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Front Cover: Tuning the Kinetic Trapping in Chemically Fueled Self-Assembly (ChemSystemsChem 1/2023) 封面：调整化学燃料自组装中的动力学陷阱（ChemSystemsChem 1/2023）
ChemSystemsChem Pub Date : 2022-12-15 DOI: 10.1002/syst.202200047
Brigitte A. K. Kriebisch, Christine M. E. Kriebisch, Alexander M. Bergmann, Dr. Caren Wanzke, Dr. Marta Tena-Solsona, Prof. Dr. Job Boekhoven
{"title":"Front Cover: Tuning the Kinetic Trapping in Chemically Fueled Self-Assembly (ChemSystemsChem 1/2023)","authors":"Brigitte A. K. Kriebisch,&nbsp;Christine M. E. Kriebisch,&nbsp;Alexander M. Bergmann,&nbsp;Dr. Caren Wanzke,&nbsp;Dr. Marta Tena-Solsona,&nbsp;Prof. Dr. Job Boekhoven","doi":"10.1002/syst.202200047","DOIUrl":"https://doi.org/10.1002/syst.202200047","url":null,"abstract":"<p><b>The Front Cover</b> represents an energy landscape of kinetically trapped chemical-fueled fibers, which reminds of a mountain landscape. Our work unravels how tuning the kinetic trapping in chemical-fueled self-assemblies can recover dynamic instabilities, such as microtubule-like growth and shrinkage. This opens the door to the creation of new adaptive nanotechnologies. More information can be found in the Research Article by Job Boekhoven and co-workers.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200047","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50150952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A Primer on Building Life-Like Systems 构建类生命系统的入门手册
ChemSystemsChem Pub Date : 2022-12-08 DOI: 10.1002/syst.202200033
Dr. Mahesh A. Vibhute, Prof. Dr. Hannes Mutschler
{"title":"A Primer on Building Life-Like Systems","authors":"Dr. Mahesh A. Vibhute,&nbsp;Prof. Dr. Hannes Mutschler","doi":"10.1002/syst.202200033","DOIUrl":"10.1002/syst.202200033","url":null,"abstract":"<p>The quest to understand life and recreate it in vitro has been undertaken through many different routes. These different approaches for experimental investigation of life aim to piece together the puzzle either by tracing life's origin or by synthesizing life-like systems from non-living components. Unlike efforts to define life, these experimental inquiries aim to recapture specific features of living cells, such as reproduction, self-organization or metabolic functions that operate far from thermodynamic equilibrium. As such, these efforts have generated significant insights that shed light on crucial aspects of biological functions. For observers outside these specific research fields, it sometimes remains puzzling what properties an artificial system would need to have in order to be recognized as most similar to life. In this Perspective, we discuss properties whose realization would, in our view, allow the best possible experimental emulation of a minimal form of biological life.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200033","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49045803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Functional Rhythmic Chemical Systems Governed by pH-Driven Kinetic Feedback pH驱动动力学反馈控制的功能节律化学系统
ChemSystemsChem Pub Date : 2022-11-22 DOI: 10.1002/syst.202200032
Dr. Brigitta Dúzs, Dr. István Lagzi, Dr. István Szalai
{"title":"Functional Rhythmic Chemical Systems Governed by pH-Driven Kinetic Feedback","authors":"Dr. Brigitta Dúzs,&nbsp;Dr. István Lagzi,&nbsp;Dr. István Szalai","doi":"10.1002/syst.202200032","DOIUrl":"10.1002/syst.202200032","url":null,"abstract":"<p>Hydrogen ion autocatalytic reactions, especially in combination with an appropriate negative feedback process, show a wide range of dynamical phenomena, like clock behavior, bistability, oscillations, waves, and stationary patterns. The temporal or spatial variation of pH caused by these reactions is often significant enough to control the actual state (geometry, conformation, reactivity) or drive the mechanical motion of coupled pH-sensitive physico-chemical systems. These autonomous operating systems provide nonlinear chemistry's most reliable applications, where the hydrogen ion autocatalytic reactions act as engines. This review briefly summarizes the nonlinear dynamics of these reactions and the different approaches developed to properly couple the pH-sensitive units (e. g., pH-sensitive equilibria, gels, molecular machines, colloids). We also emphasize the feedback of the coupled processes on the dynamics of the hydrogen ion autocatalytic reactions since the way of coupling is a critical operational issue.