Fractions in Bipolar Disorder. 背纹状体转录组反褶积显示双相情感障碍中单核细胞比例增加。

Complex psychiatry Pub Date : 2021-02-01 Epub Date: 2020-10-01 DOI: 10.1159/000511887

Sai Batchu

{"title":"Transcriptomic Deconvolution of Dorsal Striata Reveals Increased Monocyte Fractions in Bipolar Disorder.","authors":"Sai Batchu","doi":"10.1159/000511887","DOIUrl":"https://doi.org/10.1159/000511887","url":null,"abstract":"Introduction: Accumulating evidence suggests a relationship between the immune system, neuroinflammation, and mood disorders such as bipolar disorder (BD). However, the immunological landscape of critical brain structures implicated with BD, such as the dorsal striatum, has yet to be characterized. This study sought to investigate the immunological composition of dorsal striata in patients with BD.Methods: CIBERSORTx, an established RNA deconvolution algorithm, was applied on RNA-sequencing data developed from dorsal striata of 18 BD patients and 17 controls. A validated gene signature matrix for 22 human hematopoietic cell subsets was used to infer the relative proportions of immune cells that were present in the original brain tissue.Results: Deconvolution of the bulk gene expression data showed that dorsal striata from BD subjects had a significantly greater relative abundance of monocytes compared to control samples.Conclusion: Monocytes may play a role in the pathogenesis of BD in dorsal striata. Further studies are warranted to confirm the computational results presented herein.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"83-88"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1159/000511887","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 3

Vol. 6, 2020 第6卷，2020

Complex psychiatry Pub Date : 2021-02-01 DOI: 10.1159/000514820

引用次数: 0

Emergence 出现

Complex psychiatry Pub Date : 2021-01-06 DOI: 10.1002/cplx.10009

H. Morowitz

引用次数: 0

Introducing Complex Psychiatry. 介绍复杂精神病学。

Complex psychiatry Pub Date : 2020-10-01 DOI: 10.1159/000508645

Joel Gelernter, Renato Polimanti

引用次数: 0

Genomic Chaos Begets Psychiatric Disorder. 基因组混乱导致精神失常

Complex psychiatry Pub Date : 2020-10-01 Epub Date: 2020-04-21 DOI: 10.1159/000507988

Donard S Dwyer

{"title":"Genomic Chaos Begets Psychiatric Disorder.","authors":"Donard S Dwyer","doi":"10.1159/000507988","DOIUrl":"10.1159/000507988","url":null,"abstract":"The processes that created the primordial genome are inextricably linked to current day vulnerability to developing a psychiatric disorder as summarized in this review article. Chaos and dynamic forces including duplication, transposition, and recombination generated the protogenome. To survive early stages of genome evolution, self-organization emerged to curb chaos. Eventually, the human genome evolved through a delicate balance of chaos/instability and organization/stability. However, recombination coldspots, silencing of transposable elements, and other measures to limit chaos also led to retention of variants that increase risk for disease. Moreover, ongoing dynamics in the genome creates various new mutations that determine liability for psychiatric disorders. Homologous recombination, long-range gene regulation, and gene interactions were all guided by spooky action-at-a-distance, which increased variability in the system. A probabilistic system of life was required to deal with a changing environment. This ensured the generation of outliers in the population, which enhanced the probability that some members would survive unfavorable environmental impacts. Some of the outliers produced through this process in man are ill suited to cope with the complex demands of modern life. Genomic chaos and mental distress from the psychological challenges of modern living will inevitably converge to produce psychiatric disorders in man.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"20-29"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673594/pdf/cxp-0006-0020.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706299","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Brain Microvascular Endothelial Cell and Blood-Brain Barrier Dysfunction in Schizophrenia. 脑微血管内皮细胞和血脑屏障功能障碍在精神分裂症中的作用

Complex psychiatry Pub Date : 2020-10-01 Epub Date: 2020-09-14 DOI: 10.1159/000511552

Sovannarath Pong, Rakesh Karmacharya, Marianna Sofman, Jeffrey R Bishop, Paulo Lizano

{"title":"The Role of Brain Microvascular Endothelial Cell and Blood-Brain Barrier Dysfunction in Schizophrenia.","authors":"Sovannarath Pong, Rakesh Karmacharya, Marianna Sofman, Jeffrey R Bishop, Paulo Lizano","doi":"10.1159/000511552","DOIUrl":"10.1159/000511552","url":null,"abstract":"Background: Despite decades of research, little clarity exists regarding pathogenic mechanisms related to schizophrenia. Investigations on the disease biology of schizophrenia have primarily focused on neuronal alterations. However, there is substantial evidence pointing to a significant role for the brain's microvasculature in mediating neuroinflammation in schizophrenia.Summary: Brain microvascular endothelial cells (BMEC) are a central element of the microvasculature that forms the blood-brain barrier (BBB) and shields the brain against toxins and immune cells via paracellular, transcellular, transporter, and extracellular matrix proteins. While evidence for BBB dysfunction exists in brain disorders, including schizophrenia, it is not known if BMEC themselves are functionally compromised and lead to BBB dysfunction.Key messages: Genome-wide association studies, postmortem investigations, and gene expression analyses have provided some insights into the role of the BBB in schizophrenia pathophysiology. However, there is a significant gap in our understanding of the role that BMEC play in BBB dysfunction. Recent advances differentiating human BMEC from induced pluripotent stem cells (iPSC) provide new avenues to examine the role of BMEC in BBB dysfunction in schizophrenia.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"30-46"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673590/pdf/cxp-0006-0030.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability. 突触中的 FMRP 和 CYFIP1 及其在精神病易感性中的作用

