Advanced pharmaceutical bulletin最新文献_第5页

Discrepancies in Open Access Fees within Pharmacology, Toxicology, and Pharmaceutics Journals. 药理学、毒理学和药剂学期刊开放获取费用的差异

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2023-11-01 Epub Date: 2023-04-29 DOI: 10.34172/apb.2023.076

Rana M F Sammour, Aliasgar Shahiwala

引用次数: 0

Human Mesenchymal Stem Cell Transplantation Improved Functional Outcomes Following Spinal Cord Injury Concomitantly with Neuroblast Regeneration. 人骨髓间充质干细胞移植改善脊髓损伤后的功能结果并伴有成神经细胞再生

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2023-11-01 Epub Date: 2022-10-20 DOI: 10.34172/apb.2023.058

Maryam Lale Ataei, Mohammad Karimipour, Parviz Shahabi, Hamid Soltani-Zangbar, Maryam Pashaiasl

{"title":"Human Mesenchymal Stem Cell Transplantation Improved Functional Outcomes Following Spinal Cord Injury Concomitantly with Neuroblast Regeneration.","authors":"Maryam Lale Ataei, Mohammad Karimipour, Parviz Shahabi, Hamid Soltani-Zangbar, Maryam Pashaiasl","doi":"10.34172/apb.2023.058","DOIUrl":"10.34172/apb.2023.058","url":null,"abstract":"Purpose: Spinal cord injury (SCI) is damage to the spinal cord that resulted in irreversible neuronal loss, glial scar formation and axonal injury. Herein, we used the human amniotic fluid mesenchymal stem cells (hAF-MSCs) and their conditioned medium (CM), to investigate their ability in neuroblast and astrocyte production as well as functional recovery following SCI.Methods: Fifty-four adult rats were randomly divided into nine groups (n=6), included: Control, SCI, (SCI + DMEM), (SCI + CM), (SCI + MSCs), (SCI + Astrocyte), (SCI + Astrocyte + DMEM), (SCI + Astrocyte + CM) and (SCI + Astrocyte + MSCs). Following laminectomy and SCI induction, DMEM, CM, MSCs, and astrocytes were injected. Western blot was performed to explore the levels of the Sox2 protein in the MSCs-CM. The immunofluorescence staining against doublecortin (DCX) and glial fibrillary acidic protein (GFAP) was done. Finally, Basso-Beattie-Brenham (BBB) locomotor test was conducted to assess the neurological outcomes.Results: Our results showed that the MSCs increased the number of endogenous DCX-positive cells and decreased the number of GFAP-positive cells by mediating juxtacrine and paracrine mechanisms (P<0.001). Transplanted human astrocytes were converted to neuroblasts rather than astrocytes under influence of MSCs and CM in the SCI. Moreover, functional recovery indexes were promoted in those groups that received MSCs and CM.Conclusion: Taken together, our data indicate the MSCs via juxtacrine and paracrine pathways could direct the spinal cord endogenous neural stem cells (NSCs) to the neuroblasts lineage which indicates the capability of the MSCs in the increasing of the number of DCX-positive cells and astrocytes decline.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"1 1","pages":"806-816"},"PeriodicalIF":3.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41817050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translational challenges in cancer nanotherapy 癌症纳米治疗的转化挑战

Advanced pharmaceutical bulletin Pub Date : 2023-10-25 DOI: 10.34172/apb.2024.021

Ravi Kiran V V V Ammu, Kusuma Kumari Garikapati, Praveen T. Krishnamurthy, Bhadram Kalyan Chekraverthy

引用次数: 0

Potential applications of mitochondrial therapy with a focus on Parkinson's disease and mitochondrial transplantation 线粒体治疗的潜在应用，重点是帕金森病和线粒体移植