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200032","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"42345101","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Generation of Bilayer Asymmetry and Membrane Curvature by the Sugar-Cleaving Enzyme Invertase 糖裂解酶转化酶产生双层不对称性和膜曲率
ChemSystemsChem Pub Date : 2022-11-07 DOI: 10.1002/syst.202200027
Abhimanyu Nowbagh, Akshi Deshwal, Mayur Kadu, Dr. Abhishek Chaudhuri, Dr. Subhabrata Maiti, Prof. Dr. Reinhard Lipowsky, Dr. Tripta Bhatia
{"title":"Generation of Bilayer Asymmetry and Membrane Curvature by the Sugar-Cleaving Enzyme Invertase","authors":"Abhimanyu Nowbagh,&nbsp;Akshi Deshwal,&nbsp;Mayur Kadu,&nbsp;Dr. Abhishek Chaudhuri,&nbsp;Dr. Subhabrata Maiti,&nbsp;Prof. Dr. Reinhard Lipowsky,&nbsp;Dr. Tripta Bhatia","doi":"10.1002/syst.202200027","DOIUrl":"10.1002/syst.202200027","url":null,"abstract":"<p>The catalytic action of invertase generates bilayer asymmetry that stabilises membrane curvature. The driving mechanism for the generation of membrane curvature by invertase is investigated using giant unilamellar vesicles (GUVs). The invertase cleaves the sucrose in the exterior compartment, thereby creating a sugar asymmetry across the bilayer membrane that is measured for GUV membranes consisting of the lipid Dioleoylphosphatidylcholine (DOPC). Finally, the advantage of this method to control membrane curvature and to stabilize multi-sphere morphologies is demonstrated. The GUV system in the presence of invertase is beneficial as a tool to generate multiple on-demand compartments with more extended stability after the enzymatic activity has established the asymmetry.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200027","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41325048","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 2
Designed Complex Peptide-Based Adaptive Systems: A Bottom-Up Approach 设计复杂的基于肽的自适应系统:一种自下而上的方法
ChemSystemsChem Pub Date : 2022-11-03 DOI: 10.1002/syst.202200040
Dr. Salma Kassem, Prof. Dr. Rein V. Ulijn
{"title":"Designed Complex Peptide-Based Adaptive Systems: A Bottom-Up Approach","authors":"Dr. Salma Kassem,&nbsp;Prof. Dr. Rein V. Ulijn","doi":"10.1002/syst.202200040","DOIUrl":"10.1002/syst.202200040","url":null,"abstract":"<p>Systems chemistry represents a shift from studying molecules in isolation to studying the collective behavior of mixtures or ensembles of reacting and interacting molecules. This research direction provides new ways to build and understand collective chemical properties and emergent functions that are inaccessible using conventional, reductionist, chemistry approaches. This field exemplifies fundamental connections between chemistry and biology, and has the potential to give rise to completely new ways for chemists to approach and resolve wide-ranging issues related to all aspects of living systems, that themselves are complex systems. Short peptides, while simple in design, carry rich and versatile information encoded in sequence specific side-chain interactions, that makes it possible to access a high level of complex, information rich systems with emergent properties from Life's simplified building blocks. This review focuses on recent developments in the synthesis of complex adaptive systems based on peptides, where multiple components are designed to cooperatively interact, react and collectively adapt to their context.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-11-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45747917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Carbodiimide-Induced Formation of Transient Polyether Cages 碳二酰亚胺诱导瞬态聚醚笼的形成
