Advanced pharmaceutical bulletin最新文献_第5页

Low-Affinity NMDA Receptor Antagonist Hemantane in a Topical Formulation Attenuates Arthritis Induced by Freund's Complete Adjuvant in Rats. 局部配方中的低亲和力NMDA受体拮抗剂海曼烷可减轻大鼠由弗氏完全佐剂引起的关节炎

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2024-03-01 Epub Date: 2023-07-19 DOI: 10.34172/apb.2024.002

Elena Ivanova, Alexander Matyushkin, Alexandra Sorokina, Svetlana Alexeeva, Irina Miroshkina, Kirill Kachalov, Tatyana Voronina, Andrey Durnev

{"title":"Low-Affinity NMDA Receptor Antagonist Hemantane in a Topical Formulation Attenuates Arthritis Induced by Freund's Complete Adjuvant in Rats.","authors":"Elena Ivanova, Alexander Matyushkin, Alexandra Sorokina, Svetlana Alexeeva, Irina Miroshkina, Kirill Kachalov, Tatyana Voronina, Andrey Durnev","doi":"10.34172/apb.2024.002","DOIUrl":"10.34172/apb.2024.002","url":null,"abstract":"Purpose: N-methyl-D-aspartate (NMDA) receptors that are expressed by T-cells modulate T-cell proliferation, cytotoxicity and cell migration toward chemokines. Several studies have shown an anti-inflammatory effect of NMDA receptor antagonists. This study compares the effect of the noncompetitive low-affinity NMDA receptor antagonist N-(2-adamantyl)-hexamethyleneimine hydrochloride (hemantane) in a topical formulation (gel) with the cyclooxygenase (COX) inhibitor diclofenac in a topical formulation (gel) in rats with arthritis induced by Freund's Complete Adjuvant (FCA).Methods: On day 14 after an FCA injection into the left hind paw, rats with contralateral hind paw edema were selected for further investigation (29/65). They were treated with 5% hemantane gel or 1% diclofenac gel applied locally to hind paws daily for 2 weeks starting 14 days after the FCA injection. Rats with arthritis were examined hind paw edema, hyperalgesia, and motor deficits; their body weight and hematological parameters were recorded. The rats were euthanized on day 28, followed by histological examination of the ankle joint (HE stain).Results: Rats with arthritis exhibited hind paw inflammation and hyperalgesia, motor deficits, changes of hematological parameters, reduced weight gain and spleen hypertrophy. Histological examination of the ankle joint revealed degenerative-dystrophic lesions of the cartilaginous tissue, proliferative inflammation of the synovium, edema and lymphocytic/macrophage infiltration of periarticular tissues. Hemantane gel reduced hind paw edema, pain, motor deficits and histological signs of inflammation; its effect was comparable to diclofenac gel.Conclusion: Hemantane gel alleviates FCA-induced arthritis in rats, and its effect is comparable to diclofenac gel.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10997923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46124355","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultrasensitive Quantification of MUC16 Antigen/Amine-terminated Aptamer Interaction by Surface Plasmon Resonance: Kinetic and Thermodynamic Studies 通过表面等离子体共振对 MUC16 抗原/氨端肽相互作用进行超灵敏定量：动力学和热力学研究

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2024-01-13 DOI: 10.34172/apb.2024.028

Shahnam Valizadeh Shahbazlou, S. Vandghanooni, Bahareh Dabirmanesh, M. Eskandani, S. Hasannia

