Acupuncture in Medicine最新文献

{"title":"Electroacupuncture promotes functional recovery and activates energy metabolism in a rat model of sciatic nerve injury.","authors":"Jian-Lan Wang, Lin An, Xiao-Hong Du, Ming Lu, Wei Qu, Shuang Zhang, Yu-Xuan Wu","doi":"10.1177/09645284251399240","DOIUrl":"10.1177/09645284251399240","url":null,"abstract":"<p><strong>Background: </strong>Electroacupuncture (EA) accelerates repair of peripheral nerve injury. The aim of this study was to explore how EA regulates energy metabolism by examining its effects on glucose transport and mitochondrial dynamic balance in a rat model of sciatic nerve injury.</p><p><strong>Methods: </strong>In experiment 1, expression of glucose transporter (GLUT)4 was measured in n = 16 rats at 1, 3, 5 and 7 days following EA to identify the optimal glucose uptake time. In experiment 2, n = 32 rats were randomly divided into the following four groups: Normal, Injury, EA and ES (electrical stimulation). Three days after sciatic nerve injury modeling, micro-positron emission tomography/computed tomography (PET/CT) was performed to observe glucose uptake in the sciatic nerve and surrounding tissues. After 1 week, we measured nerve conduction velocity and expression of nerve growth factor (NGF), brain-derived neurotrophic factor (BDNF), mitofusin (Mfn)1/2 and dynamin-related protein (Drp)1 in the sciatic nerve (by Western blotting) and observed pathological changes in the sciatic nerve and gastrocnemius.</p><p><strong>Results: </strong>Protein expression levels of GLUT4, Mfn1/2 and Drp1 were significantly higher in the EA group, and histopathological changes were improved, compared with other groups. Glucose uptake by micro-PET/CT in the target area in the EA group was significantly higher than that in the other groups. Furthermore, nerve conduction velocity and NGF/BDNF expression was significantly higher in the EA group compared with the other three groups.</p><p><strong>Conclusion: </strong>EA accelerated the repair and regeneration of the injured sciatic nerve, activated glucose transport and improved mitochondrial dynamic balance, in a rat model.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"354-364"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review of pre-operative and intra-operative acupuncture in total hip and knee arthroplasty.","authors":"Kira K Tanghe, Zodina A Beiene, Stephanie I Cheng, Elizabeth B Gausden","doi":"10.1177/09645284251400384","DOIUrl":"10.1177/09645284251400384","url":null,"abstract":"<p><strong>Objective: </strong>Total hip arthroplasty (THA) and total knee arthroplasty (TKA) are common elective surgical procedures that are often associated with significant post-operative pain, commonly leading to opioid use. Acupuncture has been studied as a non-invasive approach to alleviate post-operative pain and reduce opioid consumption. Our aim was to review the literature to assess the efficacy of pre-operative and intra-operative acupuncture as an analgesic adjunct for arthroplasty patients.</p><p><strong>Methods: </strong>This systematic review followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement guidelines. A comprehensive search was conducted in multiple databases to identify studies that utilized acupuncture in primary THA and TKA patients from their inception to June 2023. Inclusion criteria included full-text availability and publication in the English language.</p><p><strong>Results: </strong>Eight studies were included in the final analysis, comprising seven randomized controlled trials and one prospective cohort study. Meta-analysis was not feasible due to the heterogeneity of study design and outcome measures. Acupuncture use led to a significant reduction in total intra-operative fentanyl and post-operative patient-controlled analgesia (PCA) use in THA and TKA patients. Patients who received acupuncture reported fewer analgesic-related side effects. However, patient-reported outcome measures (PROMs) varied among studies, with no consistent trend observed.</p><p><strong>Conclusion: </strong>The incorporation of pre- and intra-operative acupuncture into arthroplasty protocols may help reduce opioid usage and minimize analgesia-related side effects. It appears, based on the available literature, that acupuncture has the potential to improve pain management in arthroplasty patients. Although the number of studies remains limited, the cost-effectiveness and ease of implementation of acupuncture suggest that it could be an advantageous adjunct in the peri-operative setting. Further research is needed to establish best practices and guide healthcare professionals on the use of acupuncture in arthroplasty patients.