Cholesterol最新文献_第4页

HDL-C Response Variability to Niacin ER in US Adults. 美国成人对烟酸ER的HDL-C反应变异性

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-02-26 DOI: 10.1155/2013/681475

Jennifer B Christian, Eric J Olson, Jeffery K Allen, Kimberly A Lowe

{"title":"HDL-C Response Variability to Niacin ER in US Adults.","authors":"Jennifer B Christian, Eric J Olson, Jeffery K Allen, Kimberly A Lowe","doi":"10.1155/2013/681475","DOIUrl":"https://doi.org/10.1155/2013/681475","url":null,"abstract":"Background. Niacin is the most effective treatment currently available for raising HDL-C levels. Objective. To evaluate if gender and baseline lipid levels have an effect on the HDL-C response of niacin ER and to identify factors that predict response to niacin ER at the 500 mg dose. Material and Methods. The change in HDL-C effect between baseline and follow-up levels was quantified in absolute change as well as dichotomized into high versus low response (high response was defined as an HDL-C effect of >15% increase and low response was HDL-C <5%) in a sample of 834 individuals. Results. Both males and females with low HDL-C levels at baseline exhibited a response to treatment in the multivariate model (males, HDL-C <40 mg/dL: OR = 5.18, 95% CI: 2.36-11.39; females, HDL-C <50 mg/dL: OR = 5.40, 95% CI: 1.84-15.79). There was also a significant difference in the mean HDL-C effect between baseline and follow-up HDL-C levels in the 500 mg niacin ER dose group for both males (mean HDL-C effect = 0.08, P < 0.001) and females (mean HDL-C effect = 0.10, P = 0.019). Conclusion. Baseline HDL-C levels are the biggest predictor of response to niacin ER treatment for both males and females among the factors evaluated.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":" ","pages":"681475"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/681475","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"40227412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 2

Current views on genetics and epigenetics of cholesterol gallstone disease. 胆固醇胆结石病的遗传学和表观遗传学研究进展。

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-04-14 DOI: 10.1155/2013/298421

Agostino Di Ciaula, David Q-H Wang, Leonilde Bonfrate, Piero Portincasa

{"title":"Current views on genetics and epigenetics of cholesterol gallstone disease.","authors":"Agostino Di Ciaula, David Q-H Wang, Leonilde Bonfrate, Piero Portincasa","doi":"10.1155/2013/298421","DOIUrl":"https://doi.org/10.1155/2013/298421","url":null,"abstract":"Cholesterol gallstone disease, one of the commonest digestive diseases in western countries, is induced by an imbalance in cholesterol metabolism, which involves intestinal absorption, hepatic biosynthesis, and biliary output of cholesterol, and its conversion to bile acids. Several components of the metabolic syndrome (e.g., obesity, type 2 diabetes, dyslipidemia, and hyperinsulinemia) are also well-known risk factors for gallstones, suggesting the existence of interplay between common pathophysiological pathways influenced by insulin resistance, genetic, epigenetic, and environmental factors. Cholesterol gallstones may be enhanced, at least in part, by the abnormal expression of a set of the genes that affect cholesterol homeostasis and lead to insulin resistance. Additionally, epigenetic mechanisms (mainly DNA methylation, histone acetylation/deacetylation, and noncoding microRNAs) may modify gene expression in the absence of an altered DNA sequence, in response to different lithogenic environmental stimuli, such as diet, lifestyle, pollutants, also occurring in utero before birth. In this review, we will comment on various steps of the pathogenesis of cholesterol gallstones and interaction between environmental and genetic factors. The epigenomic approach may offer new options for therapy of gallstones and better possibilities for primary prevention in subjects at risk.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"298421"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/298421","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31538615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 40

APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism. APOA2多态性与肥胖和脂质代谢的关系

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-12-09 DOI: 10.1155/2013/289481