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.019

Pranay Wal, Ankita Wal, Himangi Vig, Danish Mahmood, Mohd Masih Uzzaman Khan

{"title":"Potential applications of mitochondrial therapy with a focus on Parkinson's disease and mitochondrial transplantation","authors":"Pranay Wal, Ankita Wal, Himangi Vig, Danish Mahmood, Mohd Masih Uzzaman Khan","doi":"10.34172/apb.2024.019","DOIUrl":"https://doi.org/10.34172/apb.2024.019","url":null,"abstract":"Purpose: Both aging and neurodegenerative illnesses are thought to be influenced by mitochondrial malfunction and free radical formation. Deformities of the energy metabolism, mitochondrial genome polymorphisms, nuclear DNA genetic abnormalities associated with mitochondria, modifications of mitochondrial fusion or fission, variations in shape and size, variations in transit, modified mobility of mitochondria, transcription defects, and the emergence of misfolded proteins associated with mitochondria are all linked to Parkinson's disease. Method: This review is a condensed compilation of data from research that have been published between the years of 2014 and 2022, using search engines like Google Scholar, PubMed, and Scopus. Result: Mitochondrial transplantation is a one-of-a-kind treatment for mitochondrial diseases and deficits in mitochondrial biogenesis. The replacement of malfunctioning mitochondria with transplanted viable mitochondria using innovative methodologies has shown promising outcomes as a cure for Parkinson's, involving tissue sparing coupled with enhanced energy generation and lower oxidative damage. Numerous mitochondria-targeted therapies, including mitochondrial gene therapy, redox therapy, and others, have been investigated for their effectiveness and potency. Conclusion: The development of innovative therapeutics for mitochondria-directed treatments in Parkinson's disease may be aided by optimising mitochondrial dynamics. Many neurological diseases have been studied in animal and cellular models, and it has been found that mitochondrial maintenance can slow the death of neuronal cells. It has been hypothesised that drug therapies for neurodegenerative diseases that focus on mitochondrial dysfunction will help to delay the onset of neuronal dysfunction.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers 转运蛋白18kda (TSPO):一个有前途的分子靶标，用于图像引导的实体癌手术

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.015

Hendris Wongso, Ahmad Kurniawan, Yanuar Setiadi, Crhisterra E. Kusumaningrum, Eva M. Widyasari, Teguh H.A. Wibawa, Isa Mahendra, Muhamad B. Febrian, Maula E. Sriyani, Iim Halimah, Isti Daruwati, Rudi Gunawan, Arifudin Achmad, Dwianto H. Nugraha, Ronny Lesmana, Ari S. Nugraha

{"title":"Translocator Protein 18 kDa (TSPO): A Promising Molecular Target for Image-Guided Surgery of Solid Cancers","authors":"Hendris Wongso, Ahmad Kurniawan, Yanuar Setiadi, Crhisterra E. Kusumaningrum, Eva M. Widyasari, Teguh H.A. Wibawa, Isa Mahendra, Muhamad B. Febrian, Maula E. Sriyani, Iim Halimah, Isti Daruwati, Rudi Gunawan, Arifudin Achmad, Dwianto H. Nugraha, Ronny Lesmana, Ari S. Nugraha","doi":"10.34172/apb.2024.015","DOIUrl":"https://doi.org/10.34172/apb.2024.015","url":null,"abstract":"Translocator protein 18-kDa, broadly known as TSPO, is a mitochondrial membrane protein, previously identified as the peripheral benzodiazepine receptor (PBR). TSPO involves in a broad number of biochemical events, such as steroidogenesis, mitochondrial cholesterol transport, cell survival and death, cell proliferation, and carcinogenesis. Several investigations have reported the roles of TSPO in various types of cancers, including colorectal cancer, brain cancer, melanoma, breast cancer, prostate cancer, and lung cancer. It was found that TSPO is upregulated in cancer cells, and it appears that its expression is parallel with an aggressive phenotype and/or poor prognosis. As a consequence, there is great potential for developing diagnostic and prognostic tools targeting the TSPO. In this regard, several radioligands targeting the TSPO have been identified, and some of the candidates have advanced to clinical trials. In recent years, image-guided surgery using hybrid probes bearing radioactive and fluorescence molecules has demonstrated promising outcomes in animal and human studies, and thus might serve as a valuable surgical navigator during cancer surgery. In general, current hybrid probes are built from various molecular platforms, including small molecules, nanoparticles, and antibodies. Although several TSPO-targeted imaging probes have been developed, their development for image-guided surgery of cancers is scarce. This review highlights recent findings of the involvement of TSPO in carcinogenesis, and provides a new perspective on the potential application of TSPO-targeted hybrid probes for image-guided surgery.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"45 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803837","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnosis Reliability of ChatGPT for Journal Evaluation ChatGPT在期刊评估中的诊断可靠性