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"307-315"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145647042","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Manual acupuncture alleviates bladder dysfunction and ameliorates oxidative stress in a rat model of diabetic neurogenic bladder.","authors":"Yujun He, Rui Lin, Ningjing Qin, Yushan Fan, Furui Miao, Jingwen Huang, Hui Zhang","doi":"10.1177/09645284251381834","DOIUrl":"10.1177/09645284251381834","url":null,"abstract":"<p><strong>Objective: </strong>To investigate the effect of manual acupuncture (MA) in a rat model of diabetic neurogenic bladder (DNB) based on protein and mRNA expression of nuclear factor erythroid 2-related factor 2 (Nrf2), nicotinamide adenine dinucleotide phosphate quinone oxidoreductase-1 (NQO1) and glutathione peroxidase (GSH-Px) in bladder tissue.</p><p><strong>Methods: </strong>A DNB rat model was established via intraperitoneal injection of streptozotocin (STZ). The rats were randomly divided into a control group, a model group and an MA group (n = 10 per group). In the MA group, MA was applied after modeling. Body weight, fasting blood glucose (FBG) and bladder wet weight were measured, and urodynamics and bladder histomorphology were performed to verify whether the DNB model had been successfully established. Protein and mRNA expression levels of Nrf2, NQO1 and GSH-Px in the bladder tissue were determined by Western blotting and real-time polymerase chain reaction (PCR) analysis.</p><p><strong>Results: </strong>Bladder wet weight, urodynamic parameters and bladder histomorphology in the MA group were significantly improved compared to the untreated DNB group; however, MA had no significant effect on body weight or blood glucose. In addition, protein and mRNA expression of Nrf2, NQO1 and GSH-Px in the bladder tissues of rats in the MA group was significantly increased.</p><p><strong>Conclusions: </strong>Our findings suggest that MA improved bladder dysfunction and that this may be related to upregulation of mRNA and protein expression of Nrf2, NQO1 and GSH-Px, which may reduce oxidative stress and protect bladder smooth muscle.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"344-353"},"PeriodicalIF":2.7,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145436696","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of acupuncture for chronic prostatitis/chronic pelvic pain syndrome among men with a sedentary lifestyle: secondary analysis of a randomized controlled trial.","authors":"Shuai Gao, Yuanjie Sun, Lili Zhu, Shiyan Yan, Xinlu Wang, Xi Wang, Zhishun Liu","doi":"10.1177/09645284251379493","DOIUrl":"10.1177/09645284251379493","url":null,"abstract":"<p><strong>Background: </strong>Acupuncture was shown to be efficacious for chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) in a prior randomized controlled trial (RCT). The purpose of this secondary analysis was to evaluate the efficacy of acupuncture in the subgroup of CP/CPPS patients with a sedentary lifestyle and to compare outcomes between sedentary and non-sedentary participants in the group receiving acupuncture.</p><p><strong>Methods: </strong>In the original RCT, 440 patients with moderate to severe CP/CPPS received 20 sessions of acupuncture or sham acupuncture (SA) over 8 weeks and were followed up for 24 weeks after the treatment was completed. The primary outcome was the proportion of sustained responders, defined as those with a reduction of at least six points in the National Institute of Health-chronic prostatitis symptom index (NIH-CPSI) total score at weeks 8, 20 and 32. In this secondary analysis, we compared n = 147 participants in the acupuncture group with a sedentary lifestyle group: (1) n = 148 participants with a sedentary lifestyle in the SA group ; and (2) n = 62 participants with a non-sedentary lifestyle in the acupuncture group.</p><p><strong>Results: </strong>Among those with a sedentary lifestyle, the proportion of sustained responders was 38.3% in the acupuncture group versus 20.1% in the SA group (odds ratio (OR) 2.52 [95% confidence interval (CI) 1.45-4.10]; <i>P</i> = 0.001). However, among those receiving verum acupuncture, response rates were higher in non-sedentary compared with sedentary participants at 56.9% vs 38.3% (OR 1.32 [95% CI 1.19- 3.49]; <i>P</i> = 0.044).</p><p><strong>Conclusion: </strong>Acupuncture appears to be an efficacious for the treatment of CP/CPPS patients with a sedentary lifestyle. However, compared with a non-sedentary population, sedentary patients are less likely to achieve a significant/sustained treatment response following acupuncture.