ChemSystemsChem Pub Date : 2022-10-17 DOI: 10.1002/syst.202200037
Dr. Mohammad Mosharraf Hossain, Dr. Isuru M. Jayalath, Renuka Baral, Dr. C. Scott Hartley
{"title":"Carbodiimide-Induced Formation of Transient Polyether Cages","authors":"Dr. Mohammad Mosharraf Hossain,&nbsp;Dr. Isuru M. Jayalath,&nbsp;Renuka Baral,&nbsp;Dr. C. Scott Hartley","doi":"10.1002/syst.202200037","DOIUrl":"https://doi.org/10.1002/syst.202200037","url":null,"abstract":"<p>The front cover artwork is provided by the Hartley group at Miami University. The image shows a cartoon of transient molecular cages generated through the action of a chemical fuel on macrocycles with pendant groups. The cages are able to bind ions. Read the full text of the Research Article at 10.1002/syst.202200016.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200037","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137692424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cover Feature: Dissipative Dynamic Libraries (DDLs) and Dissipative Dynamic Combinatorial Chemistry (DDCC) (ChemSystemsChem 6/2022) 封面特征:耗散动态库(ddl)和耗散动态组合化学(DDCC) (chemsystemscheme 6/2022)
ChemSystemsChem Pub Date : 2022-10-17 DOI: 10.1002/syst.202200039
Daniele Del Giudice, Emanuele Spatola, Matteo Valentini, Prof. Gianfranco Ercolani, Prof. Stefano Di Stefano
{"title":"Cover Feature: Dissipative Dynamic Libraries (DDLs) and Dissipative Dynamic Combinatorial Chemistry (DDCC) (ChemSystemsChem 6/2022)","authors":"Daniele Del Giudice,&nbsp;Emanuele Spatola,&nbsp;Matteo Valentini,&nbsp;Prof. Gianfranco Ercolani,&nbsp;Prof. Stefano Di Stefano","doi":"10.1002/syst.202200039","DOIUrl":"https://doi.org/10.1002/syst.202200039","url":null,"abstract":"<p><b>The Cover Feature</b> shows puzzle pieces that initially change their shape, and consequently their interconnection, to eventually go back to their initial state, resembling the behavior of the components in a dissipative dynamic combinatorial library. Design by Daniele Del Giudice. More information can be found in the Concept by Gianfranco Ercolani, Stefano Di Stefano and co-workers.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200039","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137692421","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Front Cover: Carbodiimide-Induced Formation of Transient Polyether Cages (ChemSystemsChem 6/2022) 封面:碳二酰亚胺诱导形成瞬态聚醚笼(chemsystemscheme 6/2022)
ChemSystemsChem Pub Date : 2022-10-17 DOI: 10.1002/syst.202200038
Dr. Mohammad Mosharraf Hossain, Dr. Isuru M. Jayalath, Renuka Baral, Dr. C. Scott Hartley
{"title":"Front Cover: Carbodiimide-Induced Formation of Transient Polyether Cages (ChemSystemsChem 6/2022)","authors":"Dr. Mohammad Mosharraf Hossain,&nbsp;Dr. Isuru M. Jayalath,&nbsp;Renuka Baral,&nbsp;Dr. C. Scott Hartley","doi":"10.1002/syst.202200038","DOIUrl":"https://doi.org/10.1002/syst.202200038","url":null,"abstract":"<p><b>The Front Cover</b> illustrates the formation of molecular cages through the action of a chemical “fuel” on macrocyclic precursors. The cages exist for only a short time but are able to bind appropriate cations. More information can be found in the Research Article by C. Scott Hartley and co-workers.\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure>\u0000 </p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://chemistry-europe.onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200038","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"137692425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Iron-Mediated Peptide Formation in Water and Liquid Sulfur Dioxide under Prebiotically Plausible Conditions** 益生元条件下水和液体二氧化硫中铁介导的肽形成