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.020

Mehdi Dadkhah, Marilyn H Oermann, Mihály Hegedüs, Raghu Raman, Lóránt Dénes Dávid

引用次数: 0

Lipid-based nanoparticles as oral drug delivery systems: overcoming poor gastrointestinal absorption and enhancing bioavailability of peptide/protein-based drugs 脂质纳米颗粒作为口服给药系统:克服胃肠道吸收不良和提高肽/蛋白基药物的生物利用度

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.016

Soheil Mehrdadi

{"title":"Lipid-based nanoparticles as oral drug delivery systems: overcoming poor gastrointestinal absorption and enhancing bioavailability of peptide/protein-based drugs","authors":"Soheil Mehrdadi","doi":"10.34172/apb.2024.016","DOIUrl":"https://doi.org/10.34172/apb.2024.016","url":null,"abstract":"Delivery and formulation of oral therapeutic peptide/protein-based biotechnological drugs have always been a challenge for the pharmaceutical industry. The bioavailability of oral biopharmaceuticals mainly relies on their gastrointestinal solubility and permeability which are affected by their poor membrane penetration, high molecular weight and proteolytic (chemical and enzymatic) degradation resulting in limited delivery and therapeutic efficacy. The present review article highlights the challenges and limitations of oral delivery of therapeutic peptide/protein-based drugs focusing on the application, potential and importance of solid lipid nanoparticles (SLNs) and nanostructure lipid carriers (NLCs) as lipid-based drug delivery systems (LBDDSs) and their advantages and drawbacks. LBDDSs, due to their lipid-based matrix can encapsulate both lipophilic and hydrophilic drugs, and by reducing the first-pass effect and avoiding proteolytic degradation offer improved drug stability, dissolution rate, absorption, bioavailability and controlled drug release. Furthermore, their small size, high surface area and surface modification increase their mucosal adhesion, tissue-targeted distribution, physiological function and half-life. Properties such as simple preparation, high-scale manufacturing, biodegradability, biocompatibility, prolonged half-life, lower toxicity, lower adverse effects, lipid-based structure, higher drug encapsulation rate and various drug release profile compared to other similar carrier systems makes LBDDSs a promising drug delivery system. Nevertheless, undesired physicochemical features of peptide/protein drug development and discovery such as plasma stability, membrane permeability and circulation half-life remain a serious challenge which should be addressed in future.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"22 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135804136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Intranasal insulin and Cholinergic agonist improve PostCovid-19 Cognition Impairment? 鼻内胰岛素和胆碱能激动剂能改善covid -19后认知障碍吗?

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.017

Amr kamel Ahmed, Mahmoud Elkazzaz, Aml M Brakat

引用次数: 0

The apoptotic, oxidative and histological changes induced by different diameters of sphere gold nanoparticles (GNPs) with special emphasis on the hepatoprotective role of Quercetin 不同直径球形金纳米颗粒(GNPs)诱导的细胞凋亡、氧化和组织学改变，特别强调槲皮素的肝保护作用