Moushira Erfan Zaki, Khalda Sayed Amr, Mohamed Abdel-Hamid

{"title":"APOA2 Polymorphism in Relation to Obesity and Lipid Metabolism.","authors":"Moushira Erfan Zaki, Khalda Sayed Amr, Mohamed Abdel-Hamid","doi":"10.1155/2013/289481","DOIUrl":"https://doi.org/10.1155/2013/289481","url":null,"abstract":"Objectives. This study aims to analysis the relationship between c.-492T>C polymorphism in APOA2 gene and the risk for obesity in a sample of Egyptian adolescents and investigates its effect on body fat distribution and lipid metabolism. Material and Methods. A descriptive, cross-sectional study was conducted on 303 adolescents. They were 196 obese and 107 nonobese, aged 16-19 years old. Variables examined included body mass index (BMI), waist circumference (WC), waist to hip ratio (WHR), systolic and diastolic blood pressure (BP), body fat percentage (BF%), abdominal visceral fat layer, and dietary intake. Abdominal visceral fat thickness was determined by ultrasonography. The polymorphism in the APOA2 c.-492T>C was analyzed by PCR amplification. Results. Genotype frequencies were in Hardy-Weinberg equilibrium. The frequency of the mutant C allele was significantly higher in obese cases compared to nonobese. After multivariate adjustment, waist, BF% and visceral adipose layer, food consumption, and HDL-C were significantly higher in homozygous allele CC carriers than TT+TC carriers. Conclusions. Homozygous individuals for the C allele had higher obesity risk than carriers of the T allele and had elevated levels of visceral adipose tissue and serum HDL-C. Moreover, the study shows association between the APOA2 c.-492T>C polymorphism and food consumption. ","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"289481"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/289481","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31993361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 24

Discordance of Non-HDL and Directly Measured LDL Cholesterol: Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate? 非高密度脂蛋白和直接测量的低密度脂蛋白胆固醇的不一致:当计算的低密度脂蛋白不准确时，哪种脂质测量是首选?

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-04-23 DOI: 10.1155/2013/502948

Lawrence Baruch, Valerie J Chiong, Sanjay Agarwal, Bhanu Gupta

{"title":"Discordance of Non-HDL and Directly Measured LDL Cholesterol: Which Lipid Measure is Preferred When Calculated LDL Is Inaccurate?","authors":"Lawrence Baruch, Valerie J Chiong, Sanjay Agarwal, Bhanu Gupta","doi":"10.1155/2013/502948","DOIUrl":"https://doi.org/10.1155/2013/502948","url":null,"abstract":"Objective. To determine if non-HDL cholesterol (N-HDL) and directly measured LDL cholesterol (D-LDL) are clinically equivalent measurements. Patients and Methods. Eighty-one subjects recruited for 2 cholesterol treatment studies had at least 1 complete fasting lipid panel and D-LDL performed simultaneously; 64 had a second assessment after 4 to 6 weeks, resulting in 145 triads of C-LDL, D-LDL, and N-HDL. To directly compare N-HDL to D-LDL and C-LDL, we normalized the N-HDL by subtracting 30 from the N-HDL (N-HDLA). Results. There was significant correlation between N-HDLA, D-LDL, and C-LDL. Correlation was significantly greater between N-HDLA and C-LDL than between N-HDLA and D-LDL. A greater than 20 mg/dL difference between measures was observed more commonly between N-HDLA and D-LDL, 29%, than between C-LDL and N-HDLA, 11% (P < 0.001), and C-LDL and D-LDL, 17% (P = 0.028). Clinical discordance was most common, and concordance was least common between N-HDL and D-LDL. Conclusions. Our findings suggest that N-HDL cholesterol and D-LDL cholesterol are not clinically equivalent and frequently discordant. As N-HDL may be superior to even C-LDL for predicting events in statin-treated patients, utilizing N-HDL to guide therapy would appear to be preferable to D-LDL when C-LDL is inaccurate.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"502948"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/502948","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31459665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 9

Predictors of metabolic syndrome in the Iranian population: waist circumference, body mass index, or waist to hip ratio? 伊朗人群代谢综合征的预测因素:腰围、体重指数还是腰臀比?