{"title":"Ultrasensitive Quantification of MUC16 Antigen/Amine-terminated Aptamer Interaction by Surface Plasmon Resonance: Kinetic and Thermodynamic Studies","authors":"Shahnam Valizadeh Shahbazlou, S. Vandghanooni, Bahareh Dabirmanesh, M. Eskandani, S. Hasannia","doi":"10.34172/apb.2024.028","DOIUrl":"https://doi.org/10.34172/apb.2024.028","url":null,"abstract":"MUC16 is a commonly employed biomarker in the identification and prognosis of ovarian cancer (OC). Precise measurement of MUC16 levels is essential for the accurate diagnosis, prediction, and management of OC. This research seeks to introduce a new surface plasmon resonance (SPR) biosensor design that utilizes aptamer-based technology to enable the sensitive and real-time detection of MUC16. In this study, the sensor chip was immobilized with an anti-MUC16 aptamer (Ap) by utilizing 11-mercaptoundecanoic acid (MUA) as a linker to attach the amine-terminated Ap to the chip using EDC/NHS chemistry. The results indicated that the newly created aptasensor had a detection limit of 0.03 U mL-1 for MUC16 concentration, with a linear range of 0.09 to 0.027 U mL-1. The findings demonstrate good precision and accuracy (<15%) for each MUC16 concentration, with recoveries ranging from 93% to 96%. Additionally, the aptasensor exhibited high selectivity, good repeatability, stability, and applicability in real human serum samples, indicating its potential as a valuable tool for the diagnosis and treatment of ovarian cancer.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Co-targeting of HMG-Co-A Reductase and Cycloxygenase-2 for the Treatment of Non-small Cell Lung Cancer 共同靶向 HMG-Co-A 还原酶和环氧合酶-2 治疗非小细胞肺癌

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2024-01-13 DOI: 10.34172/apb.2024.026

Ashutosh Sharma, Ravi Kiran V V V Ammu, P. Krishnamurthy

引用次数: 0

Ready to Eat Food: A Reason for Enhancement in Multidrug Resistance in Humans 即食食品：人类耐多药能力增强的原因之一

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2024-01-13 DOI: 10.34172/apb.2024.023

Sheetal Negi, Sarika Sharma

{"title":"Ready to Eat Food: A Reason for Enhancement in Multidrug Resistance in Humans","authors":"Sheetal Negi, Sarika Sharma","doi":"10.34172/apb.2024.023","DOIUrl":"https://doi.org/10.34172/apb.2024.023","url":null,"abstract":"The increasing trend of consuming ready-to-eat (RTE) food has become a global phenomenon, and this has raised concerns about the potential negative impacts on human health. Recent studies have shown a correlation between the consumption of RTE foods and the expansion of multidrug resistance (MDR) in humans. MDR is a significant challenge in the effective theory of infectious diseases, as it limits the effectiveness of antibiotics and other drugs used in therapy. Consumption of RTE food contribute to the development of MDR in humans. Additionally, there are potential risks of consuming RTE food contaminated with antibiotic-resistant bacteria, which can cause severe health consequences. The article highlights the need for awareness campaigns on the potential hazard related to the ingestion of RTE food and the importance of responsible and safe food production practices. It also recommends the need for regulatory bodies to establish strict guidelines for the production and distribution of RTE food to ensure that they are free from harmful contaminants and that their consumption does not lead to the development of MDR in humans. Overall, this article provides a comprehensive analysis of the potential negative impacts of RTE food consumption on human health and emphasizes the need for a more cautious approach to food consumption to protect public health.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Methylglyoxal Affects the Expression of miR-125b, miR-107, and Oxidative Stress Pathway-associated Genes in the SH-SY5Y Cell Line 甲基乙二酸影响 miR-125b、miR-107 和氧化应激途径相关基因在 SH-SY5Y 细胞系中的表达

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2024-01-13 DOI: 10.34172/apb.2024.024