Complex psychiatry Pub Date : 2020-10-01 Epub Date: 2020-03-03 DOI: 10.1159/000506858

Nicholas E Clifton, Kerrie L Thomas, Lawrence S Wilkinson, Jeremy Hall, Simon Trent

{"title":"FMRP and CYFIP1 at the Synapse and Their Role in Psychiatric Vulnerability.","authors":"Nicholas E Clifton, Kerrie L Thomas, Lawrence S Wilkinson, Jeremy Hall, Simon Trent","doi":"10.1159/000506858","DOIUrl":"10.1159/000506858","url":null,"abstract":"There is increasing awareness of the role genetic risk variants have in mediating vulnerability to psychiatric disorders such as schizophrenia and autism. Many of these risk variants encode synaptic proteins, influencing biological pathways of the postsynaptic density and, ultimately, synaptic plasticity. Fragile-X mental retardation 1 (FMR1) and cytoplasmic fragile-X mental retardation protein (FMRP)-interacting protein 1 (CYFIP1) contain 2 such examples of highly penetrant risk variants and encode synaptic proteins with shared functional significance. In this review, we discuss the biological actions of FMRP and CYFIP1, including their regulation of (i) protein synthesis and specifically FMRP targets, (ii) dendritic and spine morphology, and (iii) forms of synaptic plasticity such as long-term depression. We draw upon a range of preclinical studies that have used genetic dosage models of FMR1 and CYFIP1 to determine their biological function. In parallel, we discuss how clinical studies of fragile X syndrome or 15q11.2 deletion patients have informed our understanding of FMRP and CYFIP1, and highlight the latest psychiatric genomic findings that continue to implicate FMRP and CYFIP1. Lastly, we assess the current limitations in our understanding of FMRP and CYFIP1 biology and how they must be addressed before mechanism-led therapeutic strategies can be developed for psychiatric disorders.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":" ","pages":"5-19"},"PeriodicalIF":0.0,"publicationDate":"2020-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7673588/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"39706300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prophylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models 利鲁唑对两种啮齿动物应激模型中焦虑和抑郁样行为的预防作用

Complex psychiatry Pub Date : 2020-08-07 DOI: 10.1101/2020.08.07.242057

Y. Bansal, Corey Fee, Keith A. Misquitta, S. Codeluppi, E. Sibille, R. Berman, V. Coric, G. Sanacora, M. Banasr

{"title":"Prophylactic Efficacy of Riluzole against Anxiety- and Depressive-Like Behaviors in Two Rodent Stress Models","authors":"Y. Bansal, Corey Fee, Keith A. Misquitta, S. Codeluppi, E. Sibille, R. Berman, V. Coric, G. Sanacora, M. Banasr","doi":"10.1101/2020.08.07.242057","DOIUrl":"https://doi.org/10.1101/2020.08.07.242057","url":null,"abstract":"Background Chronic stress-related illnesses, such as major depressive disorder and post-traumatic stress disorder share symptomatology, including anxiety, anhedonia, and helplessness. Across disorders, neurotoxic dysregulated glutamate (Glu) signaling may underlie symptom emergence. Current first-line antidepressant drugs, which do not directly target Glu signaling, fail to provide adequate benefit for many patients and are associated with high relapse rates. Riluzole modulates glutamatergic neurotransmission by increasing metabolic cycling and modulating signal transduction. Clinical studies exploring riluzole’s efficacy in stress-related disorders have provided varied results. However, the utility of riluzole for treating specific symptom dimensions or as a prophylactic treatment has not been comprehensively assessed. Methods We investigated whether chronic prophylactic riluzole (~12-15mg/kg/day p.o.) could prevent the emergence of behavioral deficits induced by unpredictable chronic mild stress (UCMS) in mice. We assessed: i) anxiety-like behavior using the elevated-plus maze, open field test, and novelty-suppressed feeding, ii) mixed anxiety/anhedonia-like behavior in the novelty-induced hypophagia test and, iii) anhedonia-like behavior using the sucrose consumption test. Z-scoring summarized changes across tests measuring similar dimensions. In a separate learned helplessness (LH) cohort, we investigated whether chronic prophylactic riluzole treatment could block the development of helplessness-like behavior. Results UCMS induced an elevation in anhedonia-like behavior, and overall behavioral emotionality that was blocked by prophylactic riluzole. In the LH cohort, prophylactic riluzole blocked the development of helplessness-like behavior. Conclusion This study supports the utility of riluzole as a prophylactic medication for preventing anhedonia, and helplessness symptoms associated with stress-related disorders.","PeriodicalId":72654,"journal":{"name":"Complex psychiatry","volume":"30 1","pages":"57 - 69"},"PeriodicalIF":0.0,"publicationDate":"2020-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85639230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

An Agent-Based Model of Opinion Polarization Driven by Emotions 基于agent的情绪驱动意见极化模型

Complex psychiatry Pub Date : 2020-03-16 DOI: 10.31235/osf.io/8m2wq

F. Schweitzer, Tamás Kriváchy, David García

引用次数: 10

Wavelets 小波

Complex psychiatry Pub Date : 2018-10-08 DOI: 10.1002/(SICI)1099-0526(199611/12)2:2%3C31::AID-CPLX7%3E3.0.CO;2-Q

M. Greiner, P. Lipa, P. Carruthers

引用次数: 989