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"247-255"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rupture of the liver secondary to acupuncture: a case report.","authors":"Huiqi Zhai, Yihua Li, Mei Chen, Liang Kang, Xinjun Zhao, Rong Li","doi":"10.1177/09645284251379494","DOIUrl":"10.1177/09645284251379494","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"299-301"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Electroacupuncture ameliorates gastrointestinal motility and modulates PLC-IP3 signaling in a rat model of functional dyspepsia.","authors":"Deqian Yang, Liyuan Fang, Qi Chen, Shuwen Jin, Xiaoli Pan, Junying Luo, Paidi Xu","doi":"10.1177/09645284251359305","DOIUrl":"10.1177/09645284251359305","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to determine whether electroacupuncture (EA) modulates the phospholipase C-inositol-1,4,5-trisphosphate (PLC-IP3) pathway and platelet-derived growth factor receptor (PDGFR)α⁺ cells in a rat model of functional dyspepsia (FD) characterized by gastrointestinal (GI) motor dysfunction.</p><p><strong>Methods: </strong>Forty Sprague-Dawley (SD) rats were allocated into five groups: control, model, EA, U73122 and U73122 + EA groups (n = 8 each). All groups except the control group underwent a multifactorial method to induce FD. The EA group received EA, the U73122 group received the PLC inhibitor U73122, and the U73122 + EA group received U73122 prior to EA. The control and model groups received no interventions. After 10 days of treatment, behavioral and GI motility tests were conducted. Gastric antrum tissues were analyzed post-euthanasia to determine PDGFRα, PLC, phosphorylated (<i>P</i>)-PLC, and IP3 expression and co-localization using Western blotting, RT-qPCR and immunofluorescence. Electron microscopy was used to examine gastric antrum gap junctions (GJs) and PDGFRα⁺ cells.</p><p><strong>Results: </strong>The FD model rats displayed reduced activity, weight gain and food intake, with altered GI motility, widened gastric antrum GJs and decreased mRNA/protein expression of PDGFRα, PLC, <i>P</i>-PLC and IP3. Post-EA, rats showed improved weight gain, food intake, GI motility and mRNA/protein expression, as well as normal GJs. The U73122 group failed to demonstrate significant improvements in motility or PDGFRα⁺ cell morphology, with lower protein/mRNA expression of key pathway intermediates than the EA group.</p><p><strong>Conclusion: </strong>EA enhances GI function in FD rats by activating the PDGFRα⁺ cell-associated PLC-IP3 pathway, demonstrating potential as a therapeutic target for FD.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"265-277"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acupuncture analgesia in radiofrequency ablation for hepatocellular carcinoma: a case report.","authors":"Tongbiao Wang, Guochu Huang, Sheng Xie, Wei Shi, Lian Chen","doi":"10.1177/09645284251331982","DOIUrl":"10.1177/09645284251331982","url":null,"abstract":"","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"302-303"},"PeriodicalIF":2.6,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors predicting quality of life among patients with cervical spondylosis undergoing acupuncture in China: a cross-sectional study.","authors":"Xiuhong Zhang, Chintana Wacharasin, Jinjutha Chaisena Dallas, Maiyun Ye","doi":"10.1177/09645284251379944","DOIUrl":"10.1177/09645284251379944","url":null,"abstract":"<p><strong>Background: </strong>The quality of life (QoL) of individuals with cervical spondylosis (CS) can be impaired due to both physical discomfort and psychological harm. Acupuncture is known to be an effective treatment approach for CS; however, the relevant factors affecting QoL in this patient population remain unclear.</p><p><strong>Objective: </strong>The purpose of this study was to assess QoL and investigate related factors among patients with CS undergoing acupuncture.</p><p><strong>Methods: </strong>A predictive correlational study was conducted among 265 participants with CS undergoing acupuncture as part of routine clinical care. The following questionnaires were used to collect data on QoL and related factors: healthy lifestyle questionnaire (HLQ), Pittsburgh sleep quality index (PSQI), Chinese version of the perceptual stress scale (CPSS), self-rated abilities for health practices scale (SRAHP), social support rating scale (SSRS), cervical spine disease health knowledge awareness questionnaire and 12-item short form survey (SF-12). Standard multiple linear regression analysis was applied to determine the predictors of QoL in this patient population.</p><p><strong>Results: </strong>The mean total score of the QoL scale was 37.8 ± 10.57 (mean ± SD), indicating moderate QoL levels among patients with CS undergoing acupuncture. Based on multiple regression, lifestyle (β = 0.25, p < 0.01), health behavior (β = 0.379, p < 0.01), social support (β = 0.098, p < 0.01), knowledge about CS (β = 0.107, p < 0.01) and PSQI scores (β = -0.196, p < 0.001) explained 71% of the variance of QoL.</p><p><strong>Conclusion: </strong>Lifestyle, health behavior, social support and knowledge about CS significantly and positively predict the level of QoL, while PSQI scores negatively predicted QoL.