B. Shademan, Hadi Yousefi, Alireza Nourazarian

{"title":"Methylglyoxal Affects the Expression of miR-125b, miR-107, and Oxidative Stress Pathway-associated Genes in the SH-SY5Y Cell Line","authors":"B. Shademan, Hadi Yousefi, Alireza Nourazarian","doi":"10.34172/apb.2024.024","DOIUrl":"https://doi.org/10.34172/apb.2024.024","url":null,"abstract":"Purpose: Alzhеimеr's disеasе (AD) is thе most prеvalеnt form of dеmеntia globally. Rеsеarch links thе incrеasе of rеactivе oxidativе spеciеs (ROS) to thе pathogеnеsis of AD; thus, this study invеstigatеd thе impact of mеthylglyoxal (MGO) on thе еxprеssion of miR-125b, miR-107, and gеnеs involvеd in oxidativе strеss signaling in SH-SY5Y cеlls. Methods: Thе MTT assay assеssеd MGO's еffеcts on SH-SY5Y viability. miR-125b and miR-107 еxprеssion was analyzеd via rеal-timе PCR. Additionally, thе Human Oxidativе Strеss Pathway Plus RT2 Profilеr PCR array quantifiеd oxidativе pathway gеnе еxprеssion. Results: MGO concеntrations undеr 700μM did not significantly rеducе SH–SY5Y viability. MiR-125b and miR-107 еxprеssion in SH-SY5Y cеlls incrеasеd and dеcrеasеd rеspеctivеly (p<0. 05). Cеlls trеatеd with 700μM MGO еxhibitеd incrеasеd CCS, CYBB, PRDX3, SPINK1, CYGB, DHCR24 and BAG2 еxprеssion (p<0. 05). Thosе trеatеd with 1400μM MGO showеd incrеasеd CCS, CYBB, PRDX3, SPINK1, DUSP1, EPHX2, EPX, FOXM1, and GPX3 еxprеssion (p<0. 05). Conclusion: MGO altеrs oxidativе strеss pathway gеnе, miR-125b, and miR-107 еxprеssion in SH-SY5Y cеlls. Targеting MGO or miR-125b and miR-107 may providе novеl AD thеrapеutic stratеgiеs or improvе sеvеrе symptoms. Furthеr rеsеarch should еlucidatе thе prеcisе mеchanisms.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139531161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fabrication of Anti-Glaucoma Nanofibers as Controlled-Release Inserts for Ophthalmic Delivery of Brimonidine Tartrate: In Vivo Evaluation in Caprine Eye 制备抗青光眼纳米纤维作为酒石酸溴莫尼定眼部给药的控释插入物：在黄牛眼中进行体内评估

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2024-01-13 DOI: 10.34172/apb.2024.025

Fariba Shaikhi Shoushtari, Mohammadshakib Naghshbandy, Leila Rezaei, Saba Mehrandish, S. Mirzaeei

{"title":"Fabrication of Anti-Glaucoma Nanofibers as Controlled-Release Inserts for Ophthalmic Delivery of Brimonidine Tartrate: In Vivo Evaluation in Caprine Eye","authors":"Fariba Shaikhi Shoushtari, Mohammadshakib Naghshbandy, Leila Rezaei, Saba Mehrandish, S. Mirzaeei","doi":"10.34172/apb.2024.025","DOIUrl":"https://doi.org/10.34172/apb.2024.025","url":null,"abstract":"Background and Purpose: Chronic ailments usually decrease the quality of life due to the requirement for repetitive administration of drugs. Glaucoma is a chronic eye disease occurred because of increased intraocular pressure (IOP). Controlled-release inserts can overcome this challenge by a gradual release of the antiglaucoma drugs. This study aimed to fabricate ocular inserts of brimonidine tartrate (BMD) for the management of glaucoma. Methods: Different polymers including poly (D, L-lactide), polycaprolactone, cellulose acetate, and Eudragit RL100® were used to develop the BMD-loaded nanofibrous inserts by electrospinning technique. The inserts were characterized. The morphology and drug-polymer compatibility were examined by scanning electron microscopy (SEM), and Fourier-transform infrared (FTIR) spectroscopy and in vitro drug release in PBS. The IOP-lowering efficacy and irritancy of optimized formulation were assessed in the Caprines. Results: SEM images demonstrated nanofibers with uniform morphology and a mean diameter < 300 nm were fabricated. The nanofibers were high-strength and flexible enough to be placed in the conjunctival sac. FTIR showed drug-polymer compatibility. In vitro release study indicated a sustained-release profile of the drug during 6 days for inserts. In vivo evaluation indicated that the optimized formulation is capable of maintaining the IOP in a non-glaucomatous range for an extended duration of 6 days. In addition, the formulation was non-irritant to the Caprine eye. Conclusions: Due to the prolonged IOP-lowering efficiency, BMD-loaded nanofibrous inserts can be considered suitable for the controlled release of drugs and thus enhance patient compliance by reducing the frequency of administration.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139530564","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Anti-Inflammatory Potency of Human Wharton’s Jelly Mesenchymal Stem Cell-Derived Exosomes on L2 Cell Line Induced by Lipopolysaccharides 人沃顿果冻间充质干细胞衍生的外泌体对脂多糖诱导的 L2 细胞系的抗炎效力

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2024-01-13 DOI: 10.34172/apb.2024.027