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.014

Wael Ghonimi

{"title":"The apoptotic, oxidative and histological changes induced by different diameters of sphere gold nanoparticles (GNPs) with special emphasis on the hepatoprotective role of Quercetin","authors":"Wael Ghonimi","doi":"10.34172/apb.2024.014","DOIUrl":"https://doi.org/10.34172/apb.2024.014","url":null,"abstract":"Purpose: Gold nanoparticles (GNPs) as pharmaceutical and drug delivery tools exhibited harmful effects on human health and other living species. Quercetin reveals various pharmacological effects specially antioxidant, anti-inflammatory and antiapoptotic. This study is directed to investigate hepatotoxicity of GNPs, in addition, to assess the impact of quercetin in mitigating the toxicological effects of GNPs. Methods: Groups of rats were treated with or without sphere GNPs (10, 20 and 50 nm) and quercetin (200 mg/kg b.wt.). Blood and liver samples from euthanized rats were subjected to biochemical, hematological, histopathological, and immunohistochemical investigations. Results: In comparison with 20 and 50 nm treated groups, the 10 nm GNPs significantly increased serum hepatic enzymes; AST, ALT, ALP and bilirubin. These 10 nm GNPs were associated with oxidative stress and markedly decreased antioxidant enzymes: GPX, CAT and SOD. Immunohistochemically, 10 nm GNPs expressed intense positive signals in nuclei of hepatocytes when stained with anti-caspase-3 antibody confirming extensive apoptosis. Pre-cotreatment with quercetin decreased all tested hepatic enzymes and increased serum level of antioxidant enzymes compared to 10 nm GNPs. Quercetin treatment strongly exhibited anti-Ki67 antibody (proliferative marker) indicating high proliferation of hepatic parenchyma. Histopathologically, 10 nm GNPs revealed diffuse hydropic degenerations, severe sinusoidal congestion, coagulative necrosis, sever steatosis and diffuse hemosiderosis within the hepatic parenchyma. Quercetin treatment ameliorated most of these pathological effects. Conclusion: The smaller diameters of GNPs induce potential oxidative stress, cytotoxic, and apoptotic effects in hepatic tissues rather than larger ones. In addition, quercetin demonstrated a significant prophylactic role against hepatotoxicity of GNPs.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"117 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement 透皮给药系统:渗透增强物理方法的重点综述

Advanced pharmaceutical bulletin Pub Date : 2023-10-14 DOI: 10.34172/apb.2024.018

Rifath Sheikh Vaseem, Alison D’cruz, Srishti Shetty, Hafsa -, Aditya Vardhan, Shreya Shenoy R, Shirleen Miriam Marques, Lalit Kumar, Ruchi Verma

{"title":"Transdermal Drug Delivery Systems: A Focused Review of the Physical Methods of Permeation Enhancement","authors":"Rifath Sheikh Vaseem, Alison D’cruz, Srishti Shetty, Hafsa -, Aditya Vardhan, Shreya Shenoy R, Shirleen Miriam Marques, Lalit Kumar, Ruchi Verma","doi":"10.34172/apb.2024.018","DOIUrl":"https://doi.org/10.34172/apb.2024.018","url":null,"abstract":"The skin is the body's largest organ and serves as a site of administration for various medications. Transdermal drug delivery systems have several advantages over traditional delivery systems. It has both local and systemic therapeutic properties. Controlled plasma drug levels, reduced dosing frequency, and avoidance of hepatic first-pass metabolism are just a few of these systems' advantages. To achieve maximum efficacy, it is critical to understand the kinetics, physiochemical properties of the drug moiety, and drug transport route. This manuscript focused on the principles of various physical means to facilitate transdermal drug delivery. Some examples are iontophoresis, electrophoresis, photomechanical waves, ultrasound, needleless injections, and microneedles. Mechanical, chemical, magnetic, and electrical energy are all used in physical methods. A major advantage of physical methods is their capability to abbreviate pain, which can be used for effective disease management. Further investigation should be carried out at the clinical level to understand these methods for effective drug delivery.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":"2011 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-10-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135803828","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0