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"256-264"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224678","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of electroacupuncture on interleukin-6 and procalcitonin expression in the astrocytes and neurons of the spinal cord dorsal horn in a rat model of incisional pain.","authors":"Ying Jin, Liqian Ma, Qingfeng Cui, Ping Wang, Xinyuan Wang, Zhilai Lou, Jia Zhou, Bing Xiong, Xianming Lin","doi":"10.1177/09645284251379490","DOIUrl":"10.1177/09645284251379490","url":null,"abstract":"<p><strong>Objective: </strong>Incisional pain, which is the most commonly observed postoperative complication, is closely related to the release of inflammatory mediators and cytokines. Although electroacupuncture (EA) has been demonstrated to reduce incisional pain, its analgesic mechanisms remain unclear. We aimed to investigate whether EA alleviates incisional pain in rats by regulating the expression of interleukin (IL)-6 and procalcitonin (PCT) in the astrocytes and neurons of the spinal cord dorsal horn.</p><p><strong>Methods: </strong>Forty-six healthy male Sprague-Dawley rats were included, of which n = 8 were assigned to the control group. The remaining 38 rats were used to establish the incisional pain model. Finally, 32 successfully modeled rats were obtained and randomly divided into model, sham EA, 2 Hz and 20/100 Hz EA groups. Mechanical pain withdrawal threshold (MPWT) was measured before modeling, 6 h after modeling, and 3 days after EA intervention. Enzyme-linked immunosorbent assay, Western blotting and immunofluorescence were used to detect IL-6 and PCT protein and mRNA expression, as well as their co-expression with glial fibrillary acidic protein (GFAP, a marker of astrocytes) and NeUN (a marker of neurons) in the spinal dorsal horn of rats in each group after 3 days of EA intervention.</p><p><strong>Results: </strong>Reduced IL-6 and PCT levels in the astrocytes and neurons were observed in the spinal dorsal horn of the incisional pain model after EA intervention, and incisional pain was also significantly relieved.</p><p><strong>Conclusion: </strong>Both 2 Hz and 20/100 Hz EA appear to relieve incisional pain in rats and these effects may be related to inhibition of IL-6 and PCT expression in the spinal dorsal horn.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"290-298"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145224720","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analgesic effects of electroacupuncture via the EphBs-p38 MAPK signaling pathway and microglial suppression in the chronic constriction injury rat model of neuropathic pain.","authors":"Yi Ying, Guodong Yang, Xiaoyu Li, Feifei Wang, Guobing Zhang","doi":"10.1177/09645284251363987","DOIUrl":"10.1177/09645284251363987","url":null,"abstract":"<p><strong>Objective: </strong>To explore the analgesic effects of electroacupuncture (EA) and its impact on the EphBs-p38 mitogen-activated protein kinase (MAPK) pathway and microglia in a rat model of neuropathic pain (NP).</p><p><strong>Methods: </strong>Following adaptive training, 60 male Sprague Dawley (SD) rats were allocated to one of two experiments. In experiment 1, rats received intrathecal SB203580 (p38 MAPK inhibitor), intramuscular EphB1-Fc (EphBs inhibitor) or no injection before undergoing chronic constrictive injury (CCI). In experiment 2, CCI model rats received EA either alone or combined with either anisomycin (p38 MAPK agonist) or EphrinB1-Fc (EphBs agonist) versus minimal acupuncture (MA) as a control intervention. A sham surgery group was included in both experiments as a control for CCI. All groups consisted of n = 6 rats (four in experiment 1 and six in experiment 2). Behavioral hyperalgesia was examined and the spinal L5-6 region was harvested and subjected to enzyme-linked immunosorbent assay to assess tumor necrosis factor (TNF)-α and interleukin (IL)-1β levels. Western blotting and immunofluorescence were used to assess protein expression of B-cell lymphoma (Bcl)-2, Bcl-2 associated X-protein (BAX), EphB1, EphrinB1, p38 MAPK, phosphorylated (p)-p38 MAPK and ionized calcium binding adaptor molecule (Iba)-1.</p><p><strong>Results: </strong>CCI induced behavioral hyperalgesia, as demonstrated by altered paw withdrawal latency (PWL), paw withdrawal threshold (PWT) and cytokine levels, and increased p38 MAPK phosphorylation and microglial activation. However, inhibitors SB203580 and EphB1-Fc reversed these effects. Notably, EA showed similar beneficial effects, but these were counteracted when combined with anisomycin and EphrinB1-Fc.</p><p><strong>Conclusions: </strong>The analgesic effects of EA in this rat model of NP appear to be linked to diminished p-p38 MAPK expression and subsequent microglial deactivation. EA has a potential role as a complementary therapy for NP.</p>","PeriodicalId":7257,"journal":{"name":"Acupuncture in Medicine","volume":" ","pages":"278-289"},"PeriodicalIF":2.7,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144938546","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}