Ika Adhani Sholihah, A. Barlian

{"title":"Anti-Inflammatory Potency of Human Wharton’s Jelly Mesenchymal Stem Cell-Derived Exosomes on L2 Cell Line Induced by Lipopolysaccharides","authors":"Ika Adhani Sholihah, A. Barlian","doi":"10.34172/apb.2024.027","DOIUrl":"https://doi.org/10.34172/apb.2024.027","url":null,"abstract":"Purpose: At present, therapeutic interventions to treat acute lung injury (ALI) remain largely limited to lung-protective strategies, as no real molecular-driven therapeutic intervention has yet become available. The administration of bacterial lipopolysaccharides (LPS) is known as an inflammatory activator, representing a frequently used model of ALI. This study investigated the biological function of normoxic (21% O2) vs. hypoxic conditions (5% O2) obtained from human Wharton’s Jelly Mesenchymal Stem Cells (hWJ-MSCs) and discovered that exosomes have the ability to suppress inflammatory responses by specifically targeting TNF-α, IL-1β, IL-6. and identify the TLR4 NF-κβ gene expression. Methods: Primer culture hWJ-MSCs characterization with trilineage differentiation and CD markers was conducted. To obtain exosomes, hWJ-MSCs were stimulated with two different oxygen levels: 21% (nor-exo) and 5% (hypo-exo). Then, the L2 cell line was induced with LPS 1 µg/mL. Inflamed-L2 was treated with nor-exo, hypo-exo, and dexamethasone as a positive control. The RNA extracted from treated L2 cells was utilized to examine the gene expression profiles of TLR4 and NF-κβ, and the medium was used to measure TNF-α, IL-1β, and IL-6 levels using ELISA. Lastly, proteomic analysis of the exosome using LC/MS-MS was conducted. Results: Nor-exo and hypo-exo can be characterized and can produce higher yields exosomes under hypoxic conditions. The expression of TLR4 and NF-κβ genes and the proinflammatory levels such as IL-6, IL-1β, and TNF-α levels in nor-exo and hypo-exo treatments decreased. Conclusion: Nor-exo and hypo-exo derived from hWJ-MSCs were proven to have anti-inflammatory activities.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2024-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139530569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Xenogeneic Transplantation Promoted Human Exosome Sequestration in Rat Specific Organs 异种器官移植促进人类外泌体在大鼠特定器官中的封存

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2023-12-04 DOI: 10.34172/apb.2024.022

Halimeh Mobarak, M. Mahdipour, Arshad Ghaffari-Nasab, R. Rahbarghazi

{"title":"Xenogeneic Transplantation Promoted Human Exosome Sequestration in Rat Specific Organs","authors":"Halimeh Mobarak, M. Mahdipour, Arshad Ghaffari-Nasab, R. Rahbarghazi","doi":"10.34172/apb.2024.022","DOIUrl":"https://doi.org/10.34172/apb.2024.022","url":null,"abstract":"Purpose Exosomes (Exos) are introduced as novel cell-free therapeutics with multiple benefits alongside and/or over-cell therapy. Here, we aimed to study the distribution pattern of normal and cancer xenogeneic Exos and possible interspecies reactions in a rat model. Methods Exos were isolated from normal HUVECs and MDA-MB-231 breast cancer cells. Values like mean diameter size and zeta potential distribution were studied using DLS. The morphology of isolated Exos was monitored by SEM images. Using western blotting, protein levels of exosomal tetraspanins were detected. For the in vivo study, Dil-labeled normal and cancer Exos were injected into the tail vein (100 µg exosomal protein/rat) three times at 1-hour intervals. After 24 hours, rats were euthanized and the cellular uptake of Exos was monitored in different organs using immunofluorescence staining (IF). Results The size distribution and mean zeta potential of HUVEC and MDA-MB-231 cells Exos were 80 ± 29.94 and 64.77 ± 25.49 nm, and −7.58 and −11.8 mV, respectively. Western blotting revealed CD9, CD81, and CD63 in normal and cancer Exos. The SEM images exhibited typical nano-sized round-shape Exo particles. IF staining indicated sequestration of administrated Exos in splenic tissue and lungs. The distribution of Exo in kidneys, aorta, and hepatic tissue was less. These features were more evident in the group that received cancer Exos. We found no obvious adverse effects in rats that received normal or cancer Exos. Conclusion Data indicated that both normal and cancerous xenogeneic human Exos can be sequestrated prominently in splenic tissue and lungs. Novel delivery approaches and engineering tools are helpful in the target delivery of administrated Exos to the injured sites","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138604455","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching. Crispr/cas9切除BCL11A揭示可能具有球蛋白转换作用的基因