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-03-24 DOI: 10.1155/2013/198384

Mojgan Gharipour, Nizal Sarrafzadegan, Masoumeh Sadeghi, Elham Andalib, Mohammad Talaie, Davood Shafie, Esmaiel Aghababaie

{"title":"Predictors of metabolic syndrome in the Iranian population: waist circumference, body mass index, or waist to hip ratio?","authors":"Mojgan Gharipour, Nizal Sarrafzadegan, Masoumeh Sadeghi, Elham Andalib, Mohammad Talaie, Davood Shafie, Esmaiel Aghababaie","doi":"10.1155/2013/198384","DOIUrl":"10.1155/2013/198384","url":null,"abstract":"This study aimed to investigate whether body mass index (BMI), waist circumference (WC), or waist to hip ratio (WHR) could be a better predictor of metabolic syndrome and, if so, what would be the cutoff points for these surrogates to appropriately differentiate metabolic syndrome in different age and sex subgroups. Methods. The present cross-sectional study was conducted on a sample of Isfahan Cohort Study (ICS). In total, 468 individuals (194 with and 274 subjects without metabolic syndrome) according to the National Cholesterol Education Program's Adult Treatment Panel III (ATP-III) criteria were selected. Anthropometric indices were measured and plotted using receiver-operating characteristic (ROC) curves. Results. According to ROC curve analysis, WC and WHR parameters were better indicators of metabolic syndrome compared to BMI in women, whereas in men WHR had a lower discriminating value compared to the other two parameters. Among these three anthropometric parameters, BMI had a lower sensitivity and WC and WHR both had a higher sensitivity for predicting metabolic syndrome in women compared with in men. The cut points for WC were nearly equal in men and women, 90.3 versus 90.0, respectively. Women had higher cut points for BMI (28.5 kg/m(2)) compared to men (26.0 kg/m(2)). Our results showed the highest sensitivity and specificity for WC cut points specially in women. To predict metabolic syndrome, we looked into optimal age-specific cut points for BMI, WC, and WHR. The results indicated that WC had the highest discriminating value compared to other indicators in the different age subgroups. The optimal cut points for all three parameters gradually increased with age. Conclusion. Our results demonstrated that regardless of gender and age variables, WC could be a preferred parameter for predicting metabolic syndrome compared to BMI and WHR in Iranian population.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"198384"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/198384","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31491098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 86

Leishmania major Self-Limited Infection Increases Blood Cholesterol and Promotes Atherosclerosis Development. 利什曼原虫自限性感染增加血胆固醇，促进动脉粥样硬化发展。

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-04-28 DOI: 10.1155/2013/754580

Luciana R Fernandes, Ana Cecília C Ribeiro, Marcela Segatto, Luís Felipe F F Santos, Joana Amaral, Luciane R Portugal, Jacqueline I A Leite

{"title":"Leishmania major Self-Limited Infection Increases Blood Cholesterol and Promotes Atherosclerosis Development.","authors":"Luciana R Fernandes, Ana Cecília C Ribeiro, Marcela Segatto, Luís Felipe F F Santos, Joana Amaral, Luciane R Portugal, Jacqueline I A Leite","doi":"10.1155/2013/754580","DOIUrl":"https://doi.org/10.1155/2013/754580","url":null,"abstract":"Leishmania major infection of resistant mice causes a self-limited lesion characterized by macrophage activation and a Th1 proinflammatory response. Atherosclerosis is an inflammatory disease involving hypercholesterolemia and macrophage activation. In this study, we evaluated the influence of L. major infection on the development of atherosclerosis using atherosclerosis-susceptible apolipoprotein E-deficient (apoE KO) mice. After 6 weeks of infection, apoE KO mice exhibited reduced footpad swelling and parasitemia similar to C57BL/6 controls, confirming that both strains are resistant to infection with L. major. L. major-infected mice had increased plasma cholesterol levels and reduced triacylglycerols. With regard to atherosclerosis, noninfected mice developed only fatty streak lesions, while the infected mice presented with advanced lesions containing a necrotic core and an abundant inflammatory infiltrate. CD36 expression was increased in the aortic valve of the infected mice, indicating increased macrophage activation. In conclusion, L. major infection, although localized and self-limited in resistant apoE KO mice, has a detrimental effect on the blood lipid profile, increases the inflammatory cell migration to atherosclerotic lesions, and promotes atherogenesis. These effects are consequences of the stimulation of the immune system by L. major, which promotes the inflammatory components of atherosclerosis, which are primarily the parasite-activated macrophages.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"754580"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/754580","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31459666","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 4

Short-term effect of pitavastatin treatment on glucose and lipid metabolism and oxidative stress in fasting and postprandial state using a test meal in Japanese men. 吡伐他汀治疗对日本男性空腹和餐后糖脂代谢和氧化应激的短期影响

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-12-10 DOI: 10.1155/2013/314170