ChemSystemsChem Pub Date : 2022-10-17 DOI: 10.1002/syst.202200034
Constanze Sydow, Dr. Fabian Sauer, Dr. Alexander F. Siegle, Prof. Dr. Oliver Trapp
{"title":"Iron-Mediated Peptide Formation in Water and Liquid Sulfur Dioxide under Prebiotically Plausible Conditions**","authors":"Constanze Sydow,&nbsp;Dr. Fabian Sauer,&nbsp;Dr. Alexander F. Siegle,&nbsp;Prof. Dr. Oliver Trapp","doi":"10.1002/syst.202200034","DOIUrl":"10.1002/syst.202200034","url":null,"abstract":"<p>Peptides have essential structural and catalytic functions in living organisms. The formation of peptides requires the overcoming of thermodynamic and kinetic barriers. In recent years, various formation scenarios that may have occurred during the origin of life have been investigated, including iron(III)-catalyzed condensations. However, iron(III)-catalysts require elevated temperatures and the catalytic activity in peptide bond forming reactions is often low. It is likely that in an anoxic environment such as that of the early Earth, reduced iron compounds were abundant, both on the Earth's surface itself and as a major component of iron meteorites. In this work, we show that reduced iron activated by acetic acid mediates efficiently peptide formation. We recently demonstrated that, compared to water, liquid sulfur dioxide (SO<sub>2</sub>) is a superior reaction medium for peptide formations. We thus investigated both and observed up to four amino acid/peptide coupling steps in each solvent. Reaction with diglycine (G<sub>2</sub>) formed 2.0 % triglycine (G<sub>3</sub>) and 7.6 % tetraglycine (G<sub>4</sub>) in 21 d. Addition of G<sub>3</sub> and dialanine (A<sub>2</sub>) yielded 8.7 % G<sub>4</sub>. Therefore, this is an efficient and plausible route for the formation of the first peptides as simple catalysts for further transformations in such environments.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200034","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49619883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Tuning the Kinetic Trapping in Chemically Fueled Self-Assembly** 调整化学燃料自组装中的动力学捕获
ChemSystemsChem Pub Date : 2022-10-06 DOI: 10.1002/syst.202200035
Brigitte A. K. Kriebisch, Christine M. E. Kriebisch, Alexander M. Bergmann, Dr. Caren Wanzke, Dr. Marta Tena-Solsona, Prof. Dr. Job Boekhoven
{"title":"Tuning the Kinetic Trapping in Chemically Fueled Self-Assembly**","authors":"Brigitte A. K. Kriebisch,&nbsp;Christine M. E. Kriebisch,&nbsp;Alexander M. Bergmann,&nbsp;Dr. Caren Wanzke,&nbsp;Dr. Marta Tena-Solsona,&nbsp;Prof. Dr. Job Boekhoven","doi":"10.1002/syst.202200035","DOIUrl":"10.1002/syst.202200035","url":null,"abstract":"<p>Nature uses dynamic, molecular self-assembly to create cellular architectures that adapt to their environment. For example, a guanosine triphosphate (GTP)-driven reaction cycle activates and deactivates tubulin for dynamic assembly into microtubules. Inspired by dynamic self-assembly in biology, recent studies have developed synthetic analogs of assemblies regulated by chemically fueled reaction cycles. A challenge in these studies is to control the interplay between rapid disassembly and kinetic trapping of building blocks known as dynamic instabilities. In this work, we show how molecular design can tune the tendency of molecules to remain trapped in their assembly. We show how that design can alter the dynamic of emerging assemblies. Our work should give design rules for approaching dynamic instabilities in chemically fueled assemblies to create new adaptive nanotechnologies.</p>","PeriodicalId":72566,"journal":{"name":"ChemSystemsChem","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/syst.202200035","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"44623026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 3
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