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2023-11-01 Epub Date: 2023-02-21 DOI: 10.34172/apb.2023.074

Fatemeh Movahedi Motlagh, Hamid Reza Soleimanpour-Lichaei, Mehdi Shamsara, Azadeh Etemadzadeh, Mohammad Hossein Modarressi

{"title":"CRISPR/Cas9 Ablated BCL11A Unveils the Genes with Possible Role of Globin Switching.","authors":"Fatemeh Movahedi Motlagh, Hamid Reza Soleimanpour-Lichaei, Mehdi Shamsara, Azadeh Etemadzadeh, Mohammad Hossein Modarressi","doi":"10.34172/apb.2023.074","DOIUrl":"10.34172/apb.2023.074","url":null,"abstract":"Purpose: Fetal hemoglobin (HbF) upregulation is a mitigating factor in β-hemoglobinopathies therapy like β-thalassemia and sickle cell diseases. Finding molecular mechanisms and the key regulators responsible for globin switching could be helpful to develop effective ways to HbF upregulation. In our prior in silico report, we identified a few factors that are likely to be responsible for globin switching. The goal of this study is to experimentally validate the factors.Methods: We established K562 cell line with BCL11A knock down leading to increase in HBG1/2 using CRISPR/Cas9 system. Then, using quantitative polymerase chain reaction (qPCR), we determined the expression level of the factors which were previously identified in our prior in silico study.Results: our analysis showed that BCL11A was substantially knocked down, resulting in the upregulation of HBG1/2 in the BCL11A-ablated K562 cells using CRISPR/Cas9 system. Additionally, the experimental data acquired in this study validated our prior bioinformatics findings about three potentially responsible genes for globin switching, namely HIST1H2Bl, TRIM58, and Al133243.2.Conclusion: BCL11A is a promising candidate for the treatment of β-hemoglobinopathies, with high HbF reactivation. In addition, HIST1H2BL, TRIM58 and Al133243.2 are likely to be involved in the mechanism of hemoglobin switching. To further validate the selected genes, more experimental in vivo and in vitro studies are required.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676543/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43326046","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Toolkit for Detecting Fallacious Calls for Papers from Potential Predatory Journals. 用于检测潜在掠夺性期刊对论文的虚假呼吁的工具包

IF 3.6

Advanced pharmaceutical bulletin Pub Date : 2023-11-01 Epub Date: 2023-01-23 DOI: 10.34172/apb.2023.068

Mehdi Dadkhah, Abdul Majed Raja, Aamir Raoof Memon, Glenn Borchardt, Prema Nedungadi, Khaled Abu-Eteen, Raghu Raman

{"title":"A Toolkit for Detecting Fallacious Calls for Papers from Potential Predatory Journals.","authors":"Mehdi Dadkhah, Abdul Majed Raja, Aamir Raoof Memon, Glenn Borchardt, Prema Nedungadi, Khaled Abu-Eteen, Raghu Raman","doi":"10.34172/apb.2023.068","DOIUrl":"10.34172/apb.2023.068","url":null,"abstract":"Purpose: Flattering emails are crucial in tempting authors to submit papers to predatory journals. Although there is ample literature regarding the questionable practices of predatory journals, the nature and detection of spam emails need more attention. Current research provides insight into fallacious calls for papers from potential predatory journals and develops a toolkit in this regard.Methods: In this study, we analyzed three datasets of calls for papers from potential predatory journals and legitimate journals using a text mining approach and R programming language.Results: Overall, most potential predatory journals use similar language and templates in their calls for papers. Importantly, these journals praise themselves in glorious terms involving positive words that may be rarely seen in emails from legitimate journals. Based on these findings, we developed a lexicon for detecting unsolicited calls for papers from potential predatory journals.Conclusion: We conclude that calls for papers from potential predatory journals and legitimate journals are different, and it can help to distinguish them. By providing an educational plan and easily usable tools, we can deal with predatory journals better than previously.","PeriodicalId":7256,"journal":{"name":"Advanced pharmaceutical bulletin","volume":null,"pages":null},"PeriodicalIF":3.6,"publicationDate":"2023-11-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10676554/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45176237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 1