Hirokazu Kakuda, Junji Kobayashi, Mio Nakato, Noboru Takekoshi

{"title":"Short-term effect of pitavastatin treatment on glucose and lipid metabolism and oxidative stress in fasting and postprandial state using a test meal in Japanese men.","authors":"Hirokazu Kakuda, Junji Kobayashi, Mio Nakato, Noboru Takekoshi","doi":"10.1155/2013/314170","DOIUrl":"https://doi.org/10.1155/2013/314170","url":null,"abstract":"Introduction. The objective of this study was to clarify how pitavastatin affects glucose and lipid metabolism, renal function, and oxidative stress. Methods. Ten Japanese men (average age of 33.9 years) were orally administered 2 mg of pitavastatin for 4 weeks. Postprandial glucose, lipoprotein metabolism, and oxidative stress markers were evaluated at 0 and 4 weeks of pitavastatin treatment (2 mg once daily) with a test meal consisting of total calories: 460 kcal, carbohydrates: 56.5 g (226 kcal), protein: 18 g (72 kcal), lipids: 18 g (162 kcal), and NaCl: 1.6 g. Metabolic parameters were measured at 0, 60, and 120 minutes after test meal ingestion. Results. After administration of pitavastatin, serum total cholesterol, low-density lipoprotein cholesterol, apolipoprotein B, arachidonic acid, insulin, and adjusted urinary excretion of uric acid decreased, whereas creatinine clearance (C Cr) and uric acid clearance (C UA) increased. And postprandial versus fasting urine 8-hydroxydeoxyguanosine remained unchanged, while postprandial versus fasting isoprostane decreased after pitavastatin treatment. Next, we compared postprandial glucose and lipid metabolism after test meal ingestion before and after pitavastatin administration. Incremental areas under the curve significantly decreased for triglycerides (P < 0.05) and remnant-like particle cholesterol (P < 0.01), while those for apolipoprotein E (apoE), glucose, insulin, and high-sensitivity C-reactive protein remained unchanged. Conclusion. Pitavastatin improves postprandial oxidative stress along with hyperlipidemia. ","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"314170"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/314170","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31996138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 14

Cholesterol metabolism and weight reduction in subjects with mild obstructive sleep apnoea: a randomised, controlled study. 轻度阻塞性睡眠呼吸暂停患者的胆固醇代谢和体重减轻:一项随机对照研究。

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-05-16 DOI: 10.1155/2013/769457

Maarit Hallikainen, Henri Tuomilehto, Tarja Martikainen, Esko Vanninen, Juha Seppä, Jouko Kokkarinen, Jukka Randell, Helena Gylling

{"title":"Cholesterol metabolism and weight reduction in subjects with mild obstructive sleep apnoea: a randomised, controlled study.","authors":"Maarit Hallikainen, Henri Tuomilehto, Tarja Martikainen, Esko Vanninen, Juha Seppä, Jouko Kokkarinen, Jukka Randell, Helena Gylling","doi":"10.1155/2013/769457","DOIUrl":"https://doi.org/10.1155/2013/769457","url":null,"abstract":"To evaluate whether parameters of obstructive sleep apnoea (OSA) associate with cholesterol metabolism before and after weight reduction, 42 middle-aged overweight subjects with mild OSA were randomised to intensive lifestyle intervention (N = 23) or to control group (N = 18) with routine lifestyle counselling only. Cholesterol metabolism was evaluated with serum noncholesterol sterol ratios to cholesterol, surrogate markers of cholesterol absorption (cholestanol and plant sterols) and synthesis (cholestenol, desmosterol, and lathosterol) at baseline and after 1-year intervention. At baseline, arterial oxygen saturation (SaO2 ) was associated with serum campesterol (P < 0.05) and inversely with desmosterol ratios (P < 0.001) independently of gender, BMI, and homeostasis model assessment index of insulin resistance (HOMA-IR). Apnoea-hypopnoea index (AHI) was not associated with cholesterol metabolism. Weight reduction significantly increased SaO2 and serum cholestanol and decreased AHI and serum cholestenol ratios. In the groups combined, the changes in AHI were inversely associated with changes of cholestanol and positively with cholestenol ratios independent of gender and the changes of BMI and HOMA-IR (P < 0.05). In conclusion, mild OSA seemed to be associated with cholesterol metabolism independent of BMI and HOMA-IR. Weight reduction increased the markers of cholesterol absorption and decreased those of cholesterol synthesis in the overweight subjects with mild OSA.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"769457"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/769457","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31503615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 5

Functionally defective high-density lipoprotein and paraoxonase: a couple for endothelial dysfunction in atherosclerosis. 功能缺陷的高密度脂蛋白和对氧磷酶:动脉粥样硬化中内皮功能障碍的一对。

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-10-07 DOI: 10.1155/2013/792090

Esin Eren, Necat Yilmaz, Ozgur Aydin

{"title":"Functionally defective high-density lipoprotein and paraoxonase: a couple for endothelial dysfunction in atherosclerosis.","authors":"Esin Eren, Necat Yilmaz, Ozgur Aydin","doi":"10.1155/2013/792090","DOIUrl":"10.1155/2013/792090","url":null,"abstract":"The endothelium is the primary target for biochemical or mechanical injuries caused by the putative risk factors of atherosclerosis. Endothelial dysfunction represents the ultimate link between atherosclerotic risk factors that promote atherosclerosis. HDL-C is thought to exert at least some parts of its antiatherogenic facilities via stimulating endothelial NO production, nearby inhibiting oxidative stress and inflammation. HDL-C is capable of opposing LDL's inductive effects and avoiding the ox-LDL's inhibition of eNOS. Paraoxonase 1 (PON1) is an HDL-associated enzyme esterase which appears to contribute to the antioxidant and antiatherosclerotic capabilities of HDL-C. \"Healthy HDL,\" namely the particle that contains the active Paraoxonase 1, has the power to suppress the formation of oxidized lipids. \"Dysfunctional HDL,\" on the contrary, has reduced Paraoxonase 1 enzyme activity and not only fails in its mission but also potentially leads to greater formation of oxidized lipids/lipoproteins to cause endothelial dysfunction. The association of HDL-C PON1 and endothelial dysfunction depends largely on the molecules with exact damaging effect on NO synthase coupling. Loss of nitric oxide bioavailability has a pivotal role in endothelial dysfunction preceding the appearance of atherosclerosis. Analyses of HDL-C and Paraoxonase1 would be more important in the diagnosis and treatment of atherosclerosis in the very near future. ","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"792090"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://sci-hub-pdf.com/10.1155/2013/792090","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31858064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 59

HDL, Atherosclerosis, and Emerging Therapies. 高密度脂蛋白、动脉粥样硬化和新兴疗法。

Cholesterol Pub Date : 2013-01-01 Epub Date: 2013-05-28 DOI: 10.1155/2013/891403

Anouar Hafiane, Jacques Genest

{"title":"HDL, Atherosclerosis, and Emerging Therapies.","authors":"Anouar Hafiane, Jacques Genest","doi":"10.1155/2013/891403","DOIUrl":"10.1155/2013/891403","url":null,"abstract":"This review aims to provide an overview on the properties of high-density lipoproteins (HDLs) and their cardioprotective effects. Emergent HDL therapies will be presented in the context of the current understanding of HDL function, metabolism, and protective antiatherosclerotic properties. The epidemiological association between levels of HDL-C or its major apolipoprotein (apoA-I) is strong, graded, and coherent across populations. HDL particles mediate cellular cholesterol efflux, have antioxidant properties, and modulate vascular inflammation and vasomotor function and thrombosis. A link of causality has been cast into doubt with Mendelian randomization data suggesting that genes causing HDL-C deficiency are not associated with increased cardiovascular risk, nor are genes associated with increased HDL-C, with a protective effect. Despite encouraging data from small studies, drugs that increase HDL-C levels have not shown an effect on major cardiovascular end-points in large-scale clinical trials. It is likely that the cholesterol mass within HDL particles is a poor biomarker of therapeutic efficacy. In the present review, we will focus on novel therapeutic avenues and potential biomarkers of HDL function. A better understanding of HDL antiatherogenic functions including reverse cholesterol transport, vascular protective and antioxidation effects will allow novel insight on novel, emergent therapies for cardiovascular prevention.","PeriodicalId":72589,"journal":{"name":"Cholesterol","volume":"2013 ","pages":"891403"},"PeriodicalIF":0.0,"publicationDate":"2013-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3678415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